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Excitatory Amino Acids
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ALX-550-017 Revised 17-Jan-05
cis-ACPD
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SYNONYMS (±)-1-Aminocyclopentane-cis-1,3-dicarboxylic acid
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Glutamate Receptors (Metabotropic) / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-550-017-M005   5 mg 60.00 USD Add To Cart
Product Specification
FORMULA: C7H11NO4
MW: 173.2
CAS NUMBER: 39026-63-6
PURITY: ≥97%
APPEARANCE: White solid.
SOLUBILITY: Soluble in dilute aqueous base.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.

(1S,3S)-ACPD
(1R,3R)-ACPD
Product Description
Potent NMDA agonist. Equimolar mixture of (1R,3R)-ACPD (Prod. No. ALX-550-018) and (1S,3S)-ACPD (Prod. No. ALX-550-019).
Product Specific Literature References
Receptors for the excitatory amino acids in the mammalian central nervous system: H. McLennan; Prog. Neurobiol. 20, 251 (1983) Abstract
Structure/activity relations of N-methyl-D-aspartate receptor ligands as studied by their inhibition of [3H]D-2-amino-5-phosphonopentanoic acid binding in rat brain membranes: H.J. Olverman, et al.; Neuroscience 26, 17 (1988) Abstract
In vitro and in vivo pharmacology of trans- and cis-(+-)-1-amino-1,3-cyclopentanedicarboxylic acid: dissociation of metabotropic and ionotropic excitatory amino acid receptor effects: D.D. Schoepp, et al.; J. Neurochem. 56, 1789 (1991) Abstract
Pharmacological agents acting at subtypes of metabotropic glutamate receptors: D.D. Schoepp, et al.; Neuropharmacology 38, 1431 (1999), (Review) Abstract
Further Categories Containing This Product:
NMDA Receptors / Related Products • Excitatory Amino Acids
 
 
ALX-550-020 Revised 11-Mar-08
trans-ACPD
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SYNONYMS (±)-1-Aminocyclopentane-trans-1,3-dicarboxylic acid
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Glutamate Receptors (Metabotropic) / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-550-020-M005   5 mg 55.00 USD Add To Cart
ALX-550-020-M025   25 mg 220.00 USD Add To Cart
Product Specification
FORMULA: C7H11NO4
MW: 173.2
CAS NUMBER: 67684-64-4, 39026-64-7
RTECS: GY4060000
PURITY: ≥97% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in dilute aqueous base or water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.
HAZARD: HARMFUL.
IDENTITY: Identity determined by NMR.

 (1R,3S)-ACPD
Product Description
Equimolar mixture of (1S,3R)-ACPD (Prod. No. ALX-550-021) and (1R,3S)-ACPD. Selective agonist for mGluRs (active at both group I and group II mGluRs).
Product Specific Literature References
The excitatory amino acid receptors: their classes, pharmacology, and distinct properties in the function of the central nervous system: D.T. Monaghan, et al.; Annu. Rev. Pharmacol. Toxicol. 29, 365 (1989) Abstract
Trans-ACPD, a selective agonist of the phosphoinositide-coupled excitatory amino acid receptor: E. Palmer, et al.; Eur. J. Pharmacol. 166, 585 (1989) Abstract
In vitro and in vivo pharmacology of trans- and cis-(+-)-1-amino-1,3-cyclopentanedicarboxylic acid: dissociation of metabotropic and ionotropic excitatory amino acid receptor effects: D.D. Schoepp, et al.; J. Neurochem. 56, 1789 (1991) Abstract
Molecular diversity of glutamate receptors and implications for brain function: S. Nakanishi; Science 258, 597 (1992) Abstract
Neuroprotective sigma ligands attenuate NMDA and trans-ACPD-induced calcium signaling in rat primary neurons: K.L. Klette, et al.; Brain Res. 756, 231 (1997) Abstract
Pharmacological agents acting at subtypes of metabotropic glutamate receptors: D.D. Schoepp, et al.; Neuropharmacology 38, 1431 (1999), (Review) Abstract
Metabotropic glutamate receptor agonists reduce glutamate release from cultured astrocytes: Z.C. Ye & H. Sontheimer; Glia 25, 270 (1999) Abstract
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Further Categories Containing This Product:
Excitatory Amino Acids
 
