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ALX-167-001 Revised 25-Sep-07
Sarafotoxin S6b
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Endothelins [ETs] & Endothelin Receptors / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-167-001-PC01   0.1 mg* 80.00 USD Add To Cart
ALX-167-001-PC05   0.5 mg* 280.00 USD Add To Cart
ALX-167-001-P001   1 mg* 530.00 USD Add To Cart
Product Specification
SEQUENCE: H-Cys-Ser-Cys-Lys-Asp-Met-Thr-Asp-Lys-Glu-Cys-Leu-Tyr-Phe-Cys-His-Gln-Asp-Val-Ile-Trp-OH
(Disulfide bonds between Cys1-Cys15 and Cys3-Cys11)
FORMULA: C110H159N27O34S5
MW: 2564.0
CAS NUMBER: 116303-65-2
SOURCE/HOST: Synthetic. Originally isolated from Atractaspis engaddensis.
QUANTITY: *Sold as net peptide weight.
PURITY: ≥97%
APPEARANCE: White lyophilized powder.
SOLUBILITY: Soluble in 5% acetic acid.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: TOXIC.
Product Description
Potent vasoconstrictor peptide. Causes hydrolysis of phosphoinositides in atrial and brain membranes.
Product Specific Literature References
Sarafotoxin, a novel vasoconstrictor peptide: phosphoinositide hydrolysis in rat heart and brain: Y. Kloog, et al.; Science 242, 268 (1988) Abstract
Similarity of endothelin to snake venom toxin: Nature 335, 303 (1988) Abstract
Sarafotoxins S6: several isotoxins from Atractaspis engaddensis (burrowing asp) venom that affect the heart: C. Takasaki, et al.; Toxicon 26, 543 (1988) Abstract
Competitive interaction between endothelin and sarafotoxin: Binding and phosphoinositides hydrolysis in rat atria and brain: I. Ambar, et al.; BBRC 158, 195 (1989) Abstract
Functional endothelin/sarafotoxin receptors in the rat uterus: D. Bousso-Mittler, et al.; BBRC 162, 952 (1989) Abstract
Immunological and structural characterization of sarafotoxin/endothelin family of peptides: G. Fleminger, et al.; BBRC 162, 1317 (1989) Abstract
Biochemical identification of two types of phenamil binding sites associated with amiloride-sensitive Na+ channels: R. Galron, et al.; BBRC 163, 936 (1989) Abstract
Interaction of synthetic sarafotoxin with rat vascular endothelin receptors: Y. Hirata, et al.; BBRC 162, 441 (1989) Abstract
Synthesis of endothelin-1 analogues, endothelin-3, and sarafotoxin S6b: structure-activity relationships: N. Nakajima, et al.; J. Cardiovasc. Pharmacol. 13, S8 (1989) Abstract
Sarafotoxin S6c is a relatively weak displacer of specifically bound 125I-endothelin: W.G. Nayler, et al.; BBRC 161, 89 (1989) Abstract
Vasoconstrictor effects of sarafotoxins in rabbit aorta: structure- function relationships: Z. Wollberg, et al.; BBRC 162, 371 (1989) Abstract
Comparison of the contractile effects and binding kinetics of endothelin-1 and sarafotoxin S6b in rat isolated renal artery: P.S. Devadason & P.J. Henry; Br. J. Pharmacol. 121, 253 (1997) Abstract
Further Categories Containing This Product:
Peptides • Other Toxins
 
 
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