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ALX-152-001
Revised 26-Sep-08
Big Endothelin-1 (1-38) (human)
SYNONYMS
Big ET-1 (1-38) (human)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Endothelins [ETs] & Endothelin Receptors / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-152-001-PC01
0.1 mg*
100.00 USD
ALX-152-001-PC05
0.5 mg*
400.00 USD
ALX-152-001-P001
1 mg*
650.00 USD
Product Specification
SEQUENCE:
H-Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp-Val-Asn-Thr-Pro-Glu-His-Val-Val-Pro-Tyr-Gly-Leu-Gly-Ser-Pro-Arg-Ser-OH
(Disulfide bonds between Cys
1
-Cys
15
and Cys
3
-Cys
11
)
FORMULA:
C
189
H
282
N
48
O
56
S
5
MW:
4283.0
CAS NUMBER:
121014-53-7
QUANTITY:
*Sold as net peptide weight.
PURITY:
≥98% (HPLC)
APPEARANCE:
White to off-white powder.
SOLUBILITY:
1mg/ml soluble in water; also soluble in 0.5% acetic acid.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Specific Literature References
Cloning and sequence analysis of cDNA encoding the precursor of a human endothelium-derived vasoconstrictor peptide, endothelin: identity of human and porcine endothelin:
Y. Itoh, et al.; FEBS Lett.
231
, 440 (1988)
Abstract
Putative precursors of endothelin have less vasoconstrictor activity in vitro but a potent pressor effect in vivo:
T. Kashiwabara, et al.; FEBS Lett.
247
, 73 (1989)
Abstract
Further Categories Containing This Product:
Peptides
ALX-152-007
Revised 14-Dec-04
Big Endothelin-1 (1-39) (bovine)
SYNONYMS
Big ET-1 (1-39) (bovine)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Endothelins [ETs] & Endothelin Receptors / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-152-007-PC01
0.1 mg*
140.00 USD
ALX-152-007-PC05
0.5 mg*
560.00 USD
Product Specification
SEQUENCE:
H-Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp-Val-Asn-Thr-Pro-Glu-His-Val-Val-Pro-Tyr-Gly-Leu-Gly-Ser-Pro-Ser-Arg-Ser-OH
(Disulfide bonds between Cys
1
-Cys
15
and Cys
3
-Cys
11
)
FORMULA:
C
192
H
287
N
49
O
58
S
5
MW:
4370.0
QUANTITY:
*Sold as net peptide weight.
PURITY:
≥98%
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Specific Literature References
Cloning and sequencing of a bovine preproendothelin cDNA:
G.J. Price & L. Malone; Nucl. Acid Res.
18
, 3658 (1990)
Abstract
Further Categories Containing This Product:
Peptides
ALX-152-002
Revised 26-Nov-04
Big Endothelin-1 (1-39) (pig)
SYNONYMS
Big ET-1 (1-39) (pig)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Endothelins [ETs] & Endothelin Receptors / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-152-002-PC01
0.1 mg*
140.00 USD
ALX-152-002-PC05
0.5 mg*
560.00 USD
Product Specification
SEQUENCE:
H-Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp-Val-Asn-Thr-Pro-Glu-His-Ile-Val-Pro-Tyr-Gly-Leu-Gly-Ser-Pro-Ser-Arg-Ser-OH
(Disulfide bonds between Cys
1
-Cys
15
and Cys
3
-Cys
11
)
FORMULA:
C
193
H
289
N
49
O
58
S
5
MW:
4384.1
CAS NUMBER:
121014-54-8
QUANTITY:
*Sold as net peptide weight.
PURITY:
≥97%
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Specific Literature References
Cloning and sequence analysis of cDNA encoding the precursor of a human endothelium-derived vasoconstrictor peptide, endothelin: identity of human and porcine endothelin:
Y. Itoh, et al.; FEBS Lett.
231
, 440 (1988)
Abstract
A novel potent vasoconstrictor peptide produced by vascular endothelial cells [see comments]:
M. Yanagisawa, et al.; Nature
332
, 411 (1988)
Abstract
Putative precursors of endothelin have less vasoconstrictor activity in vitro but a potent pressor effect in vivo:
