ALEXIS Biochemicals: S14-95

ALX-350-299

Revised 25-May-07

S14-95
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Other Natural Products for Inflammation Research

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-350-299-MC05		0.5 mg	250.00 USD

Product Specification

FORMULA:	C₂₈H₃₄O₅
MW:	450.6
SOURCE/HOST:	Isolated from Penicillium sp.
PURITY:	≥95% (HPLC)
APPEARANCE:	Yellow powder.
SOLUBILITY:	Soluble in methanol.
SHIPPING:	AMBIENT
SHORT TERM STORAGE:	+4°C
LONG TERM STORAGE:	-20°C

Product Description

Potent inhibitor of cytokine-induced activation of STAT1α leading to the inhibition of inducible expression of proinflammatory enzymes (COX-2, iNOS (NOS II)) and cytokines (TNF-α).

Product Specific Literature References

S14-95, a novel inhibitor of the JAK/STAT pathway from a Penicillium species: G. Erkel, et al.; J. Antibiot. 56, 337 (2003) Abstract
Sporogen, S14-95, and S-curvularin, three inhibitors of human inducible nitric-oxide synthase expression isolated from fungi: Y. Yao, et al.; Mol. Pharmacol. 63, 383 (2003) Abstract; Full Text

Further Categories Containing This Product:

Natural Products - Protein Kinase Inhibitors • NOS Inhibitors (NOS Induction & Enzyme Activity) • COX Inhibitors • Natural Products - Nitric Oxide Pathway Modulators • MAPK Pathway Inhibitors

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