 
ALX-550-018 Revised 03-Mar-05
(1R,3R)-ACPD
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SYNONYMS (1R,3R)-1-Aminocyclopentane-1,3-dicarboxylic acid
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Glutamate Receptors (Metabotropic) / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-550-018-M005   5 mg 90.00 USD Add To Cart
Product Specification
FORMULA: C7H11NO4
MW: 173.2
CAS NUMBER: 111900-33-5
PURITY: ≥97%
APPEARANCE: White solid.
SOLUBILITY: Soluble in water or dilute aqueous base.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

(1R,3R)-ACPD
Product Description
Active isomer of cis-ACPD (Prod. No. ALX-550-017). Potent and specific NMDA receptor agonist.
Product Specific Literature References
Receptors for the excitatory amino acids in the mammalian central nervous system: H. McLennan; Prog. Neurobiol. 20, 251 (1983) Abstract
Synthesis, resolution, and absolute configuration of the isomers of the neuronal excitant 1-amino-1,3-cyclopentanedicarboxylic acid: K. Curry, et al.; J. Med. Chem. 31, 864 (1988) Abstract
Differences in agonist and antagonist activities for two indices of metabotropic glutamate receptor-stimulated phosphoinositide turnover: R. Mistry & R.A. Challiss; Br. J. Pharmacol. 117, 1735 (1996) Abstract
Pharmacological agents acting at subtypes of metabotropic glutamate receptors: D.D. Schoepp, et al.; Neuropharmacology 38, 1431 (1999), (Review) Abstract
Further Categories Containing This Product:
NMDA Receptors / Related Products • Excitatory Amino Acids
 
 
ALX-550-021 Revised 07-Mar-08
(1S,3R)-ACPD
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SYNONYMS (1S,3R)-1-Aminocyclopentane-1,3-dicarboxylic acid
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Glutamate Receptors (Metabotropic) / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-550-021-M005   5 mg 75.00 USD Add To Cart
ALX-550-021-M025   25 mg 320.00 USD Add To Cart
Product Specification
FORMULA: C7H11NO4
MW: 173.2
CAS NUMBER: 111900-32-4
RTECS: GY4060000
PURITY: ≥97% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in dilute aqueous base or water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.
HAZARD: HARMFUL.
IDENTITY: Identity determined by NMR.

Product Description
Active isomer of trans-ACPD (Prod. No. ALX-550-020).
Product Specific Literature References
Synthesis, resolution, and absolute configuration of the isomers of the neuronal excitant 1-amino-1,3-cyclopentanedicarboxylic acid: K. Curry, et al.; J. Med. Chem. 31, 864 (1988) Abstract
Selective activation of phosphoinositide hydrolysis by a rigid analogue of glutamate: M.A. Desai & P.J. Conn; Neurosci. Lett. 109, 157 (1990) Abstract
1S,3R-ACPD stimulates and L-AP3 blocks Ca2+ mobilization in rat cerebellar neurons: A.J. Irving, et al.; Eur. J. Pharmacol. 186, 363 (1990) Abstract
Evidence for presynaptic depression of monosynaptic excitation in neonatal rat motoneurones by (1S,3S)- and (1S,3R)-ACPD: P.C. Pook, et al.; Exp. Physiol. 77, 529 (1992) Abstract
In vitro and in vivo pharmacology of 1S,3R- and 1R,3S-ACPD: evidence for a role of metabotropic glutamate receptors in striatal motor function: D.D. Schoepp; Mol. Neuropharmacol. 2, 33 (1992)
Seizures and brain injury in neonatal rats induced by 1S,3R-ACPD, a metabotropic glutamate receptor agonist: J.W. McDonald, et al.; J. Neurosci. 13, 4445 (1993) Abstract
Metabotropic glutamate receptors in brain function and pathology: D.D. Schoepp & P.J. Conn; TIPS 14, 13 (1993), (Review) Abstract
Intracerebral 1S,3R-1-aminocyclopentane-1,3-dicarboxylic acid (1S,3R- ACPD) produces limbic seizures that are not blocked by ionotropic glutamate receptor antagonists: J.P. Tizzano, et al.; Neurosci. Lett. 162, 12 (1993) Abstract
Metabotropic glutamate receptors: novel targets for drug development: T. Knöpfel, et al.; J. Med. Chem. 38, 1417 (1995) Abstract
Metabotropic glutamate receptors, transmitter output and fatty acids: studies in rat brain slices: G. Lombardi, et al.; Br. J. Pharmacol. 117, 189 (1996) Abstract
Differences in agonist and antagonist activities for two indices of metabotropic glutamate receptor-stimulated phosphoinositide turnover: R. Mistry & R.A. Challiss; Br. J. Pharmacol. 117, 1735 (1996) Abstract
Pharmacological agents acting at subtypes of metabotropic glutamate receptors: D.D. Schoepp, et al.; Neuropharmacology 38, 1431 (1999), (Review) Abstract
Related Products
Further Categories Containing This Product:
Excitatory Amino Acids
 
