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ALX-307-018
Revised 04-Mar-05
3-Deoxy-3-bromo-D-myo-inositol 1,4,5-trisphosphate . hexasodium salt
SYNONYMS
3-Br-Deoxy-Ins(1,4,5)P
3
. 6Na
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Inositols & Inositolphosphates/Related Products
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ALX-307-018-M001
1 mg
80.00 USD
Product Specification
FORMULA:
C
6
H
8
BrO
14
P
3
. 6Na
MW:
477.0 . 137.9
PURITY:
≥95%
APPEARANCE:
Brown solid.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HANDLING:
Very hygroscopic.
ALX-307-021
Revised 20-Feb-08
3-Deoxy-3-fluoro-D-myo-inositol 1,4,5-trisphosphate . hexasodium salt
SYNONYMS
3-F-Deoxy-Ins(1,4,5)P
3
. 6Na
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Inositols & Inositolphosphates/Related Products
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ALX-307-021-C100
100 µg
40.00 USD
Product Specification
FORMULA:
C
6
H
8
FO
14
P
3
. 6Na
MW:
416.0 . 137.9
CAS NUMBER:
129365-68-0
PURITY:
≥99%
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Hygroscopic.
Product Description
Equipotent to Ins(1,4,5)P
3
in releasing intracellular calcium. The 3-position is blocked by fluorine, hence it cannot be converted to Ins(1,3,4,5)P
4
by the action of 3-kinases. It may therefore provide a useful tool for studying the complex biochemical pathways in which InsP
3
and InsP
4
are closely interactive.
Product Specific Literature References
Synthesis of the First Optically Pure, Fluorinated Inositol 1,4,5-Trisphosphate of myo-Inositol Stereochemistry and Its Effect on Ca2+ Release in Swiss 3T3 Cells:
A.P. Kozikowski, et al.; JACS
112
, 7403 (1990)
ALX-307-002
Revised 24-Feb-05
1-D-3-Deoxy-phosphatidylinositol
SYNONYMS
DPI
3-Deoxy-D-
myo
-inositol 1-[(R)-2,3-bis(hexa-
decanoyloxy)propyl hydrogenphosphate]
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Inositols & Inositolphosphates/Related Products
Ordering Information
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ALX-307-002-C100
100 µg
30.00 USD
ALX-307-002-M001
1 mg
150.00 USD
Product Specification
FORMULA:
C
41
H
79
O
12
P
MW:
795.0
PURITY:
≥98%
APPEARANCE:
Off-white amorphous solid.
SOLUBILITY:
Solube in DMSO or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
Product Description
Antimetabolite of phosphatidylinositol-3-phosphate. Inhibitor of cancer cell colony formation.
Product Specific Literature References
Synthesis and biology of 1D-3-deoxyphosphatidylinositol: a putative antimetabolite of phosphatidylinositol-3-phosphate and an inhibitor of cancer cell colony formation:
A.P. Kozikowski, et al.; J. Med. Chem.
38
, 1053 (1995)
Abstract
Further Categories Containing This Product:
Chemopreventive Agents Other Products
ALX-307-063
Revised 24-Jun-05
1,2-Di-O-butyryl-D-myo-inositol 3,4,5,6-tetrakisphosphate octakis(propionoxymethyl)ester
SYNONYMS
Bt
2
Ins(3,4,5,6)P
4
/PM
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Inositols & Inositolphosphates/Related Products
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ALX-307-063-1
1 Vial
320.00 USD
Product Specification
FORMULA:
C
46
H
76
O
36
P
4
MW:
1329.0
QUANTITY:
1µmol
PURITY:
≥
98% (HPLC)
APPEARANCE:
Clear syrup.
SOLUBILITY:
Soluble in toluol and DMSO.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Do not freeze mixtures of Pluronic
®
, DMSO and inositolphosphates!
HANDLING:
Protect from moisture.
IDENTITY:
Identity determined by
1
H-NMR,
31
P-NMR and MS.
Product Description
Cell permeable derivative of Prod. No.
ALX-307-061
.
Product Specific Literature References
Long-term uncoupling of chloride secretion from intracellular calcium levels by Ins(3,4,5,6)P4
:
M. Vajanaphanich, et al.; Nature
371
, 711 (1994)
Abstract
myo-inositol 3,4,5,6-tetrakisphosphate inhibits an apical calcium-activated chloride conductance in polarized monolayers of a cystic fibrosis cell line
:
M.A. Carew, et al.; J. Biol. Chem.
