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Ca2+ / Calmodulin-dependent Protein Kinases [CAM] / Related Products
You are here: Product Lines > Signal Transduction > Calcium Signalling (Intracellular) > Ca2+ / Calmodulin-dependent Protein Kinases [CAM] / Related Products
 
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ALX-151-023 Revised 23-Nov-06
Autocamtide-2
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY CAM Kinase Substrates
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-151-023-M001   1 mg 80.00 USD Add To Cart
ALX-151-023-M005   5 mg 320.00 USD Add To Cart
Product Specification
SEQUENCE: H-Lys-Lys-Ala-Leu-Arg-Arg-Gln-Glu-Thr-Val-Asp-Ala-Leu-OH
FORMULA: C65H118N22O20
MW: 1527.8
PURITY: ≥98%
APPEARANCE: Lyophilized.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Very selective substrate for Ca2+/calmodulin-dependent protein kinase II.
Product Specific Literature References
Expression of a multifunctional Ca2+/calmodulin-dependent protein kinase and mutational analysis of its autoregulation: P.I. Hanson, et al.; Neuron 3, 59 (1989) Abstract
Further Categories Containing This Product:
Peptides
 
 
ALX-151-029 Revised 23-Nov-06
Autocamtide-2-Related Inhibitory Peptide
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SYNONYMS AIP
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY CAM Kinase Inhibitors
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-151-029-M001   1 mg 75.00 USD Add To Cart
ALX-151-029-M005   5 mg 300.00 USD Add To Cart
Product Specification
SEQUENCE: H-Lys-Lys-Ala-Leu-Arg-Arg-Gln-Glu-Ala-Val-Asp-Ala-Leu-OH
FORMULA: C64H116N22O19
MW: 1497.8
PURITY: ≥98%
APPEARANCE: Lyophilized.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Highly specific and potent inhibitor of Ca2+/calmodulin-dependent protein kinase II without affecting cAMP-dependent protein kinase (PKA), protein kinase C (PKC) and Ca2+/calmodulin-dependent protein kinase IV.
Product Specific Literature References
A novel highly specific and potent inhibitor of calmodulin-dependent protein kinase II: A. Ishida, et al.; BBRC 212, 806 (1995) Abstract
Stabilization of calmodulin-dependent protein kinase II through the autoinhibitory domain: A. Ishida & H. Fujisawa; J. Biol. Chem. 270, 2163 (1995) Abstract; Full Text
Further Categories Containing This Product:
Peptides
 
 
ALX-151-030 Revised 05-Feb-08
Autocamtide-2-Related Inhibitory Peptide (Myristoylated)
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SYNONYMS AIP Myristoylated
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY CAM Kinase Inhibitors
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ALX-151-030-MC05   0.5 mg 90.00 USD Add To Cart
Product Specification
SEQUENCE: Myr-Lys-Lys-Ala-Leu-Arg-Arg-Gln-Glu-Ala-Val-Asp-Ala-Leu-OH
FORMULA: C78H142N22O20
MW: 1708.1
PURITY: ≥98%
APPEARANCE: Lyophilized.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Corresponds to Prod. No. ALX-151-029 but this one is N-terminal myristoylated to increase cell permeability.
Further Categories Containing This Product:
Peptides
 
 
ALX-202-026 Revised 30-Aug-07
Ca2+/Calmodulin-dependent Protein Kinase II (rat brain)
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SYNONYMS CaM Kinase II (rat brain)
CAMK2 (rat brain)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY CAM Kinases
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-202-026-C001   1 µg 295.00 USD Add To Cart
Product Specification
MW: ~65kDa. Composed of 60kDa and 50kDa subunits in ratios of 1:3 to 1:4.
EC: 2.7.1.123
SOURCE/HOST: Isolated from rat brain. Requires activation.
CONCENTRATION: 20µg/ml
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Liquid. In 25mM TRIS/HCl, pH 7.5, 0.5mM EDTA, 10mM β-mercaptoethanol, 10µM AEBSF, 50% glycerol and 0.1mg/ml leupeptin.
RECONSTITUTION: Reconstitute with sterile distilled water.
SPECIFIC ACTIVITY: ~1µmol/mg/min at 30°C using synapsin I as the substrate.
SHIPPING: SHIPPED ON DRY ICE
LONG TERM STORAGE: -80°C
HANDLING: Avoid freeze/thaw cycles.
General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link: Ca2+/Calmodulin-dependent Protein Kinase II (rat) α chain (P11275), β chain (P08413), γ chain (P11730), δ chain (P15791)
AfCS Signalling Gateway link: Ca2+/Calmodulin-dependent Protein Kinase II (mouse) α chain (A000456), β chain (A000457), γ chain (A000459), δ chain (A000458)
Further Categories Containing This Product:
Enzymes • Natural Proteins
 
