ALEXIS Biochemicals: Sarafotoxin S6c

ALX-167-002

Revised 25-Sep-07

Sarafotoxin S6c
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	Endothelins [ETs] & Endothelin Receptors / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-167-002-PC01		0.1 mg*	80.00 USD
ALX-167-002-PC05		0.5 mg*	280.00 USD
ALX-167-002-P001		1 mg*	530.00 USD

Product Specification

SEQUENCE:	H-Cys-Thr-Cys-Asn-Asp-Met-Thr-Asp-Glu-Glu-Cys-Leu-Asn-Phe-Cys-His-Gln-Asp-Val-Ile-Trp-OH (Disulfide bonds between Cys¹-Cys¹⁵ and Cys³-Cys¹¹)
FORMULA:	C₁₀₃H₁₄₇N₂₇O₃₇S₅
MW:	2515.8
CAS NUMBER:	121695-87-2
SOURCE/HOST:	Synthetic. Originally isolated from Atractaspis engaddensis.
QUANTITY:	*Sold as net peptide weight.
PURITY:	≥97%
APPEARANCE:	White lyophilized powder.
SOLUBILITY:	Soluble in 5% acetic acid.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HAZARD:	TOXIC.

Product Description

Potent vasoconstrictor peptide. Causes hydrolysis of phosphoinositides in atrial and brain membranes.

Product Specific Literature References

Sarafotoxins S6: several isotoxins from Atractaspis engaddensis (burrowing asp) venom that affect the heart: C. Takasaki, et al.; Toxicon 26, 543 (1988) Abstract
Sarafotoxin S6c is a relatively weak displacer of specifically bound 125I-endothelin: W.G. Nayler, et al.; Biochem. Biophys. Res. Commun. 161, 89 (1989) Abstract
Sarafotoxin S6c: an agonist which distinguishes between endothelin receptor subtypes: D.L. Williams, Jr., et al.; Biochem. Biophys. Res. Commun. 175, 556 (1991) Abstract
Endothelium-dependent modulation of venoconstriction to sarafotoxin S6c in human veins in vivo: F.E. Strachan, et al.; J. Cardiovasc. Pharmacol. 26 Suppl. 3, S180 (1995) Abstract
Simultaneous changes in intracellular calcium and tension induced by endothelin-1 and sarafotoxin S6c in guinea pig isolated gallbladder: influence of indomethacin: A.M. Cardozo, et al.; Can. J. Physiol. Pharmacol. 80, 458 (2002) Abstract

Further Categories Containing This Product:

Peptides • Other Toxins

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