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ALX-630-055 Revised 10-Oct-08
ω-Conotoxin GVIA
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Neurotoxins
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-630-055-C500   500 µg 790.00 USD Add To Cart
Product Specification
SEQUENCE: H-Cys-Lys-Ser-Hyp-Gly-Ser-Ser-Cys-Ser-Hyp-Thr-Ser-Tyr-Asn-Cys-Cys-Arg-Ser-Cys-Asn-Hyp-Tyr-Thr-Lys-Arg-Cys-Tyr-NH2
(Disulfide bonds between Cys1-Cys16, Cys8-Cys19and Cys15-Cys26)
FORMULA: C120H182N38O43S6
MW: 3037.3
CAS NUMBER: 106375-28-4
SOURCE/HOST: Synthetic. Originally isolated from Conus geographus.
QUANTITY:  
CONCENTRATION: 0.1mM after reconstitution.
PURITY: ≥97%
APPEARANCE: Lyophilized.
SOLUBILITY: Soluble in water.
RECONSTITUTION: Do not remove the cap. Inject distilled water into the vial using a calibrated syringe. Dissolve all contents thoroughly.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 1 year after receipt when stored at -20°C. The aqueous solution is stable for a few weeks when stored at -20°C.
HANDLING: After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
HAZARD: VERY TOXIC.
Product Description
Neurotoxin. Potent and selective blocker of neuronal N-type, voltage-dependent Ca2+ channels. Not for sale in U.S.A.
Product Specific Literature References
Peptide neurotoxins from fish-hunting cone snails: B.M. Olivera, et al.; Science 230, 1338 (1985) Abstract
Characterization of the omega-conotoxin target. Evidence for tissue-specific heterogeneity in calcium channel types: L.J. Cruz, et al.; Biochemistry 26, 820 (1987) Abstract
Presynaptic Ca-antagonist omega-conotoxin irreversibly blocks N-type Ca-channels in chick sensory neurons: H. Kasai, et al.; Neurosci. Res. 4, 228 (1987) Abstract
Omega-conotoxin: direct and persistent blockade of specific types of calcium channels in neurons but not muscle: E.W. McCleskey, et al.; PNAS 84, 4327 (1987) Abstract
Omega-conotoxin-sensitive voltage-operated calcium channels in vertebrate cells: E. Sher & F. Clementi; Neuroscience 42, 301 (1991) Abstract
omega-Conotoxin GVIA receptors of Discopyge electric organ. Characterization of omega-conotoxin binding to the nicotinic acetylcholine receptor: W.A. Horne, et al.; J. Biol. Chem. 266, 13719 (1991) Abstract; Full Text
Conotoxins: B.M. Olivera, et al.; J. Biol. Chem. 266, 22067 (1991), (Minireview) Abstract; Full Text
Solution structure of omega-conotoxin GVIA using 2-D NMR spectroscopy and relaxation matrix analysis: J.H. Davis, et al.; Biochemistry 32, 7396 (1993) Abstract
Preparation and characterization of biotinylated analogs of the calcium channel blocker omega-conotoxin: O.T. Jones & A.P. So; Anal. Biochem. 214, 227 (1993), (Biotinylation) Abstract
Structural determinants of the blockade of N-type calcium channels by a peptide neurotoxin: P.T. Ellinor, et al.; Nature 372, 272 (1994) Abstract
Calcium channel diversity and neurotransmitter release: the omega-conotoxins and omega-agatoxins: B.M. Olivera, et al.; Annu. Rev. Biochem. 63, 823 (1994), (Review) Abstract
Exocytotic Ca2+ channels in mammalian central neurons: K. Dunlap, et al.; TINS 18, 89 (1995) Abstract
Structure-activity relationships of omega-conotoxins at N-type voltage-sensitive calcium channels: K.J. Nielsen, et al.; J. Mol. Recognit. 13, 55 (2000), (Review) Abstract
Rapid and reversible block of N-type calcium channels (CaV 2.2) by omega-conotoxin GVIA in the absence of divalent cations: H. Liang & K. S. Elmslie; J. Neurosci. 22, 8884 (2002) Abstract
Further Categories Containing This Product:
Peptides • Ca2+ Channels (N-type) • Marine Natural Products
 
