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ALX-550-271
Revised 06-Nov-07
Glipizide
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
K+ Channel Blockers & Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-550-271-M100
100 mg
15.00 USD
ALX-550-271-G001
1 g
40.00 USD
ALX-550-271-G005
5 g
160.00 USD
Product Specification
FORMULA:
C
21
H
27
N
5
O
4
S
MW:
445.5
CAS NUMBER:
29094-61-9
MERCK INDEX:
14:
4442
PURITY:
≥99%
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in DMSO or methanol; insoluble in 100 % ethanol or water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+20°C
Product Description
ATP-dependent K
+
channel blocker.
Product Specific Literature References
RP 49356 and cromakalim relax airway smooth muscle in vitro by opening a sulphonylurea-sensitive K+ channel: a comparison with nifedipine:
D. Raeburn & T.J. Brown; J. Pharmacol. Exp. Ther.
256
, 480 (1991)
Abstract
Quantitative autoradiography of the binding sites for [125I] iodoglyburide, a novel high-affinity ligand for ATP-sensitive potassium channels in rat brain:
D.R. Gehlert, et al.; J. Pharmacol. Exp. Ther.
257
, 901 (1991)
Abstract
Further Categories Containing This Product:
Antidiabetic Agents / Related Products
ALX-306-030
Revised 06-Dec-06
Globotrihexosylceramide
SYNONYMS
Gb3
PRODUCT LINE
Immunology
PRODUCT CATEGORY
Natural Killer T [NKT] Cells / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-306-030-C100
100 µg
85.00 USD
ALX-306-030-M001
1 mg
455.00 USD
Product Specification
FORMULA:
C
62
H
117
NO
18
MW:
1164.6
PURITY:
≥95% (
1
H-NMR)
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in pyridine or chloroform:methanol (2:1).
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
Product Description
Negative control for isoglobotrihexosylceramide (iGb3) (Prod. No.
ALX-306-028
). Does not stimulate natural killer T (NKT) cells.
Product Specific Literature References
Chemoenzymatic Syntheses of iGb3 and Gb3:
Q. Yao et al.; Org. Lett.
8
, 911 (2006)
Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION
Solubilization
:
Our recommendation is to dissolve product in chloroform: abs. methanol 2:1.
Aliquot into glass tubes
, dry and store at 4°C. Resuspended in abs. methanol (at concentrations not higher than 1%) prior to cell assays.
Related Products
ALX-306-028
Isoglobotrihexosylceramide
Further Categories Containing This Product:
Ceramides / Cerebrosides / Sphingolipids / Related Products
ALX-850-021
Revised 17-Sep-07
Glucocorticoid Receptor Discovery Kit
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Glucocorticoids & Glucocorticoid Receptors / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-850-021-KI01
1 Set
367.00 USD
Product Specification
QUANTITY:
50 assays.
KIT/SET CONTAINS:
Recombinant human glucocorticoid receptor (full length) expressed in insect cells and enriched by ammonium sulfate precipitation, followed by dialysis in KED buffer with 20% glycerol.
Oligonucleotide double stranded DNA corresponding to the human tyrosine amino transferase gene response element:
5’...CTA GGC TGT ACA GGA TGT TCT GCC TAG...3’
3’...GAT CCG ACA TGT CCT ACA AGA CGG ATC...5’
APPLICATION:
Components of this kit may be used to perform gel shift assays or as a control for Western blot detection with anti-human glucocorticoid receptor antibodies (Prod. No.
ALX-210-155
,
ALX-210-131
or
ALX-210-153
).
Complete system can be used as a control system into which the researcher may introduce other components such as other putative response elements or other glucocorticoid receptors (mutants, from various tissue sources, etc.).
Recombinant protein may also be used to perform DNase I footprinting experiments or as a control in Western blot experiments or for
in vitro
transcription assays.
SHIPPING:
SHIPPED ON DRY ICE
LONG TERM STORAGE:
-80°C
HANDLING:
Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Detection Kits
ALX-157-014
Revised 14-Dec-04
H-Gly-Arg-Gly-Leu-Ser-Leu-Ser-Arg-OH
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
PKA Substrates
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-157-014-M001
1 mg
50.00 USD
ALX-157-014-M005
5 mg
200.00 USD
Product Specification
FORMULA:
C
34
H
64
N
14
O
11
MW:
845.0
PURITY:
≥98%
APPEARANCE:
White lyophilized powder.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Substrate for cAMP-dependent protein kinase (PKA). The peptide corresponds to the amino acid sequence 106-113 of the human myelin basic protein.
