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ALX-420-030
Revised 24-Sep-08
BAY 41-2272
SYNONYMS
3-(4-Amino-5-cyclopropylpyrimidine-2-yl)-1-(2-fluorobenzyl)-1
H
-pyrazolo[3,4-b]pyridine
PRODUCT LINE
Nitric Oxide Pathway
PRODUCT CATEGORY
Guanylyl Cyclases, Guanosine Phosphate Metabolism / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-420-030-M005
5 mg
92.00 USD
ALX-420-030-M025
25 mg
358.00 USD
Product Specification
FORMULA:
C
20
H
17
FN
6
MW:
360.4
CAS NUMBER:
256376-24-6
PURITY:
≥98%
APPEARANCE:
White to off-white needles.
SOLUBILITY:
Soluble in DMSO, dichloromethane, 100% ethanol or 2-pyrrolidone; practically insoluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HAZARD:
IRRITANT.
Product Description
NO-independent activator of soluble guanylyl cyclase (sGC) [1,2]. Activates both isoforms α
1
β
1
and α
1
β
2
of sGC [3]. While the related compound YC-1 (Prod. No.
ALX-420-025
) also acts as a non-specific phosphodiesterase inhibitor, BAY 41-2272 has no effect on phosphodiesterases. Stimulation of sGC is not blocked by high concentrations of NO scavengers (e.g. PTIO, Prod. No.
ALX-430-007
) and the combination of BAY 41-2272 with the NO donor DEA NONOate (Prod. No.
ALX-430-034
) potentiates the activation of sGC. Although BAY 41-2272 alone is not as strong a stimulator of sGC as NO, concentrations as low as 10-100nM stimulate sGC to a level that would be expected to cause biologically important increases in cGMP [1]. ODQ (Prod. No.
ALX-270-034
), a potent and selective inhibitor of sGC, completely inhibited the effect of BAY 41-2272 [1]. The activity of BAY 41-2272 is described in selected literature references [4-6].
Product Specific Literature References
[1]
NO-independent regulatory site on soluble guanylate cyclase
:
J.P. Stasch, et al.; Nature
410
, 212 (2001)
Abstract
[2]
NO-independent regulatory site of direct sGC stimulators like YC-1 and BAY 41-2272
:
E.M. Becker, et al.; BMC Pharmacol.
1
, 13 (2001)
Abstract
;
Full Text
NO-independent stimulators of soluble guanylate cyclase:
A. Straub, et al.; Bioorg. Med. Chem. Lett.
11
, 781 (2001)
Abstract
[3]
BAY 41-2272 activates two isoforms of nitric oxide-sensitive guanylyl cyclase
:
M. Koglin, et al.; BBRC
292
, 1057 (2002)
Abstract
[4]
Cardiorenal and humoral properties of a novel direct soluble guanylate cyclase stimulator BAY 41-2272 in experimental congestive heart failure:
G. Boerrigter, et al.; Circulation
107
, 686 (2003)
Abstract
[5]
BAY 41-2272: a stimulator of soluble guanylyl cyclase induces nitric oxide-dependent penile erection in vivo
:
E. Bischoff, et al.; Urology
61
, 464 (2003)
Abstract
[6]
Macrophage endothelial nitric oxide synthase auto-regulates cellular activation and pro-inflammatory protein expression
:
L. Connelly, et al.; J. Biol. Chem
278
, 26480 (2003)
Abstract
;
Full Text
Antiinflammatory activity of soluble guanylate cyclase: cGMP-dependent down-regulation of P-selectin expression and leukocyte recruitment:
A. Ahluwalia, et al.; PNAS
101
, 1386 (2004)
Abstract
;
Full Text
Identification of residues crucially involved in soluble guanylate cyclase activation:
C. Rothkegel, et al.; FEBS Lett.
580
, 4205 (2006)
Abstract
ALX-152-022
Revised 04-Jul-03
BPDEtide
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
PKG Substrates
Ordering Information
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ALX-152-022-M001
1 mg
60.00 USD
ALX-152-022-M005
5 mg
240.00 USD
Product Specification
SEQUENCE:
H-Arg-Lys-Ile-Ser-Ala-Ser-Glu-Phe-Asp-Arg-Pro-Leu-Arg-OH
FORMULA:
C
68
H
115
N
23
O
20
MW:
1574.8
PURITY:
≥97%
APPEARANCE:
White lyophilized powder.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Substrate for cGMP-dependent protein kinase corresponding to a peptide sequence surrounding the phosphorylation site of cGMP-binding cGMP-specific phosphodiesterase.
