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ALX-480-060 Revised 05-Aug-08
SQ 22,536
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SYNONYMS 9-(Tetrahydro-2-furanyl)-9H-purin-6-amine
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Adenylyl Cyclase Inhibitors
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-480-060-M001   1 mg 30.00 USD Add To Cart
ALX-480-060-M005   5 mg 86.00 USD Add To Cart
Product Specification
FORMULA: C9H11N5O
MW: 205.2
CAS NUMBER: 17318-31-9
PURITY: ≥98% (TLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in water (25mg/ml) or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
USE/STABILITY: Stock solutions are stable for up to 3 months at -20°C.

Product Description
Cell permeable adenylate cyclase inhibitor. Blocks PTH-stimulation of adenylate cyclase. Reduces PGE2-induced inhibition of O2- production. Useful as a probe for adenylate cyclase in a variety of receptor systems including prostaglandins and neurotransmitters.
Product Specific Literature References
Inhibition of adenylate cyclase of catfish and rat hepatocyte membranes by 9-(tetrahydro-2-furyl)adenine (SQ 22536): E. Fabbri, et al.; J. Enzym. Inhib. 5, 87 (1991) Abstract
Reversal of synaptic depression by serotonin at Aplysia sensory neuron synapses involves activation of adenylyl cyclase: B.A. Goldsmith & T.W. Abrams; PNAS 88, 9021 (1991) Abstract
Actions of vasopressin and isoprenaline on the ionic transport across the isolated frog skin in the presence and the absence of adenyl cyclase inhibitors MDL12330A and SQ22536: C Lippe & C. Ardizzone; Comp. Biochem. Physiol. 99, 209 (1991) Abstract
cAMP modulates multiple K+ currents, increasing spike duration and excitability in Aplysia sensory neurons: B.A. Goldsmith & T.W. Abrams; PNAS 89, 11481 (1992) Abstract
Roles of intracellular cAMP and protein kinase A in the actions of dopamine and neurotensin on midbrain dopamine neurons: W.X. Shi & B.S. Bunney; J. Neurosci. 12, 2433 (1992) Abstract
Relaxation and inhibition of contractile response to electrical field stimulation by Beraprost sodium in canine airway smooth muscle: J. Tamaoki, et al.; Proaglandins 45, 363 (1993) Abstract
Characterization of the PGE receptor subtype mediating inhibition of superoxide production in human neutrophils: E. Talpain, et al.; Br. J. Pharmacol. 114, 1459 (1995) Abstract
 
 
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