Advanced Search
© 2008 Alexis Corporation
You are here:
Product Lines
>
Signal Transduction
> Adaptor Proteins & Interaction Domains / Related Products
14-3-3 Proteins / Related Products
Adaptor Proteins for Death Receptors / Related Products
Adaptor Proteins in T Cell Signal Transduction / Related Products
Caspase Recruitment Domain [CARD] Proteins / Related Products
Caveolae / Related Products
SH2 & SH3 Domains
Shc & Other Ras Adaptors / Related Products
Toll-IL-1 Receptor Adaptors / Related Products
TRAFs / Related Products
Adaptor Proteins & Interaction Domains Other Products
Toolbar - View Selection
Current View:
Price List
Brief
Detail
Search Results
Current Sort:
Sort by Product Name
Sort by Product ID
Sort by Result Relevance
Sort by Class
Show:
20 Products
50 Products
100 Products
All Products
Show Selected Products Only
Show
Products Only
Items
20-40
of 104
Page 2
of 6
Select Page:
<<
1
2
3
4
5
6
>>
ALX-210-373
Revised 02-Apr-07
Polyclonal Antibody to Nod2 (human)
SYNONYMS
anti-CARD15 (human) PAb
anti-Caspase Recruitment Domain-containing Protein 15 (human) PAb
anti-Ibd1 (human) PAb
anti-Inflammatory Bowel Disease Protein 1 (human) PAb
PRODUCT LINE
Inflammation
PRODUCT CATEGORY
Nod-complex / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-373-1
1 Vial
330.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From rabbit.
FORMULATION:
Lyophilized.
RECONSTITUTION:
Reconstitute with 100µl water containing 0.05% sodium azide.
IMMUNOGEN:
Recombinant human Nod2 (CARD15) (aa 28-301).
SPECIFICITY:
Recognizes human Nod2.
APPLICATION:
Immunoprecipitation*
Western Blot (1:500 to 1:1'000)*
*) tested with cells overexpressing Nod2. In monocytes, Nod2 is expressed at low levels and may not be detected with this antibody.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 2 years after receipt when stored at -20°C.
HANDLING:
Avoid freeze/thaw cycles. After reconstitution store at +4°C.
Further Categories Containing This Product:
Caspase Recruitment Domain [CARD] Proteins / Related Products
•
Polyclonal Antibodies
ALX-210-535
Revised 31-Oct-06
Polyclonal Antibody to Shc
SYNONYMS
anti-Shc Transforming Protein 1 PAb
anti-SH2 Domain Protein C1 PAb
anti-Shc1 PAb
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
SH2 & SH3 Domains
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-535-R100
100 µl
220.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
SOURCE/HOST:
From rabbit.
PURITY:
Liquid. Neat serum containing 0.05% sodium azide.
IMMUNOGEN:
Recombinant human Shc portion (aa 1180-1620).
SPECIFICITY:
Recognizes human, mouse and hamster p46shc, p52shc and p66shc isoforms of phosphorylated and unphosphorylated Shc.
APPLICATION:
ELISA
Immunoprecipitation
Western Blot
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
General Information
There are 3 alternatively spliced isoforms of the Shc adapter pro-tein: p46SHC, p52SHC and p66SHC, that link activated growth factor receptors to signalling pathway. Isoform p46SHC and p52SHC, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS com-plex and are implicated in mitogenic signalling. They function as initiators of the Ras signalling cascade in various non-neuronal systems. The isoform p66SHC does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. It acts as a downstream target of the tumor suppressor p53 and is indispen-sable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis.
Further Categories Containing This Product:
Phospho-specific Antibodies
•
Shc & Other Ras Adaptors / Related Products
•
Polyclonal Antibodies
ALX-210-536
Revised 31-Oct-06
Polyclonal Antibody to p130Cas
SYNONYMS
anti-CRK-associated Substrate PAb
anti-CRKAS PAb
anti-Breast Cancer anti-estrogen Resistance 1 Protein PAb
anti-BCAR1 PAb
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Adaptor Proteins & Interaction Domains Other Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-536-R100
100 µl
220.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
SOURCE/HOST:
From rabbit.
PURITY:
Liquid. Neat serum containing 0.05% sodium azide.
IMMUNOGEN:
Recombinant mouse p130Cas (CRK-associated substrate; BCAR1) C-terminal portion (aa 675-874).
SPECIFICITY:
Recognizes human and mouse p130Cas.
APPLICATION:
ELISA
Immunoprecipitation
Note:
Does not work for Western Blot.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Tyrosine Kinases Other Products
•
Cancer Other Products
•
Polyclonal Antibodies
ALX-210-564
Revised 29-Nov-04
Polyclonal Antibody to Lck-interacting Molecule (human)
SYNONYMS
anti-LIME (human) PAb
PRODUCT LINE
Immunology
PRODUCT CATEGORY
Adaptor Proteins in T Cell Signal Transduction / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-564-C100
100 µg
270.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml.
PURITY:
>95% (SDS-PAGE).
