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ALX-151-026
Revised 20-Jun-08
N-Acetyl-Asp-Tyr(2-malonyl)-Val-Pro-Met-Leu-NH2
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Tyrosine Kinase Inhibitors
Ordering Information
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ALX-151-026-M001
1 mg
90.00 USD
Product Specification
FORMULA:
C
39
H
57
N
7
O
14
S
MW:
880.0
PURITY:
≥96% (HPLC)
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in water (1mg/ml).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Peptide is very unstable.
Product Description
Peptide containing a phosphotyrosyl mimetic. Effective protein tyrosine kinase inhibitor. Inhibits the phosphoinositide 3-kinase (PI(3)K) C-terminal p85 SH2 domain.
Product Specific Literature References
L-O-(2-malonyl)tyrosine: a new phosphotyrosyl mimetic for the preparation of Src homology 2 domain inhibitory peptides:
B. Ye, et al.; J. Med. Chem.
38
, 4270 (1995)
Abstract
Further Categories Containing This Product:
Peptides
•
Phosphoinositide 3-kinase [PI(3)K] / Related Products
ALX-151-027
Revised 17-Jan-05
N-Acetyl-Asp-Tyr(PO3H2)-Val-Pro-Met-Leu-NH2
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Tyrosine Kinase Inhibitors
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ALX-151-027-M001
1 mg
90.00 USD
Product Specification
FORMULA:
C
36
H
57
N
7
O
13
SP
MW:
858.9
PURITY:
≥96%
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Phosphotyrosine containing peptide. Effective protein tyrosine kinase inhibitor. Inhibits the phosphoinositide 3-kinase (PI(3)K) C-terminal p85 SH2 domain.
Product Specific Literature References
L-O-(2-malonyl)tyrosine: a new phosphotyrosyl mimetic for the preparation of Src homology 2 domain inhibitory peptides:
B. Ye, et al.; J. Med. Chem.
38
, 4270 (1995)
Abstract
Further Categories Containing This Product:
Peptides
•
Phosphoinositide 3-kinase [PI(3)K] / Related Products
ALX-165-004
Revised 07-Feb-05
pp60v-src (137-157)
SYNONYMS
Peptide A
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Src Family Kinases / Related Products
Ordering Information
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ALX-165-004-MC01
0.1 mg
40.00 USD
ALX-165-004-M001
1 mg
160.00 USD
Product Specification
SEQUENCE:
H-Val-Ala-Pro-Ser-Asp-Ser-Ile-Gln-Ala-Glu-Glu-Trp-Tyr-Phe-Gly-Lys-Ile-Thr-Arg-Arg-Glu-OH
FORMULA:
C
111
H
168
N
30
O
35
MW:
2482.7
PURITY:
≥98%
APPEARANCE:
White lyophilized powder.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Inhibitor of Src and EGF receptor tyrosine kinases. The peptide sequence corresponds to residues 137-157 of the noncatalytic domain of the transforming protein of
Rous sarcoma
virus (pp60
v-scr
).
Product Specific Literature References
A synthetic peptide corresponding to residues 137 to 157 of p60v-src inhibits tyrosine-specific protein kinases:
K. Sato, et al.; BBRC
171
, 1152 (1990)
Abstract
Evidence for autoinhibitory regulation of the c-src gene product. A possible interaction between the src homology 2 domain and autophosphorylation site:
Y. Fukami, et al.; J. Biol. Chem.
268
, 1132 (1993)
Abstract
;
Full Text
Further Categories Containing This Product:
Peptides
•
Tyrosine Kinase Inhibitors
ALX-165-022
Revised 04-Mar-05
pp60c-src (521-533) (phosphorylated)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Src Family Kinases / Related Products
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ALX-165-022-MC05
0.5 mg
50.00 USD
ALX-165-022-M001
1 mg
80.00 USD
ALX-165-022-M005
5 mg
320.00 USD
Product Specification
SEQUENCE:
H-Thr-Ser-Thr-Glu-Pro-Gln-Tyr(PO
3
H
2
)-Gln-Pro-Gly-Glu-Asn-Leu-OH
FORMULA:
C
62
H
95
N
16
O
28
P
MW:
1543.5
PURITY:
≥98%
APPEARANCE:
White lyophilized powder.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
This peptide is derived from the C-terminal region of the c-Src protooncogene pp60
c-src
and binds intramolecularly or intermolecularly to the SH2 domain of the same protein.