 
ALX-630-056 Revised 14-Oct-08
ω-Conotoxin MVIIA
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SYNONYMS Ziconotide
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Neurotoxins
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ALX-630-056-C500   500 µg 640.00 USD Add To Cart
Product Specification
SEQUENCE: H-Cys-Lys-Gly-Lys-Gly-Ala-Lys-Cys-Ser-Arg-Leu-Met-Tyr-Asp-Cys-Cys-Thr-Gly-Ser-Cys-Arg-Ser-Gly-Lys-Cys-NH2
(Disulfide bonds between Cys1-Cys16, Cys8-Cys20and Cys15-Cys25)
FORMULA: C102H169N36O32S7
MW: 2636.2
CAS NUMBER: 107452-89-1
SOURCE/HOST: Synthetic. Originally isolated from Conus magus.
PURITY: ≥97%
APPEARANCE: Lyophilized.
SOLUBILITY: Soluble in water.
RECONSTITUTION: Do not remove the cap. Inject distilled water into the vial using a calibrated syringe. Dissolve all contents thoroughly to receive a 0.1mM solution.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for 1 year when stored at -20°C. After reconstitution, stable for up to 2 weeks when stored at +4°C; up to 3 months when stored at -20°C.
HANDLING: After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
HAZARD: VERY TOXIC.
Product Description
Neurotoxin. Selectively and reversibly blocks the n-type, voltage gated Ca2+ channels. Not for sale in U.S.A.
Product Specific Literature References
Neuronal calcium channel antagonists. Discrimination between calcium channel subtypes using omega-conotoxin from Conus magus venom: B.M. Olivera, et al.; Biochemistry 26, 2086 (1987) Abstract
Conotoxins: B.M. Olivera, et al.; J. Biol. Chem. 266, 22067 (1991), (Minireview) Abstract; Full Text
A selective N-type calcium channel antagonist protects against neuronal loss after global cerebral ischemia: K. Valentino, et al.; PNAS 90, 7894 (1993) Abstract
Calcium channel diversity and neurotransmitter release: the omega-conotoxins and omega-agatoxins: B.M. Olivera, et al.; Ann. Rev. Biochem. 63, 823 (1994), (Review) Abstract
Three-dimensional structure in solution of the calcium channel blocker omega-conotoxin MVIIA: T. Kohno, et al.; Biochemistry 34, 10256 (1995) Abstract
A consensus structure for omega-conotoxins with different selectivities for voltage-sensitive calcium channel subtypes: comparison of MVIIA, SVIB and SNX-202: K.J. Nielsen, et al.; J. Mol. Biol. 263, 297 (1996) Abstract
Pharmacotherapeutic potential of omega-conotoxin MVIIA (SNX-111), an N-type neuronal calcium channel blocker found in the venom of Conus magus: S. S. Bowersox & R. Luther; Toxicon 36, 1651 (1998) Abstract
Structure-activity relationships of omega-conotoxins at N-type voltage-sensitive calcium channels: K.J. Nielsen, et al.; J. Mol. Recognit. 13, 55 (2000), (Review) Abstract
Further Categories Containing This Product:
Peptides • Ca2+ Channels (N-type) • Marine Natural Products
 
 
ALX-630-057 Revised 10-Oct-08
ω-Conotoxin MVIIC
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Neurotoxins
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ALX-630-057-C100   100 µg 340.00 USD Add To Cart
Product Specification
SEQUENCE: H-Cys-Lys-Gly-Lys-Gly-Ala-Pro-Cys-Arg-Lys-Thr-Met-Tyr-Asp-Cys-Cys-Ser-Gly-Ser-Cys-Gly-Arg-Arg-Gly-Lys-Cys-NH2
(Disulfide bonds between Cys1-Cys16, Cys8-Cys20 and Cys15-Cys26)
FORMULA: C106H178N40O32S7
MW: 2749.3
CAS NUMBER: 147794-23-8
SOURCE/HOST: Synthetic. Originally isolated from Conus magus.
QUANTITY:   
PURITY: ≥97%
APPEARANCE: Lyophilized.
SOLUBILITY: Soluble in water.
RECONSTITUTION: Do not remove the cap. Inject distilled water into the vial using a calibrated syringe. Dissolve all contents thoroughly to receive a 0.1mM solution.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for 1 year when stored at -20°C. After reconstitution, stable for up to 2 weeks when stored at +4°C; up to 3 months when stored at -20°C.
HANDLING: After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
HAZARD: VERY TOXIC.
Product Description
Neurotoxin. Potent and selective blocker of P/Q-type, voltage-gated Ca2+ channels. Not for sale in U.S.A.
Product Specific Literature References
Conotoxins: B.M. Olivera, et al.; J. Biol. Chem. 266, 22067 (1991), (Minireview) Abstract; Full Text
A new Conus peptide ligand for mammalian presynaptic Ca2+ channels: D.R. Hillyard, et al.; Neuron 9, 69 (1992) Abstract
Calcium channel diversity and neurotransmitter release: the omega-conotoxins and omega-agatoxins: B.M. Olivera, et al.; Ann. Rev. Biochem. 63, 823 (1994), (Review) Abstract
Roles of N-type and Q-type Ca2+ channels in supporting hippocampal synaptic transmission: D.B. Wheeler; Science 264, 107 (1994) Abstract
Inhibition of calcium channels in rat central and peripheral neurons by omega-conotoxin MVIIC: S.I. McDonough, et al.; J. Neurosci. 16, 2612 (1996) Abstract
Structure-activity relationships of omega-conotoxins at N-type voltage-sensitive calcium channels: K.J. Nielsen, et al.; J. Mol. Recognit. 13, 55 (2000), (Review) Abstract
Further Categories Containing This Product:
Peptides • Ca2+ Channels (P / Q-type) • Marine Natural Products
 
