ALEXIS Biochemicals: SH-6

ALX-270-350

Revised 25-Jul-07

SH-6
SYNONYMS	D-2,3-Dideoxy-myo-inositol 1-[(R)-2-methoxy-3-(octadecyloxy)propyl hydrogen phosphate]
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	Akt [PKB] / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-350-MC05		0.5 mg	140.00 USD
ALX-270-350-M001		1 mg	225.00 USD

Product Specification

FORMULA:	C₂₈H₅₇O₉P
MW:	568.7
PURITY:	≥98%
APPEARANCE:	White to off-white solid.
SOLUBILITY:	Soluble in DMSO (10mg/ml) or methanol; slightly soluble in water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C

Product Description

Inhibitor of Akt (PKB) activation without affecting activation of the upstream kinase PDK-1, or other kinases downstream of Ras such as MAPK. Induces apoptosis and kills a variety of cancer cell lines containing high levels of active Akt and depending upon Akt for survival.

Product Specific Literature References

Novel PI analogues selectively block activation of the pro-survival serine/threonine kinase, Akt.: A.P. Kozikowski, et al.; JACS 125, 1144 (2003) Abstract

Further Categories Containing This Product:

Apoptosis Inducers & Inhibitors Other Products • Antitumor Agents (Enzyme Inhibitors) • Protein Kinase Inhibitors Other Products

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