Product Specific Literature References
Oncogenes and signal transduction [published erratum appears in Cell 1991 May 31;65(5):following 914]:
L.C. Cantley, et al.; Cell
64
, 281 (1991), (Review)
Abstract
Selective binding of activated pp60c-src by an immobilized synthetic phosphopeptide modeled on the carboxyl terminus of pp60c-src:
R.R. Roussel, et al.; PNAS
88
, 10696 (1991)
Abstract
Further Categories Containing This Product:
Peptides
•
Tyrosine Kinase Inhibitors
ALX-168-003
Revised 02-Apr-03
Tyrosine Phosphorylation Site Inhibitor
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Tyrosine Kinase Inhibitors
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ALX-168-003-M001
1 mg
60.00 USD
ALX-168-003-M005
5 mg
240.00 USD
Product Specification
SEQUENCE:
H-Gly-Ser-Phe-Leu-Val-Arg-Glu-Ser-OH
FORMULA:
C
39
H
63
N
11
O
13
MW:
894.0
PURITY:
≥97%
APPEARANCE:
White lyophilized powder.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Inhibitor of EGF receptor binding to SH2. The peptide corresponds to a highly conserved amino acid sequence common in a variety of SH2-containing proteins. It is the minimum essential sequence for recognition of the phosphotyrosine site.
Product Specific Literature References
Highly conserved eight amino acid sequence in SH2 is important for recognition of phosphotyrosine site:
M. Hidaka, et al.; BBRC
180
, 1490 (1991)
Abstract
Further Categories Containing This Product:
Peptides
•
SH2 & SH3 Domains
ALX-270-035
Revised 07-Dec-04
Tyrphostin AG 1295
SYNONYMS
6,7-Dimethyl-2-phenylquinoxaline
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Tyrphostins
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ALX-270-035-M001
1 mg
30.00 USD
ALX-270-035-M005
5 mg
80.00 USD
Product Specification
FORMULA:
C
16
H
14
N
2
MW:
234.3
CAS NUMBER:
71897-07-9
PURITY:
≥98%
APPEARANCE:
Tan solid.
SOLUBILITY:
Soluble in DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Store tightly sealed in the dark. Protect from light.
Further Categories Containing This Product:
Tyrosine Kinase Inhibitors
•
EGFR Kinase Inhibitors
ALX-270-066
Revised 07-Apr-08
Lavendustin C
SYNONYMS
Compound 5
5-(N-2,5-Dihydroxybenzyl)aminosalicylic acid
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products - Protein Kinase Inhibitors
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ALX-270-066-M001
1 mg
35.00 USD
Product Specification
FORMULA:
C
14
H
13
NO
5
MW:
275.3
SOURCE/HOST:
Synthetic.
PURITY:
≥97%
APPEARANCE:
Off-white solid.
SOLUBILITY:
Soluble in DMSO or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
HAZARD:
TOXIC.
Product Description
Potent inhibitor of protein tyrosine kinases and Ca
2+
/calmodulin-dependent kinase II. Acts also as an inhibitor of EGFR tyrosine kinase and pp60
c-
src
kinase.
Product Specific Literature References
Isolation of a novel tyrosine kinase inhibitor, lavendustin A, from Streptomyces griseolavendus:
T. Onoda, et al.; J. Nat. Prod.
52
, 1252 (1989)
Abstract
Long-term potentiation in the hippocampus is blocked by tyrosine kinase inhibitors:
T.J. O'Dell, et al.; Nature
353
, 558 (1991)
Abstract
Hypericin and pseudohypericin specifically inhibit protein kinase C: possible relation to their antiretroviral activity:
I. Takahashi, et al.; BBRC
165
, 1207 (1989)
Abstract
Inhibition of crystal-induced neutrophil activation by a protein tyrosine kinase inhibitor:
H.M. Burt, et al.; J. Leukoc. Biol.
55
, 112 (1994)
Abstract
Endotoxin increases intercellular resistance in microvascular endothelial cells by a tyrosine kinase pathway:
D. Lidington, et al.; J. Cell Physiol.
185
, 117 (2000)
Abstract
Related Products
ALX-350-084
Lavendustin C methyl ester
Further Categories Containing This Product:
CAM Kinase Inhibitors
•
Tyrosine Kinase Inhibitors
•
EGFR Kinase Inhibitors
•
Lipopolysaccharides [LPS] / Related Products
ALX-270-088
Revised 07-Apr-05
ML-7 . hydrochloride
SYNONYMS
1-(5-Iodonaphthalene-1-sulfonyl)-1
H
-hexahydro-1,4-diazepine . HCl
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Tyrosine Kinase Inhibitors
Ordering Information
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Format:
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ALX-270-088-M005
5 mg
40.00 USD
ALX-270-088-M025
25 mg
160.00 USD
Product Specification
FORMULA:
C
15
H
17
IN
2
O
2
S . HCl
MW:
416.0 . 36.5
CAS NUMBER:
110448-33-4
PURITY:
≥98%
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in DMSO (can be further diluted with water), 100% ethanol (warm) or methanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
Product Description
Inhibits smooth-muscle myosin light chain kinase, protein kinase C (PKC), and cAMP-dependent protein kinase (PKA).
