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Receptors
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ALX-550-315 Revised 22-Aug-02
2-Bromomelatonin
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PRODUCT LINE Neurobiology
PRODUCT CATEGORY Melatonin Receptors / Related Products
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ALX-550-315-M001   1 mg 60.00 USD Add To Cart
Product Specification
FORMULA: C13H16N2O2Br
MW: 312.2
PURITY: ≥95%
APPEARANCE: Yellow solid.
SOLUBILITY: Soluble in ethyl acetate.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
Melatonin agonist with high affinity for chicken brain membrane melatonin receptors.
Product Specific Literature References
2-Bromomelatonin: synthesis and characterization of a potent melatonin agonist: E. Duranti, et al.; Life Sci. 51, 479 (1992) Abstract
2-Substituted 5-methoxy-N-acyltryptamines: synthesis, binding affinity for the melatonin receptor, and evaluation of the biological activity: G. Spadoni, et al.; J. Med. Chem. 36, 4069 (1993) Abstract
 
 
ALX-550-524 Revised 19-Jul-07
1,3-bis(4-Bromophenyl)-5-phenyl-2,4-imidazolidinedione
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SYNONYMS Compound 25
CB1 Cannabinoid Receptor Inverse Agonist
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Cannabinoid Receptor Agonists & Antagonists / Related Products
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ALX-550-524-M005   5 mg 25.00 USD Add To Cart
Product Specification
FORMULA: C21H14Br2N2O2
MW: 486.2
CAS NUMBER: 878533-35-8
PURITY: ≥98%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in DMSO or dimethyl formamide; sparingly soluble in aqueous buffers.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 2 years after receipt when stored at -20°C.

Product Description
Potent and selective inverse agonist of CB1 receptor (Ki=243nM and EC50=195nM).
Product Specific Literature References
Synthesis and activity of 1,3,5-triphenylimidazolidine-2,4-diones and 1,3,5-triphenyl-2-thioxoimidazolidin-4-ones: characterization of new CB1 cannabinoid receptor inverse agonists/antagonists: G.G. Muccioli, et al.; J. Med. Chem. 49, 872 (2006) Abstract
 
