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Signal Transduction
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ALX-201-388 Revised 18-Mar-08
CX3CL1, Soluble  (human) (recombinant)
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SYNONYMS Fractalkine, Soluble (human) (recombinant)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY CX3C Chemokines & Receptors/Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-388-C010   10 µg 170.00 USD Add To Cart
ALX-201-388-C050   50 µg 590.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in HEK 293 cells. Signal peptide and extracellular domain of human CX3CL1 (fractalkine) (aa 1-339) is fused at the C-terminus to a FLAG®-tag.
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2µm-filtered solution in PBS.
ENDOTOXIN CONTENT: <0.1EU/µg protein (LAL-test).
BIOLOGICAL ACTIVITY: Chemotaxis effect of soluble recombinant human CX3CL1 (fractalkine) in THP-1 cells (see Figure 2).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
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General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link P78423: Fractalkine (human) [Precursor]

FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER Manufactured by AdipoGen, Inc.
Further Categories Containing This Product:
Recombinant Proteins/Fusion Proteins
 
 
ALX-270-282 Revised 18-Jul-07
9-Cyanopaullone
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SYNONYMS 9-Cyano-7,12-dihydroindolo-[3,2-d][1]benzazepin-6[5H]-one
PRODUCT LINE Cell Cycle
PRODUCT CATEGORY CDK & Cyclin Inhibitors
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-282-M001   1 mg 70.00 USD Add To Cart
ALX-270-282-M005   5 mg 280.00 USD Add To Cart
Product Specification
FORMULA: C17H11N3O
MW: 273.3
PURITY: ≥95%
SOLUBILITY: Soluble in DMSO; insoluble in water or ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
Very potent inhibitor of CDK1/cyclin B (IC50=25nM). Also inhibits CDK5/p25 (IC50=44nM ) and GSK-3β (IC50=10nM).
 Licensed from NCI.
Product Specific Literature References
ATP-site directed inhibitors of cyclin-dependent kinases: N. Gray, et al.; Curr. Med. Chem. 6, 859 (1999) Abstract
Fused azepinones with antitumor activity: C. Kunick; Curr. Pharm. Des. 5, 181 (1999) Abstract
Paullones, a series of cyclin-dependent kinase inhibitors: synthesis, evaluation of CDK1/cyclin B inhibition, and in vitro antitumor activity: C. Schultz, et al.; J. Med. Chem. 42, 2609 (1999) Abstract
Discovery and initial characterization of the paullones, a novel class of small-molecule inhibitors of cyclin-dependent kinases: D.W. Zaharevitz, et al.; Cancer Res. 59, 2566 (1999) Abstract
Structure-based design modifications of the paullone molecular scaffold for cyclin-dependent kinase inhibition: R. Gussio, et al.; Anticancer Drug Des. 15, 53 (2000) Abstract
2-Substituted paullones: CDK1/cyclin B-inhibiting property and in vitro antiproliferative activity: C. Kunick, et al.; Bioorg. Med. Chem. Lett. 10, 567 (2000) Abstract
Paullones are potent inhibitors of glycogen synthase kinase-3beta and cyclin-dependent kinase 5/p25: M. Leost, et al.; Eur. J. Biochem. 267, 5983 (2000) Abstract
Inhibition of CDKs as a therapeutic modality: E.A. Sausville, et al.; Ann. NY Acad. Sci. 910, 207 (2000) Abstract
 
 
ALX-153-012 Revised 04-Mar-05
Cyclin-dependent Kinase 2 Inhibitor
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SYNONYMS CDK2/Cyclin Inhibitor
PRODUCT LINE Cell Cycle
PRODUCT CATEGORY CDK & Cyclin Inhibitors
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-153-012-M001   1 mg 120.00 USD Add To Cart
ALX-153-012-M005   5 mg 480.00 USD Add To Cart
Product Specification
SEQUENCE: H-Tyr-Ser-Phe-Val-His-His-Gly-Phe-Phe-Asn-Phe-Arg-Val-Ser-Trp-Arg-Glu-Met-Leu-Ala-OH
FORMULA: C121H164N32O27S
MW: 2530.9
PEPTIDE CONTENT: 75-95%
PURITY: ≥97%
APPEARANCE: White to off-white lyophilized solid.
SOLUBILITY: Soluble in DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Keep cool and dry.
Product Description
Inhibitor of cyclin-dependent kinase 2 (CDK2).
Product Specific Literature References
Genetic selection of peptide aptamers that recognize and inhibit cyclin- dependent kinase 2: P. Colas, et al.; Nature 380, 548 (1996) Abstract
Further Categories Containing This Product:
Peptides
 
