Advanced Search
© 2008 Alexis Corporation
You are here:
Product Lines
>
Signal Transduction
> Signal Transduction Enzymes / Related Products
ATPases / Related Products
Coenzymes & Vitamins / Related Products
Cyclases / Related Products
Kinases / Related Products
Oxygenases / Related Products
Phosphatases / Related Products
Phosphodiesterases / Related Products
Proteases / Related Products
Transglutaminases / Related Products
Toolbar - View Selection
Current View:
Price List
Brief
Detail
Search Results
Current Sort:
Sort by Product Name
Sort by Product ID
Sort by Result Relevance
Sort by Class
Show:
20 Products
50 Products
100 Products
All Products
Show Selected Products Only
Show
Products Only
Items
140-160
of 1333
Page 8
of 67
Select Page:
<<
1
2
3
4
5
6
7
8
9
10
>>
ALX-260-034
Revised 10-Feb-05
Biotinyl-DEVD-CHO
SYNONYMS
Caspase-3 Inhibitor (Aldehyde)
Caspase-7 Inhibitor (Aldehyde)
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Caspase Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-260-034-M001
1 mg
82.00 USD
ALX-260-034-M005
5 mg
323.00 USD
Product Specification
SEQUENCE:
Biotinyl-Asp-Glu-Val-Asp-CHO
FORMULA:
C
28
H
42
N
6
O
12
S
MW:
686.7
PEPTIDE CONTENT:
65-90%.
PURITY:
≥99% (HPLC)
APPEARANCE:
White powder.
FORMULATION:
Lyophilized.
SOLUBILITY:
Soluble in 50% acetic acid with agitation (1mg/ml).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Packaged under inert gas.
Product Description
Reversible inhibitor of caspase-3 and -7. Useful for the purification or extract depletion of caspase-3 in conjunction with streptavidin conjugates.
Product Specific Literature References
Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis:
D.W. Nicholson, et al.; Nature
376
, 37 (1995)
Abstract
ALX-260-098
Revised 20-Aug-08
Biotinyl-VAD(OMe)-FMK
SYNONYMS
Caspase Family Inhibitor (Fluoromethylketone)
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Caspase Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-260-098-M001
1 mg
420.00 USD
Product Specification
SEQUENCE:
Biotinyl-Ahx-Val-Ala-Asp(OMe)-fluoromethylketone
FORMULA:
C
30
H
49
FN
6
O
8
S
MW:
672.8
PURITY:
≥90% (TLC)
APPEARANCE:
Off-white to brown powder.
SOLUBILITY:
Soluble in DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stock solutions should be divided into aliquots and stored at -20°C. The stock solution is stable at -20°C for 6-8 months.
HANDLING:
Keep cool and dry.
Product Description
Irreversible, cell permeable broad-spectrum caspase inhibitor.
Product Specific Literature References
Nitric oxide suppresses apoptosis via interrupting caspase activation and mitochondrial dysfunction in cultured hepatocytes
:
J. Li, et al.; J. Biol. Chem.
274
, 17325 (1999)
Abstract
;
Full Text
ALX-260-019
Revised 23-Jun-06
Biotinyl-YVAD-CMK
SYNONYMS
Caspase-1 Inhibitor (Chloromethylketone)
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Caspase Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-260-019-M001
1 mg
120.00 USD
ALX-260-019-M005
5 mg
480.00 USD
Product Specification
SEQUENCE:
Biotinyl-Tyr-Val-Ala-Asp-chloromethylketone
FORMULA:
C
32
H
45
N
6
O
9
SCl
MW:
725.3
PURITY:
≥98% (HPLC)
APPEARANCE:
White to off-white powder.
FORMULATION:
Lyophilized.
SOLUBILITY:
Soluble in trifluoroacetic acid (50%).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stock solutions should be divided into aliquots and stored at -20°C.
Product Description
Irreversible, cell permeable inhibitor of caspase-1. Inhibits also caspase-4.
Product Specific Literature References
Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE:
Y.A. Lazebnik, et al.; Nature
371
, 346 (1994)
Abstract
ALX-270-049
Revised 13-Nov-06
Bisindolylmaleimide I
SYNONYMS
GF-109203X
Gö 6850
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
PKC Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-049-M001
1 mg
45.00 USD
ALX-270-049-M005
5 mg
150.00 USD
Product Specification
FORMULA:
C
25
H
24
N
4
O
2
MW:
412.5
CAS NUMBER:
133052-90-1
PURITY:
≥98%
APPEARANCE:
Orange solid.