FORMULATION:
Liquid. In PBS, pH 7.4, containing 15mM sodium azide.
IMMUNOGEN:
Recombinant intracellular fragment corresponding to aa 141-295 of human LIME (Lck-interacting molecule).
SPECIFICITY:
Recognizes human LIME. Does not cross-react with mouse LIME.
APPLICATION:
Western Blot
Optimal conditions must be determined individually for each application.
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 6 months after receipt when stored at +4°C.
HANDLING:
After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Src Family Kinases / Related Products
•
Polyclonal Antibodies
ALX-210-565
Revised 29-Nov-04
Polyclonal Antibody to Lck-interacting Molecule (mouse)
SYNONYMS
anti-LIME (mouse) PAb
PRODUCT LINE
Immunology
PRODUCT CATEGORY
Adaptor Proteins in T Cell Signal Transduction / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-565-C100
100 µg
270.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml.
PURITY:
>95% (SDS-PAGE).
FORMULATION:
Liquid. Protein A affinity purified antibody in PBS, pH 7.4, containing 15mM sodium azide.
IMMUNOGEN:
Recombinant fragment of mouse LIME (Lck-interacting molecule).
SPECIFICITY:
Recognizes mouse LIME. Does not cross-react with human LIME.
APPLICATION:
Immunoprecipitation
Western Blot
Optimal conditions must be determined individually for each application.
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 6 months after receipt when stored at +4°C.
HANDLING:
After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Src Family Kinases / Related Products
•
Polyclonal Antibodies
ALX-210-566
Revised 31-Oct-06
Polyclonal Antibody to SLP-76 (human)
SYNONYMS
anti-SH2 Domain-containing Leukocyte Protein (76kDa) (human) PAb
PRODUCT LINE
Immunology
PRODUCT CATEGORY
Adaptor Proteins in T Cell Signal Transduction / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-566-C100
100 µg
270.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml.
PURITY:
>95% (SDS-PAGE).
FORMULATION:
Liquid. In PBS, pH 7.4, containing 15mM sodium azide.
IMMUNOGEN:
Recombinant human SLP-76 (SH2 domain-containing leukocyte protein (76kDa)) (aa 216-434).
SPECIFICITY:
Recognizes human SLP-76. Other species have not been tested.
APPLICATION:
Western Blot
Optimal conditions must be determined individually for each application.
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 6 months after receipt when stored at +4°C.
HANDLING:
After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Autoimmunity & Self Tolerance Other Products
•
Polyclonal Antibodies
ALX-210-567
Revised 13-Feb-07
Polyclonal Antibody to PAG/Cbp
SYNONYMS
anti-Phosphoprotein Associated with GEMS PAb
anti-Csk-binding Protein PAb
PRODUCT LINE
Immunology
PRODUCT CATEGORY
Adaptor Proteins in T Cell Signal Transduction / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-567-C100
100 µg
270.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml.
PURITY:
≥95% (SDS-PAGE).
PURITY DETAIL:
Precipitation.
FORMULATION:
Liquid. In PBS, pH 7.4, containing 15mM sodium azide.
IMMUNOGEN:
Recombinant intracellular fragment corresponding to aa 97-432 of human PAG/Cbp (phosphoprotein associated with GEMS/Csk-binding protein).
SPECIFICITY:
Recognizes human and mouse PAG/Cbp.
APPLICATION:
Immunoprecipitation
Western Blot
Optimal conditions must be determined individually for each application.
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 6 months after receipt when stored at +4°C.
HANDLING:
After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Related Products
ALX-210-579
Polyclonal Antibody to PAG/Cbp
ALX-804-437
Monoclonal Antibody to PAG/Cbp (human) (MEM-255)
ALX-804-478
Monoclonal Antibody to PAG/Cbp (PAG-C1)
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-579
Revised 21-May-08
Polyclonal Antibody to PAG/Cbp
SYNONYMS
anti-Phosphoprotein Associated with GEMS PAb
anti-Csk-binding Protein PAb
PRODUCT LINE
Immunology
PRODUCT CATEGORY
Adaptor Proteins in T Cell Signal Transduction / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-579-C100
100 µg
465.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
Rat
Others
CONCENTRATION:
1mg/ml
FORMULATION:
Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to rat PAG/Cbp cytoplasmic tail sequence.
SPECIFICITY:
Recognizes mouse and rat PAG/Cbp. Shows weak cross-reactivity with human PAG/Cbp.
APPLICATION:
Immunocytochemistry (1:50)
Immunoprecipitation (5μg/sample)
Western Blot (1:1’000)
All dilutions must be viewed as approximate. Optimal conditions must be determined individually for each application.
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
POSITIVE CONTROL:
For Western blotting use 1.5 x 10
6
total splenocytes per lane as positive control.