 
ALX-630-053 Revised 14-Oct-08
ω-Conotoxin SVIB
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Neurotoxins
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ALX-630-053-C500   500 µg 640.00 USD Add To Cart
Product Specification
SEQUENCE: H-Cys-Lys-Leu-Lys-Gly-Gln-Ser-Cys-Arg-Lys-Thr-Ser-Tyr-Asp-Cys-Cys-Ser-Gly-Ser-Cys-Gly-Arg-Ser-Gly-Lys-Cys-NH2
(Disulfide bonds between Cys1-Cys16, Cys8-Cys20and Cys15-Cys26)
FORMULA: C105H176N38O36S6
MW: 2739.2
SOURCE/HOST: Synthetic. Originally isolated from Conus striatus.
PURITY: ≥97%
APPEARANCE: Lyophilized.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: VERY TOXIC.
Product Description
Neurotoxin. N-Type Ca2+ channel blocker. Not for sale in U.S.A.
Product Specific Literature References
Conotoxins: B.M. Olivera, et al.; J. Biol. Chem. 266, 22067 (1991), (Minireview) Abstract; Full Text
Novel alpha- and omega-conotoxins from Conus striatus venom: C.A. Ramilo, et al.; Biochemistry 31, 9919 (1992) Abstract
Effects of diverse omega-conopeptides on the in vivo release of glutamic and gamma-aminobutyric acids: R. Newcomb & A. Palma; Brain Res. 638, 95 (1994) Abstract
Novel omega-conopeptides reduced field potential amplitudes in the rat hippocampal slice: J.A. Fox; Neurosci. Lett. 165, 157 (1994) Abstract
Calcium channel diversity and neurotransmitter release: the omega-conotoxins and omega-agatoxins: B.M. Olivera, et al.; Ann. Rev. Biochem. 63, 823 (1994), (Review) Abstract
A consensus structure for omega-conotoxins with different selectivities for voltage-sensitive calcium channel subtypes: comparison of MVIIA, SVIB and SNX-202: K.J. Nielsen, et al.; J. Mol. Biol. 263, 297 (1996) Abstract
Further Categories Containing This Product:
Peptides • Ca2+ Channels (N-type) • Marine Natural Products
 
 
ALX-153-012 Revised 04-Mar-05
Cyclin-dependent Kinase 2 Inhibitor
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SYNONYMS CDK2/Cyclin Inhibitor
PRODUCT LINE Cell Cycle
PRODUCT CATEGORY CDK & Cyclin Inhibitors
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ALX-153-012-M001   1 mg 120.00 USD Add To Cart
ALX-153-012-M005   5 mg 480.00 USD Add To Cart
Product Specification
SEQUENCE: H-Tyr-Ser-Phe-Val-His-His-Gly-Phe-Phe-Asn-Phe-Arg-Val-Ser-Trp-Arg-Glu-Met-Leu-Ala-OH
FORMULA: C121H164N32O27S
MW: 2530.9
PEPTIDE CONTENT: 75-95%
PURITY: ≥97%
APPEARANCE: White to off-white lyophilized solid.
SOLUBILITY: Soluble in DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Keep cool and dry.
Product Description
Inhibitor of cyclin-dependent kinase 2 (CDK2).
Product Specific Literature References
Genetic selection of peptide aptamers that recognize and inhibit cyclin- dependent kinase 2: P. Colas, et al.; Nature 380, 548 (1996) Abstract
Further Categories Containing This Product:
Peptides
 
 
ALX-153-041 Revised 04-Mar-05
Cyclin-dependent Kinase 2 Inhibitory Peptide I
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SYNONYMS CDK2/Cyclin Inhibitory Peptide I
PRODUCT LINE Cell Cycle
PRODUCT CATEGORY CDK & Cyclin Inhibitors
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ALX-153-041-C500   500 µg 145.00 USD Add To Cart
Product Specification
SEQUENCE: H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Gly-Pro-Val-Lys-Arg-Arg-Leu-Phe-Gly-OH
FORMULA: C111H196N48O23
MW: 2571.1
PURITY: ≥98% (HPLC)
APPEARANCE: Solid.
FORMULATION: Lyophilized. Counter Ion: Trifluoroacetate salt.
SOLUBILITY: Soluble in water.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Following reconstitution, aliquot and freeze (-20°C). Product is stable for 2 years as supplied. Stock solutions are stable for 3 months at -20°C.
HANDLING: Hygroscopic.
Product Description
Cell permeable inhibitor of CDK2/cyclin complexes. Blocks phosphorylation of substrates by CDK2/cyclin A and CDK/cyclin E complexes. Preferentially induces apoptosis only in transformed cells and not in non-transformed cells.

