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G-Protein Coupled Receptor Signalling
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ALX-350-104 Revised 10-May-07
Aaptamine
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SYNONYMS 8,9-Dimethoxy-1H-benzo[de][1,6]naphtyridine
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Other Toxins
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ALX-350-104-M001   1 mg 90.00 USD Add To Cart
Product Specification
FORMULA: C13H12N2O2
MW: 228.3
CAS NUMBER: 85547-22-4
SOURCE/HOST: Isolated from the sponge Aaptos aaptos.
PURITY: ≥97%
APPEARANCE: Oil.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
HAZARD: TOXIC.

Product Description
Competitive antagonist of α-adrenoceptors in vascular smooth muscle cells. Inhibits cancer cell growth.
Product Specific Literature References
Alpha-adrenoceptor blocking action of aaptamine, a novel marine natural product, in vascular smooth muscle: Y. Ohizumi, et al.; J. Pharm. Pharmacol. 36, 785 (1984) Abstract
Antineoplastic agents 491. Synthetic conversion of aaptamine to isoaaptamine, 9-demethylaaptamine, and 4-methylaaptamine: G.R. Pettit, et al.; J. Org. Chem. 69, 2251 (2004) Abstract
Aaptamine, a spongean alkaloid, activates p21 promoter in a p53-independent manner: S. Aoki, et al.; BBRC 342, 101 (2006) Abstract
 
 
ALX-550-221 Revised 17-Jan-05
ABHxD-I . hydrochloride
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SYNONYMS (1S,2S,4S,5S)-2-Aminobicyclo[2.1.1]hexene-2,5-dicarboxylic acid . HCl
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Glutamate Receptors (Metabotropic) / Related Products
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ALX-550-221-MC05   0.5 mg 60.00 USD Add To Cart
ALX-550-221-M001   1 mg 90.00 USD Add To Cart
Product Specification
FORMULA: C8H11NO4 . HCl
MW: 185.2 . 36.5
PURITY: ≥96%
SOLUBILITY: Soluble in water or methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Conformationally restricted ACPD analog. Potent mGluR ligand with similar selectivity and potency to glutamate but without ionotropic activity. Neuroprotective.
Product Specific Literature References
Synthesis and biology of the conformationally restricted ACPD analogue, 2-aminobicyclo[2.1.1]hexane-2,5-dicarboxylic acid-I, a potent mGluR agonist: A.P. Kozikowski, et al.; J. Med. Chem. 41, 1641 (1998) Abstract
 
 
ALX-151-020 Revised 10-Feb-05
N-Acetyl-Asp-Glu-OH
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SYNONYMS α-NAAG
Spaglumic acid
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Glutamate Receptors (Metabotropic) / Related Products
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ALX-151-020-M010   10 mg 35.00 USD Add To Cart
ALX-151-020-M050   50 mg 140.00 USD Add To Cart
Product Specification
FORMULA: C11H16N2O8
MW: 304.3
CAS NUMBER: 3106-85-2
PURITY: ≥98%
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
Product Description
Endogenous neurotransmitter with high affinity for the brain glutamate receptor. N-acetylated α-linked acidic dipeptidase (NAALADase), a membrane-bound peptidase, hydrolyzes α-NAAG, a major brain peptide, to N-acetylaspartate and glutamate. Discriminates between mGluR2 and mGluR3. mGluR3 activator. NMDA receptor antagonist. Neuroprotective.
Product Specific Literature References
N-acetylaspartylglutamate: an endogenous peptide with high affinity for a brain glutamate receptor: R. Zaczek, et al.; PNAS 80, 1116 (1983) Abstract
Characterization of the interactions of N-acetyl-aspartyl-glutamate with [3H]L-glutamate receptors: K.J. Koller & J.T. Coyle; Eur. J. Pharmacol. 98, 193 (1984) Abstract
The neurobiology of N-acetylaspartylglutamate: R.D. Blakely & J.T. Coyle; Int. Rev. Neurobiol. 30, 39 (1988) Abstract
Design, synthesis, and biological activity of a potent inhibitor of the neuropeptidase N-acetylated alpha-linked acidic dipeptidase: P.F. Jackson, et al.; J. Med. Chem. 39, 619 (1996) Abstract
The nagging question of the function of N-acetylaspartylglutamate: J.T. Coyle; Neurobiol. Dis. 4, 231 (1997) Abstract
N-acetylaspartylglutamate stimulates metabotropic glutamate receptor 3 to regulate expression of the GABA(A) alpha6 subunit in cerebellar granule cells: S. Ghose, et al.; J. Neurochem. 69, 2326 (1997) Abstract
N-acetylaspartylglutamate (NAAG) protects against rat striatal quinolinic acid lesions in vivo: L.R. Orlando, et al.; Neurosci. Lett. 236, 91 (1997) Abstract
N-acetylaspartylglutamate, N-acetylaspartate, and N-acetylated alpha-linked acidic dipeptidase in human brain and their alterations in Huntington and Alzheimer's diseases: L.A. Passani, et al.; Mol. Chem. Neuropathol. 31, 97 (1997) Abstract
Distribution of N-acetylaspartylglutamate immunoreactivity in human brain and its alteration in neurodegenerative disease: L.A. Passani, et al.; Brain Res. 772, 9 (1997) Abstract
N-acetylaspartylglutamate selectively activates mGluR3 receptors in transfected cells: B. Wroblewska, et al.; J. Neurochem. 69, 174 (1997) Abstract
Neuroprotective activity of N-acetylaspartylglutamate in cultured cortical cells: V. Bruno, et al.; Neuroscience 85, 751 (1998) Abstract
N-acetylaspartylglutamate activates cyclic AMP-coupled metabotropic glutamate receptors in cerebellar astrocytes: B. Wroblewska, et al.; Glia 24, 172 (1998) Abstract
A.P. Burlina, et al.; Eur. J. Pediatr. 158, 406 (1999) Abstract
Further Categories Containing This Product:
NMDA Receptors / Related ProductsNAALADase / Related ProductsPeptides
 
