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G-Protein Coupled Receptor Signalling
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ALX-550-132 Revised 24-Jun-08
Histamine . dihydrochloride
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SYNONYMS 1H-Imidazole-4-ethanamine . 2HCl
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Histaminergics & Histamine Receptors / Related Products
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ALX-550-132-G005   5 g 40.00 USD Add To Cart
Product Specification
FORMULA: C5H9N3 . 2HCl
MW: 111.1 . 73.0
CAS NUMBER: 56-92-8
MERCK INDEX: 14: 4719
RTECS: MS1575000
PURITY: ≥98%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in water (50mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HAZARD: HARMFUL.
IDENTITY: Identity determined by IR.

Further Categories Containing This Product:
Nitric Oxide Pathway Other Products
 
 
ALX-550-071 Revised 07-Mar-08
Melatonin
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SYNONYMS N-Acetyl-5-methoxytryptamine
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Melatonin Receptors / Related Products
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ALX-550-071-G001   1 g 35.00 USD Add To Cart
ALX-550-071-G005   5 g 105.00 USD Add To Cart
Product Specification
FORMULA: C13H16N2O2
MW: 232.3
CAS NUMBER: 73-31-4
MERCK INDEX: 14: 5816
RTECS: AC5955000
PURITY: ≥99%
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in dilute aqueous acid or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.

Product Specific Literature References
Physiological concentrations of melatonin inhibit nitric oxide synthase in rat cerebellum: D. Pozo, et al.; Life Sci. 55, PL455 (1994) Abstract
Melatonin receptors: are there multiple subtypes?: M.L. Dubocovich; TIPS 16, 50 (1995), (Review) Abstract
Melatonin comes of age?: R.M. Hagan & N.R. Oakley; TIPS 16, 81 (1995), (Review) Abstract
Melatonin receptors step into the light: cloning and classification of subtypes: S.M. Reppert, et al.; TIPS 17, 100 (1996), (Review) Abstract
Melatonin madness: S.M. Reppert & D.R. Weaver; Cell 83, 1059 (1995), (Minireview) Abstract
Melatonin is a scavenger of peroxynitrite: E. Gilad, et al.; Life Sci. 60, PL169 (1997) Abstract
Inhibition of cerebellar nitric oxide synthase and cyclic GMP production by melatonin via complex formation with calmodulin: D. Pozo, et al.; J. Cell Biochem. 65, 430 (1997) Abstract
Melatonin inhibits expression of the inducible isoform of nitric oxide synthase in murine macrophages: role of inhibition of NFkappaB activation: E. Gilad, et al.; FASEB J. 12, 685 (1998) Abstract; Full Text
Oxidative damage in the central nervous system: protection by melatonin: R.J. Reiter; Prog. Neurobiol. 56, 359 (1998) Abstract
The oxidant/antioxidant network: role of melatonin: R.J. Reiter, et al.; Biol. Signals Recept. 8, 56 (1999), (Review) Abstract
Interactions between melatonin, reactive oxygen species, and nitric oxide: D.K. Lahiri & C. Ghosh; Ann. N. Y. Acad. Sci. 893, 325 (1999) Abstract
Nitrosation of melatonin by nitric oxide and peroxynitrite: B. Blanchard, et al.; J. Pineal. Res. 29, 184 (2000) Abstract
Melatonin suppresses NO-induced apoptosis via induction of Bcl-2 expression in PGT-beta immortalized pineal cells: Y.M. Yoo, et al.; J. Pineal. Res. 33, 146 (2002) Abstract
Mitochondrial regulation by melatonin and its metabolites: D. Acuna-Castroviejo, et al.; Adv. Exp. Med. Biol. 527, 549 (2003), (Review) Abstract
Melatonin suppresses macrophage cyclooxygenase-2 and inducible nitric oxide synthase expression by inhibiting p52 acetylation and binding: W.G. Deng, et al.; Blood 108, 518 (2006) Abstract
Melatonin and nitric oxide: S. Aydogan, et al.; J. Endocrinol. Invest. 29, 281 (2006), (Review) Abstract
Melatonin inhibits endothelial nitric oxide production in vitro: E.K. Tamura, et al.; J. Pineal. Res. 41, 267 (2006) Abstract
Further Categories Containing This Product:
Chemopreventive Agents Other Products • Apoptosis Inducers & Inhibitors Other Products • Nitric Oxide Pathway Other Products
 
 
ALX-550-154 Revised 20-Dec-02
5-Methoxy-N-cyclopropanoyltryptamine
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PRODUCT LINE Neurobiology
PRODUCT CATEGORY Melatonin Receptors / Related Products
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ALX-550-154-M005   5 mg 35.00 USD Add To Cart
ALX-550-154-M025   25 mg 140.00 USD Add To Cart
Product Specification
FORMULA: C15H18N2O2
MW: 258.3
PURITY: ≥98%
SOLUBILITY: Soluble in 100% ethanol, methanol or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.