SOLUBILITY:
Soluble in DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
HAZARD:
MAY BE CARCINOGENIC. HARMFUL.
Product Description
Cell permeable kinase inhibitor with improved selectivity for protein kinase C (PKC) (K
i
=10nM) over several serine/threonine and tyrosine kinases as compared to staurosporine (Prod. No.
ALX-380-014
). Acts as a competetive inhibitor for the ATP-binding site of PKC. Also inhibits telomerase activity in quercetin (Prod. No.
ALX-385-001
), H-89 (Prod. No.
ALX-270-017
), or herbimycin A (Prod. No.
ALX-350-029
) treated NPC-076 cells. Inhibits protein kinase A at much higher concentrations (K
i
=2µM).
Product Specific Literature References
The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C:
D. Toullec, et al.; J. Biol. Chem.
266
, 15771 (1991)
Abstract
;
Full Text
Anti-inflammatory properties of the protein kinase C inhibitor, 3-[1-[3- (dimethylamino)propyl]-1H-indol-3-yl]-4-(1H-indol-3-yl)-1H- pyrrole-2,5- dione monohydrochloride (GF109203X) in the PMA-mouse ear edema model:
S. Kuchera, et al.; Agents Actions
39
, C169 (1993)
Abstract
The bisindolylmaleimide GF 109203X, a selective inhibitor of protein kinase C, does not inhibit the potentiating effect of phorbol ester on ethanol-induced phospholipase C-mediated hydrolysis of phosphatidylethanolamine:
Z. Kiss, et al.; Biochim. Biophys. Acta
1265
, 93 (1995)
Abstract
Effects of the selective bisindolylmaleimide protein kinase C inhibitor GF 109203X on P-glycoprotein-mediated multidrug resistance
:
V. Gekeler, et al.; Br. J. Cancer
74
, 897 (1996)
Abstract
Inhibition of telomerase activity by PKC inhibitors in human nasopharyngeal cancer cells in culture
:
W.C. Ku, et al.; Biochem. Biophys. Res. Commun.
241
, 730 (1997)
Abstract
Suprabasin, a Novel Epidermal Differentiation Marker and Potential Cornified Envelope Precursor
:
G.T. Park, et al.; JBC
277
, 45195 (2002)
Abstract
;
Full Text
ALX-270-019
Revised 27-Apr-06
Bisindolylmaleimide I . hydrochloride
SYNONYMS
GF-109203X . HCl
Gö 6850 . HCl
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
PKC Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-019-M001
1 mg
45.00 USD
ALX-270-019-M005
5 mg
150.00 USD
Product Specification
FORMULA:
C
25
H
24
N
4
O
2
. HCl
MW:
412.5 . 36.5
PURITY:
≥98%
APPEARANCE:
Orange to red powder.
SOLUBILITY:
Soluble in DMSO or methanol. Slightly soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
Product Description
Water soluble form of bisindolylmaleimide I (Prod. No.
ALX-270-049
), a protein kinase C (PKC) inhibitor.
Product Specific Literature References
The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C:
D. Toullec, et al.; J. Biol. Chem.
266
, 15771 (1991)
Abstract
;
Full Text
Anti-inflammatory properties of the protein kinase C inhibitor, 3-[1-[3- (dimethylamino)propyl]-1H-indol-3-yl]-4-(1H-indol-3-yl)-1H- pyrrole-2,5- dione monohydrochloride (GF109203X) in the PMA-mouse ear edema model:
S. Kuchera, et al.; Agents Actions
39
, C169 (1993)
Abstract
Stimulation of the ERK pathway by GTP-loaded Rap1 requires the concomitant activation of Ras, protein kinase C, and protein kinase A in neuronal cells:
T. Bouschet, et al.; J. Biol. Chem.
278
, 4778 (2003)
Abstract
;
Full Text
ALX-270-050
Revised 26-May-08
Bisindolylmaleimide II
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
PKC Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-050-M001
1 mg
45.00 USD
ALX-270-050-M005
5 mg
150.00 USD
Product Specification
FORMULA:
C
27
H
26
N
4
O
2
MW:
438.5
PURITY:
≥97% (mixture of 2 isomers)
APPEARANCE:
Orange solid.
