Advanced Search
© 2008 Alexis Corporation
You are here:
Product Lines
>
Signal Transduction
> Circadian Clock / Related Products
Casein Kinase / Related Products
Circadian Transcriptional Regulators / Related Products
Glycogen Synthase Kinase-3 [GSK-3] / Related Products
PP1 / Related Products
PP2A / Related Products
Toolbar - View Selection
Current View:
Price List
Brief
Detail
Search Results
Current Sort:
Sort by Product Name
Sort by Product ID
Sort by Result Relevance
Sort by Class
Show:
20 Products
50 Products
100 Products
All Products
Show Selected Products Only
Show
Products Only
Items
1-20
of 37
Page 1
of 2
Select Page:
1
2
>>
ALX-153-003
Revised 03-Feb-05
Casein Kinase II Substrate
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Casein Kinase Substrates
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-153-003-M001
1 mg
70.00 USD
ALX-153-003-M005
5 mg
280.00 USD
Product Specification
SEQUENCE:
H-Arg-Arg-Arg-Glu-Glu-Glu-Thr-Glu-Glu-Glu-OH
FORMULA:
C
52
H
87
N
19
O
24
MW:
1362.4
PURITY:
≥96%
APPEARANCE:
White lyophilized powder.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Specific substrate for casein kinase II, derived from the kinase II phosphorylation site found in casein. Is not being phosphorylated by casein kinase I, cAMP-dependent protein kinase, protein kinase G, myosin light chain kinase, phosphorylase kinase and EGF receptor kinase.
Product Specific Literature References
A synthetic peptide substrate specific for casein kinase II:
E.A. Kuenzel & E.D. Krebs; PNAS
82
, 737 (1985)
Abstract
Further Categories Containing This Product:
Peptides
ALX-210-243
Revised 20-Oct-04
Polyclonal Antibody to CLOCK (NT)
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Circadian Transcriptional Regulators / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-243-R200
200 µl
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
Rat
Others
SOURCE/HOST:
From rabbit.
FORMULATION:
100µg of epitope affinity purified rabbit IgG (1.0mg/ml) with 1.0mg/ml BSA and 0.05% sodium azide in PBS.
IMMUNOGEN:
Synthetic peptide corresponding to aa 11-30 of mouse CLOCK.
SPECIFICITY:
Recognizes mouse, rat and hamster CLOCK. Detects a band of ~100kDa by Western blot.
APPLICATION:
Immunohistochemistry
Western Blot (1:200)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
BLOCKING PEPTIDE:
For Blocking Peptide see Prod. No.
ALX-153-031
.
Product Description
Circadian rhythmicity is a basic property of phylogenetically diverse organisms which range from animals and plants, to fungi. Regulation of endogenous biological clocks is regulated at the genetic level by a protein mediated autoregulatory feed-back loop. In mammals, several genes that encode members of the basic helix-loop helix (bHLH) PAS (PER-ARNT-SIM) transcription factor family have been shown to play a significant role in regulating circadian oscillations. Transactivation of CLOCK-induced genes is mediated via an E box enhancer (CACGTG) found upstream of target genes. CLOCK-BMAL1 heterodimers bind to E box regulatory elements and stimulate gene transcription. CLOCK has been shown to transactivate the mammalian homolog of
Drosophila per
. PER, in concert with the product of the mammalian
timeless
gene (TIM), negatively regulates its own transcription by blocking the activity of the CLOCK-BMAL1 transactivation complex.
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-244
Revised 20-Oct-04
Polyclonal Antibody to CLOCK (mouse) (CT)
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Circadian Transcriptional Regulators / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-244-R200
200 µl
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
SOURCE/HOST:
From rabbit.
FORMULATION:
100µg of epitope affinity purified rabbit IgG (1.9mg/ml) with 1.0mg/ml BSA and 0.05% sodium azide in PBS.
IMMUNOGEN:
Synthetic peptide corresponding to aa 394-411 of mouse CLOCK.
SPECIFICITY:
Recognizes mouse CLOCK. Detects a band of ~100kDa by Western blot.
APPLICATION:
Western Blot (1:200)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
BLOCKING PEPTIDE:
For Blocking Peptide see Prod. No.
ALX-153-032
.