T. Kashiwabara, et al.; FEBS Lett.
247
, 73 (1989)
Abstract
Further Categories Containing This Product:
Peptides
ALX-152-003
Revised 26-Nov-04
Big Endothelin-1 (1-39) (rat)
SYNONYMS
Big ET-1 (1-39) (rat)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Endothelins [ETs] & Endothelin Receptors / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-152-003-PC01
0.1 mg*
110.00 USD
ALX-152-003-PC05
0.5 mg*
390.00 USD
Product Specification
SEQUENCE:
H-Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp-Val-Asn-Thr-Pro-Glu-Arg-Val-Val-Pro-Tyr-Gly-Leu-Gly-Ser-Pro-Ser-Arg-Ser-OH
(Disulfide bonds between Cys
1
-Cys
15
and Cys
3
-Cys
11
)
FORMULA:
C
192
H
292
N
50
O
58
S
5
MW:
4389.1
CAS NUMBER:
135842-15-8
QUANTITY:
*Sold as net peptide weight.
PURITY:
≥97%
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Specific Literature References
cDNA cloning, sequence analysis and tissue distribution of rat preproendothelin-1 mRNA:
T. Sakurai, et al.; BBRC
175
, 44 (1991)
Abstract
Further Categories Containing This Product:
Peptides
ALX-152-014
Revised 13-Jan-05
Big Endothelin-1 (19-37) (human), [Phe22]-
SYNONYMS
[Phe
22
]-Big ET-1 (19-37) (human)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Endothelins [ETs] & Endothelin Receptors / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-152-014-MC05
0.5 mg
120.00 USD
ALX-152-014-M001
1 mg
190.00 USD
Product Specification
SEQUENCE:
H-Ile-Ile-Trp-Val-Asn-Thr-Pro-Glu-His-Val-Val-Pro-Tyr-Gly-Leu-Gly-Ser-Pro-Arg-OH
FORMULA:
C
100
H
152
N
26
O
26
MW:
2134.5
PURITY:
≥98%
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Inhibitor of endothelin-converting enzyme (ECE).
Further Categories Containing This Product:
Peptides
ALX-152-012
Revised 14-Dec-04
Big Endothelin-1 (22-38) (human)
SYNONYMS
Big ET-1 (22-38) (human)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Endothelins [ETs] & Endothelin Receptors / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-152-012-MC05
0.5 mg
100.00 USD
ALX-152-012-M001
1 mg
180.00 USD
Product Specification
SEQUENCE:
H-Val-Asn-Thr-Pro-Glu-His-Val-Val-Pro-Tyr-Gly-Leu-Gly-Ser-Pro-Arg-Ser-OH
FORMULA:
C
80
H
125
N
23
O
25
MW:
1809.0
PURITY:
≥98%
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Specific Literature References
Cloning and sequence analysis of cDNA encoding the precursor of a human endothelium-derived vasoconstrictor peptide, endothelin: identity of human and porcine endothelin:
Y. Itoh, et al.; FEBS Lett.
231
, 440 (1988)
Abstract
Further Categories Containing This Product:
Peptides
ALX-152-004
Revised 12-May-03
Big Endothelin-2 (1-37) (human)
SYNONYMS
Big ET-2 (1-37) (human)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Endothelins [ETs] & Endothelin Receptors / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-152-004-PC01
0.1 mg*
110.00 USD
ALX-152-004-PC05
0.5 mg*
390.00 USD
Product Specification
SEQUENCE:
H-Cys-Ser-Cys-Ser-Ser-Trp-Leu-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp-Val-Asn-Thr-Pro-Glu-Gln-Thr-Ala-Pro-Tyr-Gly-Leu-Gly-Asn-Pro-Pro-OH
(Disulfide bonds between Cys
1
-Cys
15
and Cys
3
-Cys
11
)
FORMULA:
C
188
H
269
N
45
O
56
S
4
MW:
4183.8
QUANTITY:
*Sold as net peptide weight.
