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NOS Regulation
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ALX-152-006 Revised 23-Jan-07
Bradykinin
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PRODUCT LINE Neurobiology
PRODUCT CATEGORY Bradykinin Receptor / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-152-006-M005   5 mg 22.00 USD Add To Cart
ALX-152-006-M025   25 mg 86.00 USD Add To Cart
Product Specification
SEQUENCE: H-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-OH
FORMULA: C50H73N15O11
MW: 1060.3
CAS NUMBER: 5979-11-3
MERCK INDEX: 14: 1359
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in 5% acetic acid.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
Product Description
Activator of eNOS (NOS III).
Product Specific Literature References
Different activation of L-arginine pathway by bradykinin, serotonin, and clonidine in coronary arteries: V. Richard, et al.; Am. J. Physiol. 259, H1433 (1990) Abstract
Bradykinin and ATP stimulate L-arginine uptake and nitric oxide release in vascular endothelial cells: R.G. Bogle, et al.; BBRC 180, 926 (1991) Abstract
Activation of a small-conductance Ca(2+)-dependent K+ channel contributes to bradykinin-induced stimulation of nitric oxide synthesis in pig aortic endothelial cells: K. Groschner, et al.; Biochim. Biophys. Acta 1137, 162 (1992) Abstract
G proteins in aortic endothelial cells and bradykinin-induced formation of nitric oxide: J. Gil-Longo, et al.; Eur. J. Pharmacol. 247, 119 (1993) Abstract
Simultaneous measurements of Ca2+ and nitric oxide in bradykinin-stimulated vascular endothelial cells: L.A. Blatter, et al.; Circ. Res. 76, 922 (1995) Abstract; Full Text
Biosynthesis of endothelium-derived nitric oxide by bradykinin as endogenous precursor: A.R. Volpe, et al.; Immunopharmacology 33, 287 (1996) Abstract
Nitric oxide as mediator of bradykinin-induced pancreatic circulatory and metabolic responses: W.W. Pawlik, et al.; J. Physiol. Pharmacol. 48, 751 (1997) Abstract
Bradykinin-regulated interactions of the mitogen-activated protein kinase pathway with the endothelial nitric-oxide synthase: S.G. Bernier, et al.; J. Biol. Chem. 275, 30707 (2000) Abstract; Full Text
Reciprocal phosphorylation and regulation of endothelial nitric-oxide synthase in response to bradykinin stimulation: M.B. Harris, et al.; J. Biol. Chem. 276, 16587 (2001) Abstract; Full Text
Bradykinin down-regulates, whereas arginine analogs up-regulates, endothelial nitric-oxide synthase expression in coronary endothelial cells: N.D. Vaziri, et al.; J. Pharmacol. Exp. Ther. 313, 121 (2005) Abstract; Full Text
Bradykinin mediates phosphorylation of eNOS in odontoblasts: Y. Korkmaz, et al.; J. Dent. Res. 85, 536 (2006) Abstract
Further Categories Containing This Product:
Peptides • NOS Regulation • Cell Stress, Oxidative Stress & Redox Signalling Other Products
 