Product Specific Literature References
Synthetic substrate for cyclic AMP-dependent protein kinase:
P. Daile, et al.; Nature
257
, 416 (1975)
Abstract
Further Categories Containing This Product:
Peptides
ALX-157-013
Revised 04-Jul-03
[Ala9,10, Lys11,12]-Glycogen Synthase (1-12)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
PKC Substrates
Ordering Information
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ALX-157-013-M001
1 mg
80.00 USD
ALX-157-013-M005
5 mg
320.00 USD
Product Specification
SEQUENCE:
H-Pro-Leu-Ser-Arg-Thr-Leu-Ser-Val-Ala-Ala-Lys-Lys-OH
FORMULA:
C
56
H
103
N
17
O
16
MW:
1270.5
PURITY:
≥97%
APPEARANCE:
White lyophilized powder.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Substrate for protein kinase C (PKC). Peptide comprising the amino acid sequence of the glycogen synthase phosphorylation site.
Product Specific Literature References
The influence of basic residues on the substrate specificity of protein kinase C:
C. House, et al.; J. Biol. Chem.
262
, 772 (1987)
Abstract
;
Full Text
A tandem chromatographic column method for assaying cAMP-dependent protein kinase and protein kinase C with synthetic peptide substrates:
J.J. Egan, et al.; Anal. Biochem.
175
, 552 (1988)
Abstract
A protein kinase C pseudosubstrate peptide inhibits phosphorylation of the CD3 antigen in streptolysin-O-permeabilized human T lymphocytes:
D.R. Alexander, et al.; Biochem. J.
260
, 893 (1989)
Abstract
Further Categories Containing This Product:
Peptides
ALX-850-005
Revised 24-Feb-05
cGMP EIA Kit
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
PKG Kits
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-850-005-KI01
1 Kit
412.00 USD
Product Specification
QUANTITY:
96 wells (~80 tests).
APPLICATION:
For the measurement of cGMP.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
Further Categories Containing This Product:
Guanylyl Cyclases, Guanosine Phosphate Metabolism / Related Products
ELISA & EIA Kits
ALX-202-049
Revised 14-Jun-05
cGMP-dependent Protein Kinase Iα (bovine)
SYNONYMS
Protein Kinase G Iα (bovine)
cGK Iα (bovine)
PKG Iα (bovine)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
PKG
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-202-049-C005
5 µg
310.00 USD
Product Specification
MW:
~74kDa; monomer.
EC:
2.7.1.37
SOURCE/HOST:
Native protein isolated from bovine lung.
CONCENTRATION:
100µg/ml
PURITY:
≥95% (SDS-PAGE)
FORMULATION:
Liquid. In 10mM phosphate buffer, pH 6.8, containing 1mM EDTA, 15mM β-mercaptoethanol, 10U/ml Trasylol and 50% glycerol.
SPECIFIC ACTIVITY:
2U/mg protein. 10-fold stimulation by cGMP (5µM). One unit is defined as 1µmol/min/mg using VASPtide (RRKVSKQE) as substrate, under the following optimal conditions: 10mM HEPES, pH 7.4, containing 5mM MgCl
2
, 1mM DTE, 0.2mM EDTA.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
Product Specific Literature References
Immunological distinction between guanosine 3':5'-monophosphate- dependent and adenosine 3':5'-monophosphate-dependent protein kinases:
U. Walter, et al.; J. Biol. Chem.
255
, 3757 (1980)
Abstract
;
Full Text
General Information
BACKGROUND/TECHNICAL INFORMATION
Swiss-Prot link P00516:
cGMP-dependent Kinase Ia (bovine)
AfCS Signalling Gateway link A000043:
cGMP-dependent Kinase I (mouse)
Further Categories Containing This Product:
Enzymes
Natural Proteins
ALX-201-071
Revised 12-Jul-06
cGMP-dependent Protein Kinase Iβ (human) (recombinant)
SYNONYMS
Protein Kinase G Iβ (human) (recombinant)
cGK Iβ (bovine) (recombinant)
PKG Iβ (human) (recombinant)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
PKG
Ordering Information
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Format:
Size:
Unit Price:
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ALX-201-071-C005
5 µg
320.00 USD
Product Specification
MW:
~76kDa; monomer.
EC:
2.7.1.37
SOURCE/HOST:
Produced in Sf9 cells [1].
CONCENTRATION:
50µg/ml
PURITY:
≥95% (SDS-PAGE)
FORMULATION:
Liquid. In 20mM TRIS, pH 7.4, containing 1mM EDTA, 1mM β-mercaptoethanol, 100mM NaCl, 10U/ml trasylol and 50% glycerol.
SPECIFIC ACTIVITY:
~1.5-5U/mg protein. 25-fold stimulation by cGMP (5µM). One unit corresponds to 1µmol/mg/min using VASPtide (RRKVSKQE) as substrate under the following optimal conditions: 10mM HEPES, pH 7.4, containing 5mM MgCl
2
, 1mM DTE, 0.2mM EDTA.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Enzyme is relatively unstable. To prevent loss of activity when performing experiments, keep the stock vial of the enzyme on ice at all times. Enzyme loses activity during a single freeze/thaw cycle.