Product Specific Literature References
Selective inhibition of catalytic activity of smooth muscle myosin light chain kinase:
M. Saitoh, et al.; J. Biol. Chem.
262
, 7796 (1987)
Abstract
;
Full Text
Further Categories Containing This Product:
PKC Inhibitors
•
PKA Inhibitors
•
Myosin Light Chain Kinase Inhibitors
ALX-270-098
Revised 16-Nov-06
Erbstatin analog
SYNONYMS
Methyl 2,5-dihydroxycinnamate
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
EGFR Kinase Inhibitors
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ALX-270-098-M005
5 mg
55.00 USD
Product Specification
FORMULA:
C
10
H
10
O
4
MW:
194.2
CAS NUMBER:
63177-57-1
PURITY:
≥98% (HPLC)
APPEARANCE:
Off-white to light brown crystalline solid.
SOLUBILITY:
Soluble in methanol, DMSO or dilute aqueous base.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HANDLING:
Protect from light.
HAZARD:
TOXIC.
Product Description
Inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase. Considerably longer half-life in aqueous solution than erbstatin itself. Induces apoptosis.
Product Specific Literature References
Inhibition of epidermal growth factor-induced DNA synthesis by tyrosine kinase inhibitors:
K. Umezawa, et al.; FEBS Lett.
260
, 198 (1990)
Abstract
Inhibition of epidermal growth factor receptor functions by tyrosine kinase inhibitors in NIH3T3 cells:
K. Umezawa, et al.; FEBS Lett.
314
, 289 (1992)
Abstract
Induction of mouse thymocyte apoptosis by inhibitors of tyrosine kinases is associated with dephosphorylation of nuclear proteins:
Y. Azuma, et al.; Cell Immunol.
152
, 271 (1993)
Abstract
Inhibition of Abelson oncogene function by erbstatin analogues:
M. Kawada, et al.; Drugs Exp. Clin. Res.
19
, 235 (1993)
Abstract
Further Categories Containing This Product:
Tyrosine Kinase Inhibitors
•
Apoptosis Inducers & Inhibitors Other Products
ALX-270-129
Revised 18-Jan-08
Tyrphostin AG 18
SYNONYMS
Tyrphostin A23
Tyrphostin RG 50858
Tyrphostin RG 50810
(3,4-Dihydroxybenzylidene)malononitrile
α-Cyano-(3,4-dihydroxy)cinnamonitrile
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Tyrphostins
Ordering Information
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ALX-270-129-M005
5 mg
35.00 USD
ALX-270-129-M025
25 mg
100.00 USD
Product Specification
FORMULA:
C
10
H
6
N
2
O
2
MW:
186.2
CAS NUMBER:
118409-57-7
PURITY:
≥98%
APPEARANCE:
White solid.
SOLUBILITY:
Soluble in DMSO or ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Store tightly sealed in the dark. Protect from light.
Product Specific Literature References
Tyrphostins I: synthesis and biological activity of protein tyrosine kinase inhibitors:
A. Gazit, et al.; J. Med. Chem.
32
, 2344 (1989)
Abstract
Tyrphostins inhibit epidermal growth factor (EGF)-receptor tyrosine kinase activity in living cells and EGF-stimulated cell proliferation:
R.M. Lyall, et al.; J. Biol. Chem.
264
, 14503 (1989)
Abstract
;
Full Text
Cholecystokinin rapidly activates mitogen-activated protein kinase in rat pancreatic acini:
R.D. Duan & J.A. Williams; Am. J. Physiol.
267
, G401 (1994)
Abstract
Role of tyrosine kinase and protein kinase C in the steroidogenic actions of angiotensin II, alpha-melanocyte-stimulating hormone and corticotropin in the rat adrenal cortex:
S. Kapas, et al.; Biochem. J.
305
, 433 (1995)
Abstract
Differential activation of mitogen-activated protein kinase and S6 kinase signaling pathways by 12-O-tetradecanoylphorbol-13-acetate (TPA) and insulin. Evidence for involvement of a TPA-stimulated protein- tyrosine kinase:
R. Seger, et al.; J. Biol. Chem.
270
, 28325 (1995)
Abstract
;
Full Text
Further Categories Containing This Product:
EGFR Kinase Inhibitors
•
Tyrosine Kinase Inhibitors
ALX-270-141
Revised 07-Dec-04
Tyrphostin AG 527
SYNONYMS
Tyrphostin B44
(-)-(R)-N-(α-Methylbenzyl)-3,4-dihydroxybenzylidenecyanoacetamide
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Tyrphostins
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-270-141-M005
5 mg
25.00 USD
ALX-270-141-M025
25 mg
90.00 USD
Product Specification
FORMULA:
C
18
H
16
N
2
O
3
MW:
308.3
CAS NUMBER:
133550-32-0
PURITY:
≥98%
SOLUBILITY:
Soluble in DMSO or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Store tightly sealed in the dark. Protect from light.
Product Specific Literature References
Tyrphostins. 2. Heterocyclic and alpha-substituted benzylidenemalononitrile tyrphostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases:
A. Gazit, et al.; J. Med. Chem.
34
, 1896 (1991)
