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Signal Transduction Enzymes / Related Products
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ALX-270-061 Revised 30-Oct-08
t-Butylhydroquinone
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SYNONYMS tBHQ
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Ca2+-ATPase / Related Products
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ALX-270-061-G010   10 g 30.00 USD Add To Cart
Product Specification
FORMULA: C10H14O2
MW: 166.2
CAS NUMBER: 1948-33-0
PURITY: ≥97%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in DMSO or methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
IDENTITY: Identity determined by IR.

Product Description
Inhibitor of the endoplasmic reticulum Ca2+-ATPase. Activates extracellular signal-regulated protein kinase 2 (ERK2).
Product Specific Literature References
Butylated hydroxyanisole and its metabolite tert-butylhydroquinone differentially regulate mitogen-activated protein kinases. The role of oxidative stress in the activation of mitogen-activated protein kinases by phenolic antioxidants: R. Yu, et al.; J. Biol. Chem. 272, 28962 (1997) Abstract; Full Text
Further Categories Containing This Product:
MAPK Pathway Activators
 
 
ALX-270-359 Revised 08-Dec-04
3-(3-tert-Butyl-4-methoxybenzylidenyl)indolin-2-one
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Tyrosine Kinase Inhibitors
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ALX-270-359-M001   1 mg 50.00 USD Add To Cart
ALX-270-359-M005   5 mg 200.00 USD Add To Cart
Product Specification
FORMULA: C20H21NO2
MW: 307.4
CAS NUMBER: 293302-19-9
SOURCE/HOST: Synthetic.
PURITY: ≥98% (1H-NMR, HPLC)
APPEARANCE: Yellow crystals.
SOLUBILITY: Soluble in DMSO (>70mg/ml) or methanol (1.5mg/ml). Sparingly soluble in aqueous buffers (12.5µg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
USE/STABILITY: Stable as a powder for at least two years when stored at +4°C in the dark. Stock solutions made in DMSO should be stored in the dark and used within one month.
HANDLING: Protect from light. Keep cool and dry.
IDENTITY: Identity determined by 1H-NMR, 13C-NMR, IR, ESI-MS and UV.

Product Description
Selective receptor tyrosine kinase (RTK) inhibitor. Inhibits HER-2 RTK (IC50 ~13µM) [1]. Consists predominantly of the E-isomer, contains ~10% of the Z-isomer [1].
Product Specific Literature References
[1] Synthesis and biological evaluations of 3-substituted indolin-2-ones: a novel class of tyrosine kinase inhibitors that exhibit selectivity toward particular receptor tyrosine kinases: L. Sun, et al.; J. Med. Chem. 41, 2588 (1998) Abstract
 
 
ALX-350-250 Revised 22-Jul-08 New product
Butyrolactone I
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PRODUCT LINE Cell Cycle
PRODUCT CATEGORY CDK & Cyclin Inhibitors
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ALX-350-250-C200   200 µg 135.00 USD Add To Cart
Product Specification
FORMULA: C24H24O7
MW: 424.5
CAS NUMBER: 87414-49-1
PURITY: ≥99% (TLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: 25mg/ml soluble in 100% ethanol or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

Product Description
Cell permeable and selective inhibitor of the cyclin-dependent kinases CDK1/cyclin B, CDK2 and CDK5. Inhibits cell cycle progression at the G1/S and G2/M transitions. Blocks Fas-induced apoptosis. Displays antitumor activity.
Product Specific Literature References
Butyrolactone I, a selective inhibitor of cdk2 and cdc2 kinase: M. Kitagawa, et al.; Oncogene 8, 2425 (1993) Abstract
Inhibition of cell cycle oscillation of DNA replication by a selective inhibitor of the cdc2 kinase family, butyrolactone I, in Xenopus egg extracts: A. Someya, et al.; BBRC 198, 536 (1994) Abstract
A cyclin-dependent kinase inhibitor, butyrolactone I, inhibits phosphorylation of RB protein and cell cycle progression: M. Kitagawa, et al.; Oncogene 9, 2549 (1994) Abstract
Evidence for cdk5 as a major activity phosphorylating tau protein in porcine brain extract: T. Hosoi, et al.; J. Biochem. 117, 741 (1995) Abstract
Transcriptional activation of the cdc2 gene is associated with Fas- induced apoptosis of human hematopoietic cells: Y. Furukawa, et al.; J. Biol. Chem. 271, 28469 (1996) Abstract; Full Text
Antitumor effects of butyrolactone I, a selective cdc2 kinase inhibitor, on human lung cancer cell lines: K. Nishio, et al.; Anticancer Res. 16, 3387 (1996) Abstract
An exogenous cdk inhibitor, butyrolactone-I, induces apoptosis with increased Bax/Bcl-2 ratio in p53-mutated pancreatic cancer cells: M. Wada, et al.; Anticancer Res. 18, 2559 (1998) Abstract
Effects of cyclin-dependent kinase inhibitors on transcription and ocular circadian rhythm of Aplysia: N. Sankrithi and A. Eskin; J. Neurochem. 72, 605 (1999) Abstract
Butyrolactone I induces cyclin B1 and causes G2/M arrest and skipping of mitosis in human prostate cell lines: M. Suzuki, et al.; Cancer Lett. 138, 121 (1999) Abstract
Butyrolactone I reversibly inhibits meiotic maturation of bovine oocytes, without influencing chromosome condensation activity: M. Kubelka, et al.; Biol. Reprod. 62, 292 (2000) Abstract; Full Text
Involvement of Cdk5/p25 in digoxin-triggered prostate cancer cell apoptosis: H. Lin, et al.; J. Biol. Chem. 279, 29302 (2004) Abstract; Full Text
Regulation of mitotic function of Chk1 through phosphorylation at novel sites by cyclin-dependent kinase 1 (Cdk1): T. Shiromizu, et al.; Genes Cells 11, 477 (2006) Abstract
 
