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ALX-270-054
Revised 07-Dec-04
Bisindolylmaleimide VI
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
PKC Inhibitors
Ordering Information
Product Numbers:
Format:
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Unit Price:
Quantity:
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ALX-270-054-M001
1 mg
45.00 USD
ALX-270-054-M005
5 mg
150.00 USD
Product Specification
FORMULA:
C
27
H
26
N
4
O
2
MW:
438.5
PURITY:
≥96% (mixture of 2 isomers)
APPEARANCE:
Red solid.
SOLUBILITY:
Soluble in DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
Product Description
Selective inhibitor of protein kinase C (PKC).
ALX-270-055
Revised 07-Dec-04
Bisindolylmaleimide VII
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
PKC Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-270-055-M001
1 mg
45.00 USD
ALX-270-055-M005
5 mg
150.00 USD
Product Specification
FORMULA:
C
27
H
27
N
5
O
2
MW:
453.5
CAS NUMBER:
137592-47-3
PURITY:
≥96%
APPEARANCE:
Orange solid.
SOLUBILITY:
Soluble in DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
Product Description
Selective inhibitor of protein kinase C (PKC).
ALX-270-056
Revised 18-Jan-08
Bisindolylmaleimide VIII . acetate
SYNONYMS
Ro 31-7549 . acetate
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
PKC Inhibitors
Ordering Information
Product Numbers:
Format:
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ALX-270-056-M001
1 mg
45.00 USD
ALX-270-056-M005
5 mg
150.00 USD
Product Specification
FORMULA:
C
24
H
22
N
4
O
2
. CH
3
COOH
MW:
398.5 . 60.1
CAS NUMBER:
138516-31-1
PURITY:
≥98%
APPEARANCE:
Red powder.
SOLUBILITY:
Soluble in DMSO, methanol or water; slightly soluble in 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
Product Description
Selective inhibitor of protein kinase C (PKC). Enhances Fas- and TRAIL-mediated apoptosis and inhibits T cell-mediated autoimmune diseases.
Product Specific Literature References
Bisindolylmaleimide VIII facilitates Fas-mediated apoptosis and inhibits T cell-mediated autoimmune diseases
:
T. Zhou, et al.; Nat. Med.
5
, 42 (1999)
Abstract
Bisindolylmaleimide VIII enhances DR5-mediated apoptosis through the MKK4/JNK/p38 kinase and the mitochondrial pathways
:
T. Ohtsuka & T. Zhou; J. Biol. Chem.
277
, 29294 (2002)
Abstract
;
Full Text
Proteome-wide identification of cellular targets affected by bisindolylmaleimide-type protein kinase C inhibitors:
D. Brehmer, et al.; Mol. Cell Proteomics
3
, 490 (2004)
Abstract
;
Full Text
ALX-270-057
Revised 18-Jan-08
Bisindolylmaleimide X . hydrochloride
SYNONYMS
Ro 31-8425 . HCl
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
PKC Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-270-057-M001
1 mg
45.00 USD
ALX-270-057-M005
5 mg
150.00 USD
Product Specification
FORMULA:
C
26
H
24
N
4
O
2
. HCl
MW:
424.5 . 36.5
PURITY:
≥98%
APPEARANCE:
Red solid.
SOLUBILITY:
Soluble in DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
Product Description
Selective inhibitor of protein kinase C (PKC).
Product Specific Literature References
Proteome-wide identification of cellular targets affected by bisindolylmaleimide-type protein kinase C inhibitors:
D. Brehmer, et al.; Mol. Cell Proteomics
3
, 490 (2004)
Abstract
;
Full Text
ALX-270-058
Revised 28-May-08
Bisindolylmaleimide XI . hydrochloride
SYNONYMS
Ro 32-0432 . HCl
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
PKC Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-270-058-M001
1 mg
45.00 USD
ALX-270-058-M005
5 mg
150.00 USD
Product Specification
FORMULA:
C
28
H
28
N
4
O
2
. HCl
MW:
452.6 . 36.5
PURITY:
≥98% (NMR)
APPEARANCE:
Orange to brown red solid.
SOLUBILITY:
Soluble in DMSO or methanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
Product Description
Selective inhibitor of protein kinase C (PKC).
ALX-270-061
Revised 03-Feb-05
t-Butylhydroquinone
SYNONYMS
tBHQ
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Ca2+-ATPase/Related Products
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ALX-270-061-G010
10 g
30.00 USD
Product Specification
FORMULA:
C
10
H
14
O
2
MW:
166.2
CAS NUMBER:
1948-33-0
PURITY:
≥97%
APPEARANCE:
Off-white solid.
SOLUBILITY:
Soluble in DMSO or methanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+20°C
Product Description
Inhibitor of the endoplasmic reticulum Ca
2+
-ATPase. Activates extracellular signal-regulated protein kinase 2 (ERK2).
Product Specific Literature References
Butylated hydroxyanisole and its metabolite tert-butylhydroquinone differentially regulate mitogen-activated protein kinases. The role of oxidative stress in the activation of mitogen-activated protein kinases by phenolic antioxidants:
R. Yu, et al.; J. Biol. Chem.
272
, 28962 (1997)
Abstract
;
Full Text
Further Categories Containing This Product:
MAPK Pathway Activators
ALX-270-062
Revised 03-Feb-05
Cantharidic acid . disodium salt
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
PP2A/Related Products
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ALX-270-062-M010
10 mg
110.00 USD
Product Specification
FORMULA:
C
10
H
12
O
5
. 2Na
MW:
212.2 . 46.0
CAS NUMBER:
28874-45-5
PURITY:
≥95%
APPEARANCE:
White solid.
