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ALX-163-004
Revised 06-Jun-03
Neurogranin (28-43)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
PKC Substrates
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-163-004-M001
1 mg
120.00 USD
Product Specification
SEQUENCE:
H-Ala-Ala-Lys-Ile-Gln-Ala-Ser-Phe-Arg-Gly-His-Met-Ala-Arg-Lys-Lys-OH
FORMULA:
C
78
H
134
N
28
O
19
S
MW:
1800.2
PURITY:
≥97%
APPEARANCE:
White lyophilized powder.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Peptide derived from the neurogranin phosphorylation domain. Highly selective substrate for protein kinase C (PKC), but very poor substrate for Ca
2+
/calmodulin-dependent kinase II and cAMP-dependent kinase (PKA).
Product Specific Literature References
Studies with synthetic peptide substrates derived from the neuronal protein neurogranin reveal structural determinants of potency and selectivity for protein kinase C:
S.-J. Chen, et al.; Biochemistry
32
, 1032 (1993)
Abstract
Further Categories Containing This Product:
Peptides
ALX-163-011
Revised 14-Jul-08
NBD Peptide / NF-κB Blocker (cell permeable)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
NF-kB Pathway Inhibitors
Ordering Information
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ALX-163-011-1
1 Vial
240.00 USD
Product Specification
SEQUENCE:
GRKKRRQRRR-GG-TALDWSWLQTE-amide
FORMULA:
C
121
H
202
N
48
O
32
MW:
2841.2
QUANTITY:
50µl
CONCENTRATION:
10mM
PURITY:
≥95% (HPLC)
FORMULATION:
Liquid. In sterile PBS.
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
-20°C
LONG TERM STORAGE:
-80°C
HANDLING:
After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. Protect from moisture. Keep on ice at all times.
POSITIVE CONTROL:
Prod. No.
ALX-168-009/1
Product Description
For increased cell permeability the peptide was covalently linked to the 10 aa recognized by the TAT transporter.
Product Specific Literature References
Selective inhibition of NF-kappaB blocks osteoclastogenesis and prevents inflammatory bone destruction in vivo:
E. Jimi, et al.; Nature Med.
10
, 617 (2004)
Abstract
Selective inhibition of NF-kappaB activation by a peptide that blocks the interaction of NEMO with the IkappaB kinase complex:
M.J. May, et al.; Science
289
, 1550 (2000)
Abstract
Characterization of the Ikappa B-kinase NEMO binding domain:
M.J. May, et al.; J. Biol. Chem.
277
, 45992 (2002)
Abstract
Related Products
ALX-168-009/1
L-TAT Control Peptide (for Prod. No.
ALX-159-600
)
Further Categories Containing This Product:
Peptides
ALX-164-001
Revised 06-Jan-06
Orexin A (human, bovine, rat, mouse)
PRODUCT LINE
Obesity & Adipokines
PRODUCT CATEGORY
Orexins/Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-164-001-C100
100 µg
120.00 USD
ALX-164-001-C500
500 µg
370.00 USD
ALX-164-001-M001
1 mg
690.00 USD
Product Specification
SEQUENCE:
Pyr-Pro-Leu-Pro-Asp-Cys-Cys-Arg-Gln-Lys-Thr-Cys-Ser-Cys-Arg-Leu-Tyr-Glu-Leu-Leu-His-Gly-Ala-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Leu-NH
2
(Disulfide bonds between Cys
6
-Cys
12
and Cys
7
-Cys
14
).
FORMULA:
C
152
H
243
N
47
O
44
S
4
MW:
3561.2
PURITY:
≥98%
FORMULATION:
Lyophilized.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Hypothalamic neuropeptide that stimulates food intake in rats with impressive potency. Binds specifically to the OX
1
receptor.
Product Specific Literature References
Orexins and orexin receptors: a family of hypotalamic neuropeptides and G protein-coupled receptors that regulate feeding behaviour:
T. Sakurai, et al.; Cell
92
, 573 (1998)
Abstract
Orexins and appetite: the big picture of energy homeostasis gets a little bigger:
M.W. Schwartz; Nature Medicine
4
, 385 (1998)
Abstract
Further Categories Containing This Product:
Peptides
•
Neuropeptides & Receptors Other Products
ALX-164-002
Revised 06-Jan-06
Orexin B (human)
PRODUCT LINE
Obesity & Adipokines
PRODUCT CATEGORY
Orexins/Related Products
Ordering Information
Product Numbers:
Format:
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ALX-164-002-C100
100 µg
150.00 USD
Product Specification
SEQUENCE:
H-Arg-Ser-Gly-Pro-Pro-Gly-Leu-Gln-Gly-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Ala-Ser-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Met-NH
2
FORMULA:
C
122
H
212
N
44
O
34
S
MW:
2871.4
PURITY:
≥95%
FORMULATION:
Lyophilized.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Like orexin A (Prod. No.
