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ALX-550-323 Revised 28-Jan-05
S-(+)-CBPG
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SYNONYMS S-(+)-2-(3'-Carboxybicyclo[1.1.1]pentyl)glycine
UPF 596
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Glutamate Receptors (Metabotropic)/Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-550-323-M001   1 mg 50.00 USD Add To Cart
ALX-550-323-M005   5 mg 195.00 USD Add To Cart
Product Specification
FORMULA: C8H11NO4
MW: 185.2
PURITY: ≥98%
APPEARANCE: White solid.
SOLUBILITY: Soluble in water or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
Potent and selective, structurally new group I mGluR antagonist.
Product Specific Literature References
Pharmacological studies on new agonists and antagonists of mGluRs: R. Pellicciari, et al.; Neuropharmacology 35, A21 (1996)
(S)-(+)-2-(3'-carboxybicyclo[1.1.1]pentyl)-glycine, a structurally new group I metabotropic glutamate receptor antagonist: R. Pellicciari, et al.; J. Med. Chem. 39, 2874 (1996) Abstract
Presynaptic mGlu1 type receptors potentiate transmitter output in the rat cortex: F. Moroni, et al.; Eur. J. Pharmacol. 347, 189 (1998) Abstract
Biochemical and electrophysiological studies on (S)-(+)-2-(3'- carboxybicyclo[1.1.1]pentyl)-glycine (CBPG), a novel mGlu5 receptor agonist endowed with mGlu1 receptor antagonist activity: G. Mannaioni, et al.; Neuropharmacology 38, 917 (1999) Abstract
Protection with metabotropic glutamate 1 receptor antagonists in models of ischemic neuronal death: time-course and mechanisms: D.E. Pellegrini-Giampietro, et al.; Neuropharmacology 38, 1607 (1999) Abstract
1-Aminoindan-1,5-dicarboxylic acid and (S)-(+)-2-(3'- carboxybicyclo[1.1.1] pentyl)-glycine, two mGlu1 receptor-preferring antagonists, reduce neuronal death in in vitro and in vivo models of cerebral: D.E. Pellegrini-Giampietro, et al.; Eur. J. Neurosci. 11, 3637 (1999) Abstract
Metabotropic G-protein-coupled glutamate receptors as therapeutic targets: R. Pellicciari & G. Costantino; Curr. Opin. Chem. Biol. 3, 433 (1999), (Review) Abstract
Pharmacological agents acting at subtypes of metabotropic glutamate receptors: D.D. Schoepp, et al.; Neuropharmacology 38, 1431 (1999), (Review) Abstract
 
 
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