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Signal Transduction
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ALX-151-020 Revised 10-Feb-05
N-Acetyl-Asp-Glu-OH
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SYNONYMS α-NAAG
Spaglumic acid
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Glutamate Receptors (Metabotropic) / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-151-020-M010   10 mg 35.00 USD Add To Cart
ALX-151-020-M050   50 mg 140.00 USD Add To Cart
Product Specification
FORMULA: C11H16N2O8
MW: 304.3
CAS NUMBER: 3106-85-2
PURITY: ≥98%
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
Product Description
Endogenous neurotransmitter with high affinity for the brain glutamate receptor. N-acetylated α-linked acidic dipeptidase (NAALADase), a membrane-bound peptidase, hydrolyzes α-NAAG, a major brain peptide, to N-acetylaspartate and glutamate. Discriminates between mGluR2 and mGluR3. mGluR3 activator. NMDA receptor antagonist. Neuroprotective.
Product Specific Literature References
N-acetylaspartylglutamate: an endogenous peptide with high affinity for a brain glutamate receptor: R. Zaczek, et al.; PNAS 80, 1116 (1983) Abstract
Characterization of the interactions of N-acetyl-aspartyl-glutamate with [3H]L-glutamate receptors: K.J. Koller & J.T. Coyle; Eur. J. Pharmacol. 98, 193 (1984) Abstract
The neurobiology of N-acetylaspartylglutamate: R.D. Blakely & J.T. Coyle; Int. Rev. Neurobiol. 30, 39 (1988) Abstract
Design, synthesis, and biological activity of a potent inhibitor of the neuropeptidase N-acetylated alpha-linked acidic dipeptidase: P.F. Jackson, et al.; J. Med. Chem. 39, 619 (1996) Abstract
The nagging question of the function of N-acetylaspartylglutamate: J.T. Coyle; Neurobiol. Dis. 4, 231 (1997) Abstract
N-acetylaspartylglutamate stimulates metabotropic glutamate receptor 3 to regulate expression of the GABA(A) alpha6 subunit in cerebellar granule cells: S. Ghose, et al.; J. Neurochem. 69, 2326 (1997) Abstract
N-acetylaspartylglutamate (NAAG) protects against rat striatal quinolinic acid lesions in vivo: L.R. Orlando, et al.; Neurosci. Lett. 236, 91 (1997) Abstract
N-acetylaspartylglutamate, N-acetylaspartate, and N-acetylated alpha-linked acidic dipeptidase in human brain and their alterations in Huntington and Alzheimer's diseases: L.A. Passani, et al.; Mol. Chem. Neuropathol. 31, 97 (1997) Abstract
Distribution of N-acetylaspartylglutamate immunoreactivity in human brain and its alteration in neurodegenerative disease: L.A. Passani, et al.; Brain Res. 772, 9 (1997) Abstract
N-acetylaspartylglutamate selectively activates mGluR3 receptors in transfected cells: B. Wroblewska, et al.; J. Neurochem. 69, 174 (1997) Abstract
Neuroprotective activity of N-acetylaspartylglutamate in cultured cortical cells: V. Bruno, et al.; Neuroscience 85, 751 (1998) Abstract
N-acetylaspartylglutamate activates cyclic AMP-coupled metabotropic glutamate receptors in cerebellar astrocytes: B. Wroblewska, et al.; Glia 24, 172 (1998) Abstract
A.P. Burlina, et al.; Eur. J. Pediatr. 158, 406 (1999) Abstract
Further Categories Containing This Product:
NMDA Receptors / Related ProductsNAALADase / Related ProductsPeptides
 
 
ALX-151-021 Revised 14-Aug-02
H-Arg-Gly-Tyr-Ser-Leu-Gly-OH
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY PKA Inhibitors
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-151-021-M001   1 mg 40.00 USD Add To Cart
ALX-151-021-M005   5 mg 140.00 USD Add To Cart
Product Specification
FORMULA: C28H45N9O9
MW: 651.7
PURITY: ≥97%
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Substrate for cAMP-dependent protein kinase (PKA).
Product Specific Literature References
Synthetic hexapeptide substrates and inhibitors of 3':5'-cyclic AMP- dependent protein kinase: B.E. Kemp, et al.; PNAS 73, 1038 (1976) Abstract
Synthetic peptide substrates of the cAMP-dependent protein kinase: B.E. Kemp, et al.; Fed. Proc. 35, 1384 (1976)
Further Categories Containing This Product:
Peptides
 
