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Signal Transduction
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ALX-160-002 Revised 18-Dec-02
Kemptamide
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY PKA Substrates
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-160-002-M001   1 mg 50.00 USD Add To Cart
ALX-160-002-M005   5 mg 200.00 USD Add To Cart
Product Specification
SEQUENCE: H-Leu-Arg-Arg-Ala-Ser-Leu-Gly-NH2
FORMULA: C32H62N14O8
MW: 770.9
PURITY: ≥97%
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Amide analog of Kemptide (Prod. No. ALX-160-006).
Further Categories Containing This Product:
Peptides
 
 
ALX-160-006 Revised 04-Feb-05
Kemptide
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY PKA Substrates
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-160-006-M001   1 mg 30.00 USD Add To Cart
ALX-160-006-M005   5 mg 90.00 USD Add To Cart
Product Specification
SEQUENCE: H-Leu-Arg-Arg-Ala-Ser-Leu-Gly-OH
FORMULA: C32H61N13O9
MW: 771.9
CAS NUMBER: 65189-71-1
PURITY: ≥97%
APPEARANCE: White lyophilized powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Phosphate acceptor peptide. Substrate for cAMP-dependent protein kinase (PKA). The sequence defines the phosphorylation site of porcine liver pyruvate kinase.
Product Specific Literature References
Synthetic peptide substrates of the cAMP-dependent protein kinase: B.E. Kemp, et al.; Fed. Proc. 35, 1384 (1976)
Role of multiple basic residues in determining the substrate specificity of cyclic AMP-dependent protein kinase: B.E. Kemp, et al.; J. Biol. Chem. 252, 4888 (1977) Abstract; Full Text
Studies on the mechanism of phosphorylation of synthetic polypeptides by a calf thymus cyclic AMP-dependent protein kinase: A.H. Pomerantz, et al.; PNAS 74, 4261 (1977) Abstract
Adrenergic control of the cyclic AMP-dependent protein kinase and pyruvate kinase in isolated hepatocytes. Application of a synthetic peptide substrate for measuring protein kinase activity: B.E. Kemp & M.G. Clark; J. Biol. Chem. 253, 5147 (1978) Abstract; Full Text
In vivo phosphorylation of a synthetic peptide substrate of cyclic AMP- dependent protein kinase: J.L. Maller, et al.; PNAS 75, 248 (1978) Abstract
Optimal spatial requirements for the location of basic residues in peptide substrates for the cyclic AMP-dependent protein kinase: J.R. Feramisco, et al.; J. Biol. Chem. 255, 4240 (1980) Abstract; Full Text
Further Categories Containing This Product:
Peptides
 
 
ALX-160-008 Revised 13-Jan-05
[Trp4]-Kemptide
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY PKA Substrates
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ALX-160-008-M001   1 mg 50.00 USD Add To Cart
ALX-160-008-M005   5 mg 200.00 USD Add To Cart
Product Specification
SEQUENCE: H-Leu-Arg-Arg-Trp-Ser-Leu-Gly-OH
FORMULA: C40H66N14O9
MW: 887.1
PURITY: ≥98%
APPEARANCE: White lyophilized powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Substrate for cAMP-dependent protein kinase (PKA). The phosphorylated product is an active substrate for phosphoprotein phosphatase.
Product Specific Literature References
Fluorometric assay for adenosine 3',5'-cyclic monophosphate-dependent protein kinase and phosphoprotein phosphatase activities: D.E. Wright, et al.; PNAS 78, 6048 (1981) Abstract
Further Categories Containing This Product:
Peptides
 
 
ALX-162-001 Revised 07-Apr-08
Mastoparan
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Neurotoxins
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ALX-162-001-M001   1 mg 50.00 USD Add To Cart
ALX-162-001-M005   5 mg 200.00 USD Add To Cart
Product Specification
SEQUENCE: H-Ile-Asn-Leu-Lys-Ala-Leu-Ala-Ala-Leu-Ala-Lys-Lys-Ile-Leu-NH2
FORMULA: C70H131N19O15
MW: 1478.9
CAS NUMBER: 72093-21-1
SOURCE/HOST: Synthetic. Originally isolated from wasp venom.
PURITY: ≥98%
APPEARANCE: White lyophilized powder.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: POTENT NEUROTOXIN.
Product Description