275
, 26906 (2000)
Abstract
;
Full Text
General Information
BACKGROUND/TECHNICAL INFORMATION
Includes 1 vial of 10% Pluronic
®
(F127) solution in DMSO.
Recommendations on application (Cuvette Experiments)
- Prepare a 100mM stock solution by adding 20µl of DMSO to 1µmol of inositol product.
- In a fresh vial mix 1µl of the stock solution and 2µl of Pluronic
®
as supplied.
- Add 500µl of your cell suspension and mix carefully.
- Add this mixture to the remaining cell suspension (~500µl) and mix carefully.
Note:
Cell suspension should not contain more than 1% of DMSO.
MANUFACTURER
Manufactured by SiChem, Germany
ALX-307-060
Revised 24-Jun-05
2,3-Di-O-butyryl-D-myo-inositol 1,4,5,6-tetrakisphosphate octakis(propionoxymethyl)ester
SYNONYMS
Bt
2
Ins(1,4,5,6)P
4
/PM
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Inositols & Inositolphosphates/Related Products
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Product Numbers:
Format:
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ALX-307-060-1
1 Vial
320.00 USD
Product Specification
FORMULA:
C
46
H
76
O
36
P
4
MW:
1329.0
QUANTITY:
1µmol
PURITY:
≥98% (HPLC)
APPEARANCE:
Clear syrup.
SOLUBILITY:
Soluble in toluol and DMSO.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Do not freeze mixtures of Pluronic®, DMSO and inositolphosphates!
HANDLING:
Protect from moisture.
IDENTITY:
Identity determined by
1
H-NMR,
31
P-NMR and MS.
Product Description
Cell permeable derivative of Prod. No.
ALX-307-034
.
Product Specific Literature References
D-myo-Inositol 1,4,5,6-tetrakisphosphate produced in human intestinal epithelial cells in response to Salmonella invasion inhibits phosphoinositide 3-kinase signaling pathways
:
L. Eckmann, et al.; PNAS
94
, 14456 (1997)
Abstract
;
Full Text
Enzyme-assisted total synthesis of the optical antipodes D-myo-inositol 3,4,5-trisphosphate and D-myo-inositol 1,5, 6-trisphosphate: aspects of their structure-activity relationship to biologically active inositol phosphates
:
S. Adelt, et al.; J. Med. Chem.
42
, 1262 (1999)
Abstract
;
Full Text
General Information
BACKGROUND/TECHNICAL INFORMATION
Includes 1 vial of 10% Pluronic
®
(F127) solution in DMSO.
Recommendations on application (Cuvette Experiments)
- Prepare a 100mM stock solution by adding 20µl of DMSO to 1µmol of inositol product.
- In a fresh vial mix 1µl of the stock solution and 2µl of Pluronic
®
as supplied.
- Add 500µl of your cell suspension and mix carefully.
- Add this mixture to the remaining cell suspension (~500µl) and mix carefully.
Note:
Cell suspension should not contain more than 1% of DMSO.
MANUFACTURER
Manufactured by SiChem, Germany
ALX-307-003
Revised 19-Aug-08
myo-Inositol
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Inositols & Inositolphosphates/Related Products
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ALX-307-003-G025
25 g
18.00 USD
Product Specification
FORMULA:
C
6
H
12
O
6
MW:
180.2
CAS NUMBER:
87-89-8
MERCK INDEX:
14:
4978
RTECS:
NM7520800
PURITY:
≥98%
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in water; slightly soluble in 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+20°C
IDENTITY:
Identity determined by IR.
ALX-307-004
Revised 04-Apr-07
scyllo-Inositol
SYNONYMS
Scyllitol
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Inositols & Inositolphosphates/Related Products
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ALX-307-004-M005
5 mg
45.00 USD
ALX-307-004-M025
25 mg
180.00 USD
Product Specification
FORMULA:
C
6
H
12
O
6
MW:
180.2
CAS NUMBER:
488-59-5
PURITY:
≥98%
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in water (50mg/ml).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+20°C
Product Description
Naturally occuring isomer of
myo
-inositol (Prod. No.
ALX-307-003
).
Product Specific Literature References
In vivo conversion of [3H]myoinositol to [3H]chiroinositol in rat tissues:
Y. Pak, et al.; J. Biol. Chem.
267
, 16904 (1992)
Abstract
;
Full Text
Phosphoinositide metabolism in the developing conceptus. Effects of hyperglycemia and scyllo-inositol in rat embryo culture:
P.J. Strieleman, et al.; Diabetes
41
, 989 (1992)
Abstract
ALX-307-028
Revised 27-Jun-05
D-myo-Inositol 1,5-bisphosphate . tetrapotassium salt
SYNONYMS
Ins(1,5)P
2
. 4K
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Inositols & Inositolphosphates/Related Products
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ALX-307-028-C100
100 µg
60.00 USD
ALX-307-028-M001
1 mg
280.00 USD
Product Specification
FORMULA:
C
6
H
10
O
12
P
2
. 4K
MW:
336.1 . 156.4
PURITY:
≥98% (HPLC)
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Hygroscopic.
