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Receptors
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ALX-270-255 Revised 14-Sep-07
Ciglitazone
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SYNONYMS (±)-5-[4-(1-Methylcyclohexylmethoxy)benzyl]-thiazolidine-2,4-dione
U-63287
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY PPAR Agonists
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-255-M001   1 mg 30.00 USD Add To Cart
ALX-270-255-M005   5 mg 80.00 USD Add To Cart
ALX-270-255-M025   25 mg 310.00 USD Add To Cart
Product Specification
FORMULA: C18H23NO3S
MW: 333.5
CAS NUMBER: 74772-77-3
SOURCE/HOST: Synthetic.
PURITY: ≥98%
APPEARANCE: Off-white solid.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
USE/STABILITY: Stock solutions are stable for up to 3 months when stored at -20°C.

Product Description
Selective PPARγ agonist.
Product Specific Literature References
The structure-activity relationship between peroxisome proliferator-activated receptor gamma agonism and the antihyperglycemic activity of thiazolidinediones: T.M. Willson, et al.; J. Med. Chem. 39, 665 (1996) Abstract; Full Text
Detection and functional characterisation of the transcription factor peroxisome proliferator-activated receptor gamma in lutein cells: B. Löhrke, et al.; J. Endocrinol. 159, 429 (1998) Abstract; Full Text
Peroxisome proliferator-activated receptor gamma ligands are potent inhibitors of angiogenesis in vitro and in vivo: X. Xin, et al.; J. Biol. Chem. 274, 9116 (1999) Abstract; Full Text
Thiazolidinediones--the new insulin enhancers: R.J. Jha; Clin. Exp. Hypertens. 21, 157 (1999), (Review) Abstract
The nuclear receptor PPAR gamma and immunoregulation: PPAR gamma mediates inhibition of helper T cell responses: R.B. Clark, et al.; J. Immunol. 164, 1364 (2000) Abstract; Full Text
Further Categories Containing This Product:
Antidiabetic Agents / Related Products
 
 
ALX-270-475 Revised 17-Jan-08
Ciprofibrate
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SYNONYMS 2-[4-(2,2-Dichlorocyclopropyl)phenoxy]-2-methylpropanoic acid
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Cholesterol & Lipid Transport / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-475-M025   25 mg 50.00 USD Add To Cart
ALX-270-475-M100   100 mg 150.00 USD Add To Cart
ALX-270-475-M250   250 mg 300.00 USD Add To Cart
Product Specification
FORMULA: C13H14Cl2O3
MW: 289.2
CAS NUMBER: 52214-84-3
MERCK INDEX: 14: 2313
RTECS: UF0880000
PURITY: ≥98% (HPLC)
APPEARANCE: White to light yellow powder.
SOLUBILITY: Soluble in DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: TOXIC. MAY BE CARCINOGENIC.

Product Description
Hypolipidemic compound. PPARα (peroxisome proliferator-activated receptor α) agonist.
Product Specific Literature References
Comparison of the effects of various peroxisome proliferators on peroxisomal enzyme activities, DNA synthesis, and apoptosis in rat and human hepatocyte cultures: V. Goll, et al.; Toxicol. Appl. Pharmacol. 160, 21 (1999) Abstract
Phosphorylation of peroxisome proliferator-activated receptor alpha in rat Fao cells and stimulation by ciprofibrate: P. Passilly, et al.; Biochem. Pharmacol. 58, 1001 (1999) Abstract
Differences in cell proliferation in rodent and human hepatic derived cell lines exposed to ciprofibrate: M.C. Clemencet, et al.; Cancer Lett. 222, 217 (2005) Abstract
P450 CYP2C epoxygenase and CYP4A ω-hydroxylase mediate ciprofibrate-induced PPARα-dependent peroxisomal proliferation: A. Gatica, et al.; J. Lipid Res. 48, 924 (2007) Abstract; Full Text
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Further Categories Containing This Product:
PPAR Agonists • Apoptosis Inducers & Inhibitors Other Products
 
 
ALX-270-314 Revised 04-Dec-07
CL-387,785
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SYNONYMS EKI-785
N-[4-[(3-Bromophenyl)amino]-6-quinazolinyl]-2-butynamide
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY EGFR Kinase Inhibitors
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-314-M001   1 mg 130.00 USD Add To Cart
Product Specification
FORMULA: C18H13BrN4O
MW: 381.2
PURITY: ≥98% (HPLC)
APPEARANCE: Off-white to yellow solid.
SOLUBILITY: Soluble in DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Hygroscopic. Protect from light. Packaged under inert gas.