Mast cell degranulating peptide. Stimulates glycogenolysis.Stimulates phospholipase D2 PLD2 activity. Alters G-proteins in brain membranes.
Product Specific Literature References
A new mast cell degranulating peptide "mastoparan" in the venom of Vespula lewisii: Y. Hirai, et al.; Chem. Pharm. Bull. 27, 1942 (1979) Abstract
Mastoparan, a peptide toxin from wasp venom, mimics receptors by activating GTP-binding regulatory proteins (G proteins): T. Higashijima, et al.; J. Biol. Chem. 263, 6491 (1988) Abstract; Full Text
Mastoparan, a peptide toxin from wasp venom, stimulates glycogenolysis mediated by an increase of the cytosolic free Ca2+ concentration but not by an increase of cAMP in rat hepatocytes: M. Tohkin, et al.; FEBS Lett. 260, 179 (1990) Abstract
Interaction of wasp venom mastoparan with biomembranes: T. Katsu, et al.; Biochim. Biophys. Acta 1027, 185 (1990) Abstract
Effects of the wasp venom peptide, mastoparan, on GTP hydrolysis in rat brain membranes: Y. Odagaki, et al.; Br. J. Pharmacol. 121, 1406 (1997) Abstract
Mastoparan selectively activates phospholipase D2 in cell membranes: A. Chahdi, et al.; J. Biol. Chem. 278, 12039 (2003) Abstract
Mastoparan, a G protein agonist peptide, differentially modulates TLR4- and TLR2-mediated signaling in human endothelial cells and murine macrophages: A. Lentschat, et al.; J. Immunol. 174, 4252 (2005) Abstract
Biological applications of the receptor mimetic peptide mastoparan: S. Jones & J. Howl; Curr. Protein Pept. Sci. 7, 501 (2006), Review Abstract
Further Categories Containing This Product:
G-proteins & GTPases Other Products • Peptides
 
 
ALX-162-002 Revised 07-Apr-08
MCD Peptide
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SYNONYMS Mast Cell Degranulating Peptide
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Neurotoxins
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ALX-162-002-MC05   0.5 mg 360.00 USD Add To Cart
Product Specification
SEQUENCE: H-Ile-Lys-Cys-Asn-Cys-Lys-Arg-His-Val-Ile-Lys-Pro-His-Ile-Cys-Arg-Lys-Ile-Cys-Gly-Lys-Asn-NH2
(Disulfide bonds between Cys3-Cys15 and Cys5-Cys19)
FORMULA: C110H192N40O24S4
MW: 2587.2
CAS NUMBER: 83856-13-7
SOURCE/HOST: Synthetic. Originally isolated from Apis mellifera.
PURITY: ≥98%
APPEARANCE: White lyophilized powder.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: POTENT NEUROTOXIN.
Product Description
Potent anti-inflammatory agent and strong mediator of mast cell degranulation and histamine release. Neurotoxin and voltage-dependent K+ channel blocker. Inhibits the ADP-ribosylation of the small GTP-binding proteins rho.
Product Specific Literature References
Bee and wasp venoms: E. Haberman; Science 177, 314 (1972) Abstract
Potassium channel toxins: P.N. Strong; Pharmacol. Ther. 46, 137 (1990) Abstract
Mast cell degranulating peptide: a multi-functional neurotoxin: M.R. Ziai, et al.; J. Pharm. Pharmacol. 42, 457 (1990), Review Abstract
ADP-ribosylation of rho proteins is inhibited by melittin, mast cell degranulating peptide and compound 48/80: G. Koch, et al.; Eur. J. Pharmacol. 226, 87 (1992) Abstract
Further Categories Containing This Product:
Peptides • K+ Channel Blockers & Inhibitors • Natural Products - Anti-inflammatory Agents
 