 
ALX-550-005 Revised 16-Feb-05
trans-1,2-homo-ACPD
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SYNONYMS (±)-trans-1-Amino-1-carboxycyclopentane-2-acetic acid
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Glutamate Receptors (Metabotropic) / Related Products
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ALX-550-005-M005   5 mg 48.00 USD Add To Cart
Product Specification
FORMULA: C8H13NO4
MW: 187.2
PURITY: ≥97%
APPEARANCE: White powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.

Product Description
Selective antagonist for group II mGluRs.
Product Specific Literature References
New analogues of ACPD with selective activity for group II metabotropic glutamate receptors: H. Bräuner-Osborne, et al.; Eur. J. Pharmacol. 332, 327 (1997) Abstract
Pharmacological agents acting at subtypes of metabotropic glutamate receptors: D.D. Schoepp, et al.; Neuropharmacology 38, 1431 (1999), (Review) Abstract
Further Categories Containing This Product:
Excitatory Amino Acids
 
 
ALX-550-009 Revised 24-Nov-04
cis-1,3-homo-ACPD
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SYNONYMS (±)-cis-1-Amino-1-carboxycyclopentane-3-acetic acid
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Glutamate Receptors (Metabotropic) / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-550-009-M005   5 mg 65.00 USD Add To Cart
Product Specification
FORMULA: C8H13NO4
MW: 187.2
PURITY: ≥97%
APPEARANCE: White powder.
SOLUBILITY: Soluble in dilute aqueous base.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
HANDLING: Protect from light.
Product Description
Equimolar mixture of (1R,3R)-homo-ACPD (Prod. No. ALX-550-010) and (1S,3S)-homo-ACPD (Prod. No. ALX-550-011). Selective agonist for group II mGluRs. Has no effect at ionotropic excitatory amino acid receptors.
Product Specific Literature References
New analogues of ACPD with selective activity for group II metabotropic glutamate receptors: H. Bräuner-Osborne, et al.; Eur. J. Pharmacol. 332, 327 (1997) Abstract
Pharmacological agents acting at subtypes of metabotropic glutamate receptors: D.D. Schoepp, et al.; Neuropharmacology 38, 1431 (1999), (Review) Abstract
Further Categories Containing This Product:
Excitatory Amino Acids
 
 
ALX-550-006 Revised 16-Feb-05
trans-1,3-homo-ACPD
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SYNONYMS (±)-trans-1-Amino-1-carboxycyclopentane-3-acetic acid
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Glutamate Receptors (Metabotropic) / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-550-006-M005   5 mg 65.00 USD Add To Cart
Product Specification
FORMULA: C8H13NO4
MW: 187.2
PURITY: ≥97%
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.


