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Ecdysteroids
You are here: Product Lines > Signal Transduction > Hormones & Hormone Receptors / Related Products > Ecdysteroids
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ALX-370-010 Revised 21-May-08
Muristerone A
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SYNONYMS 2β,3β,5β,11α,14α,20R,22R-Heptahydroxycholest-7-en-6-one
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Ecdysteroids
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-370-010-C100   100 µg 28.00 USD Add To Cart
ALX-370-010-C250   250 µg 50.00 USD Add To Cart
ALX-370-010-C500   500 µg 80.00 USD Add To Cart
ALX-370-010-M001   1 mg 140.00 USD Add To Cart
Product Specification
FORMULA: C27H44O8
MW: 496.6
CAS NUMBER: 38778-30-2
PURITY: ≥94%
APPEARANCE: White to off-white crystals.
SOLUBILITY: Soluble in methanol, 100% ethanol, acetic acid or DMSO. Insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description

Ecdysteroid. Due to reduced availability we recommend the alternative use of ponasterone A (Prod. No. ALX-370-014).
Product Specific Literature References
Structure of muri-sterone A, a new phytoecdysone: L. Canonica, et al.; J. C. S. Chem. Commun. 1060 (1972)
A novel method of isolation of phytoecdysones from kaladana seeds: L. Canonica, et al.; Phytochemistry 14, 525 (1975)
New phytoecdysones from kaladana. I. Structure of muristerone A and kaladasterone: L. Canonica, et al.; Gazz. Chim. Ital. 107, 123 (1977)
Ecdysone-inducible gene expression in mammalian cells and transgenic mice: D. No, et al.; PNAS 93, 3346 (1996) Abstract
The ecdysone inducible gene expression system: unexpected effects of muristerone A and ponasterone A on cytokine signaling in mammalian cells: S. Constantino, et al.; Eur. Cytokine Netw. 12, 365 (2001) Abstract
Selected technologies to control genes and their products for experimental and clinical purposes: H.K. Alexander, et al.; Arch. Immunol. Ther. Exp. (Warsz.) 55, 139 (2007), Review Abstract
Further Categories Containing This Product:
Expression Systems / Related Products
 
 
ALX-370-011 Revised 07-Jan-08
Ecdysone
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SYNONYMS α-Ecdysone
2β,3β,14α,22R,25-Pentahydroxy-5β-cholest-7-en-6-one
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Ecdysteroids
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-370-011-M001   1 mg 48.00 USD Add To Cart
ALX-370-011-M005   5 mg 150.00 USD Add To Cart
ALX-370-011-M010   10 mg 240.00 USD Add To Cart
Product Specification
FORMULA: C27H44O6
MW: 464.6
CAS NUMBER: 3604-87-3
MERCK INDEX: 14: 3491
PURITY: ≥95%
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in methanol, 100% ethanol, acetic acid or DMSO. Sparingly soluble in chloroform. Insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Ecdysteroid first described as moulting hormone in insects.
Product Specific Literature References
P. Karlon, et al.; J. Liebig's Ann. Chem. 662, 1 (1963)
[Ecdysone as companion substance of ecdysterone in Polypodium vulgare L]: G. Heinrich & H. Hoffmeister; Experientia 23, 995 (1967), (Article in German) Abstract
L. Canonica, et al.; Phytochemistry 14, 525 (1975)
Hormones, puffs and flies: the molecular control of metamorphosis by ecdysone: A.J. Andres & C.S. Thummel; Trends Genet. 8, 132 (1992), Review Abstract
Ecdysone signaling cascade and regulation of Drosophila metamorphosis: E.H. Baehrecke; Arch. Insect Biochem. Physiol. 33, 231 (1996), Review Abstract
Further Categories Containing This Product:
Expression Systems / Related Products
 
 
ALX-370-012 Revised 09-Oct-07
20-Hydroxyecdysone
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SYNONYMS β-Ecdysone
2β,3β,14α,20R,22R,25-Hexahydroxy-5β-cholest-7-en-6-one
Ecdysterone
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Ecdysteroids
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-370-012-M005   5 mg 55.00 USD Add To Cart
ALX-370-012-M010   10 mg 90.00 USD Add To Cart
ALX-370-012-M050   50 mg 350.00 USD Add To Cart
Product Specification
FORMULA: C27H44O7
MW: 480.6
CAS NUMBER: 5289-74-7
MERCK INDEX: 14: 3491
PURITY: ≥95%
APPEARANCE: White powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Most widely occurring ecdysteroid in both plant and animal species. Controls cell death during metamorphosis of Drosophila melanogaster.
Product Specific Literature References
H. Hampshire and D.H.S. Horn; Chem. Commun. 37 (1966)
M.N. Galbraith and D.H.S. Horn; Chem. Commun. 905 (1966)
H. Rimpler and G. Schulz; THL 22, 2033 (1967)
L. Canonica, et al.; Phytochemistry 14, 525 (1975)
Fork head controls the timing and tissue selectivity of steroid-induced developmental cell death: C. Cao, et al.; J. Cell Biol. 176, 843 (2007) Abstract
Further Categories Containing This Product:
Forkhead Box [FOX] Proteins / Related Products • Non-apoptotic Cell Death / Necrosis
 