 
ALX-162-004 Revised 05-Feb-05
MARCKS Protein (151-175) (bovine brain)
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY PKC Substrates
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ALX-162-004-MC05   0.5 mg 120.00 USD Add To Cart
ALX-162-004-M001   1 mg 210.00 USD Add To Cart
Product Specification
SEQUENCE: H-Lys-Lys-Lys-Lys-Lys-Arg-Phe-Ser-Phe-Lys-Lys-Ser-Phe-Lys-Leu-Ser-Gly-Phe-Ser-Phe-Lys-Lys-Asn-Lys-Lys-OH
FORMULA: C147H243N41O31
MW: 3081.8
CAS NUMBER: 125267-21-2
PURITY: ≥98%
APPEARANCE: White lyophilized powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Excellent substrate for protein kinase C (PKC). The peptide consists of residues 151-175 of the myristoylated alanine-rich C-kinase substrate (MARCKS) protein phosphorylation site. Protein kinase C isotypes (including PKCε) phosphorylate serines 8, 12 and 19 of this peptide. It is a very weak substrate for cAMP- and cGMP-dependent protein kinase and CaM kinases I, II and III.
Product Specific Literature References
Protein kinase C substrate and inhibitor characteristics of peptides derived from the myristoylated alanine-rich C kinase substrate (MARCKS) protein phosphorylation site domain: J.M. Graff, et al.; J. Biol. Chem. 266, 14390 (1991) Abstract; Full Text
The MARCKS family of cellular protein kinase C substrates: P.J. Blackshear; J. Biol. Chem. 268, 1501 (1993), (Minireview) Abstract; Full Text
Further Categories Containing This Product:
Peptides
 
 
ALX-162-005 Revised 04-Jul-03
MARCKS Protein (159-165) amide (bovine brain)
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY PKC Substrates
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ALX-162-005-M001   1 mg 105.00 USD Add To Cart
ALX-162-005-M005   5 mg 420.00 USD Add To Cart
Product Specification
SEQUENCE: H-Phe-Lys-Lys-Ser-Phe-Lys-Leu-NH2
FORMULA: C45H73N11O8
MW: 896.1
PURITY: ≥98%
APPEARANCE: White lyophilized powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
The peptide consists of residues 159-165 of the myristoylated alanine-rich C-kinase substrate (MARCKS) protein. It is sufficiently selective for protein kinase C (PKC) to permit specific assay of this enzyme in crude cell extracts and permeabilized cells.
Product Specific Literature References
The MARCKS family of cellular protein kinase C substrates: P.J. Blackshear; J. Biol. Chem. 268, 1501 (1993) Abstract; Full Text
: T. Spencker, et al.; Liebigs Ann. Chem. 237, (1993)
Further Categories Containing This Product:
Peptides
 
