ALEXIS Biochemicals: Compound 48/80 . trihydrochloride

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ALX-270-089

Revised 25-May-07

D609 . potassium salt
SYNONYMS	Tricyclodecan-9-yl xanthogenate . K
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	Phospholipase C / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-089-M001		1 mg	25.00 USD
ALX-270-089-M005		5 mg	80.00 USD

Product Specification

FORMULA:	C₁₁H₁₅OS₂ . K
MW:	227.4 . 39.1
CAS NUMBER:	83373-60-8
PURITY:	≥98%
APPEARANCE:	Off-white solid.
SOLUBILITY:	Soluble in water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C
USE/STABILITY:	We recommend to prepare fresh solutions each day.

Product Description

Selective inhibitor of phosphatidylcholine-specific phospholipase C. Has been used to study the coupling of phosphatidylcholine-specific phospholipase C with sphingomyelinase. Shows antitumor and antiviral activity. Inhibits basement membrane collagen synthesis, which is the last step in the development of a new blood vessel. Inhibits induction of nitric oxide synthases (NOS). Induces apoptosis.

Product Specific Literature References

DNA and RNA virus species are inhibited by xanthates, a class of antiviral compounds with unique properties: G. Sauer, et al.; PNAS 81, 3263 (1984) Abstract
Interruption of growth signal transduction by an antiviral and antitumoral xanthate compound: K. Muller-Decker, et al.; Exp. Cell. Res. 177, 295 (1988) Abstract
Interruption of TPA-induced signals by an antiviral and antitumoral xanthate compound: inhibition of a phospholipase C-type reaction: K. Muller-Decker; BBRC 162, 198 (1989) Abstract
TNF activates NF-kappa B by phosphatidylcholine-specific phospholipase C-induced "acidic" sphingomyelin breakdown: S. Schütze, et al.; Cell 71, 765 (1992) Abstract
Inhibitors of basement membrane collagen synthesis prevent endothelial cell alignment in matrigel in vitro and angiogenesis in vivo: G.C. Haralabopoulos, et al.; Lab. Invest. 71, 575 (1994) Abstract
Induction of nitric oxide synthase activity in phagocytic cells inhibited by tricyclodecan-9-yl-xanthogenate (D609): K. Tschaikowsky, et al.; Br. J. Pharmacol. 113, 664 (1994) Abstract
Prevention of experimental allergic encephalomyelitis by targeting nitric oxide and peroxynitrite: implications for the treatment of multiple sclerosis: D.C. Hooper, et al.; PNAS 94, 2528 (1997) Abstract; Full Text
The antiviral xanthate compound D609 inhibits herpes simplex virus type 1 replication and protein phosphorylation: D.G. Walro & K.S. Rosenthal; Antiviral. Res. 36, 63 (1997) Abstract
Induction of apoptosis and potentiation of TNF- and Fas-mediated apoptosis in U937 cells by the xanthogenate compound D609: M.I. Porn-Ares, et al.; Exp. Cell Res. 235, 48 (1997) Abstract
Phosphatidylcholine-specific phospholipase inhibitor D609 differentially affects MAP kinases and immediate-early genes in PC12 cells: P.J. Kahle, et al.; Cell Signal. 10, 321 (1998) Abstract
Stimulation of DNA synthesis in untransformed cells by the antiviral and antitumoral compound tricyclodecan-9-yl-xanthogenate (D609): Z. Kiss, et al.; Biochem. Pharmacol. 55, 915 (1998) Abstract
A phosphatidylcholine phospholipase C inhibitor, D609, blocks interleukin-3 (IL-3)-induced bcl-2 expression but not c-myc expression in human IL-3-dependent cells: R.A. Mufson, et al.; Exp. Cell Res. 240, 228 (1998) Abstract
D609-phosphatidylcholine-specific phospholipase C inhibitor attenuates thapsigargin-induced sodium influx in human lymphocytes: J.R. Nofer, et al.; Cell Signal. 12, 289 (2000) Abstract
D609 inhibits ionizing radiation-induced oxidative damage by acting as a potent antioxidant: D. Zhou, et al.; J. Pharmacol. Exp. Ther. 298, 103 (2001) Abstract; Full Text
D609-sensitive tyrosine phosphorylation is involved in Fas-mediated phospholipase D activation: J.G. Kim, et al.; Exp. Mol. Med. 33, 303 (2001) Abstract; Full Text
Synthesis and phospholipase C inhibitory activity of D609 diastereomers: A. Gonzalez-Roura, et al.; Lipids 37, 401 (2002) Abstract
Sphingomyelin synthase as a potential target for D609-induced apoptosis in U937 human monocytic leukemia cells: A. Meng, et al.; Exp. Cell Res. 292, 385 (2004) Abstract
Protective effect of the xanthate, D609, on Alzheimer´s amyloid beta-peptide (1-42)-induced oxidative stress in primary neuronal cells: R. Sultana, et al.; Free Radic. Res. 38, 449 (2004) Abstract
Two distinct Fas-activated signaling pathways revealed by an antitumor drug D609: L. Zhang, et al.; Oncogene 24, 2954 (2005) Abstract
Protection against amyloid beta-peptide (1-42)-induced loss of phospholipid asymmetry in synaptosomal membranes by tricyclodecan-9-xanthogenate (D609) and ferulic acid ethyl ester: implications for Alzheimer´s disease: H. Mohmmad Abdul & D.A. Butterfield; Biochim. Biophys. Acta 1741, 140 (2005) Abstract
D609 blocks cell survival and induces apoptosis in neural stem cells: N. Wang, et al.; Bioorg. Med. Chem. Lett 16, 4780 (2006) Abstract

