ALEXIS Biochemicals: SB202190

ALX-270-259

Revised 14-Jul-03

SB202190
SYNONYMS	FHPI 4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)-1H-imidazole
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	MAPK Pathway Inhibitors

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-259-M001		1 mg	25.00 USD
ALX-270-259-M005		5 mg	60.00 USD
ALX-270-259-M050		50 mg	420.00 USD

Product Specification

FORMULA:	C₂₀H₁₄FN₃O
MW:	331.3
PURITY:	≥97%
APPEARANCE:	Light brown solid.
SOLUBILITY:	Soluble in methanol, DMSO or acetone; slightly soluble in ethyl acetate.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HANDLING:	Protect from light.

Product Description

Potent and cell permeable inhibitor of p38 (SAPK2a). For a more water soluble form of this product see SB202190 . HCl (Prod. No. ALX-270-268).

Product Specific Literature References

A protein kinase involved in the regulation of inflammatory cytokine biosynthesis: J.C. Lee, et al.; Nature 372, 739 (1994) Abstract
Characterization of the structure and function of a new mitogen-activated protein kinase (p38beta): Y. Jiang, et al.; J. Biol. Chem. 271, 17920 (1996) Abstract; Full Text
The primary structure of p38 gamma: a new member of p38 group of MAP kinases: Z. Li, et al.; BBRC 228, 334 (1996) Abstract
Regulation of stress-induced cytokine production by pyridinylimidazoles; inhibition of CSBP kinase: T.F. Gallagher, et al.; Bioorg. Med. Chem. 5, 49 (1997) Abstract
The cellular response to oxidative stress: influences of mitogen-activated protein kinase signalling pathways on cell survival: X. Wang, et al.; Biochem. J. 333, 291 (1998) Abstract

Further Categories Containing This Product:

Apoptosis Inducers & Inhibitors Other Products

another CS2 website

Online Product Ordering

Clipboard [0]

Your items will be kept only for the duration of your visit.