 
ALX-153-041 Revised 04-Mar-05
Cyclin-dependent Kinase 2 Inhibitory Peptide I
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SYNONYMS CDK2/Cyclin Inhibitory Peptide I
PRODUCT LINE Cell Cycle
PRODUCT CATEGORY CDK & Cyclin Inhibitors
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ALX-153-041-C500   500 µg 145.00 USD Add To Cart
Product Specification
SEQUENCE: H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Gly-Pro-Val-Lys-Arg-Arg-Leu-Phe-Gly-OH
FORMULA: C111H196N48O23
MW: 2571.1
PURITY: ≥98% (HPLC)
APPEARANCE: Solid.
FORMULATION: Lyophilized. Counter Ion: Trifluoroacetate salt.
SOLUBILITY: Soluble in water.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Following reconstitution, aliquot and freeze (-20°C). Product is stable for 2 years as supplied. Stock solutions are stable for 3 months at -20°C.
HANDLING: Hygroscopic.
Product Description
Cell permeable inhibitor of CDK2/cyclin complexes. Blocks phosphorylation of substrates by CDK2/cyclin A and CDK/cyclin E complexes. Preferentially induces apoptosis only in transformed cells and not in non-transformed cells.

Chimeric peptide consisting of the N-terminal sequence of the HIV-TAT protein (directing uptake across the cell membrane) and the consensus sequence PVKRRLFG that serves as the docking site for CDK2/cyclin complexes.
Product Specific Literature References
Selective killing of transformed cells by cyclin/cyclin-dependent kinase 2 antagonists: Y.N. Chen, et al.; PNAS 96, 4325 (1999) Abstract; Full Text
Further Categories Containing This Product:
Peptides • Apoptosis Inducers & Inhibitors Other Products
 
 
ALX-153-042 Revised 04-Mar-05
Cyclin-dependent Kinase 2 Inhibitory Peptide II
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SYNONYMS CDK2/Cyclin Inhibitory Peptide II
PRODUCT LINE Cell Cycle
PRODUCT CATEGORY CDK & Cyclin Inhibitors
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ALX-153-042-C500   500 µg 145.00 USD Add To Cart
Product Specification
SEQUENCE: H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Gly-Pro-Val-Lys-Arg-Arg-Leu-Asp-Leu-OH
FORMULA: C110H200N48O25
MW: 2595.1
PURITY: ≥98%
APPEARANCE: Lyophilized solid.
SOLUBILITY: Soluble in water.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Very hygroscopic.
Product Description
Cell permeable inhibitor of CDK2/cyclin complexes. Blocks phosphorylation of substrates by CDK2/cyclin A and CDK/cyclin E complexes. Preferentially induces apoptosis only in transformed cells and not in non-transformed cells.
Product Specific Literature References
Selective killing of transformed cells by cyclin/cyclin-dependent kinase 2 antagonists: Y.N. Chen, et al.; PNAS 96, 4325 (1999) Abstract; Full Text
Further Categories Containing This Product:
Peptides • Apoptosis Inducers & Inhibitors Other Products
 
 
ALX-550-314 Revised 03-Feb-05
N-Cyclobutanecarbonyl-2-phenyltryptamine
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SYNONYMS N-[2-(2-Phenylindol-3-yl)ethyl] cyclobutanecarboxyamide
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Melatonin Receptors/Related Products
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ALX-550-314-M001   1 mg 60.00 USD Add To Cart
ALX-550-314-M005   5 mg 180.00 USD Add To Cart
Product Specification
FORMULA: C21H22N2O
MW: 318.4
PURITY: ≥98%
APPEARANCE: Oil.
SOLUBILITY: Soluble in chloroform or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Melatonin receptor antagonist. More potent than Luzindole (Prod. No. ALX-550-184) in the Xenopus melanophore assay.
Product Specific Literature References
Radioligand binding affinity and biological activity of the enantiomers of a chiral melatonin analogue: D. Sugden, et al.; Eur. J. Pharmacol. 287, 239 (1995) Abstract
Mapping the melatonin receptor. 3. Design and synthesis of melatonin agonists and antagonists derived from 2-phenyltryptamines: P.J. Garratt, et al.; J. Med. Chem. 38, 1132 (1995) Abstract
Mapping the melatonin receptor. 5. Melatonin agonists and antagonists derived from tetrahydrocyclopent[b]indoles, tetrahydrocarbazoles and hexahydrocyclohept[b]indoles: D.J. Davies, et al.; J. Med. Chem. 41, 451 (1998) Abstract
 