Further Categories Containing This Product:

NOS Inhibitors (NOS Induction & Enzyme Activity) • Angiogenesis Modulators Other Products • Antitumor Agents (Enzyme Inhibitors) • Antiviral Agents Other Products

ALX-300-004

Revised 13-Mar-08

1-O-Octadecyl-2-O-methyl-sn-glycero-3-phosphocholine
SYNONYMS	2-O-Methyl-PAF-C-18 sn-ET-18-OCH₃ Edelfosine
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	Phospholipids / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-300-004-M050		50 mg	40.00 USD
ALX-300-004-M250		250 mg	160.00 USD
ALX-300-004-G001		1 g	480.00 USD

Product Specification

FORMULA:	C₂₇H₅₈NO₆P
MW:	523.7
CAS NUMBER:	77286-66-9
PURITY:	≥98%
APPEARANCE:	White amorphous powder.
SOLUBILITY:	Soluble in 100% ethanol, DMSO or dimethyl formamide.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HANDLING:	Hygroscopic.

Product Description

Produces strong antitumor and antimetastatic activities. Inhibits phosphatidylinositol specific phospholipase C and protein kinase C from various leukemic cells. Antineoplastic activity.

Product Specific Literature References

Selective destruction of human leukemic cells by alkyl- lysophospholipids: R. Andreesen, et al.; Cancer Res. 38, 3894 (1978) Abstract
Disturbance of phospholipid metabolism during the selective destruction of tumor cells induced by alkyl-lysophospholipids: M. Modolell, et al.; Cancer Res. 39, 4681 (1979) Abstract
Phospholipid-sensitive Ca2+-dependent protein phosphorylation system in various types of leukemic cells from human patients and in human leukemic cell lines HL60 and K562, and its inhibition by alkyl- lysophospholipid: D.M. Helfman, et al.; Cancer Res. 43, 2955 (1983) Abstract
Purging leukemic cells from simulated human remission marrow with alkyl- lysophospholipid: S. Okamoto, et al.; Blood 69, 1381 (1987) Abstract
HL-60 cells become resistant towards antitumor ether-linked phospholipids following differentiation into a granulocytic form: D.S. Vallari, et al.; BBRC 156, 1 (1988) Abstract
The ether lipid 1-octadecyl-2-methyl-rac-glycero-3-phosphocholine induces expression of fos and jun proto-oncogenes and activates AP-1 transcription factor in human leukaemic cells: F. Mollinedo, et al.; Biochem. J. 302, 325 (1994) Abstract
Ether lipids enhance the cytotoxic effect of teniposide and paclitaxel in liposomes against leukaemic cells in culture: B.B. Lundberg; Anticancer Drug Des. 12, 503 (1997) Abstract
Selective induction of apoptosis in cancer cells by the ether lipid ET- 18-OCH3 (Edelfosine): molecular structure requirements, cellular uptake, and protection by Bcl-2 and Bcl-X(L): F. Mollinedo, et al.; Cancer Res. 57, 1320 (1997) Abstract
