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Protein Tyrosine Phosphatases / Related Products
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ALX-350-144 Revised 03-Apr-08
Bakuchiol
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SYNONYMS 4-(3-Ethenyl-3,7-dimethyl-1,6-octadienyl)phenol
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Other Signal Transduction Pathway Modulators
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ALX-350-144-M001   1 mg 170.00 USD Add To Cart
Product Specification
FORMULA: C18H24O
MW: 256.4
CAS NUMBER: 10309-37-2
SOURCE/HOST: Isolated from plant Psoralea corylifolia.
PURITY: ≥97% (HPLC)
APPEARANCE: Yellow to brownish oil.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
IDENTITY: Determined by 1H-NMR, 13C-NMR and MS.

Product Description
Inhibitor of protein tyrosine phosphatase 1B (PTB1B). Antioxidant. Inhibitor of mitochondrial lipid peroxidation. Inhibitor of inducible nitric oxide synthase (iNOS; NOS II) expression. DNA polymerase inhibitor. Shows antimicrobial and cytotoxic activity.
Product Specific Literature References
Plant antimutagenic agents, 2. Flavonoids: M.E. Wall, et al.; J. Nat. Prod. 51, 1084 (1988) Abstract
DNA polymerase and topoisomerase II inhibitors from Psoralea corylifolia: N.J. Sun, et al.; J. Nat. Prod. 61, 362 (1998) Abstract
Inhibition of mitochondrial lipid peroxidation by Bakuchiol, a meroterpene from Psoralea corylifolia: H. Haraguchi, et al.; Planta Med. 66, 569 (2000) Abstract
Active constituents isolated from Psoralea glandulosa L. with antiinflammatory and antipyretic activities: C.N. Backhouse, et al.; J. Ethnopharmacol. 78, 27 (2001) Abstract
Bakuchiol: a hepatoprotective compound of Psoralea corylifolia on tacrine-induced cytotoxicity in Hep G2 cells: H. Cho, et al.; Planta Med. 67, 750 (2001) Abstract
In vitro antimicrobial activities of bakuchiol against oral microorganisms: H. Katsura, et al.; Antimicrob. Agents Chemother. 45, 3009 (2001) Abstract; Full Text
Bakuchiol from Psoralea corylifolia inhibits the expression of inducible nitric oxide synthase gene via the inactivation of nuclear transcription factor-kappaB in RAW 264.7 macrophages: H.O. Pae, et al.; Int. Immunopharmacol. 1, 1849 (2001) Abstract
Antioxidative components of Psoralea corylifolia (Leguminosae): H. Haraguchi, et al.; Phytother. Res. 16, 539 (2002) Abstract
The evaluation of forty-three plant species for in vitro antimycobacterial activities; isolation of active constituents from Psoralea corylifolia and Sanguinaria canadensis: S.M. Newton, et al.; J. Ethnopharmacol. 79, 57 (2002) Abstract
Antioxidant activity of bakuchiol: experimental evidences and theoretical treatments on the possible involvement of the terpenoid chain: S. Adhikari, et al.; Chem. Res. Toxicol. 16, 1062 (2003) Abstract
Preparation and in vitro evaluation of radioiodinated bakuchiol as an anti tumor agent: K. Bapat, et al.; Appl. Radiat. Isot. 62, 389 (2005) Abstract
In vitro protein tyrosine phosphatase 1B inhibitory phenols from the seeds of Psoralea corylifolia: Y.C. Kim, et al.; Planta Med. 71, 87 (2005) Abstract
Protective effect of (S)-bakuchiol from Psoralea corylifolia on rat liver injury in vitro and in vivo: E.J. Park, et al.; Planta Med. 71, 508 (2005) Abstract
Bakuchiol-induced caspase-3-dependent apoptosis occurs through c-Jun NH2-terminal kinase-mediated mitochondrial translocation of Bax in rat liver myofibroblasts: E.J. Park, et al.; Eur. J. Pharmacol. 559, 115 (2007) Abstract
Further Categories Containing This Product:
NOS Inhibitors (NOS Induction & Enzyme Activity) • Natural Products - DNA Replication Inhibitors • Natural Products - Nitric Oxide Pathway Modulators • Lipid Peroxidation • Natural Products - Topoisomerase Inhibitors • Natural Products - Antioxidants • Natural Products with Antibiotic Activity • Protein Tyrosine Phosphatases Other Products
 
 
ALX-270-207 Revised 24-Jun-05
bpV(bipy)
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SYNONYMS Potassium bisperoxo (bipyridine) oxovanadate (V)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Oxovanadates
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ALX-270-207-M005   5 mg 65.00 USD Add To Cart
ALX-270-207-M025   25 mg 195.00 USD Add To Cart
Product Specification
FORMULA: K[VO(O2)2C10H8N2]
MW: 326.2
PURITY: ≥95%
APPEARANCE: Yellow to orange powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.