 
ALX-630-075 Revised 10-Oct-08
α-Bungarotoxin
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SYNONYMS α-BuTx
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Neurotoxins
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ALX-630-075-M001   1 mg 65.00 USD Add To Cart
Product Specification
SEQUENCE: H-Ile-Val-Cys-His-Thr-Thr-Ala-Thr-Ser-Pro-Ile-Ser-Ala-Val-Thr-Cys-Pro-Pro-Gly-Glu-Asn-Leu-Cys-Tyr-Arg-Lys-Met-Trp-Cys-Asp-Ala-Phe-Cys-Ser-Ser-Arg-Gly-Lys-Val-Val-Glu-Leu-Gly-Cys-Ala-Ala-Thr-Cys-Pro-Ser-Lys-Lys-Pro-Tyr-Glu-Glu-Val-Thr-Cys-Cys-Ser-Thr-Asp-Lys-Cys-Asn-Pro-His-Pro-Lys-Gln-Arg-Pro-Gly-OH
(Disulfide bonds between Cys3-Cys23, Cys16-Cys44, Cys29-Cys33, Cys48-Cys59 and Cys60-Cys65)
MW: 7984.2
CAS NUMBER: 11032-79-4
MERCK INDEX: 14: 1488
RTECS: EI6201400
SOURCE/HOST: Isolated from Bungarus multicinctus.
PURITY: ≥98%
APPEARANCE: Lyophilized.
SOLUBILITY: Soluble in water or aqueous buffers.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: HARMFUL.
Product Description
Post-synaptic neurotoxin that binds irreversibly to acetylcholine receptor sites, producing neuromuscular blockade and skeletal muscle paralysis. Prevents opening of nicotinic receptor-associated ion channels.
Product Specific Literature References
Use of a snake venom toxin to characterize the cholinergic receptor protein: J.P. Changeux, et al.; PNAS 67, 1241 (1970) Abstract
Amino acid sequence of alpha-bungarotoxin from the venom of Bungarus multicinctus: D. Mebs, et al.; BBRC 44, 711 (1971) Abstract
Elapid neurotoxins. Purification, characterization, and immunochemical studies of alpha-bungarotoxin: D.G. Clark, et al.; Biochemistry 11, 1663 (1972) Abstract
Purification, properties and amino acid sequence of alpha-bungarotoxin from the venom of Bungarus multicinctus: D. Mebs, et al.; Hoppe Seylers Z. Physiol. Chem. 353, 243 (1972) Abstract
alpha-Bungarotoxin binding sites in the CNS: B.J. Morley, et al.; Life Sci. 24, 859 (1979) Abstract
Alpha-bungarotoxin binding and central nervous system nicotinic acetylcholine receptors: R.E. Oswald & J.A. Freeman; Neuroscience 6, 1 (1981) Abstract
Determination of the primary amino acid sequence specifying the alpha-bungarotoxin binding site on the alpha subunit of the acetylcholine receptor from Torpedo californica: P.T. Wilson, et al.; PNAS 82, 8790 (1985) Abstract
The crystal structure of alpha-bungarotoxin at 2.5 A resolution: relation to solution structure and binding to acetylcholine receptor: R.A. Love & R.M. Stroud; Protein Eng. 1, 37 (1986) Abstract
Neuronal nicotinic alpha-bungarotoxin sites: M. Quik & S. Geertsen; Can. J. Physiol. Pharmacol. 66, 971 (1988) Abstract
The fall and rise of neuronal alpha-bungarotoxin binding proteins: P.B. Clarke; TIPS 13, 407 (1992), (Review) Abstract
Three subtypes of alpha-bungarotoxin-sensitive nicotinic acetylcholine receptors are expressed in chick retina: K.T. Keyser, et al.; J. Neurosci. 13, 442 (1993) Abstract
Neuronal acetylcholine receptors that bind alpha-bungarotoxin mediate neurite retraction in a calcium-dependent manner: P.C. Pugh and D.K. Berg; J. Neurosci. 14, 889 (1994) Abstract
The alpha-bungarotoxin binding site on the nicotinic acetylcholine receptor: analysis using a phage-epitope library: M. Balass, et al.; PNAS 94, 6054 (1997) Abstract
Nicotine blocks TNF-alpha-mediated neuroprotection to NMDA by an alpha-bungarotoxin-sensitive pathway: N.G. Carlson, et al.; J. Neurobiol. 35, 29 (1998) Abstract
Alpha-Bungarotoxin binding to human muscle acetylcholine receptor measurement of affinity, delineation of AChR subunit residues crucial to binding, and protection of AChR function by synthetic peptide: A. Vincent, et al.; Neurochem. Int. 32, 427 (1998) Abstract
Alpha-bungarotoxin binding to acetylcholine receptor membranes studied by low angle X-ray diffraction: H.S. Young, et al.; Biophys. J. 83, 943 (2003) Abstract
Imaging of receptor trafficking by using alpha-bungarotoxin-binding-site-tagged receptors: Y. Sekine-Aizawa & R. L. Huganir; PNAS 101, 17114 (2004) Abstract
The cholinergic antagonist alpha-bungarotoxin also binds and blocks a subset of GABA receptors: C.M. McCann, et al.; PNAS 103, 5149 (2006) Abstract
MD and NMR studies of alpha-bungarotoxin surface accessibility: V. Venditti, et al.; Biochem. Biophys. Res. Commun . 356, 114 (2007) Abstract
Further Categories Containing This Product:
Acetylcholine Receptors (Nicotinic) / Related Products
 
 
ALX-550-144 Revised 09-Dec-04
Buspirone . hydrochloride
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SYNONYMS 8-[4-[4-(2-Pyrimidinyl)-1-piperazinyl]butyl]-8-azaspiro[4,5]decane-7,9-dione . HCl
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Serotonergics & Serotonin Receptors / Related Products
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ALX-550-144-G001   1 g 48.00 USD Add To Cart
Product Specification
FORMULA: C21H31N5O2 . HCl
MW: 385.5 . 36.5
CAS NUMBER: 33386-08-2
MERCK INDEX: 14: 1504
PURITY: ≥96%
APPEARANCE: White solid.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HAZARD: TOXIC.