HANDLING:
After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Specific Literature References
[1]
Expression, purification, and characterization of the cGMP-dependent protein kinases I beta and II using the baculovirus system:
D. Pöhler, et al.; FEBS Lett.
374
, 419 (1995)
Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION
Swiss-Prot link P14619:
PKG Iβ (human)
AfCS Signalling Gateway link A000043:
PKG I (mouse)
Further Categories Containing This Product:
Enzymes
Recombinant Proteins / Fusion Proteins
ALX-201-072
Revised 06-Oct-06
cGMP-dependent Protein Kinase II (rat) (recombinant)
SYNONYMS
PKG II (rat) (recombinant)
cGK II (rat) (recombinant)
Protein Kinase G II (rat) (recombinant)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
PKG
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-201-072-C005
5 µg
320.00 USD
Product Specification
MW:
~86kDa; monomer.
EC:
2.7.1.37
SOURCE/HOST:
Produced in Sf9 cells [1].
CONCENTRATION:
50µg/ml
PURITY:
≥90% (SDS-PAGE)
FORMULATION:
Liquid. In 20mM TRIS, pH 7.4, containing 1mM EDTA, 5mM β-mercaptoethanol, 100mM NaCl, 10U/ml trasylol, 0.015% NP40 and 50% glycerol.
SPECIFIC ACTIVITY:
~0.5-2.0U/mg protein. 5-fold activation by cGMP (5µM). One unit corresponds to 1µmol/mg/min using VASPtide (RRKVSKQE) as substrate, under the following optimal conditions: 10mM HEPES (pH 7.4), 5mM MgCl
2
, 1mM DTE, 0.2mM EDTA.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
USE/STABILITY:
The enzyme is relatively unstable. To prevent loss of activity when performing experiments, keep the stock vial of the enzyme on ice (0-4°C) at all times. The enzyme loses activity during a single freeze/thaw cycle.
To avoid adherence of the product to plastic, the use of siliconized vials and tips is recommended.
HANDLING:
Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Product Specific Literature References
[1]
Expression, purification, and characterization of the cGMP-dependent protein kinases I beta and II using the baculovirus system:
D. Pöhler, et al.; FEBS Lett.
374
, 419 (1995)
Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION
Swiss-Prot link Q64595:
cGMP-dependent Kinase II (rat)
AfCS Signalling Gateway link A000044:
cGMP-dependent Kinase II (mouse)
Further Categories Containing This Product:
Enzymes
Recombinant Proteins / Fusion Proteins
ALX-270-021
Revised 03-Jul-08
Gö 6976
SYNONYMS
12-(2-Cyanoethyl)-6,7,12,13-tetrahydro-13-methyl-5-oxo-5
H
-indolo[2,3-a]pyrrolo[3,4-c]carbazole
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
PKC Inhibitors
Ordering Information
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ALX-270-021-MC05
0.5 mg
160.00 USD
Product Specification
FORMULA:
C
24
H
18
N
4
O
MW:
378.4
CAS NUMBER:
136194-77-9
PURITY:
≥95% (HPLC)
APPEARANCE:
Off-white to yellow solid.
SOLUBILITY:
Soluble in DMSO (25mg/ml).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stock solutions are stable for at least 3-4 months when stored at -20°C.
HANDLING:
Protect from light.
Product Description
Very potent protein kinase C (PKC) inhibitor with high selectivity for the PKC isotypes (α, β and γ). Potent antagonist of HIV-1 induction.
Product Specific Literature References
Non-glycosidic/non-aminoalkyl-substituted indolocarbazoles as inhibitors of protein kinase C:
J. Kleinschroth, et al.; Bioorg. Med. Chem. Lett
3
, 1959 (1993)
Selective inhibition of protein kinase C isozymes by the indolocarbazole Go 6976:
G. Martiny-Baron, et al.; J. Biol. Chem.
268
, 9194 (1993)
Abstract
;
Full Text
Go 6976, a selective inhibitor of protein kinase C, is a potent antagonist of human immunodeficiency virus 1 induction from latent/low- level-producing reservoir cells in vitro:
K.O. Qatsha, et al.; PNAS
90
, 4674 (1993)
Abstract
N-protein kinase C isoenzymes may be involved in the regulation of various neutrophil functions:
K. Wenzel-Seifert, et al.; BBRC
200
, 1536 (1994)
Abstract
Atypical isoforms of pKc and insulin secretion from pancreatic beta- cells: evidence using Go 6976 and Ro 31-8220 as Pkc inhibitors:
T.E. Harris, et al.; BBRC
227
, 672 (1996)
Abstract
ALX-350-307
Revised 05-Apr-08
Gonyautoxin 2/3 Epimers
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Neurotoxins
Ordering Information
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ALX-350-307-C010
10 µg
230.00 USD
Product Specification
FORMULA:
C
10
H
17
N
7
O
8
S
MW:
395.4
CAS NUMBER:
60508-89-6 (GTX II); 60537-65-7 (GTX III)
SOURCE/HOST:
Isolated from
Alexandrium tamarense
.
CONCENTRATION:
~5.08µg/ml (GTX II); ~1.96µg/ml (GTX III)
PURITY:
≥95%
APPEARANCE:
Liquid. Solution in 0.3M acetic acid.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HAZARD:
TOXIC.