 
ALX-162-006 Revised 07-Apr-08
Melittin (natural)
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Protein Kinase Inhibitors
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ALX-162-006-M001   1 mg 40.00 USD Add To Cart
ALX-162-006-M005   5 mg 160.00 USD Add To Cart
Product Specification
SEQUENCE: H-Gly-Ile-Gly-Ala-Val-Leu-Lys-Val-Leu-Thr-Thr-Gly-Leu-Pro-Ala-Leu-Ile-Ser-Trp-Ile-Lys-Arg-Lys-Arg-Gln-Gln-NH2
FORMULA: C131H229N39O31
MW: 2846.5
CAS NUMBER: 37231-28-0
MERCK INDEX: 14: 5824
RTECS: OS3960000
SOURCE/HOST: Isolated from bee venom.
PURITY: ≥85% (HPLC)
APPEARANCE: Off-white to faint tan powder.
PURITY DETAIL: Phospholipase A2 impurity: <5 units per mg solid.
SOLUBILITY: Soluble in PBS (5mg/ml) or water (5mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Very hygroscopic. Protect from light.
HAZARD: HARMFUL.
Product Description
Causes disruption of normal cellular activity and cell lysis. Binds calmodulin in a calcium-dependent manner. Activates phospholipase A2 (PLA2) and inhibits protein kinase C (PKC) by binding to the catalytic domain in a Mg-ATP sensitive manner. Antirheumatic.
Product Specific Literature References
Rapid purification of calmodulin and S-100 protein by affinity chromatography with melittin immobilized to sepharose: R.L. Kincaid & C.C. Coulson; BBRC 133, 256 (1985) Abstract
Comparison of S100b protein with calmodulin: interactions with melittin and microtubule-associated tau proteins and inhibition of phosphorylation of tau proteins by protein kinase C: J. Baudier, et al.; Biochemistry 26, 2886 (1987) Abstract
Possible mechanisms of action of cobra snake venom cardiotoxins and bee venom melittin: J.E. Fletcher & M.S. Jiang; Toxicon. 31, 669 (1993) Abstract
Melittin and phospholipase A2 from bee (Apis mellifera) venom cause necrosis of murine skeletal muscle in vivo: C.L. Ownby, et al.; Toxicon. 35, 67 (1997) Abstract
Melittin binds to secretory phospholipase A2 and inhibits its enzymatic activity: S.S. Saini, et al.; BBRC 238, 436 (1997) Abstract
Phospholipase A2-independent Ca2+ entry and subsequent apoptosis induced by melittin in human MG63 osteosarcoma cells: S.T. Chu, et al.; Life Sci. 80, 364 (2007) Abstract
Further Categories Containing This Product:
Calmodulin Other Products • PKC Inhibitors • Peptides • PLA2 Activators
 
 
ALX-162-007 Revised 12-May-05
Melittin (synthetic)
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Protein Kinase Inhibitors
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-162-007-MC05   0.5 mg 70.00 USD Add To Cart
ALX-162-007-M001   1 mg 120.00 USD Add To Cart
Product Specification
SEQUENCE: H-Gly-Ile-Gly-Ala-Val-Leu-Lys-Val-Leu-Thr-Thr-Gly-Leu-Pro-Ala-Leu-Ile-Ser-Trp-Ile-Lys-Arg-Lys-Arg-Gln-Gln-NH2
FORMULA: C131H229N39O31
MW: 2846.5
CAS NUMBER: 37231-28-0
MERCK INDEX: 14: 5824
SOURCE/HOST: Synthetic.
PURITY: ≥97%
APPEARANCE: White lyophilized powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
HAZARD: TOXIC.
Product Description
For technical information see melittin (natural) (Prod. No. ALX-162-006).
Further Categories Containing This Product:
PLA2 Activators • Calmodulin Other Products • PKC Inhibitors • Peptides
 
 
ALX-162-009 Revised 04-Jul-07
Myelin Basic Protein (4-14) (bovine)
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SYNONYMS MBP (4-14) (bovine)
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Myelin Basic Protein / Related Products
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ALX-162-009-M001   1 mg 85.00 USD Add To Cart
ALX-162-009-M005   5 mg 330.00 USD Add To Cart
Product Specification
SEQUENCE: H-Gln-Lys-Arg-Pro-Ser-Gln-Arg-Ser-Lys-Tyr-Leu-OH
FORMULA: C60H103N21O17
MW: 1390.6
PURITY: ≥96%
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Specific and convenient substrate for protein kinase C (PKC). Very poor substrate for phosphorylase kinase, CaM kinase II, casein kinases I and II and cAMP-dependent protein kinase (PKA).
Product Specific Literature References
A phosphatase resistant substrate for the assay of protein kinase C in crude tissue extracts: Y.J.K. Farrar, et al.; BBRC 180, 694 (1991) Abstract
A synthetic peptide substrate for selective assay of protein kinase C: I. Yasuda, et al.; BBRC 166, 1220 (1990) Abstract
Further Categories Containing This Product:
PKC Substrates • Peptides
 
 
ALX-162-010 Revised 28-Jul-08
Myelin Basic Protein (104-118) (bovine)