PURITY:
≥98%
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Specific Literature References
Specific expression of human endothelin-2 (ET-2) gene in a renal adenocarcinoma cell line. Molecular cloning of cDNA encoding the precursor of ET-2 and its characterization
:
S. Ohkubo, et al.; FEBS Lett.
274
, 136 (1990)
Abstract
Further Categories Containing This Product:
Peptides
ALX-430-032
Revised 24-Feb-05
Bioallethrin
SYNONYMS
D-
trans
-Allethrin
(S)-3-Allyl-2-methyl-4-oxocyclopent-2-enyl-(1R,3R)-2,2-dimethyl-3-(2-methyl-prop-1-enyl)cyclopropancarboxylate
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
PP2B [Calcineurin] / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-430-032-M025
25 mg
90.00 USD
ALX-430-032-M100
100 mg
270.00 USD
Product Specification
FORMULA:
C
19
H
26
O
3
MW:
302.4
CAS NUMBER:
22431-63-6
PURITY:
≥97%
SOLUBILITY:
Soluble in hot water, diluted acids or alkaline solutions; hardly soluble in cold water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HANDLING:
Protect from light. Avoid alkalies.
HAZARD:
HARMFUL.
Product Description
Although bioallethrin is a type I pyrethroid, its effects on calcineurin (protein phosphatase 2B) resembles those of type II pyrethrins. Unlike most type I pyrethrins, which are very weak, bioallethrin is a potent calcineurin inhibitor.
Product Specific Literature References
Specific inhibition of calcineurin by type II synthetic pyrethroid insecticides:
E. Enan & F. Matsumura; Biochem. Pharmacol.
43
, 1777 (1992)
Abstract
Further Categories Containing This Product:
Pyrethroids
ALX-460-002
Revised 13-Mar-06
D-(+)-Biotin
SYNONYMS
Vitamin H
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Vitamins
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-460-002-G001
1 g
30.00 USD
ALX-460-002-G005
5 g
140.00 USD
Product Specification
FORMULA:
C
10
H
16
N
2
O
3
S
MW:
244.3
CAS NUMBER:
58-85-5
MERCK INDEX:
14:
1231
PURITY:
≥98%
SOLUBILITY:
Soluble in hot water, diluted acids and alkaline solutions; hardly soluble in cold water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+20°C
HAZARD:
MAY BE CARCINOGENIC.
ALX-260-034
Revised 10-Feb-05
Biotinyl-DEVD-CHO
SYNONYMS
Caspase-3 Inhibitor (Aldehyde)
Caspase-7 Inhibitor (Aldehyde)
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Caspase Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-260-034-M001
1 mg
82.00 USD
ALX-260-034-M005
5 mg
323.00 USD
Product Specification
SEQUENCE:
Biotinyl-Asp-Glu-Val-Asp-CHO
FORMULA:
C
28
H
42
N
6
O
12
S
MW:
686.7
PEPTIDE CONTENT:
65-90%.
PURITY:
≥99% (HPLC)
APPEARANCE:
White powder.
FORMULATION:
Lyophilized.
SOLUBILITY:
Soluble in 50% acetic acid with agitation (1mg/ml).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Packaged under inert gas.
Product Description
Reversible inhibitor of caspase-3 and -7. Useful for the purification or extract depletion of caspase-3 in conjunction with streptavidin conjugates.
Product Specific Literature References
Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis:
D.W. Nicholson, et al.; Nature
376
, 37 (1995)
Abstract
ALX-260-098
Revised 20-Aug-08
Biotinyl-VAD(OMe)-FMK
SYNONYMS
Caspase Family Inhibitor (Fluoromethylketone)
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Caspase Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-260-098-M001
1 mg
420.00 USD
Product Specification
SEQUENCE:
Biotinyl-Ahx-Val-Ala-Asp(OMe)-fluoromethylketone
FORMULA:
C
30
H
49
FN
6
O
8
S
MW:
672.8
PURITY:
≥90% (TLC)
APPEARANCE:
Off-white to brown powder.
SOLUBILITY:
Soluble in DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stock solutions should be divided into aliquots and stored at -20°C. The stock solution is stable at -20°C for 6-8 months.
HANDLING:
Keep cool and dry.
Product Description
Irreversible, cell permeable broad-spectrum caspase inhibitor.
Product Specific Literature References
Nitric oxide suppresses apoptosis via interrupting caspase activation and mitochondrial dysfunction in cultured hepatocytes
:
J. Li, et al.; J. Biol. Chem.
274
, 17325 (1999)
Abstract
;
Full Text
ALX-260-019
Revised 23-Jun-06
Biotinyl-YVAD-CMK
SYNONYMS
Caspase-1 Inhibitor (Chloromethylketone)
PRODUCT LINE
