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ALX-210-304
Revised 27-Dec-06
Polyclonal Antibody to XRCC1 (human)
SYNONYMS
anti-X-ray Repair Cross-complementing Group 1 (human) PAb
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
XRCC Proteins / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-304-R050
50 µl
235.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From rabbit.
FORMULATION:
Liquid. Contains 0.1% sodium azide.
IMMUNOGEN:
Recombinant human XRCC1 (X-ray repair cross-complementing group 1).
SPECIFICITY:
Recognizes human XRCC1.
APPLICATION:
ELISA
Immunocytochemistry
Immunoprecipitation
Western Blot
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
+4°C
HANDLING:
Avoid freeze/thaw cycles.
Product Specific Literature References
XRCC1 is specifically associated with poly(ADP-ribose) polymerase and negatively regulates its activity following DNA damage:
M. Masson, et al.; Mol. Cell. Biol.
18
, 3563 (1998)
Abstract
;
Full Text
Poly(ADP-ribose) polymerase-2 (PARP-2) is required for efficient base excision DNA repair in association with PARP-1 and XRCC1
:
V. Schreiber, et al.; J. Biol. Chem.
277
, 23028 (2002)
Abstract
;
Full Text
General Information
XRCC1 (X-ray repair cross-complementing 1) exerts multiple functions in repairing base damage and frank single strand breaks. These functions include stabilizing DNA ligase 3, bridging the steps in base excision repair (BER) through protein interactions (via its BRCT motif), directly detecting breaks produced by chemical or enzymatic action, coordinating the binding and polymerase activity of DNA polymerase β, promoting an S phase-specific mode of single strand break repair. XRCC1 is specifically associated with poly(ADP-ribose) polymerase (PARP) and negatively regulates its activity following DNA damage.
Related Products
ALX-210-539
Polyclonal Antibody to XRCC1 (human)
Further Categories Containing This Product:
PARP Other Products
•
Polyclonal Antibodies
ALX-210-319
Revised 12-Apr-07
Polyclonal Antibody to Proteasome 19S (Subunit S4) (human)
PRODUCT LINE
Ubiquitin & Proteasome
PRODUCT CATEGORY
Proteasome / Related Products
Ordering Information
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Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-319-R100
100 µl
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From rabbit.
PURITY DETAIL:
Purified total IgG.
FORMULATION:
Liquid. In PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN:
Recombinant proteasome 19S subunit S4.
SPECIFICITY:
Recognizes subunit S4 located in the 19S regulatory subunit of human 26S proteasome. Detects a band of ~56kDa by Western blot. Also detects a weak band of ~35kDa, which may correspond to subunit degradation product.
APPLICATION:
Immunoprecipitation
Western Blot (1:1'000)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-320
Revised 10-Oct-05
Polyclonal Antibody to Proteasome 19S (Subunit S5A) (human)
PRODUCT LINE
Ubiquitin & Proteasome
PRODUCT CATEGORY
Proteasome / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-320-R200
200 µl
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From rabbit.
PURITY DETAIL:
Purified total IgG.
FORMULATION:
Liquid. In PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN:
Recombinant human proteasome 19S subunit S5A.
SPECIFICITY:
Recognizes subunit S5A located in the 19S regulatory subunit of human 26S proteasome. Detects a band of ~50kDa by Western blot.
APPLICATION:
Immunoprecipitation
Western Blot (1:500)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-321
Revised 12-Jan-05
Polyclonal Antibody to Proteasome 19S (Subunit S6) (human)
PRODUCT LINE
Ubiquitin & Proteasome
PRODUCT CATEGORY
Proteasome / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-321-R100
100 µl
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From rabbit.
FORMULATION:
Liquid. Purified total IgG in PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN:
Recombinant human proteasome 19S subunit S6.
SPECIFICITY:
Recognizes subunit S6 located in the 19S regulatory subunit of human 26S proteasome. Detects a band of ~48kDa by Western blot.
