ALEXIS Biochemicals: Rosiglitazone

ALX-350-125

Revised 21-Sep-07

Rosiglitazone
PRODUCT LINE	DNA Regulation / Transcription
PRODUCT CATEGORY	PPAR Agonists

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-350-125-M025		25 mg	98.00 USD
ALX-350-125-M100		100 mg	280.00 USD

Product Specification

FORMULA:	C₁₈H₁₉N₃O₃S
MW:	357.4
CAS NUMBER:	122320-73-4
MERCK INDEX:	14: 8265
PURITY:	≥97% (¹H-NMR)
APPEARANCE:	White to off-white solid.
SOLUBILITY:	Soluble in DMSO (>25mg/ml), 100% ethanol or methanol.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C
USE/STABILITY:	Stable for 2 years after receipt when stored at +4°C. Stock solutions are stable for up to 3 months when stored at -20°C.

Product Description

Potent insulin sensitizing agent. Peroxisome proliferator-activated receptor γ (PPAR-γ) agonist. Hepatoxic. Antidiabetic.

Product Specific Literature References

Differential activity of rosiglitazone enantiomers at PPAR gamma: D.J. Parks, et al.; Bioorg. Med. Chem. Lett. 81, 3657 (1998) Abstract
Rosiglitazone: J.A. Balfour & G.L. Plosker; Drugs 57, 921 (1999), (Review) Abstract
Differential effects of insulin-sensitizers troglitazone and rosiglitazone on ion currents in rat vascular myocytes: G.A. Knock, et al.; Eur. J. Pharmacol. 368, 103 (1999) Abstract
Rosiglitazone: an agent from the thiazolidinedione class for the treatment of type 2 diabetes: A. Cheng-Lai & A. Levine; Heart Dis. 2, 326 (2000), (Review) Abstract
Rosiglitazone in the treatment of type 2 diabetes mellitus: a critical review: J.M. Malinowski & S. Bolesta; Clin. Ther. 22, 1151 (2000), (Review) Abstract
Rosiglitazone (Avandia): hepatic, cardiac and hematological reactions: M. McMorran & D. Vu; CMAJ 165, 82 (2001) Abstract
A review of rosiglitazone in type 2 diabetes mellitus: A.L. Werner & M.T. Travaglini; Pharmacotherapy 21, 1082 (2001), (Review) Abstract

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