Product Description
Irreversibly inhibits EGF-stimulated autophosphorylation of tyrosine residues in the epidermal growth factor receptor (EGFR) in vivo (IC50=250-490pM) and blocks EGF-mediated growth.
Product Specific Literature References
Irreversible inhibition of epidermal growth factor receptor tyrosine kinase with in vivo activity by N-[4-[(3-bromophenyl)amino]-6-quinazolinyl]-2-butynamide (CL-387,785): C.M. Discafani, et al.; Biochem. Pharmacol. 57, 917 (1999) Abstract
 
 
ALX-550-077 Revised 26-Apr-07
Clenbuterol . hydrochloride
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SYNONYMS 4-Amino-3,5-dichloro-α-[[(1,1-dimethylethyl)amino]methyl]benzenemethanol . HCl
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Adrenergics & Adrenergic Receptors / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-550-077-M050   50 mg 20.00 USD Add To Cart
ALX-550-077-M250   250 mg 50.00 USD Add To Cart
ALX-550-077-G001   1 g 150.00 USD Add To Cart
Product Specification
FORMULA: C12H18Cl2N2O . HCl
MW: 277.2 . 36.5
CAS NUMBER: 21898-19-1
MERCK INDEX: 14: 2347
RTECS: DN3180000
PURITY: ≥99%
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in water, methanol or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
HAZARD: TOXIC.

Product Description
β2-Adrenergic receptor agonist. Bronchodilator.
Product Specific Literature References
Thiokynurenates: a new group of antagonists of the glycine modulatory site of the NMDA receptor: F. Moroni, et al.; Eur. J. Pharmacol. 199, 227 (1991) Abstract
Function and regulation of the beta 3-adrenoceptor: A.D. Strosberg & F. Pietri-Rouxel; TIPS 17, 373 (1996), (Review) Abstract
 
 
ALX-270-256 Revised 28-Apr-05
Clofibrate
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SYNONYMS 2-(p-Chlorophenoxy)-2-methylpropionic acid ethyl ester
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY PPAR Agonists
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-256-M500   500 mg 15.00 USD Add To Cart
ALX-270-256-G001   1 g 25.00 USD Add To Cart
Product Specification
FORMULA: C12H15ClO3
MW: 242.7
CAS NUMBER: 637-07-0
MERCK INDEX: 14: 2377
PURITY: ≥98%
APPEARANCE: Colorless oil.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
USE/STABILITY: Solutions are stable for up to 6 months when stored at –20°C.

Product Description
Activates PPARα and induces cytochrome P450 4A1 and 4A3.
Product Specific Literature References
Fatty acids activate a chimera of the clofibric acid-activated receptor and the glucocorticoid receptor: M. Göttlicher, et al.; PNAS 89, 4653 (1992) Abstract
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Further Categories Containing This Product:
Cytochrome P450 [CYP450] / Related Products • Carcinogens & Tumor Promoters Other Products • Apoptosis Inducers & Inhibitors Other Products
 
 
ALX-550-087 Revised 15-Sep-08
Clonidine . hydrochloride
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SYNONYMS
2-(2,6-Dichloroanilino)-2-imidazoline . hydrochloride
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Adrenergics & Adrenergic Receptors / Related Products
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ALX-550-087-M050   50 mg 23.00 USD Add To Cart
Product Specification
FORMULA: C9H9Cl2N3 . HCl
MW: 230.1 . 36.5
CAS NUMBER: 4205-91-8
MERCK INDEX: 14: 2390
RTECS: NJ2490000
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in water (50mg/ml) or methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HAZARD: VERY TOXIC.

Product Description
α2-Adrenergic receptor agonist. Antihypertensive.
Further Categories Containing This Product:
Imidazoline Binding Site Ligands
 