The inhibition of cell signaling pathways by antitumor ether lipids: G. Arthur & R. Bittman; Biochim. Biophys. Acta. 1390, 85 (1998) Abstract
Cytotoxic etherphospholipid analogues: D. Berkovic; Gen Pharmacol. 31, 511 (1998) Abstract
Involvement of c-Jun NH2-terminal kinase activation and c-Jun in the induction of apoptosis by the ether phospholipid 1-O-octadecyl-2-O- methyl-rac-glycero-3-phosphocholine: C. Gajate, et al.; Mol. Pharmacol. 53, 602 (1998) Abstract
The anticancer drug edelfosine is a potent inhibitor of neovascularization in vivo: W.R. Vogler, et al.; Cancer Invest. 16, 549 (1998) Abstract
Liposomal ET-18-OCH(3) induces cytochrome c-mediated apoptosis independently of CD95 (APO-1/Fas) signaling: O. Cuvillier, et al.; Blood 94, 3583 (1999) Abstract
Alkyl-lysophospholipids activate the SAPK/JNK pathway and enhance radiation-induced apoptosis: G.A. Ruiter, et al.; Cancer Res. 59, 2457 (1999) Abstract
Induction of apoptosis in human mitogen-activated peripheral blood T- lymphocytes by the ether phospholipid ET-18-OCH3: involvement of the Fas receptor/ligand system: C. Cabaner, et al.; Br. J. Pharmacol. 127, 813 (1999) Abstract
Intracellular triggering of Fas, independently of FasL, as a new mechanism of antitumor ether lipid-induced apoptosis: C. Gajate, et al.; Int. J. Cancer 85, 674 (2000) Abstract
Involvement of mitochondria and caspase-3 in ET-18-OCH(3)-induced apoptosis of human leukemic cells: C. Gajate, et al.; Int. J. Cancer 86, 208 (2000) Abstract

Further Categories Containing This Product:

Phospholipase C / Related Products • PKC Inhibitors • Antitumor Agents (Enzyme Inhibitors)

ALX-300-006

Revised 03-Jul-06

1-O-Octadecyl-2-O-methyl-rac-glycero-3-phosphocholine
SYNONYMS	rac-ET-18-OCH₃ Edelfosine
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	Phospholipids / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-300-006-M050		50 mg	45.00 USD
ALX-300-006-M250		250 mg	180.00 USD

Product Specification

FORMULA:	C₂₇H₅₈NO₆P
MW:	523.7
CAS NUMBER:	70641-51-9
RTECS:	YK0718000
PURITY:	≥99%
APPEARANCE:	White to off-white amorphous solid.
SOLUBILITY:	Soluble in chloroform (50mg/ml), 100% ethanol (5mg/ml) or water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HANDLING:	Hygroscopic.
HAZARD:	MAY BE MUTAGENIC. HARMFUL.

Product Description

Produces strong antitumor and antimetastatic activities. Inhibits phosphatidylinositol specific phospholipase C and protein kinase C (PKC). Induces apoptosis.