 
ALX-153-064 Revised 31-Aug-07
Caveolin-1 Scaffolding Domain Peptide
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SYNONYMS Cavtratin
AP-Cav
Pen-C1-SD
PRODUCT LINE Protein Synthesis, Modification & Degradation
PRODUCT CATEGORY Caveolae / Related Products
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ALX-153-064-M001   1 mg 140.00 USD Add To Cart
ALX-153-064-M005   5 mg 560.00 USD Add To Cart
Product Specification
SEQUENCE: H-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-Asp-Gly-Ile-Trp-Lys-Ala-Ser-Phe-Thr-Thr-Phe-Thr-Val-Thr-Lys-Tyr-Trp-Phe-Tyr-Arg-OH
FORMULA: C228H335N61O49S
MW: 4746.6
APPEARANCE: ≥97% (HPLC)
SOLUBILITY: Soluble in DMSO or acentonitrile:water (50:50).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Stock solutions are stable for up to 3 months when stored at -20°C.
HANDLING: Hygroscopic. Protect from light.
HAZARD: MAY BE CARCINOGENIC. HARMFUL.
Product Description
Cell permeable peptide that blocks eNOS (NOS III) activity and cellular nitric oxide (NO) release in vitro and reduces inflammation and tumorigenesis in vivo. Caveolin-1 interacts with several lipid-modified signalling ligands, such as EGFR, eNOS, G-protein α-subunits, PKCα, H-Ras, and Src, via the C1-SD82-101 sequence.
Product Specific Literature References
Caveolins, a family of scaffolding proteins for organizing "preassembled signaling complexes" at the plasma membrane: T. Okamoto, et al.; J. Biol. Chem. 273, 4519 (1998) Abstract; Full Text
In vivo delivery of the caveolin-1 scaffolding domain inhibits nitric oxide synthesis and reduces inflammation: M. Bucci, et al.; Nat. Med. 6, 1362 (2000) Abstract; Full Text
Selective inhibition of tumor microvascular permeability by cavtratin blocks tumor progression in mice: J.P. Gratton, et al.; Cancer Cell 4, 31 (2003) Abstract; Full Text
Caveolin-1 gene disruption promotes mammary tumorigenesis and dramatically enhances lung metastasis in vivo. Role of Cav-1 in cell invasiveness and matrix metalloproteinase (MMP-2/9) secretion: T.M. Williams, et al.; J. Biol. Chem. 279, 51630 (2004) Abstract; Full Text
Dissecting the molecular control of endothelial NO synthase by caveolin-1 using cell-permeable peptides: P.N. Bernatchez, et al.; PNAS 102, 761 (2005) Abstract; Full Text
Further Categories Containing This Product:
Peptides • NOS Inhibitors (NOS Induction & Enzyme Activity) • NOS Regulation • Cancer Other Products
 
 
ALX-152-031 Revised 17-Nov-08
(Des-Arg1)-Bradykinin
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SYNONYMS Bradykinin (2-9)
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Bradykinin Receptor / Related Products
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ALX-152-031-M001   1 mg 15.00 USD Add To Cart
ALX-152-031-M005   5 mg 50.00 USD Add To Cart
Product Specification
SEQUENCE: H-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-OH
FORMULA: C44H61N11O10
MW: 904.0
CAS NUMBER: 16875-11-9
PEPTIDE CONTENT: ≥85%
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in water (1mg/ml).
QUALITY CONTROL: Identity determined by MS.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Further Categories Containing This Product:
Cell Stress, Oxidative Stress & Redox Signalling Other Products • NOS Regulation • Peptides
 
 
ALX-152-032 Revised 08-Dec-06
(Des-Arg9)-Bradykinin
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PRODUCT LINE Neurobiology
PRODUCT CATEGORY Bradykinin Receptor / Related Products
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ALX-152-032-M005   5 mg 75.00 USD Add To Cart
ALX-152-032-M025   25 mg 300.00 USD Add To Cart
Product Specification
SEQUENCE: H-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-OH
FORMULA: C44H61N11O10
MW: 904.0
CAS NUMBER: 15958-92-6
PURITY: ≥99%
APPEARANCE: White lyophilized powder.
SOLUBILITY: Soluble in water (1mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Further Categories Containing This Product:
Peptides • NOS Regulation • Cell Stress, Oxidative Stress & Redox Signalling Other Products
 
 
ALX-350-371 Revised 10-Mar-08
Harmine
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SYNONYMS Leucoharmine
Banisterine
Telepathine
Yageine
7-Methoxy-1-methyl-9H-pyrido[3,4-b]indole
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Other Natural Products - DNA Regulation / Transcription
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ALX-350-371-M250   250 mg 22.00 USD Add To Cart
Product Specification
FORMULA: C13H12N2O
MW: 212.3
CAS NUMBER: 442-51-3
MERCK INDEX: 14: 4616
RTECS: UV0175000
SOURCE/HOST: Originally isolated from Peganum harmala.
PURITY: ≥98%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in DMSO, dimethyl formamide or 100% ethanol; slightly soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: HARMFUL.

