• Home
  • Sitemap
  • Help
  • Technical Support
  • Contact
Toolbar - View Selection
 
Items 1 of 1
ALX-380-300 Revised 04-Aug-08 New product
Rufloxacin . hydrochloride
Add to Clipboard
SYNONYMS 6-Fluoro-2,3-dihydro-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzothiazine-6-carboxylic acid . hydrochloride
MF-934 . hydrochloride
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-380-300-M050   50 mg 50.00 USD Add To Cart
ALX-380-300-M250   250 mg 200.00 USD Add To Cart
Product Specification
FORMULA: C17H18FN3O3S . HCl
MW: 363.4 . 36.5
CAS NUMBER: 106017-08-7
MERCK INDEX: 14: 8294
PURITY: ≥98% (Assay)
APPEARANCE: Off-white to light green crystalline solid.
SOLUBILITY: Sparingly soluble in water; very slightly soluble in methanol; almost insoluble in chloroform or acetic acid.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
IDENTITY: Identity determined by IR.

Product Description
Fluoroquinolone antibacterial agent. Structurally similar to ofloxacin (Prod. No. ALX-380-297). Specific inhibitor of bacterial DNA gyrase (topoisomerase). Inhibits B-cell differentiation. Shows photosensitizing effects.
Product Specific Literature References
Quinolonecarboxylic acids. 2. Synthesis and antibacterial evaluation of 7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzothiazine-6-carboxylic acids: V. Cecchetti, et al.; J. Med. Chem. 30, 465 (1987) Abstract
The in-vitro activity of two new quinolones: rufloxacin and MF 961: R. Wise, et al.; J. Antimicrob. Chemother. 29, 649 (1992) Abstract
Effect of rufloxacin on in-vitro proliferation and differentiation of human mononuclear cells: S. Gollapudi, et al.; J. Antimicrob. Chemother. 29, 669 (1992) Abstract
Multiple-dose pharmacokinetics and safety of rufloxacin in normal volunteers: J.C. Kisicki, et al.; Antimicrob. Agents Chemother. 36, 1296 (1992) Abstract; Full Text
Double-blind, comparative study of rufloxacin once daily versus amoxicillin three times a day in treatment of outpatients with exacerbations of chronic bronchitis: W. Klietmann, et al.; Antimicrob. Agents Chemother. 37, 2298 (1993) Abstract; Full Text
Rufloxacin once daily versus ofloxacin twice daily for treatment of complicated cystitis and upper urinary tract infections. Italian Multicentre UTI Rufloxacin Group: R. Mattina, et al.; Infection 21, 106 (1993) Abstract
Comparison of the mechanism of action and resistance of two new fluoroquinolones, rufloxacin and MF961 with those of ofloxacin and fleroxacin in gram-negative and gram-positive bacteria: L.J. Piddock, et al.; J. Antimicrob. Chemother. 31, 855 (1993) Abstract
Molecular mechanisms of photosensitization induced by drugs. XII. Photochemistry and photosensitization of rufloxacin: an unusual photodegradation path for the antibacterials containing a fluoroquinolone-like chromophore: G. Condorelli, et al.; Photochem. Photobiol. 70, 280 (1999) Abstract
Penetration of rufloxacin into the cerebrospinal fluid in patients with inflamed and uninflamed meninges: M.V. Moretti, et al.; Antimicrob. Agents Chemother. 44, 73 (2000) Abstract; Full Text
Rufloxacin-induced photosensitization in yeast: A. Catalfo, et al.; Photochem. Photobiol. Sci. 6, 181 (2007) Abstract
 
 

Your items will be kept only for the duration of your visit.