 
ALX-151-022 Revised 14-Aug-02
H-Arg-Gly-Tyr-Ala-Leu-Gly-OH
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY PKA Substrates
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ALX-151-022-M001   1 mg 40.00 USD Add To Cart
ALX-151-022-M005   5 mg 140.00 USD Add To Cart
Product Specification
FORMULA: C28H45N9O8
MW: 635.7
PURITY: ≥97%
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Competitive inhibitor of cAMP-dependent protein kinase (PKA).
Product Specific Literature References
Synthetic hexapeptide substrates and inhibitors of 3':5'-cyclic AMP- dependent protein kinase: B.E. Kemp, et al.; PNAS 73, 1038 (1976) Abstract
Further Categories Containing This Product:
Peptides
 
 
ALX-151-023 Revised 23-Nov-06
Autocamtide-2
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY CAM Kinase Substrates
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ALX-151-023-M001   1 mg 80.00 USD Add To Cart
ALX-151-023-M005   5 mg 320.00 USD Add To Cart
Product Specification
SEQUENCE: H-Lys-Lys-Ala-Leu-Arg-Arg-Gln-Glu-Thr-Val-Asp-Ala-Leu-OH
FORMULA: C65H118N22O20
MW: 1527.8
PURITY: ≥98%
APPEARANCE: Lyophilized.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Very selective substrate for Ca2+/calmodulin-dependent protein kinase II.
Product Specific Literature References
Expression of a multifunctional Ca2+/calmodulin-dependent protein kinase and mutational analysis of its autoregulation: P.I. Hanson, et al.; Neuron 3, 59 (1989) Abstract
Further Categories Containing This Product:
Peptides
 
 
ALX-151-026 Revised 20-Jun-08
N-Acetyl-Asp-Tyr(2-malonyl)-Val-Pro-Met-Leu-NH2
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Tyrosine Kinase Inhibitors
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ALX-151-026-M001   1 mg 90.00 USD Add To Cart
Product Specification
FORMULA: C39H57N7O14S
MW: 880.0
PURITY: ≥96% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in water (1mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Peptide is very unstable.
Product Description
Peptide containing a phosphotyrosyl mimetic. Effective protein tyrosine kinase inhibitor. Inhibits the phosphoinositide 3-kinase (PI(3)K) C-terminal p85 SH2 domain.
Product Specific Literature References
L-O-(2-malonyl)tyrosine: a new phosphotyrosyl mimetic for the preparation of Src homology 2 domain inhibitory peptides: B. Ye, et al.; J. Med. Chem. 38, 4270 (1995) Abstract
Further Categories Containing This Product:
PeptidesPhosphoinositide 3-kinase [PI(3)K] / Related Products
 
 
ALX-151-027 Revised 17-Jan-05
N-Acetyl-Asp-Tyr(PO3H2)-Val-Pro-Met-Leu-NH2
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Tyrosine Kinase Inhibitors
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ALX-151-027-M001   1 mg 90.00 USD Add To Cart
Product Specification
FORMULA: C36H57N7O13SP
MW: 858.9
PURITY: ≥96%
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Phosphotyrosine containing peptide. Effective protein tyrosine kinase inhibitor. Inhibits the phosphoinositide 3-kinase (PI(3)K) C-terminal p85 SH2 domain.
Product Specific Literature References
L-O-(2-malonyl)tyrosine: a new phosphotyrosyl mimetic for the preparation of Src homology 2 domain inhibitory peptides: B. Ye, et al.; J. Med. Chem. 38, 4270 (1995) Abstract
Further Categories Containing This Product:
PeptidesPhosphoinositide 3-kinase [PI(3)K] / Related Products
 