Product Description
Potent melatonin receptor agonist.
Product Specific Literature References
Novel naphthalenic ligands with high affinity for the melatonin receptor: S. Yous, et al.; J. Med. Chem. 35, 1484 (1992) Abstract
2-Substituted 5-methoxy-N-acyltryptamines: synthesis, binding affinity for the melatonin receptor, and evaluation of the biological activity: G. Spadoni, et al.; J. Med. Chem. 36, 4069 (1993) Abstract
Synthesis and structure-activity relationships of novel naphthalenic and bioisosteric related amidic derivatives as melatonin receptor ligands: P. Depreux, et al.; J. Med. Chem. 37, 3231 (1994) Abstract
Melatonin receptors: are there multiple subtypes?: M.L. Dubocovich; TIPS 16, 50 (1995), (Review) Abstract
 
 
ALX-550-184 Revised 29-Apr-05
Luzindole
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SYNONYMS N-Acetyl-2-benzyltryptamine
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Melatonin Receptors / Related Products
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ALX-550-184-M005   5 mg 55.00 USD Add To Cart
ALX-550-184-M025   25 mg 220.00 USD Add To Cart
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Product Specification
FORMULA: C19H20N2O
MW: 292.4
CAS NUMBER: 117946-91-5
PURITY: ≥96%
APPEARANCE: White to off-white crystalline solid.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.

Product Description
Competitive melatonin receptor antagonist.
Product Specific Literature References
Luzindole (N-0774): a novel melatonin receptor antagonist: M.L. Dubocovich; J. Pharmacol. Exp. Ther. 246, 902 (1988) Abstract
Melatonin receptors: are there multiple subtypes?: M.L. Dubocovich; TIPS 16, 50 (1995), (Review) Abstract
 
 
ALX-550-185 Revised 17-Dec-04
GR-135,531
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SYNONYMS 5-Methoxy-carbonylamino-N-acetyl-tryptamine
5-MCA-NAT
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Melatonin Receptors / Related Products
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ALX-550-185-M001   1 mg 30.00 USD Add To Cart
Product Specification
FORMULA: C14H17N3O3
MW: 275.3
PURITY: ≥97%
APPEARANCE: Off-white solid.
SOLUBILITY: Soluble in 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
High affinity ligand for the MT3 melatonin receptor subtype.
Product Specific Literature References
Melatonin receptors: are there multiple subtypes?: M.L. Dubocovich; TIPS 16, 50 (1995), (Review) Abstract
Investigation into the contractile response of melatonin in the guinea-pig isolated proximal colon: the role of 5-HT4 and melatonin receptors: A. Lucchelli, et al.; Br. J. Pharmacol. 121, 1775 (1997) Abstract
Characterization of a melatonin binding site in Siberian hamster brown adipose tissue: S. Le Gouic, et al.; Eur. J. Pharmacol. 339, 271 (1997) Abstract
 
 
ALX-550-200 Revised 09-Aug-02
N-Acetyltryptamine
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PRODUCT LINE Neurobiology
PRODUCT CATEGORY Melatonin Receptors / Related Products
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ALX-550-200-M005   5 mg 50.00 USD Add To Cart
ALX-550-200-M025   25 mg 190.00 USD Add To Cart
Product Specification
FORMULA: C12H14N2O
MW: 202.3
CAS NUMBER: 1016-47-3
PURITY: ≥97%
SOLUBILITY: Soluble in methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
Partial agonist for melatonin receptors.
Product Specific Literature References
Characterization of a retinal melatonin receptor: M.L. Dubocovich; J. Pharmacol. Exp. Ther. 234, 395 (1985) Abstract
Luzindole (N-0774): a novel melatonin receptor antagonist: M.L. Dubocovich; J. Pharmacol. Exp. Ther. 246, 902 (1988) Abstract
 
 
ALX-550-208 Revised 17-Dec-04
N-Acetyl-5-hydroxytryptamine
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SYNONYMS N-Acetylserotonin
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Melatonin Receptors / Related Products
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ALX-550-208-M010   10 mg 10.00 USD Add To Cart
ALX-550-208-M050   50 mg 25.00 USD Add To Cart
ALX-550-208-M500   500 mg 125.00 USD Add To Cart
Product Specification
FORMULA: C12H14N2O2
MW: 218.3
CAS NUMBER: 1210-83-9; 17994-17-1
PURITY: ≥99%
APPEARANCE: Off-white powder.
SOLUBILITY: Soluble in ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.