Product Description
Protein phosphotyrosine phosphatase inhibitor.
Product Specific Literature References
Peroxovanadium compounds. A new class of potent phosphotyrosine phosphatase inhibitors which are insulin mimetics: B.I. Posner, et al.; J. Biol. Chem. 269, 4596 (1994) Abstract; Full Text
 
 
ALX-270-204 Revised 24-Jun-08
bpV(phen)
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SYNONYMS Potassium bisperoxo (1,10-phenanthroline) oxovanadate (V)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Oxovanadates
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ALX-270-204-M005   5 mg 53.00 USD Add To Cart
ALX-270-204-M025   25 mg 195.00 USD Add To Cart
Product Specification
FORMULA: K[VO(O2)2C12H8N2] . 3H2O
MW: 350.3 . 54.0
PURITY: ≥98% (51V-NMR)
APPEARANCE: Yellow to orange powder.
SOLUBILITY: Soluble in water (10mM).
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.
IDENTITY: Identity determined by MS and 51V-NMR (D2O)

Product Description
Potent protein phosphotyrosine phosphatase inhibitor. Also shown to be a potent insulin receptor kinase activator; excellent insulin mimetic in vitro and in vivo.
Product Specific Literature References
Peroxovanadium compounds. A new class of potent phosphotyrosine phosphatase inhibitors which are insulin mimetics: B.I. Posner, et al.; J. Biol. Chem. 269, 4596 (1994) Abstract; Full Text
Selective activation of the rat hepatic endosomal insulin receptor kinase. Role for the endosome in insulin signaling: A.P. Bevan, et al.; J. Biol. Chem. 270, 10784 (1995) Abstract; Full Text
In vivo insulin mimetic effects of pV compounds: role for tissue targeting in determining potency: A.P. Bevan, et al.; Am. J. Physiol. 268, E60 (1995) Abstract
Hypoglycemic effects of peroxovanadium compounds in Sprague-Dawley and diabetic BB rats: J.F. Yale, et al.; Diabetes 44, 1274 (1995) Abstract
A role for tyrosine phosphorylation in both activation and inhibition of the insulin receptor tyrosine kinase in vivo: P.G. Drake, et al.; Endocrinology 137, 4960 (1996) Abstract
Phosphatidylinositol 3'-kinase and p70s6k are required for insulin but not bisperoxovanadium 1,10-phenanthroline (bpV(phen)) inhibition of insulin-like growth factor binding protein gene expression. Evidence for MEK-independent activation of mitogen-activ: C.J. Band & B.I. Posner; J. Biol. Chem. 272, 138 (1997) Abstract; Full Text
Lipopolysaccharide down-regulates the leukotriene C4 synthase gene in the monocyte-like cell line, THP-1: K.J. Serio, et al.; J. Immunol. 170, 2121 (2003) Abstract; Full Text
Further Categories Containing This Product:
Insulin & Insulin Receptor / Related Products
 
 
ALX-270-205 Revised 12-Sep-08
bpV(pic)
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SYNONYMS Dipotassium bisperoxo (picolinato) oxovanadate (V)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Oxovanadates
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ALX-270-205-M005   5 mg 75.00 USD Add To Cart
ALX-270-205-M025   25 mg 275.00 USD Add To Cart
Product Specification
FORMULA: K2 [VO(O2)2C6H4NO2] . 2 H2O
MW: 331.2 . 36.0
PURITY: ≥95% (51V-NMR)
APPEARANCE: Yellow solid.
SOLUBILITY: Soluble in water (10mM).
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
USE/STABILITY: Unstable in solution; reconstitute just prior to use.
HANDLING: Protect from light.
IDENTITY: Identity determined by 1H- and 51V-NMR.