Product Specific Literature References

Antiinvasive effect of racemic 1-O-octadecyl-2-O-methylglycero-3- phosphocholine on MO4 mouse fibrosarcoma cells in vitro: G.A. Storme, et al.; Cancer Res. 45, 351 (1985) Abstract
Cytotoxic ether phospholipids. Different affinities to lysophosphocholine acyltransferases in sensitive and resistant cells: D.B.J. Herrmann & H.A. Neumann; J. Biol. Chem. 261, 7742 (1986) Abstract; Full Text
Inhibition of Na,K-ATPase and sodium pump by anticancer ether lipids and protein kinase C inhibitors ET-18-OCH3 and BM 41.440: K. Oishi, et al.; BBRC 157, 1000 (1988) Abstract
Solubilization of the NADPH-oxidase from bone marrow derived macrophages by dialkylphospholipid and purification by HPLC-anion exchange chromatography: J. Storch & E. Ferber; Biol. Chem. Hoppe-Seyler 369, 403 (1988) Abstract
Molecular dynamics of antitumor ether-linked phospholipids in model membranes: a spin-label study: C.-S. Lai, et al.; BBRC 160, 1189 (1989) Abstract
The ether lipid 1-octadecyl-2-methyl-rac-glycero-3-phosphocholine induces expression of fos and jun proto-oncogenes and activates AP-1 transcription factor in human leukaemic cells: F. Mollinedo, et al.; Biochem. J. 302, 325 (1994) Abstract
Ether lipids enhance the cytotoxic effect of teniposide and paclitaxel in liposomes against leukaemic cells in culture: B.B. Lundberg; Anticancer Drug Des. 12, 503 (1997) Abstract
Selective induction of apoptosis in cancer cells by the ether lipid ET- 18-OCH3 (Edelfosine): molecular structure requirements, cellular uptake, and protection by Bcl-2 and Bcl-X(L): F. Mollinedo, et al.; Cancer Res. 57, 1320 (1997) Abstract
The inhibition of cell signaling pathways by antitumor ether lipids: G. Arthur & R. Bittman; Biochim. Biophys. Acta. 1390, 85 (1998) Abstract
Cytotoxic etherphospholipid analogues: D. Berkovic; Gen Pharmacol. 31, 511 (1998) Abstract
Involvement of c-Jun NH2-terminal kinase activation and c-Jun in the induction of apoptosis by the ether phospholipid 1-O-octadecyl-2-O- methyl-rac-glycero-3-phosphocholine: C. Gajate, et al.; Mol. Pharmacol. 53, 602 (1998) Abstract
The anticancer drug edelfosine is a potent inhibitor of neovascularization in vivo: W.R. Vogler, et al.; Cancer Invest. 16, 549 (1998) Abstract
Liposomal ET-18-OCH(3) induces cytochrome c-mediated apoptosis independently of CD95 (APO-1/Fas) signaling: O. Cuvillier, et al.; Blood 94, 3583 (1999) Abstract
Induction of apoptosis in human mitogen-activated peripheral blood T- lymphocytes by the ether phospholipid ET-18-OCH3: involvement of the Fas receptor/ligand system: C. Cabaner, et al.; Br. J. Pharmacol. 127, 813 (1999) Abstract
Alkyl-lysophospholipids activate the SAPK/JNK pathway and enhance radiation-induced apoptosis: G.A. Ruiter, et al.; Cancer Res. 59, 2457 (1999) Abstract
Intracellular triggering of Fas, independently of FasL, as a new mechanism of antitumor ether lipid-induced apoptosis: C. Gajate, et al.; Int. J. Cancer 85, 674 (2000) Abstract
Involvement of mitochondria and caspase-3 in ET-18-OCH(3)-induced apoptosis of human leukemic cells: C. Gajate, et al.; Int. J. Cancer 86, 208 (2000) Abstract

Further Categories Containing This Product:

Phospholipase C / Related Products • PKC Inhibitors • Antitumor Agents (Enzyme Inhibitors) • Antitumor Agents (Apoptosis Inducers)

ALX-300-045

Revised 11-Apr-06

1,2-Dipalmitoyl-sn-glycero-3-phosphate . sodium salt
SYNONYMS	DPPA (1,2-Dipalmitoyl)-L-α-phosphatidic acid . Na
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	Phospholipids / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-300-045-M050		50 mg	40.00 USD
ALX-300-045-M250		250 mg	120.00 USD
ALX-300-045-G001		1 g	280.00 USD