 
ALX-260-017 Revised 07-Jul-08
CA-074
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SYNONYMS N-[L-3-trans-Propylcarbamoyloxirane-2-carbonyl]-Ile-Pro-OH
PRODUCT LINE Cancer
PRODUCT CATEGORY Cathepsin Inhibitors
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ALX-260-017-M001   1 mg 210.00 USD Add To Cart
Product Specification
FORMULA: C18H29N3O6
MW: 383.5
CAS NUMBER: 134448-10-5
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in ethyl acetate (50mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Potent and specific inhibitor of cathepsin B in vitro and in vivo.
Product Specific Literature References
Novel epoxysuccinyl peptides. Selective inhibitors of cathepsin B, in vitro: M. Murata, et al.; FEBS Lett. 280, 307 (1991) Abstract
Novel epoxysuccinyl peptides. A selective inhibitor of cathepsin B, in vivo: T. Towatari, et al.; FEBS Lett. 280, 311 (1991) Abstract
Specific assay method for the activities of cathepsin L-type cysteine proteinases: T. Inubushi, et al.; J. Biochem. 116, 282 (1994) Abstract
 
 
ALX-202-026 Revised 30-Aug-07
Ca2+/Calmodulin-dependent Protein Kinase II (rat brain)
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SYNONYMS CaM Kinase II (rat brain)
CAMK2 (rat brain)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY CAM Kinases
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ALX-202-026-C001   1 µg 295.00 USD Add To Cart
Product Specification
MW: ~65kDa. Composed of 60kDa and 50kDa subunits in ratios of 1:3 to 1:4.
EC: 2.7.1.123
SOURCE/HOST: Isolated from rat brain. Requires activation.
CONCENTRATION: 20µg/ml
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Liquid. In 25mM TRIS/HCl, pH 7.5, 0.5mM EDTA, 10mM β-mercaptoethanol, 10µM AEBSF, 50% glycerol and 0.1mg/ml leupeptin.
RECONSTITUTION: Reconstitute with sterile distilled water.
SPECIFIC ACTIVITY: ~1µmol/mg/min at 30°C using synapsin I as the substrate.
SHIPPING: SHIPPED ON DRY ICE
LONG TERM STORAGE: -80°C
HANDLING: Avoid freeze/thaw cycles.
General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link: Ca2+/Calmodulin-dependent Protein Kinase II (rat) α chain (P11275), β chain (P08413), γ chain (P11730), δ chain (P15791)
AfCS Signalling Gateway link: Ca2+/Calmodulin-dependent Protein Kinase II (mouse) α chain (A000456), β chain (A000457), γ chain (A000459), δ chain (A000458)
Further Categories Containing This Product:
Natural Proteins • Enzymes
 
 
ALX-153-009 Revised 20-Sep-05
Ca2+/Calmodulin-dependent Protein Kinase II (281-289)
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SYNONYMS CaM Kinase II (281-289)
CAMK2 (281-289)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY CAM Kinases
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ALX-153-009-M001   1 mg 70.00 USD Add To Cart
ALX-153-009-M005   5 mg 280.00 USD Add To Cart
Product Specification
SEQUENCE: H-Met-His-Arg-Gln-Glu-Thr-Val-Asp-Cys-OH
FORMULA: C43H71N15O16S2
MW: 1118.3
PURITY: ≥97%
APPEARANCE: White lyophilized powder.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Amino acid sequence defining the major Ca2+-dependent autophosphorylation site of Ca2+/calmodulin-dependent protein kinase II.
Product Specific Literature References
Regulatory interactions of the calmodulin-binding, inhibitory, and autophosphorylation domains of Ca2+/calmodulin-dependent protein kinase II: R.J. Colbran, et al.; J. Biol. Chem. 263, 18145 (1988) Abstract; Full Text
Functional determinants in the autoinhibitory domain of calcium/calmodulin-dependent protein kinase II. Role of His282 and multiple basic residues: M.K. Smith, et al.; J. Biol. Chem. 267, 1761 (1992) Abstract; Full Text
Ca2+/calmodulin-dependent protein kinase II is phosphorylated by protein kinase C in vitro: M.N. Waxham & J. Aronowski; Biochemistry 32, 2923 (1993) Abstract
Further Categories Containing This Product:
Peptides
 