Product Description
Circadian rhythmicity is a basic property of phylogenetically diverse organisms which range from animals and plants, to fungi. Regulation of endogenous biological clocks is regulated at the genetic level by a protein mediated autoregulatory feed-back loop. In mammals, several genes that encode members of the basic helix-loop helix (bHLH) PAS (PER-ARNT-SIM) transcription factor family have been shown to play a significant role in regulating circadian oscillations. Transactivation of CLOCK-induced genes is mediated via an E box enhancer (CACGTG) found upstream of target genes. CLOCK-BMAL1 heterodimers bind to E box regulatory elements and stimulate gene transcription. CLOCK has been shown to transactivate the mammalian homolog of
Drosophila per
. PER, in concert with the product of the mammalian
timeless
gene (TIM), negatively regulates its own transcription by blocking the activity of the CLOCK-BMAL1 transactivation complex.
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-245
Revised 21-Nov-06
Polyclonal Antibody to Ah Receptor Nuclear Translocator 3
SYNONYMS
anti-ARNT3 PAb
anti-BMAL1 PAb
anti-Brain & Muscle ARNT-like 1 PAb
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Aryl Hydrocarbon Receptor / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-245-R200
200 µl
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Others
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml
FORMULATION:
Liquid. Epitope-affinity purified IgG in PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 582-594 (CD
582
MIDNDQG
SSSPS
594
) of mouse ARNT3 (Ah receptor nuclear translocator 3).
SPECIFICITY:
Recognizes human and hamster ARNT3.
APPLICATION:
Western Blot (1:200)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
BLOCKING PEPTIDE:
For Blocking Peptide see Prod. No.
ALX-152-023
.
General Information
Circadian rhythmicity is a basic property of phylogenetically diverse organisms which range from animals and plants, to fungi. Regulation of endogenous biological clocks is regulated at the genetic level by a protein mediated autoregulatory feed-back loop. In mammals, several genes that encode members of the basic helix-loop helix (bHLH) PAS (PER-ARNT-SIM) transcription factor family have been shown to play a significant role in regulating circadian oscillations. Transactivation of CLOCK-induced genes is mediated via an E box enhancer (CACGTG) found upstream of target genes. CLOCK-BMAL1 heterodimers bind to E box regulatory elements and stimulate gene transcription. CLOCK-BMAL1 has been shown to transactivate the mammalian homolog of Drosophila per. PER, in concert with the product of the mammalian the timeless gene (TIM), negatively regulates its own transcription by blocking the activity of the CLOCK-BMAL1 transactivation complex.
Further Categories Containing This Product:
Circadian Transcriptional Regulators / Related Products
•
Polyclonal Antibodies
ALX-210-246
Revised 14-Sep-06
Polyclonal Antibody to PER1 (mouse)
SYNONYMS
anti-Period Circadian Protein 1 (mouse) PAb
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Transcriptional Repressors & Corepressors / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-246-R200
200 µl
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml.
FORMULATION:
Liquid. Epitope-affinity purified IgG in PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 39-51 (P
39
SLADDTDANSNG
51
) of mouse PER1 (period circadian protein 1).
SPECIFICITY:
Recognizes mouse PER1.
APPLICATION:
Immunohistochemistry (frozen and paraffin sections (1:500))
Western Blot (1:200)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
BLOCKING PEPTIDE:
For Blocking Peptide see Prod. No.
ALX-165-043
.
Product Description
Circadian rhythmicity is a basic property of phylogenetically diverse organisms which range from animals and plants, to fungi. Regulation of endogenous biological clocks is regulated at the genetic level by a protein mediated autoregulatory feed-back loop. In mammals, several genes that encode members of the basic helix-loop helix (bHLH) PAS (PER-ARNT-SIM) transcription factor family have been shown to play a significant role in regulating circadian oscillations. Tranasactivation of CLOCK-induced genes is mediated via an E box enhancer (CACGTG) found upstream of target genes. CLOCK-BMAL1 heterodimers bind to E box regulatory elements and stimulate gene transcription. PER, when complexed with the product of the mammalian
timeless
gene (TIM), negatively regulates its own transcription by blocking the activity of the CLOCK-BMAL1 transactivation complex.
Further Categories Containing This Product:
Circadian Transcriptional Regulators / Related Products
•
Polyclonal Antibodies
ALX-210-917
Revised 02-Nov-06
Polyclonal Antibody to SET (human)
SYNONYMS
anti-PHAPII (human) PAb
anti-I
2
α
PP2A
(human) PAb
anti-Phosphatase 2A Inhibitor Protein 2α (human) PAb
anti-HLA-DR-associated Protein 2 (human) PAb
anti-IGAAD (human) PAb
anti-Inhibitor of Granzyme-activated DNase (human) PAb
anti-TAF-Iβ (human) PAb
anti-Template-activating Factor Iβ (human) PAb
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
PP2A / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-917-C050
50 µg
194.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml
PURITY DETAIL:
Protein A affinity-purified.