Product Specific Literature References
Studies of two different intrachain cGMP-binding sites of cGMP- dependent protein kinase:
J.D Corbin & S.O. Dřskeland; J. Biol. Chem.
258
, 11391 (1983)
Abstract
;
Full Text
A phenylalanine in peptide substrates provides for selectivity between cGMP- and cAMP-dependent protein kinases:
J.L. Colbran, et al.; J. Biol. Chem.
267
, 9589 (1992)
Abstract
;
Full Text
Further Categories Containing This Product:
Guanylyl Cyclases, Guanosine Phosphate Metabolism / Related Products
•
Peptides
ALX-153-055
Revised 25-May-07
Carnosine
SYNONYMS
β-Alanyl-L-histidine
PRODUCT LINE
Nitric Oxide Pathway
PRODUCT CATEGORY
Guanylyl Cyclases, Guanosine Phosphate Metabolism / Related Products
Ordering Information
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Format:
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ALX-153-055-G001
1 g
55.00 USD
Product Specification
SEQUENCE:
H-β-Ala-His-OH
FORMULA:
C
9
H
14
N
4
O
3
MW:
226.2
CAS NUMBER:
305-84-0
PURITY:
≥98%
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in 80% acetic acid (10mg/ml).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Antioxidant. Inhibits soluble guanylyl cyclase (sGC) by interacting with the heme iron to form a chelate complex.
Product Specific Literature References
Carnosine as a regulator of soluble guanylate cyclase
:
I.S. Severina, et al.; Biochemistry (Mosc)
65
, 783 (2000)
Abstract
;
Full Text
Further Categories Containing This Product:
Antioxidants, Flavonoids & Free Radical Scavengers Other Products
ALX-430-086
Revised 13-Dec-06
DD1
SYNONYMS
3-Bromo-3,4,4-trimethyl-3,4-dihydrodiazete 1,2-dioxide
PRODUCT LINE
Nitric Oxide Pathway
PRODUCT CATEGORY
Nitric Oxide Donors
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ALX-430-086-M010
10 mg
30.00 USD
ALX-430-086-M050
50 mg
90.00 USD
Product Specification
FORMULA:
C
5
H
9
BrN
2
O
2
MW:
209.0
PURITY:
≥98%
APPEARANCE:
Crystals.
SOLUBILITY:
Soluble in DMSO, 100% ethanol or water (10mM).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Guanylyl cyclase activator. Cell permeable thiol-induced nitric oxide donor with strong vasodilator effects.
Product Specific Literature References
Kinetics of nitric oxide liberation by 3,4-dihydro-1,2-diazete 1,2- dioxides and their vasodilatory properties in vitro and in vivo:
D.I. Utepbergenov, et al.; BBRC
214
, 1023 (1995)
Abstract
Thiol-induced nitric oxide release from 3-halogeno-3,4-dihydrodiazete 1,2-dioxides:
I.A. Kirilyuk, et al.; J. Med. Chem.
41
, 1027 (1998)
Abstract
Geldanamycin leads to superoxide formation by enzymatic and non-enzymatic redox cycling. Implications for studies of Hsp90 and endothelial cell nitric-oxide synthase:
S. Dikalov, et al.; J. Biol. Chem.
277
, 25480 (2002)
Abstract
;
Full Text
Inflammatory cytokines induce apoptosis of corneal endothelium through nitric oxide:
P. Sagoo, et al.; Invest. Ophthalmol. Vis. Sci.
45
, 3964 (2004)
Abstract
;
Full Text
Further Categories Containing This Product:
Guanylyl Cyclases, Guanosine Phosphate Metabolism / Related Products
ALX-430-087
Revised 23-Feb-05
DD2
SYNONYMS
3-Bromo-4-methyl-3,4-hexamethylene-3,4-dihydrodiazete 1,2-dioxide
PRODUCT LINE
Nitric Oxide Pathway
PRODUCT CATEGORY
Nitric Oxide Donors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-430-087-M010
10 mg
30.00 USD
ALX-430-087-M050
50 mg
90.00 USD
Product Specification
FORMULA:
C
7
H
11
BrN
2
O
2
MW:
235.1
PURITY:
≥98%
APPEARANCE:
Crystals.
SOLUBILITY:
Soluble in water (3.5mM), DMSO or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Guanylyl cyclase activator. Cell permeable thiol-induced nitric oxide donor with strong vasodilator effects.
