ALEXIS Biochemicals: Rotenone

ALX-350-360

Revised 28-May-08

Rotenone
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Other Toxins

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-350-360-G001		1 g	45.00 USD
ALX-350-360-G005		5 g	125.00 USD

Product Specification

FORMULA:	C₂₃H₂₂O₆
MW:	394.4
CAS NUMBER:	83-79-4
MERCK INDEX:	14: 8271
RTECS:	DJ2800000
SOURCE/HOST:	Synthetic. Originally isolated from Lonchocarpus sp. or Derris sp.
PURITY:	≥98% (Assay)
APPEARANCE:	White to off-white solid.
SOLUBILITY:	Soluble in DMSO or 100% ethanol; slightly soluble in water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HANDLING:	Protect from light.
HAZARD:	TOXIC.

Product Description

Insecticide. Inhibitor of mitochondrial electron transport. Specifically inhibits NAD-linked substrate oxidation at the oxygen side of NADH dehydrogenase (EC₅₀=10pmol/mg). Inhibits mammalian cell proliferation by inhibiting microtubule assembly through tubulin binding.

Product Specific Literature References

Metabolism of rotenone in vitro by tissue homogenates from mammals and insects: J.I. Fukami, et al.; Science 155, 713 (1967) Abstract
[3H]dihydrorotenone binding to NADH: ubiquinone reductase (complex I) of the electron transport chain: an autoradiographic study: D.S. Higgins, Jr. & J.T. Greenamyre; J. Neurosci. 16, 3807 (1996) Abstract; Full Text
Rotenone induces oxidative stress and dopaminergic neuron damage in organotypic substantia nigra cultures: C.M. Testa, et al.; Brain Res. Mol. Brain Res. 134, 109 (2005) Abstract; Full Text
Fatality after deliberate ingestion of the pesticide rotenone: a case report: D.M. Wood, et al.; Crit Care 9, R280 (2005) Abstract; Full Text
Neurotrophic factors stabilize microtubules and protect against rotenone toxicity on dopaminergic neurons: Q. Jiang, et al.; J. Biol. Chem. 281, 29391 (2006) Abstract
Identification of novel proteins affected by rotenone in mitochondria of dopaminergic cells: J. Jin, et al.; BMC Neurosci. 8, 67 (2007) Abstract; Full Text
Rotenone inhibits mammalian cell proliferation by inhibiting microtubule assembly through tubulin binding: P. Srivastava & D. Panda; FEBS J. 274, 4788 (2007) Abstract
Protection by the NDI1 Gene against Neurodegeneration in a Rotenone Rat Model of Parkinson’s Disease: M. Marella, et al.; PLoS ONE 3, e1433 (2008) Abstract; Full Text

Further Categories Containing This Product:

Apoptosome Other Products • Natural Products for Cytoskeletal Research • Respiratory Chain Other Products • Pesticides / Related Products

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