ALEXIS Biochemicals: S-(+)-Niguldipine . hydrochloride

ALX-550-276

Revised 03-Mar-05

S-(+)-Niguldipine . hydrochloride
SYNONYMS	S-(+)-1,4-Dihydro-2,6-dimethyl-4-(3'-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-(4',4'-diphenyl-1'-piperidinyl)propylmethyl ester . HCl
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	Ca2+ Channels (L-type)

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-550-276-M005		5 mg	160.00 USD

Product Specification

FORMULA:	C₃₆H₃₉N₃O₆ . HCl
MW:	609.7 . 36.5
CAS NUMBER:	113165-32-5
APPEARANCE:	Yellow solid.
SOLUBILITY:	Soluble in DMSO or methanol.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HANDLING:	Protect from light. Adsorbs strongly to plastic.

Product Description

Extremely potent (picomolar range) inhibitor of α_1A-adrenergic receptors and L-type Ca²⁺ channels.

Product Specific Literature References

(+)-Niguldipine binds with very high affinity to Ca2+ channels and to a subtype of alpha 1-adrenoceptors: R. Boer, et al.; Eur. J. Pharmacol. 172, 131 (1989) Abstract
Stereoselective binding of niguldipine enantiomers to alpha 1A- adrenoceptors labeled with [3H]5-methyl-urapidil: I. Graziadei, et al.; Eur. J. Pharmacol. 172, 329 (1989) Abstract
Pharmacological modulation of calcium and potassium channels in isolated vascular smooth muscle cells: U. Klockner, et al.; Arzneimittelforschung 39, 120 (1989) Abstract
Niguldipine discriminates between alpha 1-adrenoceptor-mediated second messenger responses in rat cerebral cortex slices: J.P. Robinson & D.A. Kendall; Br. J. Pharmacol. 100, 3 (1990) Abstract

Further Categories Containing This Product:

Adrenergics & Adrenergic Receptors/Related Products

another CS2 website

Online Product Ordering

Clipboard [0]

Your items will be kept only for the duration of your visit.