ALEXIS Biochemicals: Sauchinone

ALX-350-116

Revised 29-Nov-07

Sauchinone
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Natural Products - Antioxidants

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-350-116-M001		1 mg	70.00 USD
ALX-350-116-M005		5 mg	280.00 USD

Product Specification

FORMULA:	C₂₀H₂₀O₆
MW:	356.4
SOURCE/HOST:	Isolated from Saururus chinensis.
PURITY:	≥95%
APPEARANCE:	White to off-white powder.
SOLUBILITY:	Soluble in DMSO or chloroform.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+20°C

Product Description

Diastereomeric lignan with cytoprotective and antioxidant activities in cultured hepatocytes. Inhibitor of LPS-inducible iNOS (NOS II), TNF-α and COX-2 expression in macrophages through suppression of IκBα phosphorylation and p65 nuclear translocation and of C/EBP and/or AP-1 activation, which may have constitutive anti-inflammatory effects. Suppressor of NF-κB by inhibiting transactivation activity of the RelA subunit. Inhibits staurosporine (Prod. No. ALX-380-014)-induced apoptosis. Inhibits RANKL-induced osteoclastogenesis by reducing ROS generation.

Product Specific Literature References

Sauchinone, a lignan from Saururus chinensis, attenuates CCl4-induced toxicity in primary cultures of rat hepatocytes: S.H. Sung, et al.; Biol. Pharm. Bull. 23, 666 (2000) Abstract
Hepatoprotective diastereomeric lignans from Saururus chinensis herbs: S.H. Sung & Y.C. Kim; J. Nat. Prod. 63, 1019 (2000) Abstract
Inhibition of lipopolysaccharide-inducible nitric oxide synthase, TNF-alpha and COX-2 expression by sauchinone effects on I-kappaBalpha phosphorylation, C/EBP and AP-1 activation: A.K. Lee, et al.; Br. J. Pharmacol. 139, 11 (2003) Abstract
Sauchinone, a lignan from Saururus chinensis, inhibits staurosporine-induced apoptosis in C6 rat glioma cells: H. Song, et al.; Biol. Pharm. Bull. 26, 1428 (2003) Abstract
Sauchinone, a lignan from Saururus chinensis, suppresses iNOS expression through the inhibition of transactivation activity of RelA of NF-kappaB: B.Y. Hwang, et al.; Planta Med. 69, 1096 (2003) Abstract
Inhibition of osteoclast differentiation and bone resorption by sauchinone: K.Y. Han, et al.; Biochem. Pharmacol. 74, 911 (2007) Abstract

Further Categories Containing This Product:

NOS Inhibitors (NOS Induction & Enzyme Activity) • Natural Products - Nitric Oxide Pathway Modulators • NF-kB Pathway Inhibitors • Natural Products - Apoptosis Inducers & Inhibitors • Bone Metabolism Other Products • Natural Products - NF-kB Pathway Inhibitors

another CS2 website

Online Product Ordering

Clipboard [0]

Your items will be kept only for the duration of your visit.