APPLICATION:
Immunoprecipitation
Western Blot (1:500)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-322
Revised 12-Jan-05
Polyclonal Antibody to Proteasome 19S (Subunit S6') (human)
PRODUCT LINE
Ubiquitin & Proteasome
PRODUCT CATEGORY
Proteasome / Related Products
Ordering Information
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Format:
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Unit Price:
Quantity:
Add To Cart
ALX-210-322-R100
100 µl
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From rabbit.
FORMULATION:
Liquid. Purified total IgG in PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN:
Recombinant human proteasome 19S subunit S6'.
SPECIFICITY:
Recognizes subunit S6', located in the 19S regulatory subunit of human 26S proteasome. Detects a band of ~48kDa by Western blot.
APPLICATION:
Immunoprecipitation
Western Blot (1:1'000)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-323
Revised 08-Feb-05
Polyclonal Antibody to Proteasome 19S (Subunit S7) (human)
PRODUCT LINE
Ubiquitin & Proteasome
PRODUCT CATEGORY
Proteasome / Related Products
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ALX-210-323-R100
100 µl
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From rabbit.
FORMULATION:
Liquid. Purified total IgG in PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN:
Recombinant human proteasome 19S subunit S7.
SPECIFICITY:
Recognizes subunit S7, located in the 19S regulatory subunit of human 26S proteasome. Detects a band of ~47kDa by Western blot.
APPLICATION:
Immunoprecipitation
Western Blot (1:1'000)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-324
Revised 12-Jan-05
Polyclonal Antibody to Proteasome 19S (Subunit S8) (human)
PRODUCT LINE
Ubiquitin & Proteasome
PRODUCT CATEGORY
Proteasome / Related Products
Ordering Information
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ALX-210-324-R100
100 µl
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From rabbit.
FORMULATION:
Liquid. Purified total IgG in PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN:
Recombinant human proteasome 19S subunit S8.
SPECIFICITY:
Recognizes subunit S8, located in the 19S regulatory subunit of human 26S proteasome. Detects a band of ~45kDa by Western blot.
APPLICATION:
Immunoprecipitation
Western blot (1:1'000)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-325
Revised 12-Jan-05
Polyclonal Antibody to Proteasome 19S (Subunit S10B) (human)
PRODUCT LINE
Ubiquitin & Proteasome
PRODUCT CATEGORY
Proteasome / Related Products
Ordering Information
Product Numbers:
Format:
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Quantity:
Add To Cart
ALX-210-325-R100
100 µl
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From rabbit.
FORMULATION:
Liquid. Purified total IgG in PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN:
Recombinant human proteasome 19S subunit S10B.
SPECIFICITY:
Recognizes subunit S10B, located in the 19S regulatory subunit of human 26S proteasome. Detects a band of ~42kDa by Western blot.
APPLICATION:
Immunoprecipitation
Western Blot (1:1'000)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-326
Revised 12-Jan-05
Polyclonal Antibody to Proteasome 20S (Subunit LMP7) (human)
PRODUCT LINE
Ubiquitin & Proteasome
PRODUCT CATEGORY
Proteasome / Related Products
Ordering Information
Product Numbers:
Format:
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Unit Price:
Quantity:
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ALX-210-326-C100
100 µg
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml.
FORMULATION:
Liquid. Epitope-affinity purified IgG in PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN:
Recombinant human proteasome 20S subunit LMP7.
SPECIFICITY:
Recognizes subunit LMP7, located in the 20S proteolytic core complex of human 26S proteasome. Detects a band of ~20kDa by Western blot.
APPLICATION:
Western Blot (1µg/ml)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-327
Revised 17-Jul-08
Polyclonal Antibody to XIAP
SYNONYMS
anti-X-chromosome-linked Inhibitor of Apoptosis Protein
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
ILP-2 [Ts-IAP] & XIAP [ILP-1; MIHA]
Ordering Information
Product Numbers:
Format:
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Unit Price:
Quantity:
Add To Cart
ALX-210-327-C100
100 µg
329.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
SOURCE/HOST:
From rabbit.
