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Items 16 of 16
ALX-350-104
Revised 10-May-07
Aaptamine
SYNONYMS
8,9-Dimethoxy-1
H
-benzo[
de
][1,6]naphtyridine
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Other Toxins
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ALX-350-104-M001
1 mg
90.00 USD
Product Specification
FORMULA:
C
13
H
12
N
2
O
2
MW:
228.3
CAS NUMBER:
85547-22-4
SOURCE/HOST:
Isolated from the sponge
Aaptos aaptos
.
PURITY:
≥97%
APPEARANCE:
Oil.
SOLUBILITY:
Soluble in DMSO or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
HAZARD:
TOXIC.
Product Description
Competitive antagonist of α-adrenoceptors in vascular smooth muscle cells. Inhibits cancer cell growth.
Product Specific Literature References
Alpha-adrenoceptor blocking action of aaptamine, a novel marine natural product, in vascular smooth muscle
:
Y. Ohizumi, et al.; J. Pharm. Pharmacol.
36
, 785 (1984)
Abstract
Antineoplastic agents 491. Synthetic conversion of aaptamine to isoaaptamine, 9-demethylaaptamine, and 4-methylaaptamine:
G.R. Pettit, et al.; J. Org. Chem.
69
, 2251 (2004)
Abstract
Aaptamine, a spongean alkaloid, activates p21 promoter in a p53-independent manner:
S. Aoki, et al.; BBRC
342
, 101 (2006)
Abstract
Further Categories Containing This Product:
Adrenergics & Adrenergic Receptors / Related Products
•
Natural Products - Antitumor Reagents
•
Antitumor Agents (Anti-proliferative)
•
Alkaloids
•
Marine Natural Products
ALX-550-144
Revised 09-Dec-04
Buspirone . hydrochloride
SYNONYMS
8-[4-[4-(2-Pyrimidinyl)-1-piperazinyl]butyl]-8-azaspiro[4,5]decane-7,9-dione . HCl
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Serotonergics & Serotonin Receptors / Related Products
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ALX-550-144-G001
1 g
48.00 USD
Product Specification
FORMULA:
C
21
H
31
N
5
O
2
. HCl
MW:
385.5 . 36.5
CAS NUMBER:
33386-08-2
MERCK INDEX:
14:
1504
PURITY:
≥96%
APPEARANCE:
White solid.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HAZARD:
TOXIC.
Product Description
5-HT
1A
serotonin receptor agonist.
Product Specific Literature References
The discovery and development of buspirone: a new approach to the treatment of anxiety
:
J.S. New; Med. Res. Rev.
10
, 283 (1990), (Review)
Abstract
Further Categories Containing This Product:
Dopaminergics & Dopamine Receptors / Related Products
•
Benzodiazepines / Related Products
•
Adrenergics & Adrenergic Receptors / Related Products
ALX-550-077
Revised 26-Apr-07
Clenbuterol . hydrochloride
SYNONYMS
4-Amino-3,5-dichloro-α-[[(1,1-dimethylethyl)amino]methyl]benzenemethanol . HCl
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Adrenergics & Adrenergic Receptors / Related Products
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ALX-550-077-M050
50 mg
20.00 USD
ALX-550-077-M250
250 mg
50.00 USD
ALX-550-077-G001
1 g
150.00 USD
Product Specification
FORMULA:
C
12
H
18
Cl
2
N
2
O . HCl
MW:
277.2 . 36.5
CAS NUMBER:
21898-19-1
MERCK INDEX:
14:
2347
RTECS:
DN3180000
PURITY:
≥99%
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in water, methanol or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+20°C
HAZARD:
TOXIC.
Product Description
β
2
-Adrenergic receptor agonist. Bronchodilator.
Product Specific Literature References
Thiokynurenates: a new group of antagonists of the glycine modulatory site of the NMDA receptor:
F. Moroni, et al.; Eur. J. Pharmacol.
199
, 227 (1991)
Abstract
Function and regulation of the beta 3-adrenoceptor:
A.D. Strosberg & F. Pietri-Rouxel; TIPS
17
, 373 (1996), (Review)
Abstract
ALX-550-087
Revised 15-Sep-08
Clonidine . hydrochloride
SYNONYMS
2
-
(2,6
-
Dichloroanilino)
-
2
-
imidazoline . hydrochloride
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Adrenergics & Adrenergic Receptors / Related Products
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ALX-550-087-M050
50 mg
23.00 USD
Product Specification
FORMULA:
C
9
H
9
Cl
2
N
3
. HCl
MW:
230.1 . 36.5
CAS NUMBER:
4205-91-8
MERCK INDEX:
14:
2390
RTECS:
NJ2490000
PURITY:
≥98% (HPLC)
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in water (50mg/ml) or methanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HAZARD:
VERY TOXIC.
Product Description
α
2
-Adrenergic receptor agonist. Antihypertensive.