FORMULATION:
Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 3-16 (A
3
PAAKVSKKELNSN
16
) of human SETβ.
SPECIFICITY:
Recognizes human SETβ. Detects endogenous protein by IP and WB.
APPLICATION:
Flow cytometry (1:100-1:200);
Immunocytochemistry;
Immunoprecipitation;
Western blot (1:1'000).
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least one year after receipt if stored at -20°C.
HANDLING:
Avoid freeze/thaw cycles.
Product Specific Literature References
Granzyme A activates an endoplasmic reticulum-associated caspase-independent nuclease to induce single-stranded DNA nicks
:
P.J. Beresford, et al.; J. Biol. Chem.
276
, 43285 (2001)
Abstract
;
Full Text
HMG2 interacts with the nucleosome assembly protein SET and is a target of the cytotoxic T-lymphocyte protease granzyme A
:
Z. Fan, et al.; Mol. Cell. Biol.
22
, 2810 (2002)
Abstract
;
Full Text
Cleaving the oxidative repair protein Ape1 enhances cell death mediated by granzyme A
:
Z. Fan, et al.; Nat. Immunol.
4
, 145 (2003)
Abstract
Tumor suppressor NM23-H1 is a granzyme A-activated DNase during CTL-mediated apoptosis, and the nucleosome assembly protein SET is its inhibitor
:
Z. Fan, et al.; Cell
112
, 659 (2003)
Abstract
Granzyme a induces caspase-independent mitochondrial damage, a required first step for apoptosis:
D. Martinvalet, et al.; Immunity
22
, 355 (2005)
Abstract
General Information
MANUFACTURER
Manufactured by Apotech Corporation.
Further Categories Containing This Product:
Granzymes Other Products
•
Polyclonal Antibodies
ALX-270-017
Revised 27-Apr-06
H-89 . dihydrochloride
SYNONYMS
N-[2-(
p
-Bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide . 2HCl
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
PKA Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-017-M001
1 mg
22.00 USD
ALX-270-017-M005
5 mg
55.00 USD
Product Specification
FORMULA:
C
20
H
20
BrN
3
O
2
S . 2HCl
MW:
446.4 . 73.0
CAS NUMBER:
127243-85-0
PURITY:
≥97% (
1
H-NMR)
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in DMSO or methanol; also soluble in ethanol: water (1:1).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
USE/STABILITY:
Stock solutions are stable for at least 3-4 weeks when stored at +4°C. We recommend using a fresh solution each day.
Product Description
Cell permeable potent and selective inhibitor of cAMP- and cGMP-dependent protein kinases (PKA and PKG) and protein kinase Cµ (PKCµ). In contrast, most other protein kinase C (PKC) isotypes are much more weakly inhibited. Also inhibits Ca
2+
/calmodulin-dependent protein kinase II, casein kinase I and myosin light chain kinase. Induces apoptosis.
Product Specific Literature References
Polyamines differentially inhibit cyclic AMP-dependent protein kinase- mediated phosphorylation in the brain of the tobacco hornworm, Manduca sexta:
W.L. Combest, et al.; J. Neurochem.
51
, 1581 (1988)
Abstract
Inhibition of forskolin-induced neurite outgrowth and protein phosphorylation by a newly synthesized selective inhibitor of cyclic AMP-dependent protein kinase, N-[2-(p-bromocinnamylamino)ethyl]-5- isoquinolinesulfonamide (H-89), of PC12D pheochromocytoma:
T. Chijiwa, et al.; J. Biol. Chem.
265
, 5267 (1990)
Abstract
;
Full Text
A selective inhibitor of cyclic AMP-dependent protein kinase, N-[2- bromocinnamyl(amino)ethyl]-5-isoquinolinesulfonamide (H-89), inhibits phosphatidylcholine biosynthesis in HeLa cells:
C.C. Geilen; FEBS Lett.
309
, 381 (1992)
Abstract
Protein kinase A inhibitors enhance radiation-induced apoptosis:
D. Findik, et al.; J. Cell. Biochem.
57
, 12 (1995)
Abstract
Characterization of activators and inhibitors of protein kinase C mu:
F.-J. Johannes, et al.; Eur. J. Biochem.