 
ALX-370-013 Revised 07-Jan-08
Makisterone A
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SYNONYMS 2β,3β,14α,20R,22R,25-Hexahydroxy-5β-24R-ergost-7-en-6-one
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Ecdysteroids
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-370-013-C250   250 µg 38.00 USD Add To Cart
ALX-370-013-M001   1 mg 105.00 USD Add To Cart
Product Specification
FORMULA: C28H46O7
MW: 494.7
CAS NUMBER: 20137-14-8
PURITY: ≥95%
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in methanol, 100% ethanol, acetic acid or DMSO. Sparingly soluble in chloroform. Insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Ecdysteroid.
Product Specific Literature References
The determination of absolute configuration at C-24 of the phytoecdysone makisterone A: B. Danieli, et al.; J. C. S. Chem. Commun. 745 (1974)
A novel method of isolation of phytoecdysones from kaladana seeds: L. Canonica, et al.; Phytochemistry 14, 525 (1975)
Evidence for the presence of makisterone A in Drosophila larvae and the secretion of 20-deoxymakisterone A by the ring gland: C.P. Redfern; PNAS 81, 5643 (1984) Abstract
Ecdysteroids increase the yield of recombinant protein produced in baculovirus insect cell expression system: M. Sarvari, et al.; BBRC 167, 1154 (1990) Abstract
Ecdysteroids of quinoa seeds (Chenopodium quinoa Willd.): N. Zhu, et al.; J. Agric. Food Chem. 49, 2576 (2001) Abstract
Further Categories Containing This Product:
Expression Systems / Related Products
 
 
ALX-370-014 Revised 16-May-08
Ponasterone A
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SYNONYMS 25-Deoxy-20-hydroxyecdysone
25-Deoxyecdysterone
2β,3β,14α,20R,22R-Pentahydroxy-5β-cholest-7-en-6-one
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Ecdysteroids
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-370-014-M001   1 mg 45.00 USD Add To Cart
ALX-370-014-M005   5 mg 180.00 USD Add To Cart
ALX-370-014-M100   100 mg 2'800.00 USD Add To Cart
Product Specification
FORMULA: C27H44O6
MW: 464.6
CAS NUMBER: 13408-56-5
MERCK INDEX: 14: 7588
SOURCE/HOST: Synthetic.
PURITY: ≥95% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in acetic acid, 100% ethanol, methanol or DMSO; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: To prepare a 1mM stock solution (1.1mM) in 100% ethanol: Add 2ml of 100% ethanol to 1mg (2µmol). Gently mix to dissolve the product (5 to 10 min.). Do not heat solution to dissolve the product. Store the 1mM stock solution at +4°C or at -20°C.

Product Description
A member of the ecdysteroid family. Analog of ecdysone (Prod. No. ALX-370-011) with similar properties to muristerone A (Prod. No. ALX-370-010). It is a functional, reliable and economical substitute for muristerone A as an inducer for the ecdysone-inducible mammalian expression system. Results show that ponasterone A was able to induce expression of β-galactosidase to levels similar to those obtained with muristerone A induction.
Product Specific Literature References
K. Nakanishi, et al.; Chem. Commun. 915 (1966)
H. Moriyama, et al.; THL 9, 1111 (1968)
K. Nakanishi, et al.; Bull. Soc. Chim. France 3475 (1969), (Review)
The uptake and release of ponasterone A by the Kc cell line of Drosophila melanogaster: C. Beckers, et al.; Mol. Cell. Endocrinol. 17, 51 (1980) Abstract
Past and present studies with ponasterones, the first insect molting hormones from plants: K. Nakanishi; Steroids 57, 649 (1992) Abstract
Identification of ligands and coligands for the ecdysone-regulated gene switch: E. Saez, et al.; PNAS 97, 14512 (2000) Abstract
Recent advances in inducible expression in transgenic mice: C. Albanese, et al.; Semin. Cell. Dev. Biol. 13, 129 (2002) Abstract
Development of a ponasterone A-inducible gene expression system for application in cultured skeletal muscle cells: Y.Y. Xiao, et al.; Int. J. Biochem. Cell. Biol. 35, 79 (2003) Abstract
Further Categories Containing This Product:
Expression Systems / Related Products
 
 
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