Further Categories Containing This Product:
Imidazoline Binding Site Ligands
ALX-550-316
Revised 28-Jan-05
DSP-4 . hydrochloride
SYNONYMS
N-(2-Chloroethyl)-N-ethyl-2'-bromobenzylamine . HCl
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Adrenergics & Adrenergic Receptors / Related Products
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ALX-550-316-M005
5 mg
22.00 USD
Product Specification
FORMULA:
C
11
H
15
BrClN . HCl
MW:
276.6 . 36.5
CAS NUMBER:
40616-75-9
PURITY:
≥98%
APPEARANCE:
White hygroscopic solid.
SOLUBILITY:
Soluble in ethanol or water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+20°C
Product Description
Adrenergic neuron blocking agent with long-lasting inhibitory effect on the uptake of noradrenaline (norepinephrine) in brain slices.
Product Specific Literature References
Cyclizing compounds. I. Tertiary N-(2-bromobenzyl)-N-haloalkylamines with adrenergic blocking action:
S.B. Ross, et al.; Acta Pharm. Suecica
10
, 29 (1973)
Abstract
DSP-4: a novel compound with neurotoxic effects on noradrenergic neurons of adult and developing rats:
Etcheverry, et al.; Brain Res.
188
, 513 (1980)
Abstract
DSP4 (N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine)--a useful denervation tool for central and peripheral noradrenaline neurons:
Jonsson, et al.; Eur. J. Pharmacol.
72
, 173 (1981)
Abstract
Effect of DSP-4, pCPA, and haloperidol on hippocampal electrical activity and behavior in rabbits:
Fontani, et al.; Behav. Neural Biol.
40
, 213 (1984)
Abstract
ALX-350-092
Revised 03-Apr-08
Emetine . dihydrochloride
SYNONYMS
6’,7’,10,11-Tetramethoxyemetan . 2HCl
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products - DNA Replication Inhibitors
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ALX-350-092-M050
50 mg
10.00 USD
Product Specification
FORMULA:
C
29
H
40
N
2
O
4
. 2HCl
MW:
480.7 . 73.0
CAS NUMBER:
316-42-7
MERCK INDEX:
14:
3559
SOURCE/HOST:
Isolated from ground roots of
Uragoga ipecacuanha
.
PURITY:
≥98%
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in water or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HANDLING:
Protect from light. Hygroscopic.
HAZARD:
TOXIC.
Product Description
Irreversibly blocks protein synthesis by inhibiting the movement of ribosome along the mRNA. Induces hypotension by blocking adrenoreceptors. Inhibits DNA replication in the early S phase. Inhibits HIF-1 activation by hypoxia. Induces apoptosis in leukemia cells. Antiamebic.
Product Specific Literature References
Inhibitors of protein biosynthesis. V. Effects of emetine on protein and nucleic acid biosynthesis in HeLa cells:
A.P. Grollman; J. Biol. Chem.
243
, 4089 (1968)
Abstract
Cytometric analysis of DNA replication inhibited by emetine and cyclosporin A::
A: T. Schweighoffer, et al.; Histochemistry
96
, 93 (1991)
Abstract
Emetine allows identification of origins of mammalian DNA replication by imbalanced DNA synthesis, not through conservative nucleosome segregation:
W.C. Burhans, et al.; EMBO J.
10
, 4351 (1991)
Abstract
Role of newly synthesized MHC class II molecules in antigen-specific antigen presentation by B cells:
T. Kokuho, et al.; Immunobiology
193
, 42 (1995)
Abstract
Terpenoid tetrahydroisoquinoline alkaloids emetine, klugine, and isocephaeline inhibit the activation of hypoxia-inducible factor-1 in breast tumor cells:
Y.D. Zhou, et al.; J. Nat. Prod.
68
, 947 (2005)
Abstract
The alkaloid emetine as a promising agent for the induction and enhancement of drug-induced apoptosis in leukemia cells:
M. Moller, et al.; Oncol. Rep.
18
, 737 (2007)
Abstract
Characteristics of apoptosis induction by the alkaloid emetine in human tumour cell lines:
M. Moller & M. Wink; Planta Med.
73
, 1389 (2007)
Abstract
Further Categories Containing This Product:
Other Toxins
•
Adrenergics & Adrenergic Receptors / Related Products
•
Translation Inhibitors
•
Hypoxia-inducible Factor [HIF] / Related Products
•
Natural Products - Other Anti-infective Agents
•
Parasitic Diseases Other Products
•
Natural Products for Neurological Research
•
DNA Replication Inhibitors
•
Natural Products - Apoptosis Inducers & Inhibitors
•
Alkaloids
ALX-550-274
Revised 03-Mar-05
(±)-Niguldipine . hydrochloride
SYNONYMS
(±)-1,4-Dihydro-2,6-dimethyl-4-(3'-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-(4',4'-diphenyl-1'-piperidinyl)propylmethyl ester . HCl
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Ca2+ Channels (L-type)
Ordering Information
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ALX-550-274-M005
5 mg
35.00 USD
ALX-550-274-M025
25 mg
110.00 USD
Product Specification
FORMULA:
C
36
H
39
N
3
O
6
. HCl
MW:
609.7 . 36.5
CAS NUMBER:
113317-61-6
PURITY:
≥95%
APPEARANCE:
Off-white to yellow solid.
