ALEXIS Biochemicals: SN50M Control Peptide

ALX-167-025

Revised 17-May-06

SN50M Control Peptide
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	NF-kB Pathway Inhibitors

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-167-025-C500		500 µg	125.00 USD

Product Specification

SEQUENCE:	H-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Pro-Val-Gln-Arg-Asn-Gly-Gln-Lys-Leu-Met-Pro-OH
FORMULA:	C₁₂₃H₂₁₅N₃₃O₃₀S
MW:	2668.4
PEPTIDE CONTENT:	70-90%
PURITY:	≥97% (HPLC)
APPEARANCE:	White to off-white solid.
FORMULATION:	Counter Ion: Trifluoroacetate salt.
SOLUBILITY:	Soluble in water.
RECONSTITUTION:	Reconstitute in sterile distilled water.
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Peptides in solution have limited stability.
HANDLING:	After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.

Product Description

Inactive control peptide for SN50 (Prod. No. ALX-167-024). In mouse endothelial LE-II cells, induced with LPS, 50µg/ml SN50M had no measurable effect on NF-κB translocation. In human monocytic THP-1 cells induced by LPS or TNF-α there was slight inhibition at 100µg/ml.

Product Specific Literature References

Inhibition of nuclear translocation of transcription factor NF-kappa B by a synthetic peptide containing a cell membrane-permeable motif and nuclear localization sequence: Y.Z. Lin, et al.; J. Biol. Chem. 270, 14255 (1995) Abstract; Full Text
Interruption of the NF-kappaB pathway by Bay 11-7082 promotes UCN-01-mediated mitochondrial dysfunction and apoptosis in human multiple myeloma cells: Y. Dai, et al.; Blood 103, 2761 (2004) Abstract

Further Categories Containing This Product:

Nuclear Envelope & Nuclear Transport • Peptides

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