Product Description
Potent protein phosphotyrosine phosphatase inhibitor.
Product Specific Literature References
Peroxovanadium compounds. A new class of potent phosphotyrosine phosphatase inhibitors which are insulin mimetics: B.I. Posner, et al.; J. Biol. Chem. 269, 4596 (1994) Abstract; Full Text
 
 
ALX-270-206 Revised 07-Dec-04
bpV(HOpic)
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SYNONYMS Dipotassium bisperoxo (5-hydroxypyridine-2-carboxyl) oxovanadate (V)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Oxovanadates
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ALX-270-206-M005   5 mg 75.00 USD Add To Cart
Product Specification
FORMULA: K2[VO(O2)2C6H4NO3]
MW: 347.2
PURITY: ≥90%
APPEARANCE: Yellow solid.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.

Product Description
Protein phosphotyrosine phosphatase inhibitor.
Product Specific Literature References
Peroxovanadium compounds. A new class of potent phosphotyrosine phosphatase inhibitors which are insulin mimetics: B.I. Posner, et al.; J. Biol. Chem. 269, 4596 (1994) Abstract; Full Text
 
 
ALX-430-025 Revised 13-May-03
(-)-p-Bromotetramisole . oxalate
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SYNONYMS (-)-(S)-6-(4-Bromophenyl)-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole . oxalate
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Protein Tyrosine Phosphatases Other Products
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ALX-430-025-M005   5 mg 90.00 USD Add To Cart
Product Specification
FORMULA: C11H11BrN2S . C2H2O4
MW: 283.2 . 90.0
PURITY: ≥98%
APPEARANCE: White powder.
SOLUBILITY: Soluble in water, methanol, DMF or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
Potent alkaline phosphatase inhibitor.
 
 
ALX-270-169 Revised 07-Dec-04
Dephostatin
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SYNONYMS 2,5-Dihydroxy-N-methyl-N-nitrosoaniline
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Protein Tyrosine Phosphatases Other Products
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ALX-270-169-M001   1 mg 120.00 USD Add To Cart
Product Specification
FORMULA: C7H8N2O3
MW: 168.2
CAS NUMBER: 151606-30-3
SOURCE/HOST: Synthetic.
PURITY: ≥90%
APPEARANCE: Red to brown solid.
SOLUBILITY: Soluble in DMSO, chloroform or methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light. Keep under inert gas.

Product Description
Competitive protein tyrosine phosphatase inhibitor. Protein S-nitrosating reagent.
Product Specific Literature References
Dephostatin, a novel protein tyrosine phosphatase inhibitor produced by Streptomyces. I. Taxonomy, isolation, and characterization: M. Imoto, et al.; J. Antibiot. 46, 1342 (1993) Abstract
Dephostatin, a novel protein tyrosine phosphatase inhibitor produced by Streptomyces. II. Structure determination: H. Kakeya, et al.; J. Antibiot. 46, 1716 (1993) Abstract
Synthesis and protein tyrosine phosphatase inhibitory activity of dephostatin analogs: T. Watanabe, et al.; J. Antibiot. 48, 1460 (1995) Abstract
Synthesis and Bioassay of a Protein Tyrosine Phosphatase Inhibitor, Dephostatin: L. Yu, et al.; Bioorg. Med. Chem. Lett. 5, 1003 (1995)
Further Categories Containing This Product:
Nitric Oxide Donors
 
 
ALX-805-041 Revised 04-Jan-06
Monoclonal Antibody to CD45 (human) (MEM-28)
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PRODUCT LINE Immunology
PRODUCT CATEGORY CD45 / Related Products
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ALX-805-041-C100   100 µg 195.00 USD Add To Cart
ALX-805-041F-T100 FITC 100 tests 270.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: MEM-28
ISOTYPE: Mouse IgG1
CONCENTRATION: MEM-28: 1mg/ml.
PURITY DETAIL: Protein G-affinity purified.
FORMULATION: MEM-28: Liquid. In PBS, pH 7.4, containing 15mM sodium azide.
MEM-28-FITC: Liquid. In PBS containing 15mM sodium azide and 0.2% BSA.
IMMUNOGEN: Human thymocytes and T lymphocytes.
SPECIFICITY: Recognizes all isoforms of human CD45.
APPLICATION: MEM-28:
Flow Cytometry
Immunohistochemistry (paraffin sections - no pre-treatment of tissue sections)
Immunoprecipitation
Western Blot
MEM-28-FITC:
Flow Cytometry (use 20µl for 100µl of whole blood or 106 cells in a suspension)
SHIPPING: SHIPPED ON BLUE ICE
USE/STABILITY: MEM-28: Long Term Storage: -20°C. Avoid freeze/thaw cycles.
MEM-28-FITC: Long Term Storage: +4°C. Do not freeze. Protect from light.
Product Specific Literature References
Monoclonal antibodies against human leucocyte antigens. I. Antibodies against beta-2-microglobulin, immunoglobulin kappa light chains, HLA-DR-like antigens, T8 antigen, T1 antigen, a monocyte antigen, and a pan-leucocyte antigen: V. Horejsi, et al.; Folia Biol (Praha) 32, 12 (1986) Abstract
Monoclonal antibodies against human leucocyte antigens. II. Antibodies against CD45 (T200), CD3 (T3), CD43, CD10 (CALLA), transferrin receptor (T9), a novel broadly expressed 18-kDa antigen (MEM-43) and a novel antigen of restricted expression (MEM-74): V. Horejsi, et al.; Folia Biol (Praha) 34, 23 (1988) Abstract
Molecular mechanisms involved in CD43-mediated apoptosis of TF-1 cells. Roles of transcription Daxx expression, and adhesion molecules: L. Cermak, et al.; J. Biol. Chem. 277, 7955 (2002) Abstract; Full Text
Further Categories Containing This Product:
CD Antibodies • Monoclonal Antibodies
 