 
ALX-290-001 Revised 29-Nov-04
N-Acetyl-S-farnesyl-L-cysteine
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SYNONYMS AFC
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Farnesylation / Isoprenylation Reagents
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ALX-290-001-M005   5 mg 50.00 USD Add To Cart
ALX-290-001-M025   25 mg 150.00 USD Add To Cart
Product Specification
FORMULA: C20H33NO3S
MW: 367.6
CAS NUMBER: 135304-07-3
PURITY: ≥97%
APPEARANCE: Clear oil.
SOLUBILITY: Soluble in DMSO, methanol or ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Specific inhibitor of S-farnesylcysteine methyl transferase.
 
 
ALX-290-010 Revised 20-Apr-07
N-Acetyl-S-farnesyl-L-cysteine-methyl ester
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SYNONYMS AFCME
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Farnesylation / Isoprenylation Reagents
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ALX-290-010-M010   10 mg 40.00 USD Add To Cart
Product Specification
FORMULA: C21H35NO3S
MW: 381.6
CAS NUMBER: 135304-08-4
PURITY: ≥95%
APPEARANCE: White to slightly yellow powder.
SOLUBILITY: Soluble in methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Hygroscopic.

Product Description
Substrate for studying the reversibility of carboxyl methylation in signal-transducing G-proteins.
Product Specific Literature References
Methylation and demethylation reactions of guanine nucleotide-binding proteins of retinal rod outer segments: D. Pérez-Sala, et al.; PNAS 88, 3043 (1991) Abstract
Identifying the recognition unit for G protein methylation: E.W. Tan, et al.; J. Biol. Chem. 266, 10719 (1991) Abstract; Full Text
 
 
ALX-290-007 Revised 02-Jun-08
N-Acetyl-S-geranyl-L-cysteine
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SYNONYMS AGC
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Geranyl-related Reagents
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ALX-290-007-M005   5 mg 90.00 USD Add To Cart
Product Specification
FORMULA: C15H25NO3S
MW: 299.4
PURITY: ≥98% (TLC)
APPEARANCE: Clear to pale yellow viscous oil.
SOLUBILITY: > 25mg/ml soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Solutions may be stored at -20 °C for up to 3 months. Product is not sterile.

Product Description
Negative control for AFC (Prod. No. ALX-290-001) and AGGC (Prod. No. ALX-290-008). Has a closely similar structure to these two compounds but lacks their biological activity.
 
 
ALX-290-008 Revised 13-Jul-06
N-Acetyl-S-geranylgeranyl-L-cysteine
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SYNONYMS AGGC
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Geranyl-related Reagents
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ALX-290-008-M005   5 mg 140.00 USD Add To Cart
Product Specification
FORMULA: C25H41NO3S
MW: 435.7
CAS NUMBER: 139332-94-8
PURITY: ≥98%
APPEARANCE: Viscous yellow oil.
SOLUBILITY: Soluble in 100% ethanol or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Specifically blocks methyl esterification of geranylgeranylated proteins such as Rab proteins. Blocks receptor-mediated signal transduction in human neutrophils (IC50=4µM). Induces insulin release from HIT-T15 cells by mimicking the action of Rab3A. Inhibits β2-integrin-induced actin polymerization (IC50~45nM) in neutrophils.
 