Product Specification

FORMULA:	C₃₅H₆₈O₈P . Na
MW:	647.9 . 23.0
CAS NUMBER:	71065-87-7
PURITY:	≥98%
APPEARANCE:	White to off-white solid.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C

Further Categories Containing This Product:

Phospholipase C / Related Products

ALX-350-020

Revised 27-Aug-08

Wortmannin
SYNONYMS	KY 12420
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Natural Products - Protein Kinase Inhibitors

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-350-020-M001		1 mg	40.00 USD
ALX-350-020-M005		5 mg	140.00 USD
ALX-350-020-M025		25 mg	290.00 USD

Product Specification

FORMULA:	C₂₃H₂₄O₈
MW:	428.4
CAS NUMBER:	19545-26-7
MERCK INDEX:	14: 10053
RTECS:	CB9641000
SOURCE/HOST:	Isolated from Talaromyces wortmannin KY 12420.
PURITY:	≥96% (HPLC)
APPEARANCE:	White to off-white solid.
SOLUBILITY:	Soluble in DMSO (25mg/ml), methanol (5mg/ml) or 100% ethanol.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HAZARD:	VERY TOXIC.

Product Description

Potent and specific inhibitor of phosphoinositide 3-kinase (PI(3)K), myosin light chain kinase and of neutrophil and formyl-Met-Leu-Phe-mediated phospholipase D activation. Strongly inhibits autophagy (proteolysis). Markedly potentiates the LPS-induced nitric oxide (NO) production from macrophages. Induces in vivo Alzheimer-like hyperphosphorylation in tau.

Product Specific Literature References

Activation of human neutrophil phospholipase D by three separable mechanisms: S.I. Reinhold, et al.; FASEB J. 4, 208 (1990) Abstract
Demethoxyviridin and wortmannin block phospholipase C and D activation in the human neutrophil: R.W. Bonser, et al.; Br. J. Pharmacol. 103, 1237 (1991) Abstract
Inhibition of IgE-mediated histamine release by myosin light chain kinase inhibitors: S. Kitani, et al.; BBRC 183, 48 (1992) Abstract
Wortmannin, a microbial product inhibitor of myosin light chain kinase: S. Nakanishi, et al.; J. Biol. Chem. 267, 2157 (1992) Abstract; Full Text
Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: the role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses: A. Arcaro & M.P. Wyman; Biochem. J. 296, 297 (1993) Abstract
Inhibition of histamine secretion by wortmannin through the blockade of phosphatidylinositol 3-kinase in RBL-2H3 cells: H. Yano, et al.; J. Biol. Chem. 268, 25846 (1993) Abstract; Full Text
Effects of wortmannin on increased glucose transport by insulin and norepinephrine in primary culture of brown adipocytes: Y. Shimizu & T. Shimazu; BBRC 202, 660 (1994) Abstract
A comparison of demethoxyviridin and wortmannin as inhibitors of phosphatidylinositol 3-kinase: R. Woscholski, et al.; FEBS Lett. 342, 109 (1994) Abstract
Wortmannin inhibits insulin-stimulated but not contraction-stimulated glucose transport activity in skeletal muscle: A.D. Lee, et al.; FEBS Lett. 361, 51 (1995) Abstract
Wortmannin, a specific inhibitor of phosphatidylinositol-3 kinase, blocks osteoclastic bone resorption: I. Nakamura, et al.; FEBS Lett. 361, 79 (1995) Abstract
Wortmannin, a specific phosphatidylinositol 3-kinase inhibitor, inhibits adipocytic differentiation of 3T3-L1 cells: K. Tomiyama, et al.; BBRC 212, 263 (1995) Abstract
Wortmannin as a unique probe for an intracellular signalling protein, phosphoinositide 3-kinase: M. Ui, et al.; TIBS 20, 303 (1995), (Review) Abstract
Wortmannin inhibits carcinogen-stimulated phosphorylation of ethanolamine and choline: Z. Kiss & M. Tomono; FEBS Lett. 358, 243 (1995) Abstract
Inhibitory effect of wortmannin on phosphatidylinositol 3-kinase-mediated cellular events: O. Hazeki, et al.; J. Lipid Mediat. Cell Signal. 14, 259 (1996)
The phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 inhibit autophagy in isolated rat hepatocytes: E.F. Blommaart, et al.; Eur. J. Biochem. 243, 240 (1997) Abstract
Wortmannin, a specific inhibitor of phosphatidylinositol-3-kinase, enhances LPS-induced NO production from murine peritoneal macrophages: Y.C. Park, et al.; BBRC 240, 692 (1997) Abstract
Alzheimer-like tau phosphorylation induced by wortmannin in vivo and its attenuation by melatonin: S.J. Liu & J.Z. Wang; Acta Pharmacol. Sin. 23, 183 (2002) Abstract
Chemistry and biology of wortmannin: P. Wipf & R.J. Halter; Org. Biomol. Chem. 3, 2053 (2005) Abstract