 
ALX-805-067 Revised 19-Jun-07
Monoclonal Antibody to CD45RA (human) (MEM-56)
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PRODUCT LINE Immunology
PRODUCT CATEGORY CD45 / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-805-067-C100   100 µg 195.00 USD Add To Cart
ALX-805-067F-T100 FITC 100 tests 270.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: MEM-56
ISOTYPE: Mouse IgG2b
CONCENTRATION: 1mg/ml
PURITY: >95% (SDS-PAGE)
PURITY DETAIL: Protein A-affinity purified.
FORMULATION: ALX-805-067-C100: Liquid. In PBS, pH 7.4, containing 15mM sodium azide.
ALX-805-067F-T100: Liquid. In PBS, pH 7.4, containing 0.2% BSA and 15mM sodium azide.
IMMUNOGEN: Human thymocytes and T lymphocytes.
SPECIFICITY: Recognizes human CD45RA.
APPLICATION: Flow Cytometry (20µl per 100µl of whole blood or 1 x 106 cells)
Immunohistochemistry (paraffin sections - pre-treatment not required)
Immunoprecipitation
Western Blot
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: ALX-805-067-C100: Avoid freeze/thaw cycles. After opening prepare aliquots and store at -20°C.
ALX-805-067F-T100: Store at +4°C. Do not freeze. Protect from light.
Product Specific Literature References
Monoclonal antibodies against human leucocyte antigens. III. Antibodies against CD45R, CD6, CD44 and two newly described broadly expressed glycoproteins MEM-53 and MEM-102: V. Bazil, et al.; Folia Biol (Praha) 35, 289 (1989) Abstract
Sialic acid-dependent epitopes of CD45 molecules of restricted cellular expression: V. Bazil, et al.; Immunogenetics 29, 202 (1989) Abstract
General Information
Human CD45RA is expressed on all cells of hematopoietic origin, except erythrocytes. CD45RA is a transmembrane tyrosine phosphate which can exist in at least nine different isoforms resulting from tissue-specific alternative RNA splicing of exons 4-7 of a single gene coding for the various N-terminal peptide segments. The CD45RA isoform predominates on naive/resting T cells and medullary thymocytes.
Further Categories Containing This Product:
CD Antibodies • Monoclonal Antibodies
 
 
ALX-805-069 Revised 21-Jul-03
Monoclonal Antibody to CD45RB (human) (MEM-143)
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PRODUCT LINE Immunology
PRODUCT CATEGORY CD45 / Related Products
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ALX-805-069-C100   100 µg 195.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: MEM-143
ISOTYPE: Mouse IgG1
IMMUNOGEN: Human peripheral blood lymphocytes.
SPECIFICITY: Recognizes human CD45RB. Reacts with a protein determinant of CD45RB and is therefore not neuraminidase sensitive like most other MAbs to CD45RB.
APPLICATION: Flow Cytometry.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
Further Categories Containing This Product:
CD Antibodies • Monoclonal Antibodies
 
 
ALX-805-068 Revised 07-Nov-05
Monoclonal Antibody to CD45RB (human) (MEM-55)
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PRODUCT LINE Immunology
PRODUCT CATEGORY CD45 / Related Products
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ALX-805-068-C100   100 µg