227
, 303 (1995)
Abstract
Crystal structures of catalytic subunit of cAMP-dependent protein kinase in complex with isoquinolinesulfonyl protein kinase inhibitors H7, H8, and H89. Structural implications for selectivity:
R.A. Engh, et al.; J. Biol. Chem.
271
, 26157 (1996)
Abstract
;
Full Text
Stimulation of the ERK pathway by GTP-loaded Rap1 requires the concomitant activation of Ras, protein kinase C, and protein kinase A in neuronal cells:
T. Bouschet, et al.; J. Biol. Chem.
278
, 4778 (2003)
Abstract
;
Full Text
Further Categories Containing This Product:
CAM Kinase Inhibitors
•
Myosin Light Chain Kinase Inhibitors
•
PKC Inhibitors
•
PKG Inhibitors
•
Apoptosis Inducers & Inhibitors Other Products
•
Casein Kinase Inhibitors
ALX-270-039
Revised 15-Nov-06
A-3 . hydrochloride
SYNONYMS
N-(2-Aminoethyl)-5-chloronaphthalene-1-sulfonamide . HCl
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
PKA Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-039-M010
10 mg
65.00 USD
ALX-270-039-M050
50 mg
260.00 USD
Product Specification
FORMULA:
C
12
H
13
ClN
2
O
2
S . HCl
MW:
284.8 . 36.5
PURITY:
≥98%
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in DMSO or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Inhibitor of cAMP- and cGMP-dependent protein kinase (PKA and PKG), protein kinase C (PKC), casein kinase I and II, and myosin light chain kinase.
Product Specific Literature References
Naphthalenesulfonamides as calmodulin antagonists and protein kinase inhibitors:
M. Inagaki, et al.; Mol. Pharmacol.
29
, 577 (1986)
Abstract
Further Categories Containing This Product:
Myosin Light Chain Kinase Inhibitors
•
PKC Inhibitors
•
PKG Inhibitors
•
Casein Kinase Inhibitors
ALX-270-062
Revised 03-Feb-05
Cantharidic acid . disodium salt
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
PP2A / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-062-M010
10 mg
110.00 USD
Product Specification
FORMULA:
C
10
H
12
O
5
. 2Na
MW:
212.2 . 46.0
CAS NUMBER:
28874-45-5
PURITY:
≥95%
APPEARANCE:
White solid.
SOLUBILITY:
Soluble in water; slightly soluble in DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
Product Description
Potent protein phosphatase 2A inhibitor.
Product Specific Literature References
M. Matsuzawa, et al.; J. Agric. Food Chem.
35
, 823 (1987)
Partial characterization of specific cantharidin binding sites in mouse tissues
:
M.J. Graziano, et al.; Mol. Pharmacol.
33
, 706 (1989)
Abstract
Cantharidin-binding protein: identification as protein phosphatase 2A:
Y.-M. Li & J.E. Casida; PNAS
89
, 11867 (1992)
Abstract
ALX-270-063
Revised 03-Apr-08
Cantharidin
SYNONYMS
Hexahydro-3a,7a-dimethyl-4,7-epoxyisobenzo-furan-1,3-dione
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products - Other Signal Transduction Pathway Modulators
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-063-M025
25 mg
50.00 USD
ALX-270-063-M100
100 mg
160.00 USD
Product Specification
FORMULA:
C
10
H
12
O
4
MW:
196.2
CAS NUMBER:
56-25-7
MERCK INDEX:
14:
1752
PURITY:
≥98%
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in acetone, DMSO or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+20°C
HANDLING:
Protect from light.
HAZARD:
TOXIC.
Product Description
Potent protein phosphatase 2A (PP2A) inhibitor. At higher concentrations, also inhibits protein phosphatase 1 (PP1).
Product Specific Literature References
Partial characterization of specific cantharidin binding sites in mouse tissues
:
M.J. Graziano, et al.; Mol. Pharmacol.
33
, 706 (1988)
Abstract
Cantharidin-binding protein: identification as protein phosphatase 2A:
Y.-M. Li and J.E. Casida; PNAS
89
, 11867 (1992)
Abstract
Protein phosphatase 2A and its [3H]cantharidin/[3H]endothall thioanhydride binding site. Inhibitor specificity of cantharidin and ATP analogues:
Y.-M. Li, et al.; Biochem. Pharmacol.
46
, 1435 (1993)
Abstract
Further Categories Containing This Product:
PP2A / Related Products
ALX-270-095
Revised 07-May-08
5,6-Dichloro-1-β-D-ribofuranosyl benzimidazole
SYNONYMS