Further Categories Containing This Product:

Myosin Light Chain Kinase Inhibitors • Phosphoinositide 3-kinase [PI(3)K] / Related Products • Phospholipase C / Related Products • Phospholipase D / Related Products • Tau / Related Products • Natural Products - Antifungal Agents • Natural Products - Nitric Oxide Pathway Modulators • Natural Products - Apoptosis Inducers & Inhibitors • Autophagy Other Products

ALX-350-045

Revised 07-Apr-08

Manoalide
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Natural Products - Other Signal Transduction Pathway Modulators

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-350-045-C100		100 µg	80.00 USD
ALX-350-045-M001		1 mg	190.00 USD

Product Specification

FORMULA:	C₂₅H₃₆O₅
MW:	416.6
CAS NUMBER:	75088-80-1
SOURCE/HOST:	Isolated from Luffariella variabilis.
PURITY:	≥98% (TLC)
APPEARANCE:	Colorless oil.
SOLUBILITY:	Soluble in DMSO, 100% ethanol or methanol.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C

Product Description

Inhibits irreversibly phospholipase A₂ (PLA₂) by covalently modifying lysine residues. Also inhibits phospholipase C (PLC) and Ca²⁺ channels. Inhibits superoxide generation in polymorphonuclear leukocytes. Has anti-inflammatory and analgesic properties. Shows strong quorum sensing antagonism.

Product Specific Literature References

Manoalide, a natural sesterterpenoid that inhibits calcium channels: L.A. Wheeler, et al.; J. Biol. Chem. 262, 6531 (1987) Abstract; Full Text
Inactivation of human synovial fluid phospholipase A2 by the marine natural product, manoalide: P.B. Jacobson, et al.; Biochem. Pharmacol. 39, 1557 (1990) Abstract
Inhibition of venom phospholipases A2 by manoalide and manoalogue. Stoichiometry of incorporation: L.J. Reynolds, et al.; J. Biol. Chem. 266, 16512 (1991) Abstract; Full Text
Modulation of superoxide anion generation by manoalide, arachidonic acid and staurosporine in liver infiltrated neutrophils in a rat model of endotoxemia: A.M. Mayer & J.A. Spitzer; J. Pharmacol. Exp. Ther. 267, 400 (1993) Abstract
Phospholipase A2 activation in cultured mouse hepatocytes exposed to tumor necrosis factor-alpha: G.M. Adamson, et al.; J. Biochem. Toxicol. 9, 181 (1994) Abstract
Identification of two specific lysines responsible for the inhibition of phospholipase A2 by manoalide: I.D. Bianco, et al.; Biochim. Biophys. Acta 1250, 197 (1995) Abstract
Effect of manoalide on human 5-lipoxygenase activity: F. Cabre, et al.; Inflamm. Res. 45, 218 (1996) Abstract
Manoalide: A. Soriente, et al.; Curr. Med. Chem. 6, 415 (1999), Review Abstract
Quorum Sensing Antagonism from Marine Organisms: M.E. Skindersoe, et al.; Mar. Biotechnol. (NY) 10, 56 (2008) Abstract

Further Categories Containing This Product:

PLA2 Inhibitors • Phospholipase C / Related Products • Natural Products - Anti-inflammatory Agents • Ca2+ Channels Other Products • Bacteria Other Products