 
ALX-550-208 Revised 17-Dec-04
N-Acetyl-5-hydroxytryptamine
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SYNONYMS N-Acetylserotonin
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Melatonin Receptors / Related Products
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ALX-550-208-M010   10 mg 10.00 USD Add To Cart
ALX-550-208-M050   50 mg 25.00 USD Add To Cart
ALX-550-208-M500   500 mg 125.00 USD Add To Cart
Product Specification
FORMULA: C12H14N2O2
MW: 218.3
CAS NUMBER: 1210-83-9; 17994-17-1
PURITY: ≥99%
APPEARANCE: Off-white powder.
SOLUBILITY: Soluble in ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.

Product Description
Metabolite of serotonin (Prod. No. ALX-550-328). Precursor of melatonin (Prod. No. ALX-550-071). Inhibitor of hydroxyindole-O-methyltransferase.
Product Specific Literature References
The metabolism of serotonin (5-hydroxytryptamine): W.M. McIsaac and I.H. Page; J. Biol. Chem. 234, 858 (1959) Full Text
Hydroxyindole-O-methyltransferase. I. Substrate binding: B.T. Ho, et al.; J. Pharm. Sci. 58, 130 (1969) Abstract
Hydroxyindole-O-methyltransferase. II. Inhibitory activities of some N- acyltryptamines: B.T. Ho, et al.; J. Pharm. Sci. 57, 1998 (1968) Abstract
Further Categories Containing This Product:
Serotonergics & Serotonin Receptors / Related Products
 
 
ALX-550-200 Revised 09-Aug-02
N-Acetyltryptamine
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PRODUCT LINE Neurobiology
PRODUCT CATEGORY Melatonin Receptors / Related Products
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ALX-550-200-M005   5 mg 50.00 USD Add To Cart
ALX-550-200-M025   25 mg 190.00 USD Add To Cart
Product Specification
FORMULA: C12H14N2O
MW: 202.3
CAS NUMBER: 1016-47-3
PURITY: ≥97%
SOLUBILITY: Soluble in methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
Partial agonist for melatonin receptors.
Product Specific Literature References
Characterization of a retinal melatonin receptor: M.L. Dubocovich; J. Pharmacol. Exp. Ther. 234, 395 (1985) Abstract
Luzindole (N-0774): a novel melatonin receptor antagonist: M.L. Dubocovich; J. Pharmacol. Exp. Ther. 246, 902 (1988) Abstract
 
 
ALX-550-017 Revised 17-Jan-05
cis-ACPD
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SYNONYMS (±)-1-Aminocyclopentane-cis-1,3-dicarboxylic acid
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Glutamate Receptors (Metabotropic) / Related Products
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ALX-550-017-M005   5 mg 60.00 USD Add To Cart
Product Specification
FORMULA: C7H11NO4
MW: 173.2
CAS NUMBER: 39026-63-6
PURITY: ≥97%
APPEARANCE: White solid.
SOLUBILITY: Soluble in dilute aqueous base.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.

(1S,3S)-ACPD

(1R,3R)-ACPD
Product Description
Potent NMDA agonist. Equimolar mixture of (1R,3R)-ACPD (Prod. No. ALX-550-018) and (1S,3S)-ACPD (Prod. No. ALX-550-019).
Product Specific Literature References
Receptors for the excitatory amino acids in the mammalian central nervous system: H. McLennan; Prog. Neurobiol. 20, 251 (1983) Abstract
Structure/activity relations of N-methyl-D-aspartate receptor ligands as studied by their inhibition of [3H]D-2-amino-5-phosphonopentanoic acid binding in rat brain membranes: H.J. Olverman, et al.; Neuroscience 26, 17 (1988) Abstract
In vitro and in vivo pharmacology of trans- and cis-(+-)-1-amino-1,3-cyclopentanedicarboxylic acid: dissociation of metabotropic and ionotropic excitatory amino acid receptor effects: D.D. Schoepp, et al.; J. Neurochem. 56, 1789 (1991) Abstract
Pharmacological agents acting at subtypes of metabotropic glutamate receptors: D.D. Schoepp, et al.; Neuropharmacology 38, 1431 (1999), (Review) Abstract
Further Categories Containing This Product:
NMDA Receptors / Related ProductsExcitatory Amino Acids
 
 
ALX-550-020 Revised 11-Mar-08
trans-ACPD
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SYNONYMS (±)-1-Aminocyclopentane-trans-1,3-dicarboxylic acid
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Glutamate Receptors (Metabotropic) / Related Products
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ALX-550-020-M005   5 mg 55.00 USD Add To Cart
ALX-550-020-M025   25 mg 220.00 USD Add To Cart
Product Specification
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