Product Description
5-HT1A serotonin receptor agonist.
Product Specific Literature References
The discovery and development of buspirone: a new approach to the treatment of anxiety: J.S. New; Med. Res. Rev. 10, 283 (1990), (Review) Abstract
Further Categories Containing This Product:
Dopaminergics & Dopamine Receptors / Related Products • Benzodiazepines / Related Products • Adrenergics & Adrenergic Receptors / Related Products
 
 
ALX-350-246 Revised 07-Oct-08
Butein
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SYNONYMS 2',3,4,4'-Tetrahydroxychalcone
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Protein Kinase Inhibitors
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ALX-350-246-M010   10 mg 190.00 USD Add To Cart
Product Specification
FORMULA: C15H12O5
MW: 272.3
CAS NUMBER: 487-52-5
PURITY: ≥98% (HPLC)
APPEARANCE: Yellow solid.
SOLUBILITY: Soluble in DMSO (>50mg/ml) or methanol; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light. Keep cool and dry under inert gas.
IDENTITY: Identity determined by 1H-NMR, 13C-NMR and MS.

Product Description
Plant polyphenol. Specific tyrosine kinase inhibitor. Potently inhibits the tyrosine kinase activity of the EGF receptor and p60c-src. Potent antioxidant and anti-inflammatory agent. Inhibits glutathione reductase and rat liver glutathione S-transferase. Activator of human deacetylase SIRT1. Inhibits aromatase, showing chemopreventive properties. Directly inhibits IKK.
Product Specific Literature References
Inhibition of 12-O-tetradecanoylphorbol-13-acetate-mediated epidermal ornithine decarboxylase induction and skin tumor promotion by new lipoxygenase inhibitors lacking protein kinase C inhibitory effects: E. Aizu, et al.; Carcinogenesis 7, 1809 (1986) Abstract
Protective effects of hydroxychalcones on free radical-induced cell damage: S. Sogawa, et al.; Biol. Pharm. Bull. 17, 251 (1994) Abstract
Cytotoxic effect of butein on human colon adenocarcinoma cell proliferation: C.C. Yit & N.P. Das; Cancer Lett. 82, 65 (1994) Abstract
Inhibitory effects of plant polyphenols on rat liver glutathione S-transferase: K. Zhang & N.P. Das; Biochem. Pharmacol. 47, 2063 (1994) Abstract
Endothelium-dependent relaxation of rat aorta by butein, a novel cyclic AMP-specific phosphodiesterase inhibitor: S.M. Yu, et al.; Eur. J. Pharmacol. 280, 69 (1995) Abstract
Butein (3,4,2',4'-tetrahydroxychalcone) ameliorates experimantal anti-glomerular basement membrane antibody-associated glomerulonephritis (3): K. Hayashi, et al.; Eur. J. Pharmacol. 316, 297 (1996) Abstract
Inhibition of glutathione reductase by plant polyphenols: K. Zhang, et al.; Biochem. Pharmacol 54, 1047 (1997) Abstract
Butein, a specific protein tyrosine kinase inhibitor: E.-B. Yang, et al.; BBRC 245, 435 (1998) Abstract
Antioxidant properties of butein isolated from Dalbergia odorifera: Z.J. Cheng, et al.; Biochim. Biophys. Acta 1392, 291 (1998) Abstract
Flavonoids inhibit cell growth and induce apoptosis in B16 melanoma 4A5 cells: K. Iwashita, et al.; Biosci. Biotechnol. Biochem. 64, 1813 (2000) Abstract
Butein, a plant polyphenol, induces apoptosis concomitant with increased caspase-3 activity, decreased Bcl-2 expression and increased Bax expression in HL-60 cells: N.Y. Kim, et al.; Pharmacol. Toxicol. 88, 261 (2001) Abstract
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan: K.T. Howitz, et al.; Nature 425, 191 (2003) Abstract
The plant polyphenol butein inhibits testosterone-induced proliferation in breast cancer cells expressing aromatase: Y. Wang, et al.; Life Sci. 77, 39 (2005) Abstract
Butein, a tetrahydroxychalcone, inhibits nuclear factor (NF)-kappaB and NF-kappaB-regulated gene expression through direct inhibition of IkappaBalpha kinase beta on cysteine 179 residue: M.K. Pandey, et al.; J. Biol. Chem. 282, 17340 (2007) Abstract
Further Categories Containing This Product:
Tyrosine Kinase Inhibitors • Natural Products - Anti-inflammatory Agents • EGFR Kinase Inhibitors • Glutathione / Related Products • Chalcones • Phosphodiesterases / Related Products • Natural Products - Chemopreventive Agents • Glutathione S-Transferase • Sirtuins / Related Products • Natural Products - Antioxidants • IkB Kinases [IKKs] / Related Products
 
