© 2008 Alexis Corporation
You are here:
Product Lines
>
Signal Transduction
>
JAK / STAT Signalling Pathway
> SOCS / Related Products
ALX-804-637
Revised 31-Oct-06
Monoclonal Antibody to SOCS-3 (human) (SO1)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
SOCS / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-637-C100
100 µg
270.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE:
SO1
ISOTYPE:
Mouse IgG2b
CONCENTRATION:
1mg/ml
PURITY:
>95% (SDS-PAGE)
PURITY DETAIL:
Protein A-affinity purified.
FORMULATION:
Liquid. In PBS, pH 7.4, containing 15mM sodium azide.
IMMUNOGEN:
Full-length human SOCS-3 (suppressor of cytokine signalling-3).
SPECIFICITY:
Recognizes human SOCS-3.
APPLICATION:
ELISA
Western Blot
Optimal conditions must be determined individually for each application.
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
HANDLING:
After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Monoclonal Antibodies
ALX-210-392
Revised 12-Jul-06
Polyclonal Antibody to SOCS-1
SYNONYMS
anti-Suppressor of Cytokine Signalling-1 PAb
anti-JAB PAb
anti-SSI-1 PAb
anti-TIP-3 PAb
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
SOCS / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-392-R200
200 µl
267.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
SOURCE/HOST:
From rabbit.
PURITY DETAIL:
Protein G-affinity purified.
FORMULATION:
Liquid. In PBS containing 0.1mg/ml BSA and 0.02% sodium azide.
IMMUNOGEN:
Synthetic peptide containing aa residues of human SOCS-1 (suppressor of cytokine signalling-1).
SPECIFICITY:
Recognizes human and mouse SOCS-1.
APPLICATION:
Western Blot (1:500 - 1:1'000)
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
General Information
SOCS-1 also known as JAB and (STAT)-induced STAT inhibitor 1 (SSI-1) is an SH2-domain-containing protein that is induced by and negatively regulates signalling by a number of cytokines including interleukin-4 (IL-4), IL-6, interferon (IFN)-gamma, prolactin, growth hormone, and erythropoietin. SOCS1/JAB is rapidly induced by LPS and negatively regulates LPS signalling.
General Literature References
SOCS proteins: negative regulators of cytokine signaling
:
D.L. Krebs and D.J. Hilton; Stem Cells
19
, 378 (2001)
Abstract
SOCS1/JAB is a negative regulator of LPS-induced macrophage activation
:
I. Kinjyo, et al.; Immunity
17
, 583 (2002)
Abstract
A positive regulatory role for suppressor of cytokine signaling 1 in IFN-gamma-induced MHC class II expression in fibroblasts
:
S. Ilangumaran, et al.; J. Immunol.
169
, 5010 (2002)
Abstract
Further Categories Containing This Product:
Toll-IL-1 Receptor Adapters & TLR Downstream Signalling Other Products
•
Polyclonal Antibodies
ALX-201-334
Revised 09-Jul-08
SOCS-3 (human) (recombinant) (His)
SYNONYMS
Suppressor of Cytokine Signalling-3 (human) (recombinant) (His)
CIS-3 (human) (recombinant) (His)
Cytokine-inducible SH2-containing Protein-3 (human) (recombinant) (His)
SSI-3 (human) (recombinant) (His)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
SOCS / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-201-334-C050
50 µg
395.00 USD
Product Specification
SOURCE/HOST:
Produced in
E. coli.
Full length human SOCS-3 (suppressor of cytokine signalling-3) (aa 1-225) is fused at the C-terminus to a His-tag.
CONCENTRATION:
PURITY:
≥90% (SDS-PAGE)
FORMULATION:
Liquid. 0.2µm-filtered solution in 20mM sodium phosphate, pH 6.5, containing 20mM sodium chloride, 50mM glutamate, 50mM arginine, 2mM dithiothreitol, 1mM EDTA.
ENDOTOXIN CONTENT:
<1.0EU/µg protein (LAL test).
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING:
After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. For maximum product recovery after thawing, centrifuge the vial before opening the cap.
Product Images
Please click on thumbnails to enlarge.
General Information
BACKGROUND/TECHNICAL INFORMATION
Swiss-Prot link O14543:
Suppressor of Cytokine Signaling 3 (human)
MANUFACTURER
Manufactured by AdipoGen, Inc.
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
© 2008 ALEXIS Corporation,
Privacy Policy
,
Disclaimer
,
Feedback
header picture ©
micronaut.ch
, another
CS2
website