 
ALX-153-009 Revised 20-Sep-05
Ca2+/Calmodulin-dependent Protein Kinase II (281-289)
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SYNONYMS CaM Kinase II (281-289)
CAMK2 (281-289)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY CAM Kinases
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-153-009-M001   1 mg 70.00 USD Add To Cart
ALX-153-009-M005   5 mg 280.00 USD Add To Cart
Product Specification
SEQUENCE: H-Met-His-Arg-Gln-Glu-Thr-Val-Asp-Cys-OH
FORMULA: C43H71N15O16S2
MW: 1118.3
PURITY: ≥97%
APPEARANCE: White lyophilized powder.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Amino acid sequence defining the major Ca2+-dependent autophosphorylation site of Ca2+/calmodulin-dependent protein kinase II.
Product Specific Literature References
Regulatory interactions of the calmodulin-binding, inhibitory, and autophosphorylation domains of Ca2+/calmodulin-dependent protein kinase II: R.J. Colbran, et al.; J. Biol. Chem. 263, 18145 (1988) Abstract; Full Text
Functional determinants in the autoinhibitory domain of calcium/calmodulin-dependent protein kinase II. Role of His282 and multiple basic residues: M.K. Smith, et al.; J. Biol. Chem. 267, 1761 (1992) Abstract; Full Text
Ca2+/calmodulin-dependent protein kinase II is phosphorylated by protein kinase C in vitro: M.N. Waxham & J. Aronowski; Biochemistry 32, 2923 (1993) Abstract
Further Categories Containing This Product:
Peptides
 
 
ALX-153-018 Revised 16-Feb-05
[Ala288]-Ca2+/Calmodulin-dependent Protein Kinase II (281-289)
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY CAM Kinases
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ALX-153-018-M005   5 mg 60.00 USD Add To Cart
Product Specification
SEQUENCE: H-Met-His-Arg-Gln-Glu-Thr-Val-Ala-Cys-OH
FORMULA: C42H71N15O14S2
MW: 1074.3
PURITY: ≥97%
APPEARANCE: Lyophilized powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Further Categories Containing This Product:
Peptides
 
 
ALX-153-010 Revised 16-Feb-05
[Ala286]-Ca2+/Calmodulin-dependent Protein Kinase II (281-302)
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY CAM Kinase Inhibitors
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-153-010-MC01   0.1 mg 50.00 USD Add To Cart
ALX-153-010-M001   1 mg 190.00 USD Add To Cart
Product Specification
SEQUENCE: H-Met-His-Arg-Gln-Glu-Ala-Val-Asp-Cys-Leu-Lys-Lys-Phe-Asn-Ala-Arg-Arg-Lys-Leu-Lys-Gly-Ala-OH
FORMULA: C111H191N39O29S2
MW: 2600.1
PURITY: ≥97%
APPEARANCE: White lyophilized powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Inhibitor of Ca2+/calmodulin-dependent protein kinase II catalytic fragment, competitive with ATP. The sequence for this product matches that of the original article describing this "CaM kinase II inhibitor" peptide.
Product Specific Literature References
Functional determinants in the autoinhibitory domain of calcium/calmodulin-dependent protein kinase II. Role of His282 and multiple basic residues: M.K. Smith, et al.; J. Biol. Chem. 267, 1761 (1992) Abstract; Full Text
Further Categories Containing This Product:
Peptides
 
 
ALX-153-006 Revised 20-Sep-05
Ca2+/Calmodulin-dependent Protein Kinase II (290-309)
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SYNONYMS CaM Kinase II (290-309)
CAMK2 (290-309)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY CAM Kinase Inhibitors
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ALX-153-006-MC01   0.1 mg 40.00 USD Add To Cart
ALX-153-006-M001   1 mg 120.00 USD Add To Cart
Product Specification
SEQUENCE: H-Leu-Lys-Lys-Phe-Asn-Ala-Arg-Arg-Lys-Leu-Lys-Gly-Ala-Ile-Leu-Thr-Thr-Met-Leu-Ala-OH
FORMULA: C103H185N31O24S
MW: 2273.9
PURITY: ≥98%
APPEARANCE: White lyophilized powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Potent inhibitor of Ca2+/calmodulin-dependent protein kinase II.
Product Specific Literature References
Calcium/calmodulin-dependent protein kinase II. Characterization of distinct calmodulin binding and inhibitory domains: M.E. Payne, et al.; J. Biol. Chem. 263, 7190 (1988) Abstract; Full Text
Further Categories Containing This Product:
Peptides
 
 
ALX-153-008 Revised 20-Sep-05
Ca2+/Calmodulin-dependent Protein Kinase IV Substrate
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SYNONYMS CaM Kinase IV Substrate
CAMK4 Substrate
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY CAM Kinase Substrates
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-153-008-M001   1 mg 70.00 USD Add To Cart
ALX-153-008-M005   5 mg 290.00 USD Add To Cart
Product Specification
SEQUENCE: H-Lys-Ser-Asp-Gly-Gly-Val-Lys-Lys-Arg-Lys-Ser-Ser-Ser-Ser-OH
FORMULA: C58H107N21O22
MW: 1450.6
PURITY: ≥98%
APPEARANCE: White lyophilized powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Very selective and potent substrate for a brain-specific Ca2+/calmodulin-dependent protein kinase IV over Ca2+/calmodulin-dependent protein kinase II. This peptide corresponds to aa 345-358 of Ca2+/calmodulin-dependent protein kinase II-δ.
Product Specific Literature References
Purification and characterization of a brain-specific multifunctional calmodulin-dependent protein kinase from rat cerebellum: O. Miyano, et al.; J. Biol. Chem. 267, 1198 (1992) Abstract; Full Text
Further Categories Containing This Product:
Peptides
 