ALX-164-001
), orexin B is a hypothalamatic neuropeptide stimulating food intake in rats. Stimulates food consumption in a similar manner to orexin A, but the effect did not last as long as that of orexin A. The affinity of orexin B for the OX
1
receptor is significantly lower than that of orexin A. Binding affinities for the OX
2
receptor are similar for orexin A and B.
Product Specific Literature References
Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior:
T. Sakurai, et al.; Cell
92
, 573 (1998)
Abstract
Orexins and appetite: the big picture of energy homeostasis gets a little bigger:
M.W. Schwartz; Nature Medicine
4
, 385 (1998)
Abstract
Further Categories Containing This Product:
Peptides
•
Neuropeptides & Receptors Other Products
ALX-164-003
Revised 10-Jun-03
Orexin B (rat, mouse)
PRODUCT LINE
Obesity & Adipokines
PRODUCT CATEGORY
Orexins/Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-164-003-C100
100 µg
150.00 USD
Product Specification
SEQUENCE:
H-Arg-Pro-Gly-Pro-Pro-Gly-Leu-Gln-Gly-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Ala-Asn-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Met-NH
2
FORMULA:
C
125
H
215
N
45
O
33
S
MW:
2908.5
PURITY:
≥97%
FORMULATION:
Lyophilized.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Specific Literature References
Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior:
T. Sakurai, et al.; Cell
92
, 573 (1998)
Abstract
Orexins and appetite: the big picture of energy homeostasis gets a little bigger:
M.W. Schwartz; Nature Medicine
4
, 385 (1998)
Abstract
Further Categories Containing This Product:
Peptides
•
Neuropeptides & Receptors Other Products
ALX-164-004
Revised 04-Jul-08
Obestatin (human)
PRODUCT LINE
Obesity & Adipokines
PRODUCT CATEGORY
Ghrelin/Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-164-004-M001
1 mg
130.00 USD
ALX-164-004-M005
5 mg
480.00 USD
Product Specification
SEQUENCE:
H-Phe-Asn-Ala-Pro-Phe-Asp-Val-Gly-Ile-Lys-Leu-Ser-Gly-Val-Gln-Tyr-Gln-Gln-His-Ser-Gln-Ala-Leu-NH
2
FORMULA:
C
116
H
176
N
32
O
33
MW:
2546.9
PEPTIDE CONTENT:
≥80%
PURITY:
≥97% (HPLC)
FORMULATION:
Lyophilized.
SOLUBILITY:
Soluble in DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Obestatin derives like ghrelin from proghrelin, but exhibits opposite physiological effects. Obestatin decreases food intake and body weight in rodents. Moreover, obestatin also counteracts ghrelin’s effect by decelerating gastric emptying and decreasing intestinal contractility. Obestatin binds to orphan G protein-coupled receptor GPR39. Amidation of the C-terminus seems to be important for obestatin’s activity.
Product Specific Literature References
Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin’s effects on food intake:
J.V. Zhang, et al.; Science
310
, 996 (2005)
Abstract
Biomedicine. Separation of conjoined hormones yields appetite rivals:
R. Nogueiras & M. Tschop; Science
310
, 985 (2005), (Comment)
Abstract
Further Categories Containing This Product:
Peptides
ALX-164-005
Revised 04-Jul-08
Obestatin (mouse, rat)
PRODUCT LINE
Obesity & Adipokines
PRODUCT CATEGORY
Ghrelin/Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-164-005-M001
1 mg
130.00 USD
ALX-164-005-M005
5 mg
480.00 USD
Product Specification
SEQUENCE:
H-Phe-Asn-Ala-Pro-Phe-Asp-Val-Gly-Ile-Lys-Leu-Ser-Gly-Ala-Gln-Tyr-Gln-Gln-His-Gly-Arg-Ala-Leu-NH
2
FORMULA:
C
114
H
174
N
34
O
31
MW:
2516.8
PEPTIDE CONTENT:
≥80%
PURITY:
≥97% (HPLC)
FORMULATION:
Lyophilized.
SOLUBILITY:
Soluble in DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Obestatin derives like ghrelin from proghrelin, but exhibits opposite physiological effects. Obestatin decreases food intake and body weight in rodents. Moreover, obestatin also counteracts ghrelin’s effect by decelerating gastric emptying and decreasing intestinal contractility. Obestatin binds to orphan G protein-coupled receptor GPR39. Amidation of the C-terminus seems to be important for obestatin’s activity.
Product Specific Literature References
Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin’s effects on food intake:
J.V. Zhang, et al.; Science
310
, 996 (2005)
Abstract
Biomedicine. Separation of conjoined hormones yields appetite rivals:
R. Nogueiras & M. Tschop; Science
310
, 985 (2005), (Comment)
Abstract
ALX-165-003
Revised 17-Sep-07
PACAP (1-27) (human, sheep, rat)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Adenylyl Cyclase Activators
Ordering Information
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Format:
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Quantity:
Add To Cart
ALX-165-003-MC05
0.5 mg
220.00 USD
ALX-165-003-M001
1 mg
380.00 USD
Product Specification
SEQUENCE:
H-His-Ser-Asp-Gly-Ile-Phe-Thr-Asp-Ser-Tyr-Ser-Arg-Tyr-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Ala-Ala-Val-Leu-NH
2
FORMULA:
C
142
H
224
N
40
O
39
S
MW:
3147.7
PURITY:
≥98%
APPEARANCE:
Lyophilized.