Product Description
Alkaloid of the β-carboline family. Regulates PPARγ expression. Inhibits the Wnt signalling pathway in a cell-specific manner. Down-regulates inflammatory gene expression (TNF-α, IL-1β, iNOS). Reversibly inhibits monoamine oxidase inhibitor A (MAO-A), but has no effect on MAO-B.
Product Specific Literature References
The chemotherapy of derivatives of harmine and harmaline. I: C.E. Coulthard, et al.; Biochee. J. 27, 727 (1933) Abstract; Full Text
The chemotherapy of derivatives of harmine and harmaline. II: C.E. Coulthard; Biochem. J. 28, 264 (1934) Abstract; Full Text
Interrelationships between amphetamine and harmala alkaloids: H. Schmitt; Nature 203, 877 (1964) Abstract
Effect of moclobemide on rat brain monoamine oxidase A and B: comparison with harmaline and clorgyline: J. Gerardy; Prog. Neuropsychopharmacol. Biol. Psychiatry 18, 793 (1994) Abstract
Hypothermic effect of harmala alkaloid in rats: involvement of serotonergic mechanism: A.F. Abdel-Fattah, et al.; Pharmacol. Biochem. Behav. 52, 421 (1995) Abstract
The mode of action of thiazolidinediones: H. Hauner; Diabet. Metab. Res. Rev. 18, S10 (2002) Abstract
Antitumor and neurotoxic effects of novel harmine derivatives and structure-activity relationship analysis: Q. Chen, et al.; Int. J. Cancer 114, 675 (2005) Abstract
The small molecule harmine is an antidiabetic cell-type-specific regulator of PPARgamma expression: H. Waki, et al.; Cell Metab. 5, 357 (2007) Abstract
Further Categories Containing This Product:
Natural Products - Other Signal Transduction Pathway Modulators • Interleukin-1 [IL-1] & Receptors / Related Products • TNF-alpha & TNF Receptors Other Products • Wnt Signalling Pathway Other Products • NOS Regulation • Antidiabetic Agents / Related Products • Alkaloids
 
 
ALX-804-647 Revised 13-Oct-06
Monoclonal Antibody to Bradykinin (MBK3)
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PRODUCT LINE Neurobiology
PRODUCT CATEGORY Bradykinin Receptor / Related Products
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ALX-804-647-R100   100 µl 210.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
CLONE: MBK3
ISOTYPE: Mouse IgG1
FORMULATION: Liquid. Undiluted ascites.
IMMUNOGEN: Bradykinin (H-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-OH).
SPECIFICITY: Recognizes bradykinin from various species.
APPLICATION: Western Blot (1:1’000-1:4’000)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
Anti-idiotypic antibodies bearing the internal image of a bradykinin epitope. Production, characterization, and interaction with the kinin receptor: M. Haasemann, et al.; J. Immunol. 147, 3882 (1991) Abstract
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Further Categories Containing This Product:
Cell Stress, Oxidative Stress & Redox Signalling Other Products • NOS Regulation • Monoclonal Antibodies
 
 
ALX-804-340 Revised 18-Sep-07
Monoclonal Antibody to DLC1 (10D6)
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SYNONYMS anti-Dynein Light Chain 1 MAb (10D6)
anti-LC8 MAb (10D6)
anti-Protein Inhibitor of nNOS MAb (10D6)
anti-PIN MAb (10D6)
PRODUCT LINE Cytoskeleton
PRODUCT CATEGORY Accessory Proteins & Motor Proteins Other Products
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ALX-804-340-C100   100 µg 320.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
CLONE: 10D6
ISOTYPE: Rat IgM
CONCENTRATION: 1mg/ml
PURITY DETAIL: Affinity purified.
FORMULATION: Liquid. In PBS containing 10mM sodium azide.
IMMUNOGEN: Recombinant mouse DLC1 (dynein light chain 1; LC8; PIN).
SPECIFICITY: Recognizes human and mouse DLC1. Does not cross-react with DLC2.
For detection of both DLC1 and DLC2 see MAb to DLC1 and DLC2 (11F7) (Prod. No. ALX-804-341).
APPLICATION: Flow Cytometry
Western Blot
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis: H. Puthalakath, et al.; Science 293, 1829 (2001) Abstract
Constitutive association of the proapoptotic protein Bim with Bcl-2-related proteins on mitochondria in T cells: Y. Zhu, et al.; PNAS 101, 7681 (2004) Abstract; Full Text
Related Products
Further Categories Containing This Product:
NOS Regulation • Monoclonal Antibodies
 