 
ALX-430-159 Revised 19-Aug-08 New product
Cyclopamine
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SYNONYMS 11-Deoxyjervine
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Hedgehog [Hh] Signalling Pathway
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-430-159-M001   1 mg 80.00 USD Add To Cart
ALX-430-159-M005   5 mg 320.00 USD Add To Cart
Product Specification
FORMULA: C27H41NO2
MW: 411.6
CAS NUMBER: 4449-51-8
MERCK INDEX: 14: 10201
RTECS: GY0750000
PURITY: ≥98% (TLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in 100% ethanol (20mg/ml), DMF (10mg/ml), methanol (7mg/ml) or DMSO (4mg/ml). Heating to 50-60°C may be necessary. Insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
HAZARD: MAY BE TERATOGENIC. HARMFUL.

Product Description
Steroidal alkaloid. Blocks activation of the Hedgehog (Hh) response pathway. Binds to the heptahelical protein bundle of Smoothened. Induces expression of the transcription factor Pdx-1. Disrupts cholesterol biosynthesis. Displays anti-tumor properties. Induces apoptosis. Causes cyclopia.
Product Specific Literature References
The teratogenic Veratrum alkaloid cyclopamine inhibits sonic hedgehog signal transduction: J.P. Incardona, et al.; Development 125, 3553 (1998) Abstract; Full Text
Pancreas development is promoted by cyclopamine, a hedgehog signaling inhibitor: S.K. Kim & D.A. Melton; PNAS 95, 13036 (1998) Abstract; Full Text
Teratogen-mediated inhibition of target tissue response to Shh signaling: M.K. Cooper, et al.; Science 280, 1603 (1998) Abstract
Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine: J. Taipale, et al.; Nature 406, 1005 (2000) Abstract
Cyclopamine inhibition of Sonic hedgehog signal transduction is not mediated through effects on cholesterol transport: J.P. Incardona, et al.; Dev. Biol. 224, 440 (2000) Abstract
Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened: J.K. Chen, et al.; Genes Dev. 16, 2743 (2002) Abstract; Full Text
Small molecule modulation of Smoothened activity: J.K. Chen, et al.; PNAS 99, 14071 (2002) Abstract; Full Text
Medulloblastoma growth inhibition by hedgehog pathway blockade: D.M. Berman, et al.; Science 297, 1559 (2002) Abstract
Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer: D.N. Watkins, et al.; Nature 422, 313 (2003) Abstract
Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours: D.M. Berman, et al.; Nature 425, 846 (2003) Abstract
Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis: S.P. Thayer, et al.; Nature 425, 851 (2003) Abstract
Hedgehog signalling in colorectal tumour cells: induction of apoptosis with cyclopamine treatment: D. Qualtrough, et al.; Int. J. Cancer 110, 831 (2004) Abstract
Induction of the differentiation and apoptosis of tumor cells in vivo with efficiency and selectivity: S. Tabs & O. Avci; Eur. J. Dermatol. 14, 96 (2004) Abstract; Full Text
In vitro directed differentiation of mouse embryonic stem cells into insulin-producing cells: T. Leon-Quinto, et al.; Diabetologia 47, 1442 (2004) Abstract
Transforming growth factor (TGF)beta, fibroblast growth factor (FGF) and retinoid signalling pathways promote pancreatic exocrine gene expression in mouse embryonic stem cells: A. Skoudy, et al.; Biochem. J. 379, 749 (2004) Abstract; Full Text
Purmorphamine induces osteogenesis by activation of the hedgehog signaling pathway: X. Wu, et al.; Chem. Biol. 11, 1229 (2004) Abstract
Related Products
 
 
ALX-550-269 Revised 27-Oct-06
8-Cyclopentyl-1,3-dipropylxanthine
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SYNONYMS DPCPX
PD 116,948
1,3-Dipropyl-8-cyclopentylxanthine
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Adenosine Receptors/Related Products
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ALX-550-269-M010   10 mg 35.00 USD Add To Cart
Product Specification
FORMULA: C16H24N4O2
MW: 304.4
CAS NUMBER: 102146-07-6
PURITY: ≥98% (HPLC)
APPEARANCE: White to light yellow.
SOLUBILITY: Soluble in 100% ethanol or DMSO; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
HAZARD: IRRITANT.