SOLUBILITY:
Soluble in water; slightly soluble in DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
Product Description
Potent protein phosphatase 2A inhibitor.
Product Specific Literature References
M. Matsuzawa, et al.; J. Agric. Food Chem.
35
, 823 (1987)
Partial characterization of specific cantharidin binding sites in mouse tissues
:
M.J. Graziano, et al.; Mol. Pharmacol.
33
, 706 (1989)
Abstract
Cantharidin-binding protein: identification as protein phosphatase 2A:
Y.-M. Li & J.E. Casida; PNAS
89
, 11867 (1992)
Abstract
ALX-270-063
Revised 03-Apr-08
Cantharidin
SYNONYMS
Hexahydro-3a,7a-dimethyl-4,7-epoxyisobenzo-furan-1,3-dione
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products - Other Signal Transduction Pathway Modulators
Ordering Information
Product Numbers:
Format:
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ALX-270-063-M025
25 mg
50.00 USD
ALX-270-063-M100
100 mg
160.00 USD
Product Specification
FORMULA:
C
10
H
12
O
4
MW:
196.2
CAS NUMBER:
56-25-7
MERCK INDEX:
14:
1752
PURITY:
≥98%
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in acetone, DMSO or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+20°C
HANDLING:
Protect from light.
HAZARD:
TOXIC.
Product Description
Potent protein phosphatase 2A (PP2A) inhibitor. At higher concentrations, also inhibits protein phosphatase 1 (PP1).
Product Specific Literature References
Partial characterization of specific cantharidin binding sites in mouse tissues
:
M.J. Graziano, et al.; Mol. Pharmacol.
33
, 706 (1988)
Abstract
Cantharidin-binding protein: identification as protein phosphatase 2A:
Y.-M. Li and J.E. Casida; PNAS
89
, 11867 (1992)
Abstract
Protein phosphatase 2A and its [3H]cantharidin/[3H]endothall thioanhydride binding site. Inhibitor specificity of cantharidin and ATP analogues:
Y.-M. Li, et al.; Biochem. Pharmacol.
46
, 1435 (1993)
Abstract
Further Categories Containing This Product:
PP2A/Related Products
ALX-270-064
Revised 14-Jul-03
Chaetomellic acid A . disodium salt
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Farnesylation/Isoprenylation Reagents
Ordering Information
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Format:
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ALX-270-064-M001
1 mg
30.00 USD
ALX-270-064-M005
5 mg
70.00 USD
ALX-270-064-M010
10 mg
130.00 USD
Product Specification
FORMULA:
C
19
H
32
O
4
. 2Na
MW:
324.5 . 46.0
PURITY:
≥
98%
APPEARANCE:
White solid.
SOLUBILITY:
Soluble in warm water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Potent inhibitor of farnesyltransferase in isolated enzyme assays but is inactive in whole cells. Inhibition of farnesyltransferase is selective over geranylgeranyltransferase I and II.
Product Specific Literature References
Selective inhibition of farnesyl-protein transferase blocks ras processing in vivo:
J.B. Gibbs, et al.; J. Biol. Chem.
268
, 7617 (1993)
Abstract
;
Full Text
Inhibitors of Ras farnesyltransferases:
F. Tamanoi; TIBS
18
, 349 (1993), (Review)
Abstract
ALX-270-066
Revised 07-Apr-08
Lavendustin C
SYNONYMS
Compound 5
5-(N-2,5-Dihydroxybenzyl)aminosalicylic acid
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products - Protein Kinase Inhibitors
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ALX-270-066-M001
1 mg
35.00 USD
Product Specification
FORMULA:
C
14
H
13
NO
5
MW:
275.3
SOURCE/HOST:
Synthetic.
PURITY:
≥97%
APPEARANCE:
Off-white solid.
SOLUBILITY:
Soluble in DMSO or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
HAZARD:
TOXIC.
Product Description
Potent inhibitor of protein tyrosine kinases and Ca
2+
/calmodulin-dependent kinase II. Acts also as an inhibitor of EGFR tyrosine kinase and pp60
c-
src
kinase.
Product Specific Literature References
Isolation of a novel tyrosine kinase inhibitor, lavendustin A, from Streptomyces griseolavendus:
T. Onoda, et al.; J. Nat. Prod.
52
, 1252 (1989)
Abstract
Long-term potentiation in the hippocampus is blocked by tyrosine kinase inhibitors:
T.J. O'Dell, et al.; Nature
353
, 558 (1991)
Abstract
Hypericin and pseudohypericin specifically inhibit protein kinase C: possible relation to their antiretroviral activity:
I. Takahashi, et al.; BBRC
165
, 1207 (1989)
Abstract
Inhibition of crystal-induced neutrophil activation by a protein tyrosine kinase inhibitor:
H.M. Burt, et al.; J. Leukoc. Biol.
55
, 112 (1994)
Abstract
Endotoxin increases intercellular resistance in microvascular endothelial cells by a tyrosine kinase pathway:
D. Lidington, et al.; J. Cell Physiol.
185
, 117 (2000)
Abstract
Related Products
ALX-350-084
Lavendustin C methyl ester
Further Categories Containing This Product:
CAM Kinase Inhibitors
•
Lipopolysaccharides [LPS]/Related Products
•
Tyrosine Kinase Inhibitors
•
EGFR Kinase Inhibitors
ALX-270-067
Revised 04-Mar-05
H-8 . dihydrochloride
SYNONYMS
N-[2-(Methylamino)ethyl]-5-isoquinolinesulfonamide . 2HCl
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
PKA Inhibitors
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ALX-270-067-M005
5 mg
40.00 USD
ALX-270-067-M025
