ALEXIS Biochemicals: Rolipram

ALX-270-119

Revised 09-Mar-06

Rolipram
SYNONYMS	4-[3-(Cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	Phosphodiesterases / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-119-M005		5 mg	30.00 USD
ALX-270-119-M025		25 mg	115.00 USD

Product Specification

FORMULA:	C₁₆H₂₁NO₃
MW:	275.4
CAS NUMBER:	61413-54-5
MERCK INDEX:	14: 8251
RTECS:	UY5749237
PURITY:	≥98%
APPEARANCE:	White to off-white solid.
SOLUBILITY:	Soluble in DMSO, 100% ethanol or acetone.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C
HAZARD:	IRRITANT.

Product Description

Selective inhibitor of phosphodiesterase 4 (PDE4).

Product Specific Literature References

Stereospecific binding of the antidepressant rolipram to brain protein structures: H.H. Schneider, et al.; Eur. J. Pharmacol. 127, 105 (1986) Abstract
The identification of a new cyclic nucleotide phosphodiesterase activity in human and guinea-pig cardiac ventricle. Implications for the mechanism of action of selective phosphodiesterase inhibitors: M.L. Reeves, et al.; Biochem. J. 241, 535 (1987) Abstract
Bemoradan--a novel inhibitor of the rolipram-insensitive cyclic AMP phosphodiesterase from canine heart tissue: J.B. Moore, et al.; Biochem. Pharmacol. 42, 679 (1991) Abstract
Comparison of phosphodiesterase III, IV and dual III/IV inhibitors on bronchospasm and pulmonary eosinophil influx in guinea pigs: D.C. Underwood, et al.; J. Pharmacol. Exp. Ther. 270, 250 (1994) Abstract

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