ALEXIS Biochemicals: S-2 Methanandamide

ALX-340-034

Revised 10-Jul-08

S-2 Methanandamide
SYNONYMS	(S)-(+)-Methanandamide N-(2-Hydroxypropyl)-, [S-(all-Z)]-5,8,11,14-eicosatetraenamide
PRODUCT LINE	Neurobiology
PRODUCT CATEGORY	Anandamide & Anandamide Analogs

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-340-034-M005		5 mg	63.00 USD

Product Specification

FORMULA:	C₂₃H₃₉NO₂
MW:	361.6
PURITY:	≥98%
FORMULATION:	Liquid. Solution in ethanol.
SOLUBILITY:	10mg/ml soluble in DMSO or dimethyl formamide; slightly soluble in PBS, pH 9.0 (1.5mg/ml).
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Stable for at least 1 year after receipt when stored at -20°C. Stable for at least 6 months in other organic solvents when stored at -20°C. We do not recommend storing aqueous solutions for more than one day.
HANDLING:	Protect from light and oxygen.

Product Description

CB₁ receptor agonist (K_i=26nM). About 3-fold more potent than anandamide (Prod. No. ALX-340-029).

Product Specific Literature References

(R)-methanandamide: a chiral novel anandamide possessing higher potency and metabolic stability: V. Abadji, et al.; J. Med. Chem. 37, 1889 (1994) Abstract
Head group analogs of arachidonylethanolamide, the endogenous cannabinoid ligand: A.D. Khanolkar, et al.; J. Med. Chem. 39, 4515 (1996) Abstract
Extrapyramidal effects of methanandamide, an analog of anandamide, the endogenous CB1 receptor ligand: J. Romero, et al.; Life Sci. 58, 1249 (1996) Abstract
Substrate specificity and stereoselectivity of rat brain microsomal anandamide amidohydrolase: W. Lang, et al.; J. Med. Chem. 42, 896 (1999) Abstract

General Information

BACKGROUND/TECHNICAL INFORMATION

To change the solvent, evaporate the ethanol under a gentle stream of nitrogen and immediately add the solvent of choice.

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