(1R,3S)-homo-ACPD
Product Description
Equimolar mixture of (1R,3S)-homo-ACPD (Prod. No. ALX-550-008) and (1S,3R)-homo-ACPD (Prod. No. ALX-550-007). Selective agonist for group II mGluRs. Has no effect at ionotropic excitatory amino acid receptors.
Product Specific Literature References
New analogues of ACPD with selective activity for group II metabotropic glutamate receptors: H. Bräuner-Osborne, et al.; Eur. J. Pharmacol. 332, 327 (1997) Abstract
Pharmacological agents acting at subtypes of metabotropic glutamate receptors: D.D. Schoepp, et al.; Neuropharmacology 38, 1431 (1999), (Review) Abstract
Further Categories Containing This Product:
Excitatory Amino Acids
 
 
ALX-550-010 Revised 16-Feb-05
(1R,3R)-homo-ACPD
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SYNONYMS (1R,3R)-1-Amino-1-carboxycyclopentane-3-acetic acid
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Glutamate Receptors (Metabotropic) / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-550-010-M005   5 mg 95.00 USD Add To Cart
Product Specification
FORMULA: C8H13NO4
MW: 187.2
PURITY: ≥97%
APPEARANCE: White powder.
SOLUBILITY: Soluble in dilute aqueous base.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
HANDLING: Protect from light.

Product Description
Active isomer of cis-1,3-homo-ACPD (Prod. No. ALX-550-009) Selective agonist for group II mGluRs. Has no effect at ionotropic excitatory amino acid receptors.
Product Specific Literature References
New analogues of ACPD with selective activity for group II metabotropic glutamate receptors: H. Bräuner-Osborne, et al.; Eur. J. Pharmacol. 332, 327 (1997) Abstract
Pharmacological agents acting at subtypes of metabotropic glutamate receptors: D.D. Schoepp, et al.; Neuropharmacology 38, 1431 (1999), (Review) Abstract
Further Categories Containing This Product:
Excitatory Amino Acids
 
 
ALX-550-008 Revised 24-Feb-05
(1R,3S)-homo-ACPD
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SYNONYMS (1R,3S)-1-Amino-1-carboxycyclopentane-3-acetic acid
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Glutamate Receptors (Metabotropic) / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-550-008-M005   5 mg 65.00 USD Add To Cart
Product Specification
FORMULA: C8H13NO4
MW: 187.2
PURITY: ≥97%
APPEARANCE: White crystalline powder.
SOLUBILITY: Soluble in diluted sodium hydroxide solution.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.

(1R,3S)-homo-ACPD
Product Description
Inactive isomer of trans-1,3-homo-ACPD (Prod. No. ALX-550-006).
Product Specific Literature References
Pharmacological agents acting at subtypes of metabotropic glutamate receptors: D.D. Schoepp; Neuropharmacology 38, 1431 (1999), (Review) Abstract
Further Categories Containing This Product:
Excitatory Amino Acids
 
 
ALX-550-007 Revised 26-Apr-07
(1S,3R)-homo-ACPD
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SYNONYMS (1S,3R)-1-Amino-1-carboxycyclopentane-3-acetic acid
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Glutamate Receptors (Metabotropic) / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-550-007-M005   5 mg 65.00 USD Add To Cart
Product Specification
FORMULA: C8H13NO4
MW: 187.2
PURITY: ≥97% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.

Product Description
Active isomer of trans-1,2-homo-ACPD (Prod. No. ALX-550-006). Highly selective agonist for group II mGluRs. Has no effect at ionotropic excitatory amino acid receptors.
Product Specific Literature References
New analogues of ACPD with selective activity for group II metabotropic glutamate receptors: H. Bräuner-Osborne, et al.; Eur. J. Pharmacol. 332, 327 (1997) Abstract
Pharmacological agents acting at subtypes of metabotropic glutamate receptors: D.D. Schoepp; Neuropharmacology 38, 1431 (1999), (Review) Abstract
Further Categories Containing This Product:
Excitatory Amino Acids
 
 
ALX-550-011 Revised 24-Nov-04
(1S,3S)-homo-ACPD