 
ALX-151-028 Revised 23-Nov-06
Protein Tyrosine Kinase pp60c-src Substrate
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Src Family Kinases / Related Products
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ALX-151-028-M001   1 mg 40.00 USD Add To Cart
ALX-151-028-M005   5 mg 130.00 USD Add To Cart
Product Specification
SEQUENCE: Ac-Ile-Tyr-Gly-Glu-Phe-NH2
FORMULA: C33H43N5O10
MW: 668.7
PURITY: ≥98%
APPEARANCE: Lyophilized.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Substrate for protein tyrosine kinase pp60c-src.
Product Specific Literature References
Oncogenes and signal transduction [published erratum appears in Cell 1991 May 31;65(5):following 914]: L.C. Cantley, et al.; Cell 64, 281 (1991), (Review) Abstract
Identification of efficient pentapeptide substrates for the tyrosine kinase pp60c-src: S.A. Nair, et al.; J. Med. Chem. 38, 4276 (1995) Abstract
Further Categories Containing This Product:
Peptides
 
 
ALX-151-029 Revised 23-Nov-06
Autocamtide-2-Related Inhibitory Peptide
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SYNONYMS AIP
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY CAM Kinase Inhibitors
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ALX-151-029-M001   1 mg 75.00 USD Add To Cart
ALX-151-029-M005   5 mg 300.00 USD Add To Cart
Product Specification
SEQUENCE: H-Lys-Lys-Ala-Leu-Arg-Arg-Gln-Glu-Ala-Val-Asp-Ala-Leu-OH
FORMULA: C64H116N22O19
MW: 1497.8
PURITY: ≥98%
APPEARANCE: Lyophilized.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Highly specific and potent inhibitor of Ca2+/calmodulin-dependent protein kinase II without affecting cAMP-dependent protein kinase (PKA), protein kinase C (PKC) and Ca2+/calmodulin-dependent protein kinase IV.
Product Specific Literature References
A novel highly specific and potent inhibitor of calmodulin-dependent protein kinase II: A. Ishida, et al.; BBRC 212, 806 (1995) Abstract
Stabilization of calmodulin-dependent protein kinase II through the autoinhibitory domain: A. Ishida & H. Fujisawa; J. Biol. Chem. 270, 2163 (1995) Abstract; Full Text
Further Categories Containing This Product:
Peptides
 
 
ALX-151-030 Revised 05-Feb-08
Autocamtide-2-Related Inhibitory Peptide (Myristoylated)
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SYNONYMS AIP Myristoylated
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY CAM Kinase Inhibitors
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ALX-151-030-MC05   0.5 mg 90.00 USD Add To Cart
Product Specification
SEQUENCE: Myr-Lys-Lys-Ala-Leu-Arg-Arg-Gln-Glu-Ala-Val-Asp-Ala-Leu-OH
FORMULA: C78H142N22O20
MW: 1708.1
PURITY: ≥98%
APPEARANCE: Lyophilized.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Corresponds to Prod. No. ALX-151-029 but this one is N-terminal myristoylated to increase cell permeability.
Further Categories Containing This Product:
Peptides
 
 
ALX-151-031 Revised 23-Nov-06
Caspase-3 Control Peptide
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PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Caspase Inhibitors
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ALX-151-031-M001   1 mg 35.00 USD Add To Cart
ALX-151-031-M005   5 mg 120.00 USD Add To Cart
Product Specification
SEQUENCE: Ac-Asp-Glu-Val-Asp-OH
FORMULA: C20H30N4O12
MW: 518.5
PURITY: ≥97%
APPEARANCE: Lyophilized.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Further Categories Containing This Product:
Peptides
 
 
ALX-151-037 Revised 23-Nov-06
Angiotensin I
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Angiotensin & Angiotensin Receptors / Related Products
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ALX-151-037-M005   5 mg 30.00 USD Add To Cart
ALX-151-037-M025   25 mg 125.00 USD Add To Cart
Product Specification
SEQUENCE: H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-OH
FORMULA: C62H89N17O14
MW: 1296.5
APPEARANCE: Lyophilized.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Further Categories Containing This Product:
Peptides
 
 
ALX-151-038 Revised 23-Nov-06
Angiotensin I (1-9)
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Angiotensin & Angiotensin Receptors / Related Products
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ALX-151-038-M005   5 mg 75.00 USD Add To Cart
Product Specification
SEQUENCE: H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-OH
FORMULA: C56H78N16O13
MW: 1183.3
APPEARANCE: Lyophilized.