Product Specific Literature References
Fyn regulates the duration of TCR engagement needed for commitment to effector function:
A. Filby, et al.; J. Immunol.
179
, 4635 (2007)
Abstract
Related Products
ALX-210-567
Polyclonal Antibody to PAG/Cbp
ALX-804-437
Monoclonal Antibody to PAG/Cbp (human) (MEM-255)
ALX-804-478
Monoclonal Antibody to PAG/Cbp (PAG-C1)
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-708
Revised 30-Jun-06
Polyclonal Antibody to 14-3-3 (human)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
14-3-3 Proteins / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-708-C100
100 µg
320.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From rabbit.
CONCENTRATION:
0.1mg/ml
PURITY DETAIL:
Protein A-affinity purified IgG.
FORMULATION:
Liquid. In 0.05M sodium phosphate buffer containing 0.1% sodium azide and 0.2% gelatin.
IMMUNOGEN:
Synthetic peptide corresponding to aa 221-242 of 14-3-3 protein family members.
SPECIFICITY:
Recognizes human 14-3-3 protein family members.
APPLICATION:
Western Blot (2.5µg/ml)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
+4°C
HANDLING:
Do not freeze.
General Information
General Literature References
[1]
14-3-3 proteins. Hot numbers in signal transduction:
P.D. Burbelo and A. Hall; Curr. Biol.
5
, 95 (1995)
Abstract
[2]
Isoforms of 14-3-3 protein can form homo- and heterodimers in vivo and in vitro: implications for function as adapter proteins:
D.H. Jones, et al.; FEBS Lett.
368
, 55 (1995)
Abstract
[3]
14-3-3 proteins: a highly conserved, widespread family of eukaryotic proteins:
A. Aitken, et al.; TIBS
17
, 498 (1992), (Review)
Abstract
[4]
Evolutionary conservation of the 14-3-3 protein:
G.J. Martens, et al.; BBRC
184
, 1456 (1992)
Abstract
[5]
Expression and structural analysis of 14-3-3 proteins:
D.H. Jones, et al.; D.H. Jones, et al.
245
, 375 (1995)
Abstract
[6]
Subcellular localisation of 14-3-3 isoforms in rat brain using specific antibodies :
H. Martin, et al.; J. Neurochem.
63
, 2259 (1994)
Abstract
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-746
Revised 11-Apr-06
Polyclonal Antibody to p56dok-2 (human)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Ras Signalling Pathway Other Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-746-C200
200 µg
340.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From rabbit.
CONCENTRATION:
2mg/ml.
PURITY DETAIL:
Epitope-affinity purified IgG.
FORMULATION:
Liquid. In PBS containing 1mg/ml BSA and 0.1% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to C-terminal aa 393-412(A
393
SGWQPGTEYDNVVLKKGPK
412
) of human p56
dok-2
.
SPECIFICITY:
Recognizes human p56
dok-2
. Detects a band of ~60kDa by Western blot.
APPLICATION:
Immunocytochemistry (1:300)
Western Blot (1:1'000)
QUALITY CONTROL:
Western blot on human U937 cells or human T cell line Jurkat.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
After opening, prepare aliquots and store at -20°C. For maximum product recovery after thawing, centrifuge the vial before opening the cap. Avoid freeze/thaw cycles.
BLOCKING PEPTIDE:
For Blocking Peptide see Prod. No.
ALX-165-033
.
General Information
p56
dok-2
, a 56kDa tyrosine phosphorylated protein, purified and cloned from p210
bcr-abl
expressing cells, is able to bind to p120
RasGAP
. It was shown to be 35% identical to p62
dok-1
.
General Literature References
Molecular cloning and characterization of p56dok-2 defines a new family of RasGAP-binding proteins
:
A. Di Cristofano, et al.; J. Biol. Chem.
273
, 4827 (1998)
Abstract
Related Products
PSC-1107
Polyclonal Antibody to p62
dok
(human)
Further Categories Containing This Product:
Adaptor Proteins & Interaction Domains Other Products
•
Receptor Tyrosine Kinases Other Products
•
Tyrosine Kinases Other Products
•
Polyclonal Antibodies
ALX-210-770
Revised 11-Apr-06
Polyclonal Antibody to pp36 (human)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Phosphoinositide 3-kinase [PI(3)K] / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-770-C200
200 µg
340.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From rabbit.
CONCENTRATION:
2mg/ml.
PURITY DETAIL:
Epitope-affinity purified IgG.
FORMULATION:
Liquid. In PBS containing 1mg/ml BSA and 0.1% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 29-49 (C
29
HRLPGSYDSTSSDSLYPRGI
49
) of the N-terminal extracellular domain of human pp36.
SPECIFICITY:
Recognizes human pp36. Detects a band of ~40kDa by Western blot.
APPLICATION:
Immunocytochemistry (1:300)
Immunohistochemistry (paraffin sections)
Western Blot (1:1'000)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
After opening, prepare aliquots and store at -20°C. For maximum product recovery after thawing, centrifuge the vial before opening the cap. Avoid freeze/thaw cycles.
BLOCKING PEPTIDE:
For Blocking Peptide see Prod. No.
ALX-165-042
.
General Information
pp36 is an adaptor protein that b