SOLUBILITY:
Soluble in DMSO or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
ALX-270-051
Revised 18-Jan-08
Bisindolylmaleimide III
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
PKC Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-051-M001
1 mg
45.00 USD
ALX-270-051-M005
5 mg
150.00 USD
Product Specification
FORMULA:
C
23
H
20
N
4
O
2
MW:
384.4
PURITY:
≥98%
APPEARANCE:
Red solid.
SOLUBILITY:
Soluble in methanol or DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
Product Description
Potent and selective inhibitor of protein kinase C (PKC).
Product Specific Literature References
The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C:
D. Toullec, et al.; J. Biol. Chem.
266
, 15771 (1991)
Abstract
;
Full Text
Protein kinase C inhibitors; structure-activity relationships in K252c- related compounds:
S. Fabre and M. Prudhomme; Bioorg. Med. Chem.
1
, 193 (1993)
Abstract
Inhibitors of protein kinase C. 1. 2,3-Bisarylmaleimides:
P.D. Davis, et al.; J. Med. Chem.
35
, 177 (1992)
Abstract
Proteome-wide identification of cellular targets affected by bisindolylmaleimide-type protein kinase C inhibitors:
D. Brehmer, et al.; Mol. Cell Proteomics
3
, 490 (2004)
Abstract
;
Full Text
ALX-270-052
Revised 05-Oct-06
Bisindolylmaleimide IV
SYNONYMS
Ro 31-6233
Arcyriarubin A
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
PKC Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-052-M001
1 mg
45.00 USD
ALX-270-052-M005
5 mg
150.00 USD
Product Specification
FORMULA:
C
20
H
13
N
3
O
2
MW:
327.3
CAS NUMBER:
119139-23-0
PURITY:
≥98%
APPEARANCE:
Red solid.
SOLUBILITY:
Soluble in DMSO or methanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
Product Specific Literature References
D. Toullec, et al.; J. Biol. Chem.
266
, 15771 (1991)
Abstract
;
Full Text
Protein kinase C inhibitors; structure-activity relationships in K252c- related compounds:
S. Fabre & M. Prudhomme; Bioorg. Med. Chem.
1
, 193 (1993)
Abstract
Inhibitors of protein kinase C. 1. 2,3-Bisarylmaleimides:
P.D. Davis, et al.; J. Med. Chem.
35
, 177 (1992)
Abstract
ALX-270-053
Revised 29-Jul-05
Bisindolylmaleimide V
SYNONYMS
Ro 31-6045
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
PKC Negative Controls
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-053-M001
1 mg
45.00 USD
ALX-270-053-M005
5 mg
150.00 USD
Product Specification
FORMULA:
C
21
H
15
N
3
O
2
MW:
341.4
CAS NUMBER:
113963-68-1
PURITY:
≥98%
APPEARANCE:
Red solid.
SOLUBILITY:
Soluble in DMSO or methanol; very slightly soluble in 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
Product Description
Negative control for the protein kinase C (PKC)-inhibitory activity.
Product Specific Literature References
The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C:
D. Toullec, et al.; J. Biol. Chem.
266
, 15771 (1991)
Abstract
;
Full Text
Inhibitors of protein kinase C. 1. 2,3-Bisarylmaleimides:
P.D. Davis, et al.; J. Med. Chem.
35
, 177 (1992)
Abstract
ALX-270-054
Revised 07-Dec-04
Bisindolylmaleimide VI
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
PKC Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-054-M001
1 mg
45.00 USD
ALX-270-054-M005
5 mg
150.00 USD
Product Specification
FORMULA:
C
27
H
26
N
4
O
2
MW:
438.5
PURITY:
≥96% (mixture of 2 isomers)
APPEARANCE:
Red solid.
SOLUBILITY:
Soluble in DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
Product Description
Selective inhibitor of protein kinase C (PKC).
ALX-270-055
Revised 07-Dec-04
Bisindolylmaleimide VII
PRODUCT LINE
Signal Transduction