 
ALX-550-197 Revised 03-Mar-05
(S)-3C4H-PG
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SYNONYMS (S)-3-Carboxy-4-hydroxyphenylglycine
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Glutamate Receptors (Metabotropic) / Related Products
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ALX-550-197-M001   1 mg 50.00 USD Add To Cart
ALX-550-197-M005   5 mg 195.00 USD Add To Cart
Product Specification
FORMULA: C9H9NO5
MW: 211.2
CAS NUMBER: 55136-48-6
PURITY: ≥97%
APPEARANCE: White powder.
SOLUBILITY: Soluble in dilute aqueous base.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C

Product Description
Mixed group I mGluR antagonist and group II mGluR agonist.
Product Specific Literature References
Structure-activity relationships of new agonists and antagonists of different metabotropic glutamate receptor subtypes: N. Sekiyama, et al.; Br. J. Pharmacol. 117, 1493 (1996) Abstract
Phenylglycine derivatives as antagonists of metabotropic glutamate receptors: J. Watkins and G. Collingridge; TIPS 15, 333 (1994), (Review) Abstract
Pharmacological agents acting at subtypes of metabotropic glutamate receptors: D.D. Schoepp, et al.; Neuropharmacology 38, 1431 (1999), (Review) Abstract
 
 
ALX-550-196 Revised 03-Mar-05
(RS)-3C4H-PG
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SYNONYMS (RS)-3-Carboxy-4-hydroxyphenylglycine
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Glutamate Receptors (Metabotropic) / Related Products
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ALX-550-196-M001   1 mg 30.00 USD Add To Cart
ALX-550-196-M005   5 mg 120.00 USD Add To Cart
Product Specification
FORMULA: C9H9NO5
MW: 211.2
CAS NUMBER: 64043-84-1
PURITY: ≥97%
APPEARANCE: White powder.
SOLUBILITY: Soluble in dilute aqueous base.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Specific Literature References
Phenylglycine derivatives as antagonists of metabotropic glutamate receptors: J. Watkins & G. Collingridge; TIPS 15, 333 (1994), (Review) Abstract
Pharmacological agents acting at subtypes of metabotropic glutamate receptors: D.D. Schoepp, et al.; Neuropharmacology 38, 1431 (1999), (Review) Abstract
 
 
ALX-550-119 Revised 03-Mar-05
(S)-4C3H-PG
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SYNONYMS (S)-4-Carboxy-3-hydroxyphenylglycine
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Glutamate Receptors (Metabotropic) / Related Products
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ALX-550-119-M001   1 mg 45.00 USD Add To Cart
ALX-550-119-M005   5 mg 180.00 USD Add To Cart
Product Specification
FORMULA: C9H9NO5
MW: 211.2
CAS NUMBER: 85148-82-9
PURITY: ≥98%
APPEARANCE: White powder.
SOLUBILITY: Soluble in dilute aqueous base.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C