Product Specific Literature References
Kinetics of nitric oxide liberation by 3,4-dihydro-1,2-diazete 1,2- dioxides and their vasodilatory properties in vitro and in vivo:
D.I. Utepbergenov, et al.; BBRC
214
, 1023 (1995)
Abstract
Thiol-induced nitric oxide release from 3-halogeno-3,4-dihydrodiazete 1,2-dioxides:
I.A. Kirilyuk, et al.; J. Med. Chem.
41
, 1027 (1998)
Abstract
Further Categories Containing This Product:
Guanylyl Cyclases, Guanosine Phosphate Metabolism / Related Products
ALX-480-048
Revised 06-Mar-07
2',3'-Dideoxyadenosine
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Adenosine Derivatives Other Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
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ALX-480-048-M001
1 mg
15.00 USD
ALX-480-048-M005
5 mg
30.00 USD
Product Specification
FORMULA:
C
10
H
13
N
5
O
2
MW:
235.2
CAS NUMBER:
4097-22-7
MERCK INDEX:
14:
3101
PURITY:
≥97%
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in water or DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
Product Description
Inhibitor of adenylate cyclase. Useful tool in antiviral and anticancer studies. Blocks viral reverse transcription from RNA to DNA. Inhibitor of adenosine deaminase.
Product Specific Literature References
Interpretation of the roles of adenylosuccinate lyase and of AMP deaminase in the anti-HIV activity of 2',3'-dideoxyadenosine and 2',3'- dideoxyinosine:
V. Nair & T.B. Sells; Biochim. Biophys. Acta
1119
, 201 (1992)
Abstract
Long-term inhibn. of human T-lymphotropic virus type III/lymphadenopathy-associated virus DNA synthesis and RNA expression in T cells protected by 2',3'-dideoxynucleosides in vitro:
H. Mitsuya, et al.; PNAS
84
, 2033 (1987)
Abstract
Further Categories Containing This Product:
Adenylyl Cyclase Inhibitors
•
Antiviral Agents Other Products
ALX-480-049
Revised 03-Jun-08
2',5'-Dideoxyadenosine
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Adenosine Derivatives Other Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-480-049-M001
1 mg
30.00 USD
ALX-480-049-M005
5 mg
90.00 USD
Product Specification
FORMULA:
C
10
H
13
N
5
O
2
MW:
235.2
CAS NUMBER:
6698-26-6
PURITY:
≥98% (TLC)
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in water (20mg/ml at 50°C) or DMSO (30mg/ml).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Solutions are stable for up to 3 months when stored at -20°C.
Product Description
Cell permeable inhibitor of adenylate cyclase
(ID
50
=250µM [1]; inhibition also reported at 1mM [2]). Inhibits growth and causes cell differentiation (1.5µM) in K562 cells [6].
Product Specific Literature References
[1]
Role of adenylate cyclase in immunologic release of mediators from rat mast cells: agonist and antagonist effects of purine- and ribose- modified adenosine analogs:
S.T. Holgate, et al.; PNAS
77
, 6800 (1980)
Abstract
[2]
Inhibition of adenylate cyclase attenuates adenosine receptor-mediated relaxation in coronary artery
:
M.H. Sabouni, et al.; J. Pharmacol. Exp. Ther.
259
, 508 (1991)
Abstract
[3]
Direct inhibitory effect of neurotensin on isolated gastric smooth muscle cells of guinea pig via the cyclic GMP system:
Y. Chijiiwa, et al.; Digestion
54
, 135 (1993)
Abstract
[4]
Isoproterenol antagonistic effect of 2',5'-dideoxyadenosine in the isolated perfused guinea-pig heart
:
M. Hartmann & J. Schrader; J. Mol. Cell. Cardiol.
25
, 331 (1993)
Abstract
[5]
Erythroid differentiation and growth inhibition of K562 cells by 2',5'-dideoxyadenosine: synergism with interferon-alpha
:
K. Ogawa, et al.; Leuk. Res.
19
, 749 (1995)
Abstract
Further Categories Containing This Product:
Adenylyl Cyclase Inhibitors
•
Antiviral Agents Other Products
ALX-300-147
Revised 11-Jul-08
Dihomo-γ-linolenylethanolamide
SYNONYMS
N-(2-Hydroxyethyl)-8
Z
,11
Z
,14
Z
-eicosatrienamide
HEA
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Endocannabinoids
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
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ALX-300-147-M005
5 mg
63.00 USD
Product Specification
FORMULA:
C
22
H
39
NO
2
MW:
349.6
CAS NUMBER:
150314-34-4
PURITY:
≥98%
FORMULATION:
Liquid. Solution in ethanol.