 
ALX-153-018 Revised 16-Feb-05
[Ala288]-Ca2+/Calmodulin-dependent Protein Kinase II (281-289)
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY CAM Kinases
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ALX-153-018-M005   5 mg 60.00 USD Add To Cart
Product Specification
SEQUENCE: H-Met-His-Arg-Gln-Glu-Thr-Val-Ala-Cys-OH
FORMULA: C42H71N15O14S2
MW: 1074.3
PURITY: ≥97%
APPEARANCE: Lyophilized powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Further Categories Containing This Product:
Peptides
 
 
ALX-153-010 Revised 16-Feb-05
[Ala286]-Ca2+/Calmodulin-dependent Protein Kinase II (281-302)
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY CAM Kinase Inhibitors
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ALX-153-010-MC01   0.1 mg 50.00 USD Add To Cart
ALX-153-010-M001   1 mg 190.00 USD Add To Cart
Product Specification
SEQUENCE: H-Met-His-Arg-Gln-Glu-Ala-Val-Asp-Cys-Leu-Lys-Lys-Phe-Asn-Ala-Arg-Arg-Lys-Leu-Lys-Gly-Ala-OH
FORMULA: C111H191N39O29S2
MW: 2600.1
PURITY: ≥97%
APPEARANCE: White lyophilized powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Inhibitor of Ca2+/calmodulin-dependent protein kinase II catalytic fragment, competitive with ATP. The sequence for this product matches that of the original article describing this "CaM kinase II inhibitor" peptide.
Product Specific Literature References
Functional determinants in the autoinhibitory domain of calcium/calmodulin-dependent protein kinase II. Role of His282 and multiple basic residues: M.K. Smith, et al.; J. Biol. Chem. 267, 1761 (1992) Abstract; Full Text
Further Categories Containing This Product:
Peptides
 
 
ALX-153-006 Revised 20-Sep-05
Ca2+/Calmodulin-dependent Protein Kinase II (290-309)
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SYNONYMS CaM Kinase II (290-309)
CAMK2 (290-309)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY CAM Kinase Inhibitors
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ALX-153-006-MC01   0.1 mg 40.00 USD Add To Cart
ALX-153-006-M001   1 mg 120.00 USD Add To Cart
Product Specification
SEQUENCE: H-Leu-Lys-Lys-Phe-Asn-Ala-Arg-Arg-Lys-Leu-Lys-Gly-Ala-Ile-Leu-Thr-Thr-Met-Leu-Ala-OH
FORMULA: C103H185N31O24S
MW: 2273.9
PURITY: ≥98%
APPEARANCE: White lyophilized powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Potent inhibitor of Ca2+/calmodulin-dependent protein kinase II.
Product Specific Literature References
Calcium/calmodulin-dependent protein kinase II. Characterization of distinct calmodulin binding and inhibitory domains: M.E. Payne, et al.; J. Biol. Chem. 263, 7190 (1988) Abstract; Full Text
Further Categories Containing This Product:
Peptides
 
 
ALX-153-008 Revised 20-Sep-05
Ca2+/Calmodulin-dependent Protein Kinase IV Substrate
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SYNONYMS CaM Kinase IV Substrate
CAMK4 Substrate
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY CAM Kinase Substrates
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ALX-153-008-M001   1 mg 70.00 USD Add To Cart
ALX-153-008-M005   5 mg 290.00 USD Add To Cart
Product Specification
SEQUENCE: H-Lys-Ser-Asp-Gly-Gly-Val-Lys-Lys-Arg-Lys-Ser-Ser-Ser-Ser-OH
FORMULA: C58H107N21O22
MW: 1450.6
PURITY: ≥98%
APPEARANCE: White lyophilized powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Very selective and potent substrate for a brain-specific Ca2+/calmodulin-dependent protein kinase IV over Ca2+/calmodulin-dependent protein kinase II. This peptide corresponds to aa 345-358 of Ca2+/calmodulin-dependent protein kinase II-δ.
Product Specific Literature References
Purification and characterization of a brain-specific multifunctional calmodulin-dependent protein kinase from rat cerebellum: O. Miyano, et al.; J. Biol. Chem. 267, 1198 (1992) Abstract; Full Text
Further Categories Containing This Product:
Peptides
 
 
ALX-350-220 Revised 05-May-08
Cafestol
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Chemopreventive Agents
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ALX-350-220-M050   50 mg 160.00 USD Add To Cart
Product Specification
FORMULA: C20H28O3
MW: 316.4
CAS NUMBER: 469-83-0
MERCK INDEX: 14: 1634
SOURCE/HOST: Isolated from the unsaponifiable fraction of petroleum ether extract of coffee beans.
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in DMSO, 100% ethanol or ethyl acetate.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
IDENTITY: Identity determined by 1H-NMR.