ALEXIS Biochemicals: Sanguinarine chloride

ALX-350-076

Revised 16-Jun-08

Sanguinarine chloride
SYNONYMS	Pseudochelerythrine
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Natural Products - ATPase Inhibitors

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-350-076-M005		5 mg	75.00 USD

Product Specification

FORMULA:	C₂₀H₁₄NO₄Cl
MW:	367.8
CAS NUMBER:	5578-73-4
MERCK INDEX:	14: 8356
RTECS:	VP5220000
SOURCE/HOST:	Isolated from the leaves and stems of Macleaya cordata and M. microcarpa.
PURITY:	≥98% (HPLC)
APPEARANCE:	Orange solid.
SOLUBILITY:	Soluble in methanol; slightly soluble in water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C
HAZARD:	HARMFUL.

Product Description

Na⁺/K⁺-and Mg²⁺-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. Modulates the Bcl-2 family. Shows antiplaque activity in humans.

Product Specific Literature References

Sanguinarine, inhibitor of Na-K dependent ATP'ase: K.D. Straub & P. Carver; BBRC 62, 913 (1975) Abstract
Isoquinoline alkaloids. Inhibitory actions on cation-dependent ATP-phosphohydrolases: L.R. Meyerson, et al.; Neurochem. Res. 3, 239 (1978) Abstract
Sanguinarine, a new antiplaque agent: retention and plaque specificity: G.L. Southard, et al.; J. Am. Dent. Assoc. 108, 338 (1984) Abstract
Sanguinarine-induced apoptosis is associated with an early and severe cellular glutathione depletion: E. Debiton, et al.; Cancer Chemother. Pharmacol. 51, 474 (2003) Abstract
Activation of prodeath Bcl-2 family proteins and mitochondrial apoptosis pathway by sanguinarine in immortalized human HaCaT keratinocytes: V.M. Adhami, et al.; Clin. Cancer Res. 9, 3176 (2003) Abstract
The effect of chelerythrine on cell growth, apoptosis, and cell cycle in human normal and cancer cells in comparison with sanguinarine: J. Malikova, et al.; Cell Biol. Toxicol. 22, 439 (2006) Abstract
Chelerythrine and sanguinarine dock at distinct sites on BclXL that are not the classic BH3 binding cleft: Y.H. Zhang, et al.; J. Mol. Biol. 364, 538 (2006) Abstract
Induction of apoptosis by sanguinarine in C6 rat glioblastoma cells is associated with the modulation of the Bcl-2 family and activation of caspases through downregulation of extracellular signal-regulated kinase and Akt: M.H. Han, et al.; Anticancer Drugs 18, 913 (2007) Abstract
Metabolism of sanguinarine: the facts and the myths: Z. Dvorak & V. Simanek; Curr. Drug Metab. 8, 173 (2007), Review Abstract

Further Categories Containing This Product:

Na+ / K+-ATPase / Related Products • Bcl-2 Family Modulators • Natural Products - Anti-inflammatory Agents • Natural Products - Antioxidants • Alkaloids • Natural Products - Apoptosis Inducers & Inhibitors

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