ALEXIS Biochemicals: SP600125

ALX-270-339

Revised 04-Mar-05

SP600125
SYNONYMS	Anthra(1,9-cd)pyrazol-6(2H)-one 1,9-Pyrazoloanthrone
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	JNK [SAPK1] / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-339-M005		5 mg	52.00 USD
ALX-270-339-M025		25 mg	190.00 USD

Product Specification

FORMULA:	C₁₄H₈N₂O
MW:	220.2
CAS NUMBER:	129-56-6
RTECS:	CB4585000
PURITY:	≥98%
APPEARANCE:	Yellow to brown solid.
SOLUBILITY:	Soluble in DMSO or methanol.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HANDLING:	Keep under inert gas. Protect from light.

Product Description

Potent, cell permeable, selective, and reversible inhibitor of c-Jun N-terminal kinase (JNK) (IC₅₀=40nM for JNK-1 and JNK-2 and 90nM for JNK-3). The inhibition is competitive with respect to ATP. Exhibits over 300-fold greater selectivity for JNK as compared to ERK1 and p38. Inhibits the phosphorylation of c-Jun and blocks the expression of IL-2, IFN-γ, TNF-α, and COX-2. Blocks IL-1-induced accumulation of phospho-Jun and induction of c-Jun transcription.

Product Specific Literature References

SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase: B.L. Bennett, et al.; PNAS 98, 13681 (2001) Abstract; Full Text
Role of JNK in hypertonic activation of Cl(-)-dependent Na(+)/H(+) exchange in Xenopus oocytes: G.G. Goss, et al.; Am. J. Physiol. Cell. Physiol. 281, C1978 (2001) Abstract
c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis: Z. Han, et al.; J. Clin. Invest. 108, 73 (2001) Abstract; Full Text
TAK1/JNK and p38 have opposite effects on rat hepatic stellate cells: B. Schnabl, et al.; Hepatology 34, 953 (2001) Abstract
An inhibitor of c-jun aminoterminal kinase (SP600125) represses c-Jun activation, DNA-binding and PMA-inducible 92-kDa type IV collagenase expression: M. Shin, et al.; Biochim. Biophys. Acta 1589, 311 (2002) Abstract
Inhibition of c-Jun NH2-terminal kinase activity improves ischemia/reperfusion injury in rat lungs: M. Ishii, et al.; J. Immunol. 172, 2569 (2004) Abstract

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