SOLUBILITY:
Soluble in DMSO or acetone.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light. Adsorbs strongly to plastic.
Product Description
Extremely potent (picomolar range) inhibitor of α
1A
-adrenergic receptors and L-type Ca
2+
channels.
Product Specific Literature References
Stereoselective binding of niguldipine enantiomers to alpha 1A- adrenoceptors labeled with [3H]5-methyl-urapidil:
I. Graziadei, et al.; Eur. J. Pharmacol.
172
, 329 (1989)
Abstract
Niguldipine discriminates between alpha 1-adrenoceptor-mediated second messenger responses in rat cerebral cortex slices:
J.P. Robinson & D.A. Kendall; Br. J. Pharmacol.
100
, 3 (1990)
Abstract
Further Categories Containing This Product:
Adrenergics & Adrenergic Receptors / Related Products
ALX-550-276
Revised 03-Mar-05
S-(+)-Niguldipine . hydrochloride
SYNONYMS
S-(+)-1,4-Dihydro-2,6-dimethyl-4-(3'-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-(4',4'-diphenyl-1'-piperidinyl)propylmethyl ester . HCl
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Ca2+ Channels (L-type)
Ordering Information
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ALX-550-276-M005
5 mg
160.00 USD
Product Specification
FORMULA:
C
36
H
39
N
3
O
6
. HCl
MW:
609.7 . 36.5
CAS NUMBER:
113165-32-5
APPEARANCE:
Yellow solid.
SOLUBILITY:
Soluble in DMSO or methanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light. Adsorbs strongly to plastic.
Product Description
Extremely potent (picomolar range) inhibitor of α
1A
-adrenergic receptors and L-type Ca
2+
channels.
Product Specific Literature References
(+)-Niguldipine binds with very high affinity to Ca2+ channels and to a subtype of alpha 1-adrenoceptors:
R. Boer, et al.; Eur. J. Pharmacol.
172
, 131 (1989)
Abstract
Stereoselective binding of niguldipine enantiomers to alpha 1A- adrenoceptors labeled with [3H]5-methyl-urapidil:
I. Graziadei, et al.; Eur. J. Pharmacol.
172
, 329 (1989)
Abstract
Pharmacological modulation of calcium and potassium channels in isolated vascular smooth muscle cells:
U. Klockner, et al.; Arzneimittelforschung
39
, 120 (1989)
Abstract
Niguldipine discriminates between alpha 1-adrenoceptor-mediated second messenger responses in rat cerebral cortex slices:
J.P. Robinson & D.A. Kendall; Br. J. Pharmacol.
100
, 3 (1990)
Abstract
Further Categories Containing This Product:
Adrenergics & Adrenergic Receptors / Related Products
ALX-550-076
Revised 29-Apr-08
L-Norepinephrine . bitartrate . monohydrate
SYNONYMS
L-4-(2-Amino-1-hydroxyethyl)-1,2-benzenediol . C
4
H
6
O
6
. H
2
O
L-Noradrenaline . C
4
H
6
O
6
. H
2
O
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Adrenergics & Adrenergic Receptors / Related Products
Ordering Information
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ALX-550-076-G001
1 g
60.00 USD
Product Specification
FORMULA:
C
8
H
11
NO
3
. C
4
H
6
O
6
. H
2
O
MW:
169.2 . 150.1 . 18.0
CAS NUMBER:
69815-49-2
MERCK INDEX:
14:
6695
PURITY:
≥98% (Assay)
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
USE/STABILITY:
Solutions may oxidize when exposed to air.
HANDLING:
Protect from light.
HAZARD:
VERY TOXIC.
Product Description
Adrenergic neurotransmitter.
ALX-210-147
Revised 27-Mar-08
Polyclonal Antibody to Adrenergic Receptor α2a
SYNONYMS
anti-Adrenoceptor α2a PAb
anti-Adrenoreceptor α2a PAb
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Adrenergics & Adrenergic Receptors / Related Products
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ALX-210-147-R100
100 µl
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
Rat
SOURCE/HOST:
From rabbit.
CONCENTRATION:
0.6mg/ml
PURITY DETAIL:
Epitope-affinity purified IgG.
FORMULATION:
Liquid. In PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 218-235 (R
218
IYQIAKRRTRV
PPSRRG
235
) of human AR α-2a (adrenergic receptor α-2a). This sequence is completely conserved in mouse, rat and pig AR α-2a.
SPECIFICITY:
Recognizes mouse and rat AR α-2a. Detects a band of ~45kDa by Western blot.
APPLICATION:
Immunohistochemistry (paraffin sections (1:1’000))
Western Blot (1:500)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-146
Revised 27-Mar-08
Polyclonal Antibody to Adrenergic Receptor α-1
SYNONYMS
anti-AR α-1 PAb
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Adrenergics & Adrenergic Receptors / Related Products
Ordering Information
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Format:
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ALX-210-146-R100
100 µl
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
SOURCE/HOST:
From rabbit.