SOLUBILITY:
Soluble in DMSO (30mg/ml) or dimethyl formamide (10mg/ml); 8mg/ml soluble in a 1:2 solution of ethanol:PBS (pH 7.2) (dilute the ethanol solution with PBS).
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 1 year after receipt when stored at -20°C. We do not recommend storing aqueous solutions for more than one day.
HANDLING:
Protect from light.
Product Description
Endocannabinoid. Binds to recombinant human CB
1
(K
i
=857nM) and CB
2
receptor (K
i
=598nM). Also inhibits adenylyl cyclase (IC
50
=109nM).
Product Specific Literature References
Two new unsaturated fatty acid ethanolamides in brain that bind to the cannabinoid receptor:
L. Hanus, et al.; J. Med. Chem.
36
, 3032 (1993)
Abstract
Anandamide, an endogenous cannabimimetic eicosanoid, binds to the cloned human cannabinoid receptor and stimulates receptor-mediated signal transduction
:
C.C. Felder, et al.; PNAS
90
, 7656 (1993)
Abstract
Cannabinomimetic behavioral effects of and adenylate cyclase inhibition by two new endogenous anandamides:
J. Barg, et al.; Eur. J. Pharmacol.
287
, 145 (1995)
Abstract
Comparison of the pharmacology and signal transduction of the human cannabinoid CB1 and CB2 receptors
:
C.C. Felder, et al.; Mol. Pharmacol.
48
, 443 (1995)
Abstract
Astrocytes in culture produce anandamide and other acylethanolamides
:
L. Walter, et al.; Biol. Chem.
277
, 20869 (2002)
Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION
To change the solvent, evaporate the ethanol under a gentle stream of nitrogen and immediately add the solvent of choice.
Further Categories Containing This Product:
Adenylyl Cyclase Inhibitors
ALX-300-148
Revised 11-Jul-08
Docosatetraenylethanolamide
SYNONYMS
N-(2-Hydroxyethyl)-7
Z
,10
Z
,13
Z
,16
Z
-docosatetraenamide
DEA
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Endocannabinoids
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
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ALX-300-148-M005
5 mg
63.00 USD
Product Specification
FORMULA:
C
24
H
41
NO
2
MW:
375.6
CAS NUMBER:
150314-35-5
PURITY:
≥98%
FORMULATION:
Liquid. Solution in ethanol.
SOLUBILITY:
10mg/ml soluble in DMSO or dimethyl formamide; 8mg/ml soluble in 1:2 solution of ethanol:PBS (pH 7.2) (dilute the ethanol solution with PBS).
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 1 year after receipt when stored at -20°C. We do not recommend storing aqueous solutions for more than one day.
HANDLING:
Protect from light.
Product Description
Endocannabinoid. Also inhibits adenylate cyclase (IC
50
=117nM). Does also bind to TRPV1 (K
i
=5.63µM).
Product Specific Literature References
Two new unsaturated fatty acid ethanolamides in brain that bind to the cannabinoid receptor:
L. Hanus, et al.; J. Med. Chem.
36
, 3032 (1993)
Abstract
Anandamide, an endogenous cannabimimetic eicosanoid, binds to the cloned human cannabinoid receptor and stimulates receptor-mediated signal transduction
:
C.C. Felder, et al.; PNAS
90
, 7656 (1993)
Abstract
Cannabinomimetic behavioral effects of and adenylate cyclase inhibition by two new endogenous anandamides:
J. Barg, et al.; Eur. J. Pharmacol.
287
, 145 (1995)
Abstract
Structure-activity relationship for the endogenous cannabinoid, anandamide, and certain of its analogues at vanilloid receptors in transfected cells and vas deferens
:
R.A. Ross, et al.; Br. J. Pharmacol.
132
, 631 (2001)
Abstract
Astrocytes in culture produce anandamide and other acylethanolamides
:
L. Walter, et al.; J. Biol. Chem.
277
, 20869 (2002)
Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION
To change the solvent, evaporate the ethanol under a gentle stream of nitrogen and immediately add the solvent of choice.
Further Categories Containing This Product:
Adenylyl Cyclase Inhibitors
•
TRPV1 Agonists and Antagonists / Related Products
•
Fatty Acids
ALX-350-001
Revised 05-Apr-08
Forskolin
SYNONYMS
Colforsin
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products - Other Signal Transduction Pathway Modulators
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-350-001-M001
1 mg
20.00 USD
ALX-350-001-M005
5 mg
52.00 USD
ALX-350-001-M010
10 mg
85.00 USD
ALX-350-001-M025
25 mg
185.00 USD
ALX-350-001-M050
