ALEXIS Biochemicals: Rifampicin

ALX-380-071

Revised 12-Oct-07

Rifampicin
SYNONYMS	Rifampin 3-(4-Methylpiperazinyl-iminomethyl)rifamycin SV
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Antibiotics for Cell Cycle Research

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-380-071-M100		100 mg	18.00 USD

Product Specification

FORMULA:	C₄₃H₅₈N₄O₁₂
MW:	823.0
CAS NUMBER:	13292-46-1
MERCK INDEX:	14: 8216
SOURCE/HOST:	Semisynthetic.
PURITY:	≥95%
SOLUBILITY:	Soluble in chloroform or DMSO.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HAZARD:	TOXIC.

Product Description

Antibacterial (tuberculostatic). Inhibits DNA-dependent RNA polymerase. Potent inducer of hepatic cytochrome P450 enzymes.

Product Specific Literature References

Rifampicin: a new orally active rifamycin: N. Maggi, et al.; Chemotherapy 11, 285 (1966) Abstract
Rifampicin sensitivity of the components of DNA-dependent RNA polymerase: E. di Mauro, et al.; Nature 222, 533 (1969) Abstract
Chemical and biological properties of rifampicin: S. Furesz; Antibiot. Chemother. 16, 316 (1970) Abstract
On the mechanism of rifampicin inhibition of RNA synthesis: W.R. McClure and C.L. Cech; J. Biol. Chem. 253, 8949 (1978) Abstract
Pharmacokinetic drug interactions with rifampicin: K. Venkatesan; Clin. Pharmacokinet. 22, 47 (1992), Review Abstract
Pharmacokinetic interactions with rifampicin : clinical relevance: M. Niemi, et al.; Clin. Pharmacokinet. 42, 819 (2003), Review Abstract
Roles of rifampicin in drug-drug interactions: underlying molecular mechanisms involving the nuclear pregnane X receptor: J. Chen and K. Raymond; Ann. Clin. Microbiol. Antimicrob. 50, 3 (2006), Review Abstract

Further Categories Containing This Product:

Other Antibiotics - DNA Regulation/Transcription • Cytochrome P450 [CYP450]/Related Products • RNA Polymerases/Related Products

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