Product Description
Potent and very selective A1 adenosine receptor antagonist, both in vitro and in vivo.
Product Specific Literature References
1,3-Dipropyl-8-cyclopentylxanthine (DPCPX) inhibition of [3H]N- ethylcarboxamidoadenosine (NECA) binding allows the visualization of putative non-A1 adenosine receptors: K.S. Lee & M. Reddington; Brain Res. 368, 394 (1986) Abstract
Binding of the A1-selective adenosine antagonist 8-cyclopentyl-1,3- dipropylxanthine to rat brain membranes: R.F. Bruns, et al.; Naunyn-Schmiedeberg's Arch. Pharmacol. 335, 59 (1987) Abstract
PD 116,948, a highly selective A1 adenosine receptor antagonist: S.J. Haleen, et al.; Life Sci. 40, 555 (1987) Abstract
Effects of 1,3-dipropyl-8-cyclopentylxanthine (DPCPX), a highly selective adenosine receptor antagonist, on force of contraction in guinea-pig atrial and ventricular cardiac preparations: H. von der Leyen, et al.; Naunyn-Schmiedeberg's Arch. Pharmacol. 340, 204 (1989) Abstract
Characterization of the adenosine receptors mediating hypothermia in the conscious mouse: Anderson, et al.; Br. J. Pharmacol. 113, 1386 (1994) Abstract
 
 
ALX-350-023 Revised 03-Jun-08
Cyclopiazonic acid
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SYNONYMS CPA
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - ATPase Inhibitors
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-023-M005   5 mg 42.00 USD Add To Cart
ALX-350-023-M025   25 mg 145.00 USD Add To Cart
ALX-350-023-M100   100 mg 460.00 USD Add To Cart
Product Specification
FORMULA: C20H20N2O3
MW: 336.4
CAS NUMBER: 18172-33-3
RTECS: UY8587000
SOURCE/HOST: Isolated from Penicillium griseofulvum.
PURITY: ≥98% (TLC)
APPEARANCE: Off-white to yellow powder.
SOLUBILITY: Soluble in DMSO (50mg/ml), methylene chloride or methanol (10mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: TOXIC.

Product Description
Mycotoxin. Cell permeable, reversible inhibitor of Ca2+-ATPases.
Product Specific Literature References
Cyclopiazonic acid is a specific inhibitor of the Ca2+-ATPase of sarcoplasmic reticulum: N.W. Seidler, et al.; J. Biol. Chem. 264, 17816 (1989) Abstract; Full Text
Acetylcholine Ca2+ stores refilling directly involves a dihydropyridine- sensitive channel in dog trachea: J.P. Bourreau, et al.; Am. J. Physiol. 261, C497 (1991) Abstract
Discrimination of Ca(2+)-ATPase activity of the sarcoplasmic reticulum from actomyosin-type ATPase activity of myofibrils in skinned mammalian skeletal muscle fibres: distinct effects of cyclopiazonic acid on the two ATPase activities: N. Kurebayashi & Y. Ogawa; J. Muscle Res. Cell Motility 12, 355 (1991) Abstract
Coupling between intracellular Ca2+ stores and the Ca2+ permeability of the plasma membrane. Comparison of the effects of thapsigargin, 2,5-di- (tert-butyl)-1,4-hydroquinone, and cyclopiazonic acid in rat thymic lymphocytes: M.J. Mason, et al.; J. Biol. Chem. 266, 20856 (1991) Abstract; Full Text
Cyclopiazonic acid depletes intracellular Ca2+ stores and activates an influx pathway for divalent cations in HL-60 cells: N. Demaurex, et al.; J. Biol. Chem. 267, 2318 (1992) Abstract; Full Text
Cyclopiazonic acid, an inhibitor of the sarcoplasmic reticulum Ca(2+)- pump, reduces Ca(2+)-dependent K+ currents in guinea-pig smooth muscle cells: M. Suzuki, et al.; Br. J. Pharmacol. 107, 134 (1992) Abstract
Effects of cyclopiazonic acid, a novel Ca(2+)-ATPase inhibitor, on contractile responses in skinned ileal smooth muscle: Y. Uyama, et al.; Br. J. Pharmacol. 106, 208 (1992) Abstract
Effects of cyclopiazonic acid and ryanodine on cytosolic calcium and contraction in vascular smooth muscle: F. Abe, et al.; Br. J. Pharmacol. 118, 1711 (1996) Abstract
Natural and in vitro coproduction of cyclopiazonic acid and aflatoxins: M.L. Martins & H.M. Martins; J. Food Prot. 62, 292 (1999) Abstract
Recent advances in analytical methodology for cyclopiazonic acid: J.W. Dorner; Adv. Exp. Med. Biol. 504, 107 (2002), Review Abstract
Cyclopiazonic acid reduces the coupling factor of the Ca2+-ATPase acting on Ca2+ binding: F. Martinez-Azorin; FEBS Lett. 576, 73 (2004) Abstract
Further Categories Containing This Product:
Ca2+-ATPase/Related Products • Neurotoxins • Mycotoxins