CONCENTRATION:
0.2mg/ml
PURITY DETAIL:
Affinity purified.
FORMULATION:
Liquid. In PBS, pH 7.2, containing 30% glycerol, 0.5% BSA and 0.01% thimerosal.
IMMUNOGEN:
Synthetic peptide around aa 230 of human XIAP (X-chromosome-linked inhibitor of apoptosis protein).
SPECIFICITY:
Recognizes human, mouse and rat XIAP. Detects a band of ~53kDa by Western blot.
APPLICATION:
Western Blot (0.5-4µg/ml)
Optimal conditions must be determined individually for each application.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -80°C.
Product Images
Please click on thumbnails to enlarge.
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-328
Revised 08-Dec-06
Polyclonal Antibody to SUMO-1 Activating Enzyme (Subunit SAE1) (human)
SYNONYMS
anti-SAE1 (human) PAb
PRODUCT LINE
Ubiquitin & Proteasome
PRODUCT CATEGORY
SUMOs / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-328-C050
50 µg
210.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From sheep.
CONCENTRATION:
1mg/ml
PURITY DETAIL:
Affinity purified.
FORMULATION:
Liquid. In 50mM TRIS-HCl, pH 7.5, containing 10% glycerol.
IMMUNOGEN:
Recombinant human SUMO-1 activating enzyme (subunit SAE1).
SPECIFICITY:
Recognizes human SAE1.
APPLICATION:
Immunocytochemistry
Western Blot (1:3'000)
SHIPPING:
SHIPPED ON DRY ICE
LONG TERM STORAGE:
-80°C
USE/STABILITY:
Once thawed add glycerol and store in a frost free freezer at -20°C for up to 6 months.
HANDLING:
Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-352
Revised 30-Oct-06
Polyclonal Antibody to MDA5 (mouse) (AL180)
SYNONYMS
anti-Melanoma Differentiation-associated Gene 5 (mouse) PAb (AL180)
anti-Helicard (mouse) PAb (AL180)
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
RNA Helicases / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-210-352-C100
100 µg
270.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
SOURCE/HOST:
From rabbit.
FORMULATION:
Liquid. Contains 0.02% sodium azide.
IMMUNOGEN:
Recombinant mouse MDA5 (melanoma differentiation-associated gene 5) (aa 2-208).
SPECIFICITY:
Recognizes mouse MDA5.
APPLICATION:
Western Blot
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 1 year after receipt when stored as recommended.
HANDLING:
Avoid freeze/thaw cycles.
Product Specific Literature References
Overexpression of Helicard, a CARD-Containing Helicase Cleaved during Apoptosis, Accelerates DNA Degradation:
M. Kovacsovics, et al.; Curr. Biol.
12
, 838 (2002)
Abstract
General Information
MDA5 is a highly conserved helicase whose ATPase activity can be stimulated by RNA and less potently by DNA. It contains two N-terminal CARD domains and a C-terminal helicase domain. The helicase domain, once freed from the CARD domains, then translocates from the cytoplasm to the nucleus where it acts on chromatin architecture. This could allow a more easy access of CAD, thereby accelerating the degradation of genomic DNA.
MANUFACTURER
Manufactured by Apotech Corporation.
General Literature References
Mda-5: An interferon-inducible putative RNA helicase with double-stranded RNA-dependent ATPase activity and melanoma growth-suppressive properties
:
D.C. Kang, et al.; PNAS
99
, 637 (2002)
Abstract
Related Products
ALX-210-935
Polyclonal Antibody to MDA5 (human) (AT113)
ALX-804-863
Monoclonal Antibody to MDA5 (human) (Hely-1)
APO-54N-035
MDA5 (human) (IntraCellular) Detection Set [For ELISA Application]
APO-54N-039
MDA5 (human) (IntraCellular) ELISA Kit
Further Categories Containing This Product:
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