ALEXIS Biochemicals: Scyllatoxin

ALX-630-043

Revised 31-Oct-07

Scyllatoxin
SYNONYMS	Leiurotoxin I
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Neurotoxins

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-630-043-C100		100 µg	540.00 USD

Product Specification

SEQUENCE:	H-Ala-Phe-Cys-Asn-Leu-Arg-Met-Cys-Gln-Leu-Ser-Cys-Arg-Ser-Leu-Gly-Leu-Leu-Gly-Lys-Cys-Lle-Gly-Asp-Lys-Cys-Glu-Gys-Val-Lys-His-NH₂ (Disulfide bonds are undetermined.)
FORMULA:	C₁₄₂H₂₃₇N₄₅O₃₉S₇
MW:	3423.1
SOURCE/HOST:	Synthetic. Originally isolated from Leiurus quinquestriatus hebraeus.
PURITY:	≥98%
APPEARANCE:	Lyophilized powder.
SOLUBILITY:	Soluble in water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HAZARD:	POTENT NEUROTOXIN.

Product Description

Small conductance Ca²⁺-activated K⁺ channel blocker.

Product Specific Literature References

Purification and characterization of a unique, potent inhibitor of apamin binding from Leiurus quinquestriatus hebraeus venom: G.G. Chicchi, et al.; J. Biol. Chem. 263, 10192 (1988) Abstract; Full Text
Potassium channel toxins: P.N. Strong; Pharmacol. Ther. 46, 137 (1990), (Review) Abstract
Scyllatoxin, a blocker of Ca(2+)-activated K+ channels: structure- function relationships and brain localization of the binding sites: P. Auguste, et al.; Biochemistry 31, 648 (1992) Abstract
Pharmacological characterization of small-conductance Ca(2+)-activated K(+) channels stably expressed in HEK 293 cells:: D. Strobaek, et al.; Br. J. Pharmacol. 129, 991 (2000) Abstract
Molecular determinants of Ca2+-dependent K+ channel function in rat dorsal vagal neurones: P. Pedarzani, et al.; J. Physiol. 527, 283 (2000) Abstract
An apamin- and scyllatoxin-insensitive isoform of the human SK3 channel: O.H. Wittekindt, et al.; Mol. Pharmacol. 65, 788 (2004) Abstract

Further Categories Containing This Product:

K+ Channel Blockers & Inhibitors

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