Chimeric peptide consisting of the N-terminal sequence of the HIV-TAT protein (directing uptake across the cell membrane) and the consensus sequence PVKRRLFG that serves as the docking site for CDK2/cyclin complexes.
Product Specific Literature References
Selective killing of transformed cells by cyclin/cyclin-dependent kinase 2 antagonists: Y.N. Chen, et al.; PNAS 96, 4325 (1999) Abstract; Full Text
Further Categories Containing This Product:
Peptides • Apoptosis Inducers & Inhibitors Other Products
 
 
ALX-153-042 Revised 04-Mar-05
Cyclin-dependent Kinase 2 Inhibitory Peptide II
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SYNONYMS CDK2/Cyclin Inhibitory Peptide II
PRODUCT LINE Cell Cycle
PRODUCT CATEGORY CDK & Cyclin Inhibitors
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ALX-153-042-C500   500 µg 145.00 USD Add To Cart
Product Specification
SEQUENCE: H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Gly-Pro-Val-Lys-Arg-Arg-Leu-Asp-Leu-OH
FORMULA: C110H200N48O25
MW: 2595.1
PURITY: ≥98%
APPEARANCE: Lyophilized solid.
SOLUBILITY: Soluble in water.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Very hygroscopic.
Product Description
Cell permeable inhibitor of CDK2/cyclin complexes. Blocks phosphorylation of substrates by CDK2/cyclin A and CDK/cyclin E complexes. Preferentially induces apoptosis only in transformed cells and not in non-transformed cells.
Product Specific Literature References
Selective killing of transformed cells by cyclin/cyclin-dependent kinase 2 antagonists: Y.N. Chen, et al.; PNAS 96, 4325 (1999) Abstract; Full Text
Further Categories Containing This Product:
Peptides • Apoptosis Inducers & Inhibitors Other Products
 
 
ALX-152-031 Revised 17-Nov-08
(Des-Arg1)-Bradykinin
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SYNONYMS Bradykinin (2-9)
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Bradykinin Receptor / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-152-031-M001   1 mg 15.00 USD Add To Cart
ALX-152-031-M005   5 mg 50.00 USD Add To Cart
Product Specification
SEQUENCE: H-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-OH
FORMULA: C44H61N11O10
MW: 904.0
CAS NUMBER: 16875-11-9
PEPTIDE CONTENT: ≥85%
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in water (1mg/ml).
QUALITY CONTROL: Identity determined by MS.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Further Categories Containing This Product:
Cell Stress, Oxidative Stress & Redox Signalling Other Products • NOS Regulation • Peptides
 
 
ALX-152-032 Revised 08-Dec-06
(Des-Arg9)-Bradykinin
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PRODUCT LINE Neurobiology
PRODUCT CATEGORY Bradykinin Receptor / Related Products
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ALX-152-032-M005   5 mg 75.00 USD Add To Cart
ALX-152-032-M025   25 mg 300.00 USD Add To Cart
Product Specification
SEQUENCE: H-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-OH
FORMULA: C44H61N11O10
MW: 904.0
CAS NUMBER: 15958-92-6
PURITY: ≥99%
APPEARANCE: White lyophilized powder.
SOLUBILITY: Soluble in water (1mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Further Categories Containing This Product:
Peptides • NOS Regulation • Cell Stress, Oxidative Stress & Redox Signalling Other Products
 
 
ALX-155-021 Revised 29-Jun-05
EGF Receptor (human) (651-658)
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SYNONYMS Epidermal Growth Factor Receptor (human) (651-658)
EGFR (human) (651-658)
HER-1 (human) (651-658)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY EGF / EGF Receptor [EGFR] Kinase Other Products
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ALX-155-021-M001   1 mg 50.00 USD Add To Cart
ALX-155-021-M005   5 mg 200.00 USD Add To Cart
Product Specification
SEQUENCE: H-Arg-Lys-Arg-Thr-Leu-Arg-Arg-Leu-OH
FORMULA: C46H91N21O10
MW: 1098.4
PURITY: ≥97%
APPEARANCE: White lyophilized powder.
SOLUBILITY: Soluble in water.
LONG TERM STORAGE: -20°C
Product Description
Substrate for protein kinase C (PKC).
Product Specific Literature References
A novel N-myristylated synthetic octapeptide inhibits protein kinase C activity and partially reverses murine fibrosarcoma cell resistance to adriamycin: C.A. O'Brian, et al.; Invest. New Drugs 9, 169 (1991)