 
ALX-550-088 Revised 28-Jan-05
Clozapine
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SYNONYMS 8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e]-[1,4]diazepine
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Dopaminergics & Dopamine Receptors / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-550-088-M005   5 mg 15.00 USD Add To Cart
ALX-550-088-M025   25 mg 35.00 USD Add To Cart
ALX-550-088-M100   100 mg 95.00 USD Add To Cart
Product Specification
FORMULA: C18H19ClN4
MW: 326.8
CAS NUMBER: 5786-21-0
MERCK INDEX: 14: 2423
PURITY: ≥98%
APPEARANCE: Pale yellow powder.
SOLUBILITY: Soluble in DMSO or dilute aqueous acid.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
Selective antagonist for D4-dopamine receptor. Antagonist at 5HT2A, 5HT2C, 5HT3, 5HT6 and 5HT7 receptors.
Product Specific Literature References
Binding of typical and atypical antipsychotics to 5-HT1C and 5-HT2 sites: clozapine potently interacts with 5-HT1C sites: H. Canton, et al.; Eur. J. Pharmacol. 191, 93 (1990) Abstract
The involvement of dopamine D1 and D2 receptors in the effects of the classical neuroleptic haloperidol and the atypical neuroleptic clozapine: B.A. Ellenbroek, et al.; Eur. J. Pharmacol. 196, 103 (1991) Abstract
Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine: H.H. Van Tol, et al.; Nature 350, 610 (1991) Abstract
Clozapine and N-desmethylclozapine are potent 5-HT1C receptor antagonists: M. Kuoppamaki, et al.; Eur. J. Pharmacol. 245, 179 (1993) Abstract
5-HT1C receptor-mediated phosphoinositide hydrolysis in the rat choroid plexus after chronic treatment with clozapine: M. Kuoppamaki, et al.; Eur. J. Pharmacol. 255, 91 (1994) Abstract
Clozapine is a potent and selective muscarinic M4 receptor agonist: S.H. Zorn, et al.; Eur. J. Pharmacol. 269, R1 (1994) Abstract
Interaction of clozapine with the histamine H3 receptor in rat brain: A.A. Rodrigues, et al.; Br. J. Pharmacol. 114, 1523 (1995) Abstract
Further Categories Containing This Product:
Serotonergics & Serotonin Receptors / Related Products
 
 
ALX-550-042 Revised 04-Jun-08
CNQX
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SYNONYMS 6-Cyano-7-nitroquinoxaline-2,3-dione
FG-9065
PRODUCT LINE Neurobiology
PRODUCT CATEGORY AMPA Receptors / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-550-042-M005   5 mg 43.00 USD Add To Cart
ALX-550-042-M010   10 mg 70.00 USD Add To Cart
ALX-550-042-M025   25 mg 155.00 USD Add To Cart
ALX-550-042-M050   50 mg 280.00 USD Add To Cart
Product Specification
FORMULA: C9H4N4O4
MW: 232.2
CAS NUMBER: 115066-14-3
PURITY: ≥98% (TLC)
APPEARANCE: Off-white to yellow powder.
SOLUBILITY: Soluble in DMSO (10mg/ml) or dilute aqueous base.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
USE/STABILITY: Stock solutions are stable for several months when stored at -20°C.
HANDLING: Protect from light.

Product Description
Potent, competitive kainate/quisqualate (non-NMDA) receptor antagonist. For the more soluble form see CNQX . disodium salt (Prod. No. ALX-550-283).
Product Specific Literature References
Quinoxalinediones: potent competitive non-NMDA glutamate receptor antagonists: T. Honoré, et al.; Science, 241, 701 (1988) Abstract
Differential effects of the excitatory amino acid antagonists, 6-cyano- 7-nitroquinoxaline-2,3-dione (CNQX) and 3-((+-)-2-carboxypiperazin-4- yl)-propyl-1-phosphonic acid (CPP), on spinal reflex activity in mice: L. Turski, et al.; Neurosci. Lett. 113, 66 (1990) Abstract
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Further Categories Containing This Product:
Kainate Receptors / Related Products • Glutamate Receptors (Metabotropic) / Related Products
 
 
ALX-550-283 Revised 11-Jan-05
CNQX . disodium salt
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SYNONYMS 6-Cyano-7-nitroquinoxaline-2,3-dione . 2Na
PRODUCT LINE Neurobiology
PRODUCT CATEGORY AMPA Receptors / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-550-283-M005   5 mg 55.00 USD Add To Cart
ALX-550-283-M010   10 mg 100.00 USD Add To Cart
ALX-550-283-M025   25 mg 200.00 USD Add To Cart
Product Specification
FORMULA: C9H2N4O4 . 2Na
MW: 230.2 . 46.0
PURITY: 98%
APPEARANCE: Dark purple solid.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

Product Description
Water soluble, potent competitive kainate/quisqualate (non-NMDA) receptor antagonist. More soluble form of CNQX (Prod. No. ALX-550-042).
Product Specific Literature References
Quinoxalinediones: potent competitive non-NMDA glutamate receptor antagonists: T. Honoré, et al.; Science 241, 701 (1988) Abstract
Differential effects of the excitatory amino acid antagonists, 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) and 3-((+-)-2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid (CPP), on spinal reflex activity in mice: L. Turski, et al.; Neurosci. Lett. 113, 66 (1990) Abstract
Related Products
Further Categories Containing This Product:
Kainate Receptors / Related Products • Glutamate Receptors (Metabotropic) / Related Products
 
 
ALX-350-335 Revised 14-Nov-07
Cochlioquinone A