SOLUBILITY:
Soluble in 5% acetic acid.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Adenylate cyclase activator. More potent than vasoactive intestinal peptide (VIP).
Product Specific Literature References
Isolation of a novel 38 residue-hypothalamic polypeptide which stimulates adenylate cyclase in pituitary cells:
A. Miyata, et al.; BBRC
164
, 567 (1989)
Abstract
Isolation and characterization of novel hypothalamic polypeptides homologous with VIP
:
A. Miyata, et al.; Regul. Pept.
26
, 170 (1989)
A novel peptide which stimulates adenylate cyclase: molecular cloning and characterization of the ovine and human cDNAs:
C. Kimura, et al.; BBRC
166
, 81 (1990)
Abstract
Demonstration of specific binding sites for pituitary adenylate cyclase activating polypeptide (PACAP) in rat astrocytes:
I. Tatsuno, et al.; BBRC
168
, 1027 (1990)
Abstract
L.O. Cardell, et al.; Regul. Pept.
36
, 379 (1991), (Review)
Abstract
Pituitary adenylate cyclase activating polypeptide (PACAP): discovery and current status of research:
A. Arimura; Regul. Pept.
37
, 287 (1992), (Review)
Abstract
Further Categories Containing This Product:
Peptides
ALX-165-004
Revised 07-Feb-05
pp60v-src (137-157)
SYNONYMS
Peptide A
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Src Family Kinases/Related Products
Ordering Information
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ALX-165-004-MC01
0.1 mg
40.00 USD
ALX-165-004-M001
1 mg
160.00 USD
Product Specification
SEQUENCE:
H-Val-Ala-Pro-Ser-Asp-Ser-Ile-Gln-Ala-Glu-Glu-Trp-Tyr-Phe-Gly-Lys-Ile-Thr-Arg-Arg-Glu-OH
FORMULA:
C
111
H
168
N
30
O
35
MW:
2482.7
PURITY:
≥98%
APPEARANCE:
White lyophilized powder.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Inhibitor of Src and EGF receptor tyrosine kinases. The peptide sequence corresponds to residues 137-157 of the noncatalytic domain of the transforming protein of
Rous sarcoma
virus (pp60
v-scr
).
Product Specific Literature References
A synthetic peptide corresponding to residues 137 to 157 of p60v-src inhibits tyrosine-specific protein kinases:
K. Sato, et al.; BBRC
171
, 1152 (1990)
Abstract
Evidence for autoinhibitory regulation of the c-src gene product. A possible interaction between the src homology 2 domain and autophosphorylation site:
Y. Fukami, et al.; J. Biol. Chem.
268
, 1132 (1993)
Abstract
;
Full Text
Further Categories Containing This Product:
Peptides
•
Tyrosine Kinase Inhibitors
ALX-165-005
Revised 16-Feb-05
PDGF β-Receptor (719-723) (phosphorylated)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
SH2 & SH3 Domains
Ordering Information
Product Numbers:
Format:
Size:
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ALX-165-005-M001
1 mg
130.00 USD
ALX-165-005-M005
5 mg
520.00 USD
Product Specification
SEQUENCE:
H-Tyr(PO
3
H
2
)-Val-Pro-Met-Leu-OH
FORMULA:
C
30
H
48
N
5
O
10
PS
MW:
701.8
PURITY:
≥97%
APPEARANCE:
White lyophilized powder.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Contains the PDGF β-receptor recognition sequence which specifically interacts with the SH2 domain of PI(3)K (phosphoinositide 3-kinase). In this phosphorylated form the peptide inhibits the binding of the 85kDa subunit of PI(3)K to the PDGF β-receptor.
Product Specific Literature References
Distinct phosphotyrosines on a growth factor receptor bind to specific molecules that mediate different signaling pathways:
W.J. Fantl, et al.; Cell
69
, 413 (1992)
Abstract
Closing in on SH2 specificity:
R.B. Birge & H. Hanafusa; Science
262
, 1522 (1993)
Abstract
Further Categories Containing This Product:
Peptides
•
Platelet-derived Growth Factors [PDGFs] & Receptors/Related Products
ALX-165-006
Revised 04-Jul-03
Peptide ε
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
PKC Substrates
Ordering Information
Product Numbers:
Format:
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ALX-165-006-MC01
0.1 mg
30.00 USD
ALX-165-006-M001
1 mg
120.00 USD
ALX-165-006-M005
5 mg
420.00 USD
Product Specification
SEQUENCE:
H-Glu-Arg-Met-Arg-Pro-Arg-Lys-Arg-Gln-Gly-Ser-Val-Arg-Arg-Arg-Val-OH
FORMULA:
C
83
H
155
N
39
O
21
S
MW:
2067.5
PURITY:
≥99%
APPEARANCE:
White lyophilized powder.