 
ALX-380-284 Revised 08-Apr-08
Cyclosporin D
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SYNONYMS Val2-cyclosporin
7-L-Valine-cyclosporin A
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - Immunomodulators
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ALX-380-284-M001   1 mg 80.00 USD Add To Cart
ALX-380-284-M005   5 mg 320.00 USD Add To Cart
Product Specification
FORMULA: C63H113N11O12
MW: 1216.6
CAS NUMBER: 63775-96-2
MERCK INDEX: 14: 2752
SOURCE/HOST: Isolated from Fusarium solani.
PURITY: ≥95% (HPLC)
APPEARANCE: Colorless to off-white crystalline solid.
SOLUBILITY: Soluble in 100% ethanol, acetone or ethyl acetate; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: MAY BE TERATOGENIC. TOXIC. MAY BE CARCINOGENIC.

Product Description
Weak immunosuppressor. Potent inhibitor of tumor promoting phorbol ester TPA/PMA (Prod. No. ALX-445-004) in vivo. Potent inhibitor of Ca2+/calmodulin dependent EF-2 phosphorylation in vitro.
Product Specific Literature References
The weak immunosuppressant cyclosporine D as well as the immunologically inactive cyclosporine H are potent inhibitors in vivo of phorbol ester TPA-induced biological effects in mouse skin and of Ca2+/calmodulin dependent EF-2 phosphorylation in vitro: M. Gschwendt, et al.; BBRC 150, 545 (1988) Abstract
Further Categories Containing This Product:
MPTP [Mitochondrial Transition Pore] / Related Products • CAM Kinase Inhibitors
 
 
ALX-380-286 Revised 08-Apr-08
Cyclosporin H
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SYNONYMS Csh-cyclosporin
5-(N-Methyl-D-valine)-cyclosporin A
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - Immunomodulators
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ALX-380-286-M001   1 mg 80.00 USD Add To Cart
ALX-380-286-M005   5 mg 320.00 USD Add To Cart
Product Specification
FORMULA: C62H111N11O12
MW: 1202.6
CAS NUMBER: 83602-39-5
SOURCE/HOST: Isolated from Fusarium solani.
PURITY: ≥95% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in 100% ethanol, acetone or ethyl acetate; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: MAY BE TERATOGENIC. TOXIC. MAY BE CARCINOGENIC.

Product Description

Immunologically inactive. Does not bind to immunophilin. Potent inhibitor of tumor promoting phorbol ester TPA/PMA (Prod. No. ALX-445-004) in mouse skin in vivo. Potent inhibitor of Ca2+/calmodulin dependent EF-2 phosphorylation in vitro. Potent and selective antagonist of formyl peptide receptor. Inhibits formyl peptide-induced superoxide formation.

Product Specific Literature References
The weak immunosuppressant cyclosporine D as well as the immunologically inactive cyclosporine H are potent inhibitors in vivo of phorbol ester TPA-induced biological effects in mouse skin and of Ca2+/calmodulin dependent EF-2 phosphorylation in vitro: M. Gschwendt, et al.; BBRC 150, 545 (1988) Abstract
Differential inhibition of human neutrophil activation by cyclosporins A, D, and H. Cyclosporin H is a potent and effective inhibitor of formyl peptide-induced superoxide formation: K. Wenzel-Seifert, et al.; J. Immunol. 147, 1940 (1991) Abstract
Cyclosporin H is a potent and selective formyl peptide receptor antagonist. Comparison with N-t-butoxycarbonyl-L-phenylalanyl-L-leucyl-L-phenylalanyl-L- leucyl-L-phenylalanine and cyclosporins A, B, C, D, and E: K. Wenzel-Seifert & R. Seifert; J. Immunol. 150, 4591 (1993) Abstract
Cyclosporin H is a potent and selective competitive antagonist of human basophil activation by N-formyl-methionyl-leucyl-phenylalanine: A. de Paulis, et al.; J. Allergy Clin. Immunol. 98, 152 (1996) Abstract
Cyclosporin H, Boc-MLF and Boc-FLFLF are antagonists that preferentially inhibit activity triggered through the formyl peptide receptor: A.L. Stenfeldt, et al.; Inflammation 30, 224 (2007) Abstract
Further Categories Containing This Product:
MPTP [Mitochondrial Transition Pore] / Related Products • Antibiotics - Apoptosis Inducers & Inhibitors • CAM Kinase Inhibitors • Antibiotics - Nitric Oxide Pathway Modulators • Non-apoptotic Cell Death / Necrosis