 
ALX-804-341 Revised 05-Mar-07
Monoclonal Antibody to DLC1 and DLC2 (11F7)
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SYNONYMS anti-Dynein Light Chain 1/2 MAb (11F7)
PRODUCT LINE Cytoskeleton
PRODUCT CATEGORY Accessory Proteins & Motor Proteins Other Products
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ALX-804-341-C100   100 µg 320.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
CLONE: 11F7
ISOTYPE: Rat IgG2a
CONCENTRATION: 1mg/ml
PURITY DETAIL: Protein G-affinity purified.
FORMULATION: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN: Recombinant mouse DLC1 (dynein light chain 1; LC8; PIN).
SPECIFICITY: Recognizes human and mouse DLC1 and DLC2.
APPLICATION: Flow Cytometry
Immunoprecipitation
Western Blot
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
Interaction of the postsynaptic density-95/guanylate kinase domain- associated protein complex with a light chain of myosin-V and dynein: S. Naisbitt, et al.; J. Neurosci. 20, 4524 (2000) Abstract; Full Text
Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis: H. Puthalakath, et al.; Science 293, 1829 (2001) Abstract
Further Categories Containing This Product:
NOS Regulation • Monoclonal Antibodies
 
 
ALX-804-646 Revised 08-Jan-08
Monoclonal Antibody to NOSTRIN (human) (NG6)
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SYNONYMS anti-eNOS (NOS III) Trafficking Inducer (human) MAb (NG6)
PRODUCT LINE Nitric Oxide Pathway
PRODUCT CATEGORY NOS Regulation
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ALX-804-646-R100   100 µl 210.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: NG6
ISOTYPE: Mouse IgG1
FORMULATION: Liquid. Undiluted ascites.
IMMUNOGEN: Human recombinant NOSTRIN (eNOS (NOS III) trafficking inducer) (aa 242-506).
SPECIFICITY: Recognizes human NOSTRIN.
APPLICATION: Immunocytochemistry (1:20-1:500)
Immunohistochemistry (paraffin sections (1:500-1:800))
Western Blot (1:200-1:10’000)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Product Images
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Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-210-872 Revised 11-Nov-05
Polyclonal Antibody to Bradykinin B2 Receptor
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SYNONYMS anti-B2R PAb
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Bradykinin Receptor / Related Products
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ALX-210-872-R200   200 µl 195.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
SOURCE/HOST: From rabbit.
FORMULATION: Liquid. Undiluted serum containing 0.01% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 356-391 of human B2R (bradykinin B2 receptor).
SPECIFICITY: Recognizes human, mouse and rat B2R.
APPLICATION: Immunoprecipitation (use 2-5µl of undiluted antiserum per precipitate)
Western Blot (1:100-1:500)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
Ligand-induced phosphorylation/dephosphorylation of the endogenous bradykinin B2 receptor from human fibroblasts: A. Blaukat, et al.; J. Biol. Chem. 271, 32366 (1996) Abstract; Full Text
Overexpression and functional characterization of kinin receptors reveal subtype-specific phosphorylation: A. Blaukat, et al.; Biochemistry 38, 1300 (1999) Abstract
Bradykinin-induced internalization of the human B2 receptor requires phosphorylation of three serine and two threonine residues at its carboxyl tail: A. Pizard, et al.; J. Biol. Chem. 274, 13738 (1999) Abstract; Full Text
Determination of bradykinin B2 receptor in vivo phosphorylation sites and their role in receptor function: A. Blaukat, et al.; J. Biol. Chem. 276, 40431 (2001) Abstract; Full Text
Functional specialization of calreticulin domains: K. Nakamura, et al.; J. Cell Biol. 154, 961 (2001) Abstract
Further Categories Containing This Product:
NOS Regulation • Cell Stress, Oxidative Stress & Redox Signalling Other Products • Polyclonal Antibodies
 
 
ALX-210-347 Revised 28-Jul-08
Polyclonal Antibody to Caveolin-1