ALEXIS Biochemicals: Salubrinal

ALX-270-428

Revised 25-Feb-08

Salubrinal
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	Phosphatases Other Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-428-M001		1 mg	30.00 USD
ALX-270-428-M005		5 mg	110.00 USD

Product Specification

FORMULA:	C₂₁H₂₀Cl₃N₄OS
MW:	479.8
CAS NUMBER:	405060-95-9
PURITY:	≥98%
APPEARANCE:	White to off-white powder.
SOLUBILITY:	Soluble in DMSO (10mg/ml).
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Product may darken when exposed to air. Stock solutions are stable for up to 3 months when stored at -20°C.
HANDLING:	Protect from light. Keep under inert gas.

Product Description

Cell permeable and selective inhibitor of the phosphatase complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit α (eIF-2α). Protects ER stress-induced apoptosis (EC₅₀~15µM in PC12 cells stimulated with 750ng/ml of tunicamycin (Prod. No. ALX-380-047)).

Product Specific Literature References

A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress: M. Boyce, et al.; Science 307, 935 (2005) Abstract
A pharmacoproteomic approach implicates eukaryotic elongation factor 2 kinase in ER stress-induced cell death: M. Boyce, et al.; Cell Death Differ. 15, 589 (2008) Abstract

Related Products

ALX-380-047

Tunicamycin

Further Categories Containing This Product:

Translation Initiation Factors/Related Products • Apoptosis Inducers & Inhibitors Other Products • Endoplasmatic Reticulum Stress

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