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ALX-270-118 Revised 28-Jul-08
Ro 20-1724
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SYNONYMS 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Phosphodiesterases / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-118-M050   50 mg 28.00 USD Add To Cart
ALX-270-118-M100   100 mg 45.00 USD Add To Cart
ALX-270-118-M250   250 mg 98.00 USD Add To Cart
Product Specification
FORMULA: C15H22N2O3
MW: 278.4
CAS NUMBER: 29925-17-5
PURITY: ≥99% (TLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in 100% ethanol (40mg/ml) or DMSO (200 mg/ml); insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
USE/STABILITY: Solutions are stable for up to 3 months when stored at -20°C.
MELTINGPOINT: 126-127°C

Product Description
Selective, potent cAMP phosphodiesterase inhibitor. Inhibits superoxide generation and platelet aggregation stimulated by arachidonic acid. Also inhibits fMLP-induced neutrophil adhesion to vascular endothelial cells.
Product Specific Literature References
Structure-activity relationships for inhibitors of phosphodiesterase from erythrocytes and other tissues: H. Sheppard, et al.; Adv. Cycl. Nucl. Res. 1, 103 (1972) Abstract
Effects of antiallergic agents, compound 48/80, and some reference inhibitors on the activity of partially purified human lung tissue adenosine cyclic 3',5'-monophosphate and guanosine cyclic 3',5'- monophosphate phosphodiesterases: H. Bergstrand, et al.; Mol. Pharmacol. 13, 38 (1977) Abstract
Selective inhibition of cyclic AMP and cyclic GMP phosphodiesterases of cardiac nuclear fraction: G.S. Ahluwalia & A.R. Rhoads; Biochem. Pharmacol. 31, 665 (1982) Abstract
Evidence for mediation of acetyl glyceryl ether phosphorylcholine stimulation of adenosine 3',5'-(cyclic)monophosphate levels in human polymorphonuclear leukocytes by leukotriene B4: N.K. Hopkins, et al.; Biochim. Biophys. Acta 763, 276 (1983) Abstract
Tissue and substrate specificity of inhibition by alkoxy-aryl-lactams of platelet and arterial smooth muscle cyclic nucleotide phosphodiesterases relationship to pharmacological activity: C. Lugnier, et al.; BBRC 113, 954 (1983) Abstract
Receptor-specific threshold effects of cyclic AMP are involved in the regulation of enzyme release and superoxide production from human neutrophils: P.M. Lad, et al.; Biochim. Biophys. Acta 846, 286 (1985) Abstract
The identification of a new cyclic nucleotide phosphodiesterase activity in human and guinea-pig cardiac ventricle. Implications for the mechanism of action of selective phosphodiesterase inhibitors: M.L. Reeves, et al.; Biochem. J. 241, 535 (1987) Abstract
Differential effects of Ro 20-1724 and isobutylmethylxanthine on the basal force of contraction and beta-adrenoceptor-mediated response in the rat ventricular myocardium: Y. Katano & M. Endoh; BBRC 167, 123 (1990) Abstract
A cell culture model of the blood-brain barrier: L.L. Rubin, et al.; J. Cell. Biol. 115, 1725 (1991) Abstract
Inhibition of chemotactic peptide-induced neutrophil adhesion to vascular endothelium by cAMP modulators: C.K. Derian, et al.; J. Immunol. 154, 308 (1995) Abstract
 
 
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