ALX-350-108

Revised 08-Apr-08

Pseudolaric acid B
SYNONYMS	Pseudolarix acid B PLAB PAB
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Other Natural Products - DNA Regulation / Transcription

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-350-108-MC01		0.1 mg	35.00 USD
ALX-350-108-M001		1 mg	95.00 USD

Product Specification

FORMULA:	C₂₃H₂₈O₈
MW:	432.5
CAS NUMBER:	82508-31-4
SOURCE/HOST:	Isolated from Pseudolarix kaempferi.
PURITY:	≥95%
APPEARANCE:	Off-white to light brown solid.
SOLUBILITY:	Soluble in DMSO, 100% ethanol or chloroform.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C
HANDLING:	Protect from moisture.

Product Description

Activates PPARα and the phospholipase C (PLC) signalling pathway. Stimulates peroxisomal fatty acyl-CoA oxidase activity. These effects can be blocked by staurosporine (Prod. No. ALX-380-014). Exhibits significant cytotoxic activities against numerous tumor cell lines. Binds tubulin. Inhibits angiogenesis. Reduces HIF-1α protein levels. Induces apoptosis. Antifungal.

Product Specific Literature References

Pseudolaric Acids from Pseudolarix kaempferi: B.N. Zhou, et al.; Planta Med. 47, 35 (1983) Abstract
The cytotoxic principles of Pseudolarix kaempferi: pseudolaric acid-A and -B and related derivatives: D.J. Pan, et al.; Planta Med. 56, 383 (1990) Abstract
Antifungal evaluation of pseudolaric acid B, a major constituent of Pseudolarix kaempferi: E. Li, et al.; J. Nat. Prod. 58, 57 (1995) Abstract
Pseudolaric acid analogs as a new class of peroxisome proliferator-activated receptor agonists: M.S. Jardat, et al.; Planta Med. 68, 667 (2002) Abstract
Five new diterpenoids from Pseudolarix kaempferi: S.P. Yang, et al.; J. Nat. Prod. 65, 1041 (2002) Abstract
Antifungal diterpenoids of Pseudolarix kaempferi, and their structure-activity relationship study: S.P. Yang, et al.; Bioorg. Med. Chem. 11, 4577 (2003) Abstract
Pseudolarix acid B inhibits angiogenesis by antagonizing the vascular endothelial growth factor-mediated anti-apoptotic effect: W.F. Tan, et al.; Eur. J. Pharmacol. 499, 219 (2004) Abstract
Pseudolaric acid B inhibits angiogenesis and reduces hypoxia-inducible factor 1alpha by promoting proteasome-mediated degradation: M.H. Li, et al.; Clin. Cancer Res. 10, 8266 (2004) Abstract
Pseudolaric acid B induces apoptosis through p53 and Bax/Bcl-2 pathways in human melanoma A375-S2 cells: X.F. Gong, et al.; Arch. Pharm. Res. 28, 68 (2005) Abstract
Pseudolaric acid B, a novel microtubule-destabilizing agent that circumvents multidrug resistance phenotype and exhibits antitumor activity in vivo: V.K. Wong, et al.; Clin. Cancer Res. 11, 6002 (2005) Abstract
Effect of pseudolaric acid B on gastric cancer cells: inhibition of proliferation and induction of apoptosis: K.S. Li, et al.; World J. Gastroenterol. 11, 7555 (2005) Abstract; Full Text
Pseudolarix acid B, a new tubulin-binding agent, inhibits angiogenesis by interacting with a novel binding site on tubulin: Y.G. Tong, et al.; Mol. Pharmacol. 69, 1226 (2006) Abstract
Involvement of JNK-initiated p53 accumulation and phosphorylation of p53 in pseudolaric acid B induced cell death: X. Gong, et al.; Exp. Mol. Med. 38, 428 (2006) Abstract; Full Text
Studies on anti-tumour activities of pseudolaric acid-B (PLAB) and its mechanism of action: B. Liu, et al.; J. Asian Nat. Prod. Res. 8, 241 (2006)