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Sphingolipids & Glycosphingolipids Other Products
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ALX-420-043 Revised 03-Sep-08
FTY720
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SYNONYMS 2-Amino-2-[2-(4-octylphenyl)ethyl]-1,3-propanediol . HCl
Fingolimod . HCl
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Sphingolipids & Glycosphingolipids Other Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-420-043-M001   1 mg 40.00 USD Add To Cart
ALX-420-043-M005   5 mg 190.00 USD Add To Cart
Product Specification
FORMULA: C19H33NO2 . HCl
MW: 307.5 . 36.5
CAS NUMBER: 162359-56-0
PURITY: ≥98%
APPEARANCE: White to off-white crystalline solid.
SOLUBILITY: 20mg/ml soluble in 100% ethanol, DMSO or dimethyl formamide; sparingly soluble in aqueous buffers.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: We do not recommend storing aqueous solutions for more than one day.

Product Description
Analog of myriocin (Prod. No. ALX-350-274). Novel immune modulator that alters migration and homing of lymphocytes. Acts as a potent agonist of sphingosine 1-phosphate receptors (S1P) after phosphorylation by sphingosine kinase. Also inhibits cytosolic phospholipase A2 independently of sphingosine 1-phosphate receptors.
Product Specific Literature References
The immune modulator FTY720 targets sphingosine 1-phosphate receptors: V. Brinkmann, et al.; J. Biol. Chem. 277, 21453 (2002) Abstract; Full Text
The immunosuppressant drug FTY720 inhibits cytosolic phospholipase A2 independently of sphingosine-1-phosphate receptors: S.G. Payne, et al.; Blood 109, 1077 (2007) Abstract
FTY720, a new alternative for treating blast crisis chronic myelogenous leukemia and Philadelphia chromosome-positive acute lymphocytic leukemia: P. Neviani, et al.; J. Clin. Invest. 117, 2408 (2007) Abstract; Full Text
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Further Categories Containing This Product:
PLA2 Inhibitors • Immunomodulators Other Products
 
 
ALX-350-017 Revised 18-Nov-08
Fumonisin B1
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Other Tumor Promoters
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-017-M001   1 mg 60.00 USD Add To Cart
ALX-350-017-M005   5 mg 245.00 USD Add To Cart
Product Specification
FORMULA: C34H59NO15
MW: 721.8
CAS NUMBER: 116355-83-0
MERCK INDEX: 14: 4289
RTECS: TZ8350000
SOURCE/HOST: Isolated from Fusarium moniliforme.
PURITY: ~98% (TLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in water, methanol, DMSO or acetonitrile.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: MAY BE CARCINOGENIC. MAY BE MUTAGENIC. MAY BE TERATOGENIC. HARMFUL.

Product Description
Mycotoxin. Induces DNA damage in the liver and cancer. Inhibitor of sphingosine biosynthesis. Induces apoptosis. Activates Akt (protein kinase B; PKB), which leads to increased survival, inhibition of GSK-3β activity and post-translational stabilization of cyclin D1.
Product Specific Literature References
Inhibition of sphingolipid biosynthesis by fumonisins. Implications for diseases associated with Fusarium moniliforme: E. Wang, et al.; J. Biol. Chem. 266, 14486 (1991) Abstract; Full Text
Fumonisin B1 inhibits sphingosine (sphinganine) N-acyltransferase and de novo sphingolipid biosynthesis in cultured neurons in situ: A.H. Merrill Jr., et al.; J. Biol. Chem. 268, 27299 (1993) Abstract; Full Text
Biological activities of fumonisins, mycotoxins from Fusarium moniliforme, in jimsonweed (Datura stramonium L.) and mammalian cell cultures: H.K. Abbas, et al.; Toxicon 31, 345 (1993) Abstract
Fumonisins and Alternaria alternata lycopersici toxins: sphinganine analog mycotoxins induce apoptosis in monkey kidney cells: H. Wang, et al.; PNAS 93, 3461 (1996) Abstract
A potential mechanism for fumonisin B(1)-mediated hepatocarcinogenesis: cyclin D1 stabilization associated with activation of Akt and inhibition of GSK-3beta activity: D. Ramljak, et al.; Carcinogenesis 21, 1537 (2000) Abstract
Implications of apoptosis for toxicity, carcinogenicity, and risk assessment: fumonisin B(1) as an example: Y.P. Dragan, et al.; Toxicol. Sci. 61, 6 (2001), Review Abstract
Fumonisin B(1): oxidative status and DNA damage in rats: A.M. Domijan, et al.; Toxicology 232, 163 (2007) Abstract
Further Categories Containing This Product:
Akt [PKB] / Related Products • Sphingolipids & Glycosphingolipids Other Products • Carcinogens & Tumor Promoters Other Products • Mycotoxins • DNA Damage & Repair Other Products • Natural Products - Apoptosis Inducers & Inhibitors
 
 
ALX-350-274 Revised 16-Jun-08
Myriocin
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SYNONYMS ISP-1
Thermozymocidin
2S,3R,4R,6E-2-Amino-3,4-dihydroxy-2-hydroxymethyl-14-oxo-6-eicosenoic acid
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Immunomodulators
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ALX-350-274-M005   5 mg 90.00 USD Add To Cart
Product Specification
FORMULA: C21H39NO6
MW: 401.5
CAS NUMBER: 35891-70-4
RTECS: JX3890000
PURITY: ≥98% (TLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in DMSO (25mg/ml; heat briefly in boiling water bath) or in dilute base (5mg/ml; 50mM NaOH).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HAZARD: HARMFUL.

Product Description
Potent immunosuppressant ~10 to 100-fold more potent than cyclosporin A (Prod. No. ALX-380-002). Blocks sphingolipid biosynthesis by inhibiting serine palmitoyltransferase (Ki=0.28nM). Induces apoptosis by depletion of cellular sphingolipids. Inhibits proliferation of an IL-2-dependent mouse cytotoxic cell line CTLL-1 (IC50=15nM).
Product Specific Literature References
Fungal metabolites. Part 11. A potent immunosuppressive activity found in Isaria sinclairii metabolite: T. Fujita, et al.; J. Antibiot. 47, 208 (1994) Abstract
Serine palmitoyltransferase is the primary target of a sphingosine-like immunosuppressant, ISP-1/myriocin: Y. Miyake, et al.; BBRC 211, 396 (1995) Abstract
Ceramide and its interconvertible metabolite sphingosine function as indispensable lipid factors involved in survival and dendritic differentiation of cerebellar Purkinje cells: S. Furuya, et al.; J. Neurochem. 71, 366 (1998) Abstract
Complete removal of sphingolipids from the plasma membrane disrupts cell to substratum adhesion of mouse melanoma cells: K. Hidari, et al.; J. Biol. Chem. 271, 14636 (1996) Abstract
Sli2 (Ypk1), a homologue of mammalian protein kinase SGK, is a downstream kinase in the sphingolipid-mediated signaling pathway of yeast: Y. Sun, et al.; Mol. Cell. Biol. 20, 4411 (2000) Abstract; Full Text
Effect of myriocin on plasma sphingolipid metabolism and atherosclerosis in apoE-deficient mice: M.R. Hojjati, et al.; J. Biol. Chem. 280, 10284 (2005) Abstract
Serine palmitoyltransferase inhibitor suppresses HCV replication in a mouse model: T. Umehara, et al.; BBRC 346, 67 (2006) Abstract
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Further Categories Containing This Product:
Sphingolipids & Glycosphingolipids Other Products • Natural Products - Antiviral / anti-HIV Agents • Natural Products - Apoptosis Inducers & Inhibitors
 
 
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