Product Description
Agonist for group II mGluRs. Competitive antagonist for group I mGluR1; mixed effects at mGluR5.
Product Specific Literature References
Phenylglycine derivatives as new pharmacological tools for investigating the role of metabotropic glutamate receptors in the central nervous system: E.F. Birse, et al.; Neuroscience 52, 481 (1993) Abstract
The metabotropic glutamate receptor antagonist (+)-alpha-methyl-4- carboxyphenylglycine protects hippocampal CA1 neurons of the rat from in vitro hypoxia/hypoglycemia: T. Opitz, et al.; Neuropharmacology 33, 715 (1994) Abstract
Actions of phenylglycine analogs at subtypes of the metabotropic glutamate receptor family: C. Thomsen, et al.; Eur. J. Pharmacol. 267, 77 (1994) Abstract
Phenylglycine derivatives as antagonists of metabotropic glutamate receptors: J. Watkins & G. Collingridge; TIPS 15, 333 (1994), (Review) Abstract
Pharmacological analysis of 4-carboxyphenylglycine derivatives: comparison of effects on mGluR1 alpha and mGluR5a subtypes: A.E. Kingston, et al.; Neuropharmacology 34, 887 (1995) Abstract
Metabotropic receptors in excitotoxicity: (S)-4-carboxy-3- hydroxyphenylglycine ((S)-4C3HPG) protects against rat striatal quinolinic acid lesions: L.R. Orlando, et al.; Neurosci. Lett. 202, 109 (1995) Abstract
Structure-activity relationships of new agonists and antagonists of different metabotropic glutamate receptor subtypes: N. Sekiyama, et al.; Br. J. Pharmacol. 117, 1493 (1996) Abstract
(S)-4-carboxy-3-hydroxyphenylglycine activates phosphatidyl inositol linked metabotropic glutamate receptors in different brain regions of the neonatal rat: A.I. Sacaan, et al.; Neurochem. Int. 32, 77 (1998) Abstract
Pharmacological agents acting at subtypes of metabotropic glutamate receptors: D.D. Schoepp, et al.; Neuropharmacology 38, 1431 (1999), (Review) Abstract
 
 
ALX-550-198 Revised 03-Mar-05
(RS)-4C3H-PG
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SYNONYMS (RS)-4-Carboxy-3-hydroxyphenylglycine
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Glutamate Receptors (Metabotropic) / Related Products
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ALX-550-198-M001   1 mg 20.00 USD Add To Cart
ALX-550-198-M005   5 mg 50.00 USD Add To Cart
Product Specification
FORMULA: C9H9NO5
MW: 211.2
CAS NUMBER: 134052-66-7
PURITY: ≥97%
APPEARANCE: White powder.
SOLUBILITY: Soluble in dilute aqueous base.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C

Product Specific Literature References
Phenylglycine derivatives as antagonists of metabotropic glutamate receptors: J. Watkins & G. Collingridge; TIPS 15, 333 (1994), (Review) Abstract
Pharmacological agents acting at subtypes of metabotropic glutamate receptors: D.D. Schoepp, et al.; Neuropharmacology 38, 1431 (1999), (Review) Abstract
 
 
ALX-550-313 Revised 06-Dec-04
t-CAA
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SYNONYMS (+)-trans-2-Carboxyazetidine-3-acetic acid
(2S,3S)-trans-3-(Carboxymethyl)azetidine-2-carboxylic acid
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Glutamate Receptors (Metabotropic) / Related Products
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ALX-550-313-M001   1 mg 80.00 USD Add To Cart
Product Specification
FORMULA: C6H9NO4
MW: 159.1
PURITY: ≥98%
APPEARANCE: Off-white solid.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
A potent in vivo inhibitor of glutamate uptake. Kainate receptor agonist.
Product Specific Literature References
Synthesis and biology of the rigidified glutamate analogue, trans-2-carboxyazetidine-3-acetic acid (t-CAA): A.P. Kozikowski, et al.; Bioorg. Med. Chem. Lett. 6, 2559 (1996)