Product Description
Metabolite of serotonin (Prod. No. ALX-550-328). Precursor of melatonin (Prod. No. ALX-550-071). Inhibitor of hydroxyindole-O-methyltransferase.
Product Specific Literature References
The metabolism of serotonin (5-hydroxytryptamine): W.M. McIsaac and I.H. Page; J. Biol. Chem. 234, 858 (1959) Full Text
Hydroxyindole-O-methyltransferase. I. Substrate binding: B.T. Ho, et al.; J. Pharm. Sci. 58, 130 (1969) Abstract
Hydroxyindole-O-methyltransferase. II. Inhibitory activities of some N- acyltryptamines: B.T. Ho, et al.; J. Pharm. Sci. 57, 1998 (1968) Abstract
Further Categories Containing This Product:
Serotonergics & Serotonin Receptors / Related Products
 
 
ALX-550-314 Revised 03-Feb-05
N-Cyclobutanecarbonyl-2-phenyltryptamine
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SYNONYMS N-[2-(2-Phenylindol-3-yl)ethyl] cyclobutanecarboxyamide
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Melatonin Receptors / Related Products
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ALX-550-314-M001   1 mg 60.00 USD Add To Cart
ALX-550-314-M005   5 mg 180.00 USD Add To Cart
Product Specification
FORMULA: C21H22N2O
MW: 318.4
PURITY: ≥98%
APPEARANCE: Oil.
SOLUBILITY: Soluble in chloroform or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Melatonin receptor antagonist. More potent than Luzindole (Prod. No. ALX-550-184) in the Xenopus melanophore assay.
Product Specific Literature References
Radioligand binding affinity and biological activity of the enantiomers of a chiral melatonin analogue: D. Sugden, et al.; Eur. J. Pharmacol. 287, 239 (1995) Abstract
Mapping the melatonin receptor. 3. Design and synthesis of melatonin agonists and antagonists derived from 2-phenyltryptamines: P.J. Garratt, et al.; J. Med. Chem. 38, 1132 (1995) Abstract
Mapping the melatonin receptor. 5. Melatonin agonists and antagonists derived from tetrahydrocyclopent[b]indoles, tetrahydrocarbazoles and hexahydrocyclohept[b]indoles: D.J. Davies, et al.; J. Med. Chem. 41, 451 (1998) Abstract
 
 
ALX-550-315 Revised 22-Aug-02
2-Bromomelatonin
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PRODUCT LINE Neurobiology
PRODUCT CATEGORY Melatonin Receptors / Related Products
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ALX-550-315-M001   1 mg 60.00 USD Add To Cart
Product Specification
FORMULA: C13H16N2O2Br
MW: 312.2
PURITY: ≥95%
APPEARANCE: Yellow solid.
SOLUBILITY: Soluble in ethyl acetate.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
Melatonin agonist with high affinity for chicken brain membrane melatonin receptors.
Product Specific Literature References
2-Bromomelatonin: synthesis and characterization of a potent melatonin agonist: E. Duranti, et al.; Life Sci. 51, 479 (1992) Abstract
2-Substituted 5-methoxy-N-acyltryptamines: synthesis, binding affinity for the melatonin receptor, and evaluation of the biological activity: G. Spadoni, et al.; J. Med. Chem. 36, 4069 (1993) Abstract
 
 
ALX-550-373 Revised 17-Dec-04
DH 97
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SYNONYMS N-Pentanoyl-2-benzyltryptamine
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Melatonin Receptors / Related Products
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ALX-550-373-M001   1 mg 20.00 USD Add To Cart
ALX-550-373-M005   5 mg 70.00 USD Add To Cart
Product Specification
FORMULA: C22H26N2O
MW: 334.5
PURITY: ≥95%
APPEARANCE: White solid.
SOLUBILITY: Soluble in DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.

Product Description
Selective MT2 melatonin receptor antagonist.
Product Specific Literature References
Comparison of the structure-activity relationships of melatonin receptor agonists and antagonists: lengthening the N-acyl side-chain has differing effects on potency on Xenopus melanophores: M.T. Teh & D. Sugden; Naunyn Schmiedebergs Arch. Pharmacol. 358, 522 (1998) Abstract
Molecular and pharmacological evidence for MT1 melatonin receptor subtype in the tail artery of juvenile Wistar rats: K.N. Ting, et al.; Br. J. Pharmacol. 127, 987 (1999) Abstract
 
 
ALX-106-023 Revised 13-Dec-02
5-Hydroxy-L-tryptophan
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PRODUCT LINE Neurobiology
PRODUCT CATEGORY Serotonergics & Serotonin Receptors / Related Products
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ALX-106-023-M500   500 mg 20.00 USD Add To Cart
Product Specification
FORMULA: C11H12N2O3
MW: 220.2
CAS NUMBER