IDENTITY:
Identity determined by
1
H-NMR,
31
P-NMR and MS.
General Information
MANUFACTURER
Manufactured by SiChem, Germany.
ALX-307-027
Revised 27-Jun-05
DL-myo-Inositol 1,5-bisphosphate . dipotassium salt
SYNONYMS
DL-Ins(1,5)P
2
. 2K
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Inositols & Inositolphosphates/Related Products
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ALX-307-027-C100
100 µg
60.00 USD
ALX-307-027-M001
1 mg
280.00 USD
Product Specification
FORMULA:
C
6
H
12
O
12
P
2
. 2K
MW:
338.1 . 78.2
PURITY:
≥98% (HPLC)
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Hygroscopic.
IDENTITY:
Identity determined by
1
H-NMR,
31
P-NMR and MS.
General Information
MANUFACTURER
Manufactured by SiChem, Germany.
ALX-307-038
Revised 06-Dec-07
D-myo-Inositol 3,4-bisphosphate, L-α-Phosphatidyl-(1,2-dipalmitoyl)-
SYNONYMS
PtdIns(3,4)P
2
, (1,2-dipalmitoyl)-
L-α-Phosphatidyl-(1,2-dipalmitoyl)-D-
myo
-inositol 3,4-bisphosphate
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Inositols & Inositolphosphates/Related Products
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ALX-307-038-C100
100 µg
95.00 USD
ALX-307-038-C500
500 µg
320.00 USD
Product Specification
FORMULA:
C
41
H
81
O
19
P
3
MW:
971.0
PURITY:
≥98% (HPLC)
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in DMSO or methanol.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Hygroscopic.
IDENTITY:
Identity determined by
1
H-NMR,
31
P-NMR,
13
C-NMR and MS.
Product Specific Literature References
Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate:
T.F. Franke, et al.; Science
275
, 665 (1997)
Abstract
General Information
MANUFACTURER
Manufactured by SiChem, Germany
ALX-307-039
Revised 12-May-06
D-myo-Inositol 4,5-bisphosphate, L-α-Phosphatidyl-(1,2-dipalmitoyl)-
SYNONYMS
PtdIns(4,5)P
2
, (1,2-dipalmitoyl)-
L-α-Phosphatidyl-(1,2-dipalmitoyl)-D-
myo
-inositol 4,5-bisphosphate
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Inositols & Inositolphosphates/Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-307-039-C100
100 µg
95.00 USD
Product Specification
FORMULA:
C
41
H
81
O
19
P
3
MW:
971.0
PURITY:
≥98% (HPLC)
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in DMSO or methanol.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Hygroscopic.
IDENTITY:
Identity determined by
1
H-NMR,
31
P-NMR,
13
C-NMR and MS.
Product Description
The presence of 4,5-bisphosphate group on the inositol ring has been found critical for binding specifically to PH domains that are commonly present in signalling proteins, also found in cytoskeleton.
Product Specific Literature References
Structure of the binding site for inositol phosphate in a PH domain:
M. Hyvonen, et al.; EMBO J.
14
, 4676 (1995)
Abstract
Inositolpolyphosphates and their binding proteins--a short review:
B. Huisamen & A. Lochner; Mol. Cell. Biochem.
157
, 229 (1996)
Abstract
Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate:
T.F. Franke, et al.; Science
275
, 665 (1997)
Abstract
Phosphoinositide lipids as signaling molecules: common themes for signal transduction, cytoskeletal regulation, and membrane trafficking:
T.F. Martin; Annu. Rev. Cell. Dev. Biol.
14
, 231 (1998), (Review)
Abstract
The synthesis and cellular roles of phosphatidylinositol 4,5- bisphosphate:
A. Toker; Curr. Opin. Cell Biol.
10
, 254 (1998)
Abstract
Mechanism of N-WASP activation by CDC42 and phosphatidylinositol 4, 5- bisphosphate:
R. Rohatgi, et al.; J. Cell Biol.
150
, 1299 (2000)
Abstract
General Information
MANUFACTURER
Manufactured by SiChem